{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:44:09Z","timestamp":1792806249386,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"crossref","award":["2017YFD0500203"],"award-info":[{"award-number":["2017YFD0500203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Special Fund for Agro-scientific Research in Public Interest","award":["201403054"],"award-info":[{"award-number":["201403054"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund of China","doi-asserted-by":"crossref","award":["31672574"],"award-info":[{"award-number":["31672574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Fund of China","doi-asserted-by":"crossref","award":["31872480"],"award-info":[{"award-number":["31872480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agriculture Science and Technology Innovation Fund","doi-asserted-by":"crossref","award":["CX(16)1028"],"award-info":[{"award-number":["CX(16)1028"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.vetmic.2019.04.023","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T17:06:18Z","timestamp":1555520778000},"page":"28-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Identification of novel genes associated with anti-phagocytic functions in Streptococcus equi subsp. zooepidemicus"],"prefix":"10.1016","volume":"233","author":[{"given":"Bin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2019.04.023_bib0005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/00480169.2015.1016133","article-title":"Prevalence of Streptococcus dysgalactiae subsp. equisimilis and S. equi subsp. zooepidemicus in a sample of healthy dogs, cats and horses","volume":"63","author":"Acke","year":"2015","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1017\/S0950268800061884","article-title":"Characterization of Streptococcus zooepidemicus (Lancefield group C) from human and selected animal infections","volume":"98","author":"Barnham","year":"1987","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0015","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1637\/10123-030712-Reg.1","article-title":"A major outbreak of Streptococcus equi subsp. zooepidemicus infections in free-range chickens is linked to horses","volume":"56","author":"Bisgaard","year":"2012","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0020","first-page":"8","article-title":"Genomic dissection of an Icelandic epidemic of respiratory disease in horses and associated zoonotic cases","author":"Bjornsdottir","year":"2017","journal-title":"MBio"},{"key":"10.1016\/j.vetmic.2019.04.023_bib0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mpat.1994.1058","article-title":"Characterization of the antiphagocytic activity of equine fibrinogen for Streptococcus equi subsp. equi","volume":"17","author":"Boschwitz","year":"1994","journal-title":"Microbial. Pathog."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0030","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.micro.60.080805.142139","article-title":"Induction of competence regulons as a general response to stress in gram-positive bacteria","volume":"60","author":"Claverys","year":"2006","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0035","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1128\/IAI.70.12.6646-6651.2002","article-title":"EndoS and SpeB from Streptococcus pyogenes inhibit immunoglobulin-mediated opsonophagocytosis","volume":"70","author":"Collin","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0040","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1128\/IAI.00515-08","article-title":"Four superoxide dismutases contribute to Bacillus anthracis virulence and provide spores with redundant protection from oxidative stress","volume":"77","author":"Cybulski","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.vaccine.2008.10.037","article-title":"Virulence and antigenicity of the szp-gene deleted Streptococcus equi ssp. zooepidemicus mutant in mice","volume":"27","author":"Fan","year":"2009","journal-title":"Vaccine."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0050","first-page":"7","article-title":"Outbreak of swine streptococcosis in Sichan province and identification of pathogen","volume":"2","author":"Feng","year":"1977","journal-title":"Anim. Husbad. Vet. Med. Lett."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0055","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1086\/644602","article-title":"Streptococcus suis enolase functions as a protective antigen displayed on the bacterial cell surface","volume":"200","author":"Feng","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0060","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrmicro2128","article-title":"Antimicrobial mechanisms of phagocytes and bacterial evasion strategies","volume":"7","author":"Flannagan","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.vetmic.2016.12.030","article-title":"CD44 enhances macrophage phagocytosis and plays a protective role in Streptococcus equi subsp. zooepidemicus infection","volume":"198","author":"Fu","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1574-6968.2009.01698.x","article-title":"Two novel IgG endopeptidases of Streptococcus equi","volume":"298","author":"Greta","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0075","first-page":"8","article-title":"Effects of Freund\u2019s complete adjuvant on the physiology, histology, and activity of New Zealand White Rabbits","volume":"43","author":"Halliday","year":"2004","journal-title":"Contemp. Top. Lab. Anim. Sci."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0080","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrmicro2520","article-title":"Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds","volume":"9","author":"Hendrickx","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000346","article-title":"Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens","volume":"5","author":"Holden","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0090","article-title":"Sepsis, endocarditis, and purulent arthritis due to a rare zoonotic infection with Streptococcus equi subspecies zooepidemicus","volume":"2018","author":"Hoyer-Nielsen","year":"2018","journal-title":"Case Rep. Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0095","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1007\/s00253-013-5471-z","article-title":"Vibrio parahaemolyticus enolase is an adhesion-related factor that binds plasminogen and functions as a protective antigen","volume":"98","author":"Jiang","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0100","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1128\/IAI.00837-12","article-title":"Genome-wide identification of genes required for fitness of group A Streptococcus in human blood","volume":"81","author":"Le Breton","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/01480548309072465","article-title":"Estimating LD50 using the probit technique: a BASIC computer program","volume":"6","author":"Lieberman","year":"1983","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0110","doi-asserted-by":"crossref","first-page":"27133","DOI":"10.1038\/srep27133","article-title":"A novel suicide shuttle plasmid for Streptococcus suis serotype 2 and Streptococcus equi ssp. zooepidemicus gene mutation","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vetmic.2017.04.002","article-title":"Immunogenicity of phospholipase A2 toxins and their role in Streptococcus equi pathogenicity","volume":"204","author":"Lopez-Alvarez","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0120","article-title":"Interaction between M-like protein and macrophage thioredoxin facilitates antiphagocytosis for Streptococcus equi ssp. zooepidemicus","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2019.04.023_bib0125","first-page":"83","article-title":"Extracellular nucleases of Streptococcus equi subsp. zooepidemicus degrade neutrophil extracellular traps and impair macrophage activity of the host","author":"Ma","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0130","first-page":"185","article-title":"Electrotransformation of streptococci","volume":"47","author":"McLaughlin","year":"1995","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0135","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4161\/viru.29363","article-title":"The yrpAB operon of Yersinia ruckeri encoding two putative U32 peptidases is involved in virulence and induced under microaerobic conditions","volume":"5","author":"Navais","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.vetmic.2019.04.023_bib0140","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/acs.jproteome.6b00571","article-title":"Virulent and vaccine strains of Streptococcus equi ssp. zooepidemicus have different influences on phagocytosis and cytokine secretion of macrophages","volume":"16","author":"Peng","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0145","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev-biochem-060815-014844","article-title":"Mechanisms of bacterial transcription termination: all good things must end","volume":"85","author":"Ray-Soni","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0150","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jneuroim.2011.12.013","article-title":"Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells","volume":"244","author":"Redlich","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0155","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1371\/journal.ppat.0040037","article-title":"Nucleotide biosynthesis is critical for growth of bacteria in human blood","volume":"4","author":"Samant","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0160","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1107\/S1399004715019549","article-title":"The first crystal structure of the peptidase domain of the U32 peptidase family","volume":"71","author":"Schacherl","year":"2015","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060116","article-title":"Insight into the evolution of the histidine triad protein (HTP) family in Streptococcus","volume":"8","author":"Shao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2019.04.023_bib0170","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1073\/pnas.0607669103","article-title":"Emergence of a bacterial clone with enhanced virulence by acquisition of a phage encoding a secreted phospholipase A2","volume":"103","author":"Sitkiewicz","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0175","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1128\/JCM.34.9.2201-2204.1996","article-title":"Identification and molecular characterization of serological group C streptococci isolated from diseased pigs and monkeys in Indonesia","volume":"34","author":"Soedarmanto","year":"1996","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/plas.2000.1510","article-title":"Construction and characterization of Streptococcus suis-Escherichia coli shuttle cloning vectors","volume":"45","author":"Takamatsu","year":"2001","journal-title":"Plasmid"},{"key":"10.1016\/j.vetmic.2019.04.023_bib0185","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1016\/j.vaccine.2012.04.092","article-title":"The capsule of Streptococcus equi ssp. zooepidemicus is a target for attenuation in vaccine development","volume":"30","author":"Wei","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2019.04.023_bib0190","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/rvsc.1998.0287","article-title":"The role of hyaluronic acid capsular material of Streptococcus equi subsp. zooepidemicus in mediating adherence to HeLa cells and in resisting phagocytosis","volume":"67","author":"Wibawan","year":"1999","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0195","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.vetmic.2016.03.017","article-title":"A Streptococcus suis LysM domain surface protein contributes to bacterial virulence","volume":"187","author":"Wu","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.04.023_bib0200","first-page":"363","article-title":"Capsule of Streptococcus equi subsp. zooepidemicushampers the adherence and invasion of epithelial and endothelial cells and is attenuated during internalization","author":"Xu","year":"2016","journal-title":"FEMS Microbiol. Lett."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811351831441X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811351831441X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T17:43:16Z","timestamp":1607276596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811351831441X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":40,"alternative-id":["S037811351831441X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.04.023","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel genes associated with anti-phagocytic functions in Streptococcus equi subsp. zooepidemicus","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}