{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:54:14Z","timestamp":1790049254186,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"crossref","award":["2018YFD0501506"],"award-info":[{"award-number":["2018YFD0501506"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.vetmic.2019.03.022","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T12:23:37Z","timestamp":1553257417000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Development of an attenuated live vaccine candidate of duck Tembusu virus strain"],"prefix":"10.1016","volume":"231","author":[{"given":"Dalin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxiang","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2019.03.022_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/emboj.2011.254","article-title":"A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin","author":"Cao","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0010","doi-asserted-by":"crossref","DOI":"10.3201\/eid1710.101890","article-title":"Tembusu virus in ducks","author":"Cao","year":"2011","journal-title":"China. Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0015","article-title":"Development and evaluation of a DAS-ELISA for rapid detection of tembusu virus using monoclonal antibodies against the envelope protein","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2019.03.022_bib0020","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1586\/erv.09.73","article-title":"Generating flavivirus vaccine candidates by modulating interferon sensitivity","volume":"8","author":"Funk","year":"2009","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.vetmic.2019.03.022_bib0025","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1093\/infdis\/jiv179","article-title":"Safety and immunogenicity of a live attenuated tetravalent dengue vaccine candidate in flavivirus-naive adults: a randomized, double-blinded phase 1 clinical trial","volume":"212","author":"George","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0030","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.78.9.4761-4775.2004","article-title":"Safety and efficacy of chimeric yellow fever-dengue virus tetravalent vaccine formulations in nonhuman primates","author":"Guirakhoo","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0035","doi-asserted-by":"crossref","DOI":"10.1007\/s11262-012-0753-6","article-title":"Identification and genomic analysis of two duck-origin Tembusu virus strains in southern China","author":"Li","year":"2012","journal-title":"Virus Genes"},{"key":"10.1016\/j.vetmic.2019.03.022_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-422X-10-260","article-title":"Duck Tembusu virus exhibits neurovirulence in BALB\/c mice","volume":"10","author":"Li","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0045","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1637\/10484-010713-Reg.1","article-title":"Development and validation of one-step SYBR green real-time RT-PCR for the rapid detection of newly emerged duck Tembusu virus","volume":"57","author":"Liu","year":"2013","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0050","article-title":"Efficacy, duration, and onset of immunogenicity of a West Nile virus vaccine, live Flavivirus chimera, in horses with a clinical disease challenge model","author":"Long","year":"2007","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2016.03.030","article-title":"Liposomes containing recombinant E protein vaccine against duck Tembusu virus in ducks","author":"Ma","year":"2016","journal-title":"Vaccine."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0060","doi-asserted-by":"crossref","DOI":"10.1038\/nrmicro1067","article-title":"A structural perspective of the Flavivirus life cycle","author":"Mukhopadhyay","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/0042-6822(90)90519-W","article-title":"Nucleotide sequence of the virulent SA-14 strain of Japanese encephalitis virus and its attenuated vaccine derivative, SA-14-14-2","author":"Nitayaphan","year":"1990","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2019.03.022_bib0070","doi-asserted-by":"crossref","DOI":"10.1186\/s12917-017-1134-0","article-title":"Preparation and evaluation of goose reovirus inactivated vaccine","author":"Niu","year":"2017","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018106","article-title":"Duck egg-drop syndrome caused by BYD virus, a new Tembusu-related flavivirus","author":"Su","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2019.03.022_bib0080","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1128\/CVI.00154-14","article-title":"Adaptation and attenuation of duck Tembusu virus strain Du\/CH\/LSD\/110128 following serial passage in chicken embryos","volume":"21","author":"Sun","year":"2014","journal-title":"Clin. Vaccine Immunol. Cvi."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2013.10.003","article-title":"Tembusu virus infection in Cherry Valley ducks: the effect of age at infection","author":"Sun","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0090","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1865-1682.2011.01275.x","article-title":"Analysis of the complete genome of tembusu virus, a Flavivirus isolated from ducks in China","volume":"59","author":"Tang","year":"2012","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0095","doi-asserted-by":"crossref","DOI":"10.1111\/j.1865-1682.2012.01328.x","article-title":"Characterization of a Tembusu virus isolated from naturally infected House sparrows (Passer domesticus) in Northern China","author":"Tang","year":"2013","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0100","doi-asserted-by":"crossref","DOI":"10.1111\/tbed.12085","article-title":"Tembusu virus in human, China","author":"Tang","year":"2013","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0105","doi-asserted-by":"crossref","DOI":"10.1111\/tbed.12111","article-title":"Isolation and genetic characterization of a Tembusu virus strain isolated from mosquitoes in Shandong, China","author":"Tang","year":"2015","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035161","article-title":"Transmission dynamics of the recently-identified BYD virus causing duck egg-drop syndrome","author":"Vaidya","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2019.03.022_bib0115","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1186\/1743-422X-8-553","article-title":"Rapid detection of newly isolated tembusu-related by reverse-transcription loop-mediated isothermal amplification assay","volume":"8","author":"Wang","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0120","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1186\/1743-422X-8-553","article-title":"Rapid detection of newly isolated Tembusu-related Flavivirus by reverse-transcription loop-mediated isothermal amplification assay","volume":"8","author":"Wang","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0125","doi-asserted-by":"crossref","DOI":"10.4269\/ajtmh.2011.10-0501","article-title":"Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus-naive infants","author":"Watanaveeradej","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2011.06.003","article-title":"An infectious disease of ducks caused by a newly emerged Tembusu virus strain in mainland China","author":"Yan","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2019.03.022_bib0135","article-title":"Development of a one-step real-time RT-PCR assay using a minor-groove-binding probe for the detection of duck Tembusu virus","author":"Yun","year":"2012","journal-title":"J. Virol. Methods."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0140","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.07132-11","article-title":"Complete genome sequence of a novel Flavivirus, duck tembusu virus, isolated from ducks and geese in China","author":"Yun","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0145","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01657-15","article-title":"Whole-genome sequence of duck Tembusu virus strain DTMUV\/CH\/2014, isolated in China","author":"Zhou","year":"2016","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2019.03.022_bib0150","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02361-12","article-title":"Complete genome sequence of duck Tembusu virus, isolated from muscovy ducks in Southern China","author":"Zhu","year":"2012","journal-title":"J. Virol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113518312604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113518312604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T23:38:27Z","timestamp":1590017907000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113518312604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":30,"alternative-id":["S0378113518312604"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.03.022","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of an attenuated live vaccine candidate of duck Tembusu virus strain","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}