{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:01:58Z","timestamp":1784664118335,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013931","name":"Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013931","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.vetmic.2020.108588","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T11:32:37Z","timestamp":1579174357000},"page":"108588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Efficacy in pigs of a new inactivated vaccine combining porcine circovirus type 2 and Mycoplasma hyorhinis"],"prefix":"10.1016","volume":"242","author":[{"given":"Yan-Wu","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Li","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Qiao","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2020.108588_bib0005","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.vetmic.2018.11.027","article-title":"Antibiotic susceptibility profiles of Mycoplasma hyorhinis strains isolated from swine in Hungary","volume":"228","author":"Beko","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1090-0233(03)00182-5","article-title":"Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology","volume":"168","author":"Chae","year":"2004","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2020.108588_bib0015","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1007\/s00253-015-7263-0","article-title":"Characterization and application of monoclonal antibodies against Mycoplasma hyorhinis pyruvate dehydrogenase E1 complex subunit alpha","volume":"100","author":"Chen","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.vetmic.2015.11.003","article-title":"Synergistic pathogenicity in sequential coinfection with Mycoplasma hyorhinis and porcine circovirus type 2","volume":"182","author":"Chen","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4142\/jvs.2017.18.3.283","article-title":"Survey of porcine respiratory disease complex-associated pathogens among commercial pig farms in Korea via oral","volume":"18","author":"Cheong","year":"2017","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.vetmic.2020.108588_bib0030","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/vr.104064","article-title":"Infection dynamics of Mycoplasma hyorhinis in three commercial pig populations","volume":"181","author":"Clavijo","year":"2017","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2020.108588_bib0035","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.vaccine.2007.11.053","article-title":"The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex","volume":"26","author":"Fachinger","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2020.108588_bib0040","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1128\/JVI.78.12.6297-6303.2004","article-title":"A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs","volume":"78","author":"Fenaux","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.vetmic.2019.04.010","article-title":"Pathogenicity study of Mycoplasma hyorhinis and M. flocculare in specific-pathogen-free pigs pre-infected with M. Hyopneumoniae","volume":"232","author":"Fourour","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0050","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.virusres.2011.10.005","article-title":"Porcine circovirus type 2 and its associated diseases in China","volume":"164","author":"Ge","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2020.108588_bib0055","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1939-1676.2009.0389.x","article-title":"Porcine circovirus type 2 and porcine circovirus-associated disease","volume":"23","author":"Gillespie","year":"2009","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.vetmic.2020.108588_bib0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4142\/jvs.2015.16.2.195","article-title":"Quantitative real-time polymerase chain reaction for detecting Mycoplasma hyosynoviae and Mycoplasma hyorhinis in pen-based oral, tonsillar, and nasal fluids","volume":"16","author":"Gomes Neto","year":"2015","journal-title":"J. Vet. Sci."},{"issue":"2","key":"10.1016\/j.vetmic.2020.108588_bib0065","doi-asserted-by":"crossref","first-page":"82","DOI":"10.54846\/jshap\/725","article-title":"Mycoplasma-associated arthritis: critical points for diagnosis","volume":"20","author":"Gomes Neto JC","year":"2012","journal-title":"J. Swine Health Prod."},{"key":"10.1016\/j.vetmic.2020.108588_bib0070","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.vetmic.2014.08.008","article-title":"Antibody responses of swine following infection with Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae and M. flocculare","volume":"174","author":"Gomes Neto","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0075","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1016\/j.vaccine.2015.05.056","article-title":"A commercial PCV2a-based vaccine is effective in protection from experimental challenge of PCV2 mutant with two amino acids elongation in capsid protein","volume":"33","author":"Guo","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2020.108588_bib0080","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jcpa.2010.01.012","article-title":"An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark","volume":"143","author":"Hansen","year":"2010","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.54846\/jshap\/327","article-title":"Three cases of porcine respiratory disease complex associated with porcine circovirus type 2 infection","volume":"10","author":"Harms","year":"2002","journal-title":"J. Swine Health Prod."},{"key":"10.1016\/j.vetmic.2020.108588_bib0090","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1007\/s00253-019-09715-0","article-title":"A broad spectrum monoclonal antibody against porcine circovirus type 2 for antigen and antibody detection","volume":"103","author":"Huang","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0095","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1016\/j.vaccine.2008.04.032","article-title":"Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2","volume":"26","author":"Kixmoller","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2020.108588_bib0100","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vetimm.2017.12.001","article-title":"Reduction of mycoplasmal lesions and clinical signs by vaccination against Mycoplasma hyorhinis","volume":"196","author":"Lee","year":"2018","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0105","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetimm.2016.06.008","article-title":"Mycoplasma hyorhinis is a potential pathogen of porcine respiratory disease complex that aggravates pneumonia caused by porcine reproductive and respiratory syndrome virus","volume":"177","author":"Lee","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0110","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.vetmic.2006.02.004","article-title":"Mycoplasma hyorhinis in Taiwan: diagnosis and isolation of swine pneumonia pathogen","volume":"115","author":"Lin","year":"2006","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.virusres.2007.03.026","article-title":"Construction and characterization of porcine circovirus type 2 carrying a genetic marker strain","volume":"127","author":"Liu","year":"2007","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2020.108588_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2017.02.001","article-title":"Occurrence of Mycoplasma hyorhinis infections in fattening pigs and association with clinical signs and pathological lesions of Enzootic Pneumonia","volume":"203","author":"Luehrs","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11250-011-0022-z","article-title":"Comparison of detection procedures of Mycoplasma hyopneumoniae, Mycoplasma hyosynoviae, and Mycoplasma hyorhinis in lungs, tonsils, and synovial fluid of slaughtered pigs and their distributions in Thailand","volume":"44","author":"Makhanon","year":"2012","journal-title":"Trop. Anim. Health Prod."},{"key":"10.1016\/j.vetmic.2020.108588_bib0130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.virusres.2011.11.001","article-title":"Molecular interactions of porcine circoviruses type 1 and type 2 with its host","volume":"164","author":"Mankertz","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2020.108588_bib0135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.vetmic.2017.09.005","article-title":"Age susceptibility of caesarian derived colostrum deprived pigs to Mycoplasma hyorhinis challenge","volume":"210","author":"Martinson","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0140","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.vaccine.2017.11.063","article-title":"Efficacy of an inactivated Mycoplasma hyorhinis vaccine in pigs","volume":"36","author":"Martinson","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2020.108588_bib0145","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1354\/vp.41-6-624","article-title":"Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2","volume":"41","author":"Opriessnig","year":"2004","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0150","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.vaccine.2016.11.085","article-title":"A commercial porcine circovirus (PCV) type 2a-based vaccine reduces PCV2d viremia and shedding and prevents PCV2d transmission to naive pigs under experimental conditions","volume":"35","author":"Opriessnig","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2020.108588_bib0155","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01879-16","article-title":"A novel porcine circovirus distantly related to known circoviruses is associated with porcine dermatitis and nephropathy syndrome and reproductive failure","volume":"91","author":"Palinski","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0160","first-page":"285","article-title":"Associations among Haemophilus parasuis, Mycoplasma hyorhinis, and porcine reproductive and respiratory syndrome virus infections in pigs with polyserositis","volume":"56","author":"Palzer","year":"2015","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.vetmic.2020.108588_bib0165","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.vetmic.2016.07.023","article-title":"Cross reactivity among the swine mycoplasmas as identified by protein microarray","volume":"192","author":"Petersen","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0170","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1016\/j.vaccine.2014.02.088","article-title":"Interaction of porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccines on dually infected pigs","volume":"32","author":"Seo","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2020.108588_bib0175","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.vetmic.2013.04.019","article-title":"Mycoplasma hyopneumoniae: from disease to vaccine development","volume":"165","author":"Simionatto","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0180","series-title":"Diseases of Swine","first-page":"779","article-title":"Mycoplasmosis","author":"Thacker","year":"2012"},{"key":"10.1016\/j.vetmic.2020.108588_bib0185","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1135(00)00221-2","article-title":"Antimicrobial susceptibility of Mycoplasma hyorhinis","volume":"76","author":"Wu","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0190","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1007\/s00705-019-04336-4","article-title":"The prevalence and genetic diversity of porcine circovirus types 2 and 3 in Northeast China from 2015 to 2018","volume":"164","author":"Xia","year":"2019","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2020.108588_bib0195","article-title":"Novel circovirus species identified in farmed pigs designated as Porcine circovirus 4, Hunan province","author":"Zhang","year":"2019","journal-title":"China. Transbound Emerg. Dis."},{"key":"10.1016\/j.vetmic.2020.108588_bib0200","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s12866-019-1614-4","article-title":"Identification of specific B cell linear epitopes of mycoplasma hyorhinis P37 protein using monoclonal antibodies against baculovirus-expressed P37 protein","volume":"19","author":"Zhu","year":"2019","journal-title":"BMC Microbiol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113519313288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113519313288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:06:08Z","timestamp":1759878368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113519313288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":40,"alternative-id":["S0378113519313288"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2020.108588","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy in pigs of a new inactivated vaccine combining porcine circovirus type 2 and Mycoplasma hyorhinis","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2020.108588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108588"}}