{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:18:33Z","timestamp":1784078313382,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012236","name":"Alberta Agriculture and Forestry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201708150068"],"award-info":[{"award-number":["201708150068"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.vetmic.2019.108478","type":"journal-article","created":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T10:11:18Z","timestamp":1572171078000},"page":"108478","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Genetic relatedness and antimicrobial resistance in respiratory bacteria from beef calves sampled from spring processing to 40 days after feedlot entry"],"prefix":"10.1016","volume":"240","author":[{"given":"Yongmei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennyka","family":"Hallewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Orsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor W.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2019.108478_bib0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2180-11-19","article-title":"Longitudinal characterization of antimicrobial resistance genes in feces shed from cattle fed different subtherapeutic antibiotics","volume":"11","author":"Alexander","year":"2011","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.vetmic.2019.108478_bib0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fvets.2017.00207","article-title":"Antimicrobial susceptibility of Bacteria That cause Bovine respiratory disease complex in Alberta, Canada","volume":"4","author":"Anholt","year":"2017","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.vetmic.2019.108478_bib0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/vr.c6776","article-title":"Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial","volume":"168","author":"Baggott","year":"2011","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2019.108478_bib0020","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.vetmic.2019.108478_bib0025","doi-asserted-by":"crossref","first-page":"350","DOI":"10.2460\/ajvr.78.3.350","article-title":"Comparison of the diagnostic performance of bacterial culture of nasopharyngeal swab and bronchoalveolar lavage fluid samples obtained from calves with bovine respiratory disease","volume":"78","author":"Capik","year":"2017","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2019.108478_bib0030","series-title":"Standardized Protocol for Molecular Subtyping by Pulsed Field Gel Electrophoresis","author":"Centers for disease control and prevention","year":"2013"},{"key":"10.1016\/j.vetmic.2019.108478_bib0035","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1186\/s12864-016-3316-8","article-title":"Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease, an integrative conjugative element, and antibiotic resistance genes","volume":"17","author":"Clawson","year":"2016","journal-title":"BMC Genomics"},{"key":"10.1016\/j.vetmic.2019.108478_bib0040","series-title":"Performance Standards for Antimicrobial Disk and Dilution Susceptibility Tests for Bacteria Isolated From Animals","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2015"},{"key":"10.1016\/j.vetmic.2019.108478_bib0045","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1016\/j.vaccine.2005.11.036","article-title":"Recombinant Mannheimia haemolytica serotype 1 outer membrane protein PlpE enhances commercial M. Haemolytica vaccine-induced resistance against serotype 6 challenge","volume":"24","author":"Confer","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2019.108478_bib0050","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.vaccine.2012.01.063","article-title":"Cross protection of a Mannheimia haemolytica A1 Lkt-\/Pasteurella multocida \u0394hyaE bovine respiratory disease vaccine against experimental challenge with Mannheimia haemolytica A6 in calves","volume":"30","author":"Crouch","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2019.108478_bib0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S1466252307001399","article-title":"Pasteurella multocida and bovine respiratory disease","volume":"8","author":"Dabo","year":"2007","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.vetmic.2019.108478_bib0060","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cvfa.2014.11.003","article-title":"A review of the expected effects of antimicrobials in bovine respiratory disease treatment and control using outcomes from published randomized clinical trials with negative controls","volume":"31","author":"DeDonder","year":"2015","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1016\/j.vetmic.2019.108478_bib0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cvfa.2010.03.005","article-title":"Control methods for bovine respiratory disease for feedlot cattle","volume":"26","author":"Edwards","year":"2010","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"issue":"2","key":"10.1016\/j.vetmic.2019.108478_bib0070","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cvfa.2010.04.004","article-title":"Bacterial pathogens of the bovine respiratory disease complex","volume":"26","author":"Griffin","year":"2010","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1016\/j.vetmic.2019.108478_bib0075","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12866-017-0978-6","article-title":"The nasopharyngeal microbiota of beef cattle before and after transport to a feedlot","volume":"17","author":"Holman","year":"2017","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.vetmic.2019.108478_bib0080","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.vetmic.2017.12.015","article-title":"Injectable antimicrobials in commercial feedlot cattle and their effect on the nasopharyngeal microbiota and antimicrobial resistance","volume":"214","author":"Holman","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.108478_bib0085","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cvfa.2015.05.008","article-title":"Use of antimicrobial metaphylaxis for the control of bovine respiratory disease in high-risk cattle","volume":"31","author":"Ives","year":"2015","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1016\/j.vetmic.2019.108478_bib0090","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.vetmic.2010.11.018","article-title":"Genetic characterization and antimicrobial susceptibility of Mannheimia haemolytica isolated from the nasopharynx of feedlot cattle","volume":"149","author":"Klima","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.108478_bib0095","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00051-13","article-title":"Draft genome sequence of a Mannheimia haemolytica serotype 6 isolate collected from the nasopharynx of a beef calf with bovine respiratory disease","volume":"1","author":"Klima","year":"2013","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2019.108478_bib0100","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1128\/JCM.02485-13","article-title":"Pathogens of bovine respiratory disease in North American feedlots conferring multidrug resistance via integrative conjugative elements","volume":"52","author":"Klima","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2019.108478_bib0105","first-page":"38","article-title":"Characterization of Mannheimia haemolytica isolated from feedlot cattle that were healthy or treated for bovine respiratory disease","volume":"78","author":"Klima","year":"2014","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2019.108478_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149520","article-title":"Comparative genomic analysis of Mannheimia haemolytica from bovine sources","volume":"11","author":"Klima","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2019.108478_bib0115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mimet.2017.05.010","article-title":"A multiplex PCR assay for molecular capsular serotyping of Mannheimia haemolytica serotypes 1, 2, and 6","volume":"139","author":"Klima","year":"2017","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.vetmic.2019.108478_bib0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cvfa.2011.12.005","article-title":"Evidence-based effectiveness of vaccination against Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in feedlot cattle for mitigating the incidence and effect of bovine respiratory disease complex","volume":"28","author":"Larson","year":"2012","journal-title":"Vet. Clin. Food Anim."},{"key":"10.1016\/j.vetmic.2019.108478_bib0125","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1073\/pnas.1120238109","article-title":"In-feed antibiotic effects on the swine intestinal microbiome","volume":"109","author":"Looft","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.vetmic.2019.108478_bib0130","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/1040638713485227","article-title":"Antimicrobial multidrug resistance and coresistance patterns of Mannheimia haemolytica isolated from bovine respiratory disease cases \u2013 a three-year (2009\u20132011) retrospective analysis","volume":"25","author":"Lubbers","year":"2013","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.vetmic.2019.108478_bib0135","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.vetmic.2018.09.019","article-title":"Evolution of the nasopharyngeal bacterial microbiota of beef calves from spring processing to 40 days after feedlot arrival","volume":"225","author":"McMullen","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.108478_bib0140","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/jac\/dks076","article-title":"Increased MICs of gamithromycin and tildipirosin in the presence of the genes erm (42) and msr (E)-mph (E) for bovine Pasteurella multocida and Mannheimia haemolytica","volume":"67","author":"Michael","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.vetmic.2019.108478_bib0145","series-title":"Guide to the Care and Use of Experimental Animals Vol. 2 Canadian Council on Animal Care","author":"Olfert","year":"1993"},{"key":"10.1016\/j.vetmic.2019.108478_bib0150","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cvfa.2010.04.001","article-title":"Pathogenesis and pathology of bovine pneumonia","volume":"26","author":"Panciera","year":"2010","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1016\/j.vetmic.2019.108478_bib0155","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1177\/1040638712457559","article-title":"A ten-year (2000\u20132009) study of antimicrobial susceptibility of bacteria that cause bovine respiratory disease complex\u2014mannheimia haemolytica, Pasteurella multocida, and Histophilus somni\u2014in the United States and Canada","volume":"24","author":"Portis","year":"2012","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.vetmic.2019.108478_bib0160","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.2527\/jas.2008-1283","article-title":"An evaluation of bovine respiratory disease complex in feedlot cattle: impact on performance and carcass traits using treatment records and lung lesion scores","volume":"87","author":"Schneider","year":"2009","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetmic.2019.108478_bib0165","first-page":"1124","article-title":"Prevalence of multi drug antimicrobial resistance in Mannheimia haemolytica isolated from high-risk stocker cattle at arrival and two weeks after processing","volume":"95","author":"Snyder","year":"2017","journal-title":"Am. Soc. Anim. Sci"},{"key":"10.1016\/j.vetmic.2019.108478_bib0170","first-page":"1095","article-title":"The epidemiology of bovine respiratory disease: what is the evidence for predisposing factors?","volume":"51","author":"Taylor","year":"2010","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.vetmic.2019.108478_bib0175","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.2527\/jas.2014-7814","article-title":"Comparison of tulathromycin and tilmicosin on the prevalence and severity of bovine respiratory disease in feedlot cattle in association with feedlot performance, carcass characteristics, and economic factors","volume":"92","author":"Tennant","year":"2014","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.vetmic.2019.108478_bib0180","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.vetmic.2012.07.044","article-title":"Transmission dynamics of Mannheimia haemolytica in newly-received beef bulls at fattening operations","volume":"161","author":"Timsit","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2019.108478_bib0185","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.vetmic.2017.07.013","article-title":"Prevalence and antimicrobial susceptibility of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolated from the lower respiratory tract of healthy feedlot cattle and those diagnosed with bovine respiratory disease","volume":"208","author":"Timsit","year":"2017","journal-title":"Vet. Microbiol."},{"issue":"133","key":"10.1016\/j.vetmic.2019.108478_bib0190","article-title":"Effect of subtherapeutic vs. Therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle","volume":"4","author":"Zaheer","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2019.108478_bib0195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1051\/vetres:2004065","article-title":"How Mannheimia haemolytica defeats host defense through a kiss of death mechanism","volume":"36","author":"Zecchinon","year":"2005","journal-title":"Vet. Res."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113519308764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113519308764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:04:40Z","timestamp":1759878280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113519308764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":39,"alternative-id":["S0378113519308764"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.108478","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic relatedness and antimicrobial resistance in respiratory bacteria from beef calves sampled from spring processing to 40 days after feedlot entry","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.108478","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108478"}}