{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:11:19Z","timestamp":1790673079859,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["182300410047"],"award-info":[{"award-number":["182300410047"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["162300410067"],"award-info":[{"award-number":["162300410067"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31540095"],"award-info":[{"award-number":["31540095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772761"],"award-info":[{"award-number":["31772761"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.vetmic.2019.05.006","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T08:37:56Z","timestamp":1557304676000},"page":"154-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["LuxS\/AI-2 system is involved in fluoroquinolones susceptibility in Streptococcus suis through overexpression of efflux pump SatAB"],"prefix":"10.1016","volume":"233","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baobao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2019.05.006_bib0005","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/jac\/dkp271","article-title":"Molecular cloning and characterization of SmrA, a novel ABC multidrug efflux pump from Stenotrophomonas maltophilia","volume":"64","author":"Al-Hamad","year":"2009","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/JMAU.JMAU_10_18","article-title":"Anti-quorum sensing natural compounds","volume":"6","author":"Asfour","year":"2018","journal-title":"J. Microsc. Ultrastruct."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0015","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cell.2006.04.001","article-title":"Bacterially speaking","volume":"125","author":"Bassler","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2019.05.006_bib0020","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s10096-016-2616-x","article-title":"Streptococcus suis in invasive human infections in Poland: clonality and determinants of virulence and antimicrobial resistance","volume":"35","author":"Bojarska","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0025","series-title":"Clinical and Laboratory Standards Institute (CLSI)","author":"CLSI","year":"2015"},{"key":"10.1016\/j.vetmic.2019.05.006_bib0030","doi-asserted-by":"crossref","first-page":"683","DOI":"10.26444\/aaem\/79813","article-title":"Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part I - epidemiology","volume":"24","author":"Dutkiewicz","year":"2017","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0035","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1128\/AAC.00972-06","article-title":"First characterization of fluoroquinolone resistance in Streptococcus suis","volume":"51","author":"Escudero","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0040","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1128\/AAC.00498-11","article-title":"Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrA","volume":"55","author":"Escudero","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0045","first-page":"49","article-title":"Epidemiology and pathogenicity of zoonotic streptococci","volume":"368","author":"Fulde","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0050","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/jb.176.2.269-275.1994","article-title":"Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators","volume":"176","author":"Fuqua","year":"1994","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0055","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.eimc.2008.07.012","article-title":"[Acute meningitis and spondylodiscitis due to Streptococcus suis in a patient who had no contact with pigs or porcine products]","volume":"27","author":"Galbarro","year":"2009","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/ismej.2015.84","article-title":"Can resistance against quorum-sensing interference be selected?","volume":"10","author":"Garcia-Contreras","year":"2016","journal-title":"ISME J."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0065","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.3201\/eid2312.171005","article-title":"Human case of Streptococcus suis disease, Ontario, Canada","volume":"23","author":"Gomez-Torres","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0070","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3201\/eid2101.140640","article-title":"Streptococcus equi subsp. zooepidemicus infections associated with guinea pigs","volume":"21","author":"Gruszynski","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0075","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.ARBA-0008-2017","article-title":"Antimicrobial resistance in Streptococcus spp","volume":"6","author":"Haenni","year":"2018","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0080","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1128\/AEM.70.9.5621-5627.2004","article-title":"Identification and functional characterization of a Xenorhabdus nematophila oligopeptide permease","volume":"70","author":"Orchard","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2958.2012.08010.x","article-title":"Phosphoenolpyruvate phosphotransferase system regulates detection and processing of the quorum sensing signal autoinducer-2","volume":"84","author":"Pereira","year":"2012","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0090","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12879-017-2294-z","article-title":"Case report: two human Streptococcus suis infections in Borneo, Sabah, Malaysia","volume":"17","author":"Rajahram","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0095","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrmicro1146","article-title":"Making\u2019 sense\u2019 of metabolism: autoinducer-2, LuxS and pathogenic bacteria","volume":"3","author":"Vendeville","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0100","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1574-6968.2010.02189.x","article-title":"Reduced virulence is an important characteristic of biofilm infection of Streptococcus suis","volume":"316","author":"Wang","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0105","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.vetmic.2011.04.029","article-title":"Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence","volume":"152","author":"Wang","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0110","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/924276","article-title":"Overexpression of luxS cannot increase autoinducer-2 production, only affect the growth and biofilm formation in Streptococcus suis","author":"Wang","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0115","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00284-013-0509-0","article-title":"Biofilm formation, host-cell adherence, and virulence genes regulation of Streptococcus suis in response to autoinducer-2 signaling","volume":"68","author":"Wang","year":"2014","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0120","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev.cellbio.21.012704.131001","article-title":"Quorum sensing: cell-to-cell communication in bacteria","volume":"21","author":"Waters","year":"2005","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijantimicag.2012.08.016","article-title":"LuxS\/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325","volume":"41","author":"Xue","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.vetmic.2019.05.006_bib0130","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jiac.2018.01.009","article-title":"The first report of human meningitis and pyogenic ventriculitis caused by Streptococcus suis: a case report","volume":"24","author":"Yanase","year":"2018","journal-title":"J. Infect. Chemother."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0135","first-page":"67","article-title":"Identification of isolates of swine Streptococcus in Jiangsu Province during 1998","volume":"22","author":"Yao","year":"1999","journal-title":"J. Nanjing Agric. Univ."},{"key":"10.1016\/j.vetmic.2019.05.006_bib0140","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10646-017-1886-0","article-title":"A study on the role that quorum sensing play in antibiotic-resistant plasmid conjugative transfer in Escherichia coli","volume":"27","author":"Zhang","year":"2018","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.vetmic.2019.05.006_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13567-017-0498-2","article-title":"Genomic comparisons of Streptococcus suis serotype 9 strains recovered from diseased pigs in Spain and Canada","volume":"49","author":"Zheng","year":"2018","journal-title":"Vet. Res."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113519302937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113519302937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:36:26Z","timestamp":1777566986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113519302937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":29,"alternative-id":["S0378113519302937"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.05.006","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LuxS\/AI-2 system is involved in fluoroquinolones susceptibility in Streptococcus suis through overexpression of efflux pump SatAB","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}