{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:29:16Z","timestamp":1790533756763,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["0737\/2018"],"award-info":[{"award-number":["0737\/2018"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.285983\/2018-00"],"award-info":[{"award-number":["88887.285983\/2018-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.vetmic.2019.108528","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T02:17:37Z","timestamp":1574734657000},"page":"108528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Experimental listeriosis: A study of purinergic and cholinergic inflammatory pathway"],"prefix":"10.1016","volume":"241","author":[{"given":"Antonise M.","family":"Jaguezeski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-1933","authenticated-orcid":false,"given":"Aleksandro S.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teane M.A.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathieli B.","family":"Bottari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalisson F.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan A.","family":"Cechin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera M.","family":"Morsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.C.","family":"Schetinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Giongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"de A. Vaucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2019.108528_bib0005","first-page":"121","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984"},{"key":"10.1016\/j.vetmic.2019.108528_bib0010","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bjid.2017.01.004","article-title":"Virulence genes and genetic relationship of L. monocytogenes isolated from human and food sources in Brazil","volume":"21","author":"Almeida","year":"2017","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.108528_bib0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/mpat.1997.0131","article-title":"A gerbil model for rhombencephalitis due to Listeria monocytogenes","volume":"23","author":"Blanot","year":"1997","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2019.108528_bib0020","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2019.108528_bib0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.vetmic.2019.108528_bib0030","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2121-14-32","article-title":"Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis","volume":"14","author":"Brentnall","year":"2013","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0035","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/104063871102300130","article-title":"Listeriosis outbreak in dairy cattle caused by an unusual Listeria monocytogenes serotype 4b strain","volume":"23","author":"Bundrant","year":"2011","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.vetmic.2019.108528_bib0040","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S1473-3099(16)30521-7","article-title":"Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study","volume":"17","author":"Charlier","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.vetmic.2019.108528_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodcont.2013.09.061","article-title":"Prevalence and characterization of Listeria monocytogenes isolated from retail-level ready-to-eat foods in South China","volume":"38","author":"Chen","year":"2014","journal-title":"Food Control"},{"key":"10.1016\/j.vetmic.2019.108528_bib0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clim.2017.12.006","article-title":"Extracellular ATP signaling and clinical relevance","volume":"188","author":"Dou","year":"2018","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Dr\u00f6ge","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.vetmic.2019.108528_bib0060","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bcp.2015.07.032","article-title":"Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection","volume":"97","author":"Egea","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0065","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mam.2017.01.002","article-title":"Extracellular ATP and adenosine: the Yin and Yang in immune responses?","volume":"55","author":"Faas","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.vetmic.2019.108528_bib0075","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.4049\/jimmunol.176.7.3877","article-title":"The P2X7 receptor: a key player in IL-1 processing and release","volume":"176","author":"Ferrari","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0080","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.4049\/jimmunol.164.4.2064","article-title":"Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide","volume":"164","author":"Flo","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10571-016-0358-z","article-title":"CD40 negatively regulates ATP-TLR4-activated inflammasome in microglia","volume":"37","author":"Gaikwad","year":"2017","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0090","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnmol.2012.00030","article-title":"Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions","volume":"5","author":"Gilboa-Geffen","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.vetmic.2019.108528_bib0095","first-page":"315","article-title":"Adenosine deaminase: colorimetric method","volume":"4","author":"Giusti","year":"1984"},{"key":"10.1016\/j.vetmic.2019.108528_bib0100","series-title":"Free Radicals in Biology and Medicine","first-page":"187","article-title":"Cellular responses to oxidative stress: adaptation, damage, repair, senescence and death","author":"Halliwell","year":"2007"},{"key":"10.1016\/j.vetmic.2019.108528_bib0105","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.shk.0000228168.86845.60","article-title":"Stimulation of \u03b17 nicotinic acetylcholine receptor inhibits CD14 and the toll-like receptor 4 expression in human monocytes","volume":"26","author":"Hamano","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.vetmic.2019.108528_bib0110","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature13085","article-title":"Nucleotide signalling during inflammation","volume":"509","author":"Idzko","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2019.108528_bib0115","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2018","journal-title":"Alexandria J. Med."},{"key":"10.1016\/j.vetmic.2019.108528_bib0120","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11302-013-9357-4","article-title":"Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses","volume":"9","author":"Jacob","year":"2013","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.vetmic.2019.108528_bib0125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.micpath.2018.05.054","article-title":"Experimental infection of cattle with Listeria monocytogenes: participation of purinergic metabolism in disease pathogenesis","volume":"122","author":"Jaguezeski","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2019.108528_bib0130","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.micpath.2017.10.038","article-title":"Changes on the activity of cholinesterase\u2019s in an immunomodulatory response of cattle infected by Listeria monocytogenes","volume":"114","author":"Jaguezeski","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2019.108528_bib0135","doi-asserted-by":"crossref","first-page":"103564","DOI":"10.1016\/j.micpath.2019.103564","article-title":"Effect of free and nano-encapsulated curcumin on treatment and energetic metabolism of gerbils infected by Listeria monocytogenes","volume":"134","author":"Jaguezeski","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2019.108528_bib0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0145","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijdevneu.2017.02.007","article-title":"Effect of high fat diets on the NTPDase, 5\u2019-nucleotidase and acetylcholinesterase activities in the central nervous system","volume":"64","author":"Kaizer","year":"2018","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.vetmic.2019.108528_bib0150","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2009.07.035","article-title":"Nrf2: INrf2 (Keap1) signaling in oxidative stress","volume":"47","author":"Kaspar","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.vetmic.2019.108528_bib0155","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4049\/jimmunol.1101224","article-title":"Adenosine augments IL-10 production by microglial cells through an A2B adenosine receptor-mediated process","volume":"188","author":"Koscs\u00f3","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0160","doi-asserted-by":"crossref","first-page":"ra55","DOI":"10.1126\/scisignal.2000588","article-title":"Autocrine purinergic receptor signaling is essential for macrophage chemotaxis","volume":"3","author":"Kronlage","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.vetmic.2019.108528_bib0165","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/npp.2010.26","article-title":"Adenosine A 1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death","volume":"35","author":"Lauro","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.vetmic.2019.108528_bib0170","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/13510002.2016.1173327","article-title":"Restraining reactive oxygen species in Listeria monocytogenes promotes the apoptosis of glial cells","volume":"22","author":"Li","year":"2017","journal-title":"Redox Rep."},{"key":"10.1016\/j.vetmic.2019.108528_bib0175","first-page":"73","article-title":"Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke","author":"Liu","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.vetmic.2019.108528_bib0180","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2019.108528_bib0185","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature13152","article-title":"NRROS negatively regulates reactive oxygen species during host defence and autoimmunity","volume":"509","author":"Noubade","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2019.108528_bib0190","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1182\/blood-2005-08-3240","article-title":"Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis","volume":"107","author":"Pick","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.vetmic.2019.108528_bib0195","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/vcp.12363","article-title":"Listeria monocytogenes septicemia in an immunocompromised dog","volume":"45","author":"Pritchard","year":"2016","journal-title":"Vet. Clin. Pathol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0200","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3201\/eid1701.P11101","article-title":"Foodborne illness acquired in the United States\u2014major pathogens","volume":"17","author":"Scallan","year":"2011","journal-title":"Emerg. Infect Dis."},{"key":"10.1016\/j.vetmic.2019.108528_bib0205","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1023\/A:1007500424392","article-title":"New benzodiazepines alter acetylcholinesterase and ATPDase activities","volume":"25","author":"Schetinger","year":"2000","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.vetmic.2019.108528_bib0210","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.smallrumres.2012.11.002","article-title":"Clinical diagnosis of ovine listeriosis","volume":"110","author":"Scott","year":"2013","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.vetmic.2019.108528_bib0215","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/glia.22628","article-title":"P2X7\u2010dependent, but differentially regulated release of IL\u20106, CCL2, and TNF\u2010\u03b1 in cultured mouse microglia","volume":"62","author":"Shieh","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.vetmic.2019.108528_bib0220","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.immunol.22.012703.104731","article-title":"Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors","volume":"22","author":"Sitkovsky","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0225","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/A:1016103131408","article-title":"Alterations in antioxidant enzymes and oxidative damage in experimental diabetic rat tissues: effect of Vanadate and fenugreek (Trigonella foenum graecum)","volume":"236","author":"Solomon","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.vetmic.2019.108528_bib0230","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.meegid.2012.09.019","article-title":"Characterization of Listeria monocytogenes isolated from Ganges water, human clinical and milk samples at Varanasi, India","volume":"14","author":"Soni","year":"2013","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0235","series-title":"Source Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects","article-title":"Oxidative stress, brain edema, Blood\u2013brain barrier permeability, and autonomic dysfunction from traumatic brain injury","author":"Toklu","year":"2015"},{"key":"10.1016\/j.vetmic.2019.108528_bib0240","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1136\/gut.2010.217117","article-title":"Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF\u03b1 treatment","volume":"60","author":"Veltkamp","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.vetmic.2019.108528_bib0245","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2019.108528_bib0250","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fsi.2017.04.027","article-title":"Antioxidant defenses of Onychostoma macrolepis in response to thermal stress: insight from mRNA expression and activity of superoxide dismutase and catalase","volume":"66","author":"Yu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0255","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetmic.2019.108528_bib0260","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00441-006-0239-8","article-title":"Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission","volume":"326","author":"Zimmerman","year":"2006","journal-title":"Cell Tissue Res."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113519310338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113519310338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:06:04Z","timestamp":1759878364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113519310338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":52,"alternative-id":["S0378113519310338"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.108528","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental listeriosis: A study of purinergic and cholinergic inflammatory pathway","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2019.108528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108528"}}