{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:16:33Z","timestamp":1789748193473,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Boehringer-Ingelheim"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.vetmic.2020.108805","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T12:32:39Z","timestamp":1596630759000},"page":"108805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge"],"prefix":"10.1016","volume":"248","author":[{"given":"Weidong","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangke","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.vetmic.2020.108805_bib0005","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.virusres.2012.07.030","article-title":"Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains","volume":"169","author":"Brockmeier","year":"2012","journal-title":"Virus Res."},{"issue":"22","key":"10.1016\/j.vetmic.2020.108805_bib0010","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1016\/j.vaccine.2007.03.031","article-title":"Impact of a modified-live porcine reproductive and respiratory syndrome virus vaccine intervention on a population of pigs infected with a heterologous isolate","volume":"25","author":"Cano","year":"2007","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vetmic.2020.108805_bib0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5501\/wjv.v1.i1.23","article-title":"Porcine reproductive and respiratory syndrome virus vaccines: immunogenicity, efficacy and safety aspects","volume":"1","author":"Charerntantanakul","year":"2012","journal-title":"World J. Virol."},{"issue":"1\u20132","key":"10.1016\/j.vetmic.2020.108805_bib0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.virusres.2010.08.016","article-title":"Control and elimination of porcine reproductive and respiratory syndrome virus","volume":"154","author":"Corzo","year":"2010","journal-title":"Virus Res."},{"issue":"2","key":"10.1016\/j.vetmic.2020.108805_bib0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/030098589503200218","article-title":"Immunohistochemical identification of porcine reproductive and respiratory syndrome virus (PRRSV) antigen in the heart and lymphoid system of three-week-old colostrum-deprived pigs","volume":"32","author":"Halbur","year":"1995","journal-title":"Vet. Pathol."},{"issue":"2","key":"10.1016\/j.vetmic.2020.108805_bib0030","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/030098589603300205","article-title":"Comparison of the antigen distribution of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus","volume":"33","author":"Halbur","year":"1996","journal-title":"Vet. Pathol."},{"issue":"3","key":"10.1016\/j.vetmic.2020.108805_bib0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tvjl.2012.06.035","article-title":"Comparison of the virulence of European and North American genotypes of porcine reproductive and respiratory syndrome virus in experimentally infected pigs","volume":"195","author":"Han","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2020.108805_bib0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.vetmic.2018.12.016","article-title":"Efficacy evaluation of three modified-live PRRS vaccines against a local strain of highly pathogenic porcine reproductive and respiratory syndrome virus","volume":"229","author":"Huang","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108805_bib0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.vetmic.2016.07.006","article-title":"Evaluation of a 20year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac((R)) PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea","volume":"192","author":"Jeong","year":"2016","journal-title":"Vet. Microbiol."},{"issue":"8","key":"10.1016\/j.vetmic.2020.108805_bib0050","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.2460\/ajvr.1999.60.08.1022","article-title":"Evaluation of protective immunity in gilts inoculated with the NADC-8 isolate of porcine reproductive and respiratory syndrome virus (PRRSV) and challenge-exposed with an antigenically distinct PRRSV isolate","volume":"60","author":"Lager","year":"1999","journal-title":"Am. J. Vet. Res."},{"issue":"48","key":"10.1016\/j.vetmic.2020.108805_bib0055","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1016\/j.vaccine.2014.09.046","article-title":"Efficacy of Type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs","volume":"32","author":"Lager","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2020.108805_bib0060","article-title":"Comparison of host immune responses to homologous and heterologous type II porcine reproductive and respiratory syndrome virus (PRRSV) challenge in vaccinated and unvaccinated pigs","volume":"2014","author":"Li","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"3","key":"10.1016\/j.vetmic.2020.108805_bib0065","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00330-16","article-title":"Complete genome sequence of an NADC30-like porcine reproductive and respiratory syndrome virus characterized by recombination with other strains","volume":"4","author":"Li","year":"2016","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2020.108805_bib0070","first-page":"12","article-title":"Widespread of NADC30-like PRRSV in China: another Pandora\u2019s box for Chinese pig industry as the outbreak of highly pathogenic PRRSV in 2006?","volume":"49","author":"Li","year":"2017","journal-title":"Infect. Genet. Evol. J. Molec. Epidemiol. Evolut. Genet. Infect. Dis."},{"issue":"2","key":"10.1016\/j.vetmic.2020.108805_bib0075","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.vaccine.2011.10.075","article-title":"Effect of modified-live porcine reproductive and respiratory syndrome virus (PRRSv) vaccine on the shedding of wild-type virus from an infected population of growing pigs","volume":"30","author":"Linhares","year":"2012","journal-title":"Vaccine"},{"issue":"1\u20132","key":"10.1016\/j.vetmic.2020.108805_bib0080","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.prevetmed.2014.05.010","article-title":"Comparison of time to PRRSv-stability and production losses between two exposure programs to control PRRSv in sow herds","volume":"116","author":"Linhares","year":"2014","journal-title":"Prev. Vet. Med."},{"issue":"4","key":"10.1016\/j.vetmic.2020.108805_bib0085","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1292\/jvms.15-0570","article-title":"Analysis of genetic variation of porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Central China","volume":"78","author":"Liu","year":"2016","journal-title":"J. Vet. Med. Sci. Japan. Soc. Vet. Sci."},{"key":"10.1016\/j.vetmic.2020.108805_bib0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.vetmic.2018.10.004","article-title":"High reversion potential of a cell-adapted vaccine candidate against highly pathogenic porcine reproductive and respiratory syndrome","volume":"227","author":"Liu","year":"2018","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.vetmic.2020.108805_bib0095","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/s41598-020-58626-y","article-title":"Cell-mediated immune response and protective efficacy of porcine reproductive and respiratory syndrome virus modified-live vaccines against co-challenge with PRRSV-1 and PRRSV-2","volume":"10","author":"Madapong","year":"2020","journal-title":"Sci. Rep."},{"issue":"46","key":"10.1016\/j.vetmic.2020.108805_bib0100","doi-asserted-by":"crossref","first-page":"8192","DOI":"10.1016\/j.vaccine.2011.09.013","article-title":"Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS)","volume":"29","author":"Murtaugh","year":"2011","journal-title":"Vaccine"},{"issue":"5841","key":"10.1016\/j.vetmic.2020.108805_bib0105","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1126\/science.317.5841.1017","article-title":"Virology. China, Vietnam grapple with\u2019 rapidly evolving\u2019 pig virus","volume":"317","author":"Normile","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.vetmic.2020.108805_bib0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13567-016-0331-3","article-title":"Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study","volume":"47","author":"Ouyang","year":"2016","journal-title":"Vet. Res."},{"issue":"3","key":"10.1016\/j.vetmic.2020.108805_bib0115","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.tvjl.2007.01.021","article-title":"Similarity of European porcine reproductive and respiratory syndrome virus strains to vaccine strain is not necessarily predictive of the degree of protective immunity conferred","volume":"175","author":"Prieto","year":"2008","journal-title":"Vet. J."},{"issue":"1","key":"10.1016\/j.vetmic.2020.108805_bib0120","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13028-016-0270-z","article-title":"Control and eradication of porcine reproductive and respiratory syndrome virus type 2 using a modified-live type 2 vaccine in combination with a load, close, homogenise model: an area elimination study","volume":"59","author":"Rathkjen","year":"2017","journal-title":"Acta Vet. Scand."},{"issue":"33","key":"10.1016\/j.vetmic.2020.108805_bib0125","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1016\/j.vaccine.2015.06.092","article-title":"Live porcine reproductive and respiratory syndrome virus vaccines: current status and future direction","volume":"33","author":"Renukaradhya","year":"2015","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.vetmic.2020.108805_bib0130","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tvjl.2011.11.019","article-title":"Effects of challenge with a virulent genotype II strain of porcine reproductive and respiratory syndrome virus on piglets vaccinated with an attenuated genotype I strain vaccine","volume":"193","author":"Roca","year":"2012","journal-title":"Vet. J."},{"issue":"Suppl 1","key":"10.1016\/j.vetmic.2020.108805_bib0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1865-1682.2011.01306.x","article-title":"Challenges and opportunities for the control and elimination of porcine reproductive and respiratory syndrome virus","volume":"59","author":"Rowland","year":"2012","journal-title":"Transbound. Emerg. Dis."},{"issue":"8","key":"10.1016\/j.vetmic.2020.108805_bib0140","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s00705-016-2883-y","article-title":"Pathogenicity comparison between highly pathogenic and NADC30-like porcine reproductive and respiratory syndrome virus","volume":"161","author":"Sun","year":"2016","journal-title":"Arch. Virol."},{"issue":"6","key":"10.1016\/j.vetmic.2020.108805_bib0145","doi-asserted-by":"crossref","first-page":"e526","DOI":"10.1371\/journal.pone.0000526","article-title":"Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark","volume":"2","author":"Tian","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2020.108805_bib0150","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.vetmic.2016.09.014","article-title":"Strategies to broaden the cross-protective efficacy of vaccines against porcine reproductive and respiratory syndrome virus","volume":"206","author":"Vu","year":"2017","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.vetmic.2020.108805_bib0155","doi-asserted-by":"crossref","first-page":"10781","DOI":"10.1038\/s41598-019-47239-9","article-title":"Efficacy of Type 2 PRRSV vaccine against challenge with the Chinese lineage 1 (NADC30-like) PRRSVs in pigs","volume":"9","author":"Wei","year":"2019","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.vetmic.2020.108805_bib0160","doi-asserted-by":"crossref","first-page":"10712","DOI":"10.1128\/JVI.01446-15","article-title":"Importation and recombination are responsible for the latest emergence of highly pathogenic porcine reproductive and respiratory syndrome virus in China","volume":"89","author":"Zhao","year":"2015","journal-title":"J. Virol."},{"issue":"1\u20132","key":"10.1016\/j.vetmic.2020.108805_bib0165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.virusres.2010.07.016","article-title":"Porcine reproductive and respiratory syndrome in China","volume":"154","author":"Zhou","year":"2010","journal-title":"Virus Res."},{"issue":"12","key":"10.1016\/j.vetmic.2020.108805_bib0170","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.3201\/eid2112.150360","article-title":"NADC30-like strain of porcine reproductive and respiratory syndrome virus, China","volume":"21","author":"Zhou","year":"2015","journal-title":"Emerging Infect. Dis."},{"key":"10.1016\/j.vetmic.2020.108805_bib0175","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.vetmic.2017.05.031","article-title":"Efficacy evaluation of three modified-live virus vaccines against a strain of porcine reproductive and respiratory syndrome virus NADC30-like","volume":"207","author":"Zhou","year":"2017","journal-title":"Vet. Microbiol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113520309433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113520309433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:10:19Z","timestamp":1759878619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113520309433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":35,"alternative-id":["S0378113520309433"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2020.108805","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2020.108805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108805"}}