{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:15:07Z","timestamp":1790788507900,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFE0203200"],"award-info":[{"award-number":["2016YFE0203200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFD0500704"],"award-info":[{"award-number":["2017YFD0500704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heilongjiang Province Foundation for the National Key Research and Development Program of China","award":["GX18B011"],"award-info":[{"award-number":["GX18B011"]}]},{"name":"Major Project of National Natural Science Foundation of China","award":["31430087"],"award-info":[{"award-number":["31430087"]}]},{"name":"Earmarked Fund for Modern Agriculture Industry Technology Research System","award":["CARS-41-G15"],"award-info":[{"award-number":["CARS-41-G15"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.vetmic.2020.108700","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T02:32:25Z","timestamp":1587781945000},"page":"108700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Naturally occurring homologous recombination between novel variant infectious bursal disease virus and intermediate vaccine strain"],"prefix":"10.1016","volume":"245","author":[{"given":"Tiantian","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaole","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2020.108700_bib0005","doi-asserted-by":"crossref","first-page":"11974","DOI":"10.1128\/JVI.75.24.11974-11982.2001","article-title":"Molecular determinants of virulence, cell tropism, and pathogenic phenotype of infectious bursal disease virus","volume":"75","author":"Brandt","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0168-1702(95)01253-2","article-title":"Coding sequences of both genome segments of a European \u2018very virulent\u2019 infectious bursal disease virus","volume":"40","author":"Brown","year":"1996","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2020.108700_bib0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/1587909","article-title":"An apparently new disease of chickens: avian nephrosis","volume":"6","author":"Cosgrove","year":"1962","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2020.108700_bib0020","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.vetmic.2019.01.023","article-title":"Novel variant strains of infectious bursal disease virus isolated in China","volume":"230","author":"Fan","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2019.108507","article-title":"Novel variants of infectious bursal disease virus can severely damage the bursa of fabricius of immunized chickens","volume":"240","author":"Fan","year":"2020","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.virol.2008.11.009","article-title":"Homologous recombination is apparent in infectious bursal disease virus","volume":"384","author":"He","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2020.108700_bib0035","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1099\/vir.0.2008\/004101-0","article-title":"Phylogenetic evidence for homologous recombination within the family Birnaviridae","volume":"89","author":"Hon","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0040","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1637\/10053-010912-ResNote.1","article-title":"Molecular epidemiologic evidence of homologous recombination in infectious bursal disease viruses","volume":"56","author":"Jackwood","year":"2012","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2020.108700_bib0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.vetmic.2016.11.022","article-title":"Advances in vaccine research against economically important viral diseases of food animals: infectious bursal disease virus","volume":"206","author":"Jackwood","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01731581","article-title":"A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences","volume":"16","author":"Kimura","year":"1980","journal-title":"J. Mol. Evol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0055","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1093\/bioinformatics\/btl474","article-title":"GARD: a genetic algorithm for recombination detection","volume":"22","author":"Kosakovsky Pond","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.vetmic.2020.108700_bib0060","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and Clustal X version 2.0","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.vetmic.2020.108700_bib0065","doi-asserted-by":"crossref","first-page":"12827","DOI":"10.1128\/JVI.01501-07","article-title":"Molecular and structural bases for the antigenicity of VP2 of infectious bursal disease virus","volume":"81","author":"Letzel","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0070","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/JVI.73.1.152-160.1999","article-title":"Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination","volume":"73","author":"Lole","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0075","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.virusres.2015.04.003","article-title":"Naturally occurring reassortant infectious bursal disease virus in northern China","volume":"203","author":"Lu","year":"2015","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2020.108700_bib0080","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vev003","article-title":"RDP4: detection and analysis of recombination patterns in virus genomes","volume":"1","author":"Martin","year":"2015","journal-title":"Virus Evol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0085","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1007\/s00705-017-3500-4","article-title":"Classification of infectious bursal disease virus into genogroups","volume":"162","author":"Michel","year":"2017","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/03079457.2012.661403","article-title":"Current status of vaccines against infectious bursal disease","volume":"41","author":"Muller","year":"2012","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0095","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.vetmic.2003.08.005","article-title":"Research on infectious bursal disease\u2014the past, the present and the future","volume":"97","author":"M\u00fcller","year":"2003","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0100","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1128\/JVI.74.5.2057-2066.2000","article-title":"Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus","volume":"74","author":"Petit","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0105","article-title":"Emergence and expansion of novel pathogenic reassortant strains of infectious bursal disease virus causing acute outbreaks of the disease in Europe","author":"Pikula","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2020.108700_bib0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.antiviral.2009.09.006","article-title":"Naturally occurring mutations at residues 253 and 284 in VP2 contribute to the cell tropism and virulence of very virulent infectious bursal disease virus","volume":"84","author":"Qi","year":"2009","journal-title":"Antiviral Res."},{"key":"10.1016\/j.vetmic.2020.108700_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070982","article-title":"Mutations of residues 249 and 256 in VP2 are involved in the replication and virulence of infectious bursal disease virus","volume":"8","author":"Qi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2020.108700_bib0120","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.antiviral.2010.05.004","article-title":"A single amino acid in the C-terminus of VP3 protein influences the replication of attenuated infectious bursal disease virus in vitro and in vivo","volume":"87","author":"Wang","year":"2010","journal-title":"Antiviral Res."},{"key":"10.1016\/j.vetmic.2020.108700_bib0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108620","article-title":"Naturally occurring cell-adapted classic strain of infectious bursal disease virus","volume":"243","author":"Wang","year":"2020","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108700_bib0130","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3382\/ps.0601195","article-title":"Comparative immune response from vaccinating chickens with lentogenic Newcastle disease virus strains","volume":"60","author":"Winterfield","year":"1981","journal-title":"Poultry Sci."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113520303436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113520303436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:05:03Z","timestamp":1759878303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113520303436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":26,"alternative-id":["S0378113520303436"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2020.108700","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naturally occurring homologous recombination between novel variant infectious bursal disease virus and intermediate vaccine strain","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2020.108700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108700"}}