{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:03:26Z","timestamp":1778915006731,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.vetmic.2020.108887","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T21:19:51Z","timestamp":1602537591000},"page":"108887","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Protective immunity in swine induced by Porcine Circovirus 2b inactivated vaccines with different antigen payload"],"prefix":"10.1016","volume":"252","author":[{"given":"Flavia","family":"Guarneri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico Tommaso","family":"Tresoldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Sarli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Beatrice","family":"Boniotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Lelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Bacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"D\u2019Annunzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Amadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2020.108887_bib0005","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.prevetmed.2011.06.001","article-title":"Farm level risk factors associated with severity of post-weaning multi-systemic wasting syndrome","volume":"101","author":"Alarcon","year":"2011","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.vetmic.2020.108887_bib0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/1045-1056(91)90034-H","article-title":"Potency assessment of foot-and-mouth disease vaccines in cattle by means of antibody assays","volume":"19","author":"Amadori","year":"1991","journal-title":"Biologicals"},{"key":"10.1016\/j.vetmic.2020.108887_bib0015","doi-asserted-by":"crossref","first-page":"5.4.1","DOI":"10.1002\/cpps.47","article-title":"Overview of the baculovirus expression system","volume":"91","author":"Chambers","year":"2018","journal-title":"Curr. Protoc. Protein Sci."},{"key":"10.1016\/j.vetmic.2020.108887_bib0020","first-page":"1","article-title":"Antigenic determinants of possible vaccine escape by porcine circovirus subtype 2b viruses","volume":"9","author":"Constans","year":"2015","journal-title":"Bioinform. Biol. Insights"},{"key":"10.1016\/j.vetmic.2020.108887_bib0025","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.rvsc.2010.06.011","article-title":"Comparative evaluation of PRRS virus infection in vaccinated and naive pigs","volume":"90","author":"Dotti","year":"2011","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2020.108887_bib0030","series-title":"Probit Analysis","author":"Finney","year":"1952"},{"key":"10.1016\/j.vetmic.2020.108887_bib0035","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.vetmic.2007.06.004","article-title":"Detection of neutralizing antibodies in postweaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs","volume":"125","author":"Fort","year":"2007","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108887_bib0040","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01315-15","article-title":"Whole-genome sequences of novel porcine circovirus type 2 viruses detected in Swine from Mexico and the United States","volume":"3","author":"Harmon","year":"2015","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2020.108887_bib0045","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1007\/s00253-016-7459-y","article-title":"Capsid proteins from PCV2a genotype confer greater protection against a PCV2b strain than those from PCV2b genotype in pigs: evidence for PCV2b strains becoming more predominant than PCV2a strains from 2000 to 2010s","volume":"100","author":"Huang","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.vetmic.2020.108887_bib0050","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1099\/vir.0.83280-0","article-title":"Antigenic differences among porcine circovirus type 2 strains, as demonstrated by the use of monoclonal antibodies","volume":"89","author":"Lefebvre","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2020.108887_bib0055","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.4049\/jimmunol.1102695","article-title":"Hidden memories: frontline memory T cells and early pathogen interception","volume":"188","author":"Masopust","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2020.108887_bib0060","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s007050170124","article-title":"Production, characterisation and applications of monoclonal antibodies to porcine circovirus 2","volume":"146","author":"McNeilly","year":"2001","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2020.108887_bib0065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jviromet.2003.12.007","article-title":"Comparison of porcine circovirus type 2 load in serum quantified by a real time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs","volume":"117","author":"Olvera","year":"2004","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.vetmic.2020.108887_bib0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.vetmic.2019.03.002","article-title":"Evaluation of a porcine circovirus type 2a (PCV2a) vaccine efficacy against experimental PCV2a, PCV2b, and PCV2d challenge","volume":"231","author":"Park","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2020.108887_bib0075","series-title":"Proceedings 5th International Congress of Veterinary Virology","first-page":"253","article-title":"Development of monoclonal antibodies-based ELISAs for the detection of antibodies against porcine circovirus type 1 and type 2","author":"Sala","year":"2000"},{"key":"10.1016\/j.vetmic.2020.108887_bib0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.virusres.2011.10.007","article-title":"Porcine circovirus type 2 (PCV2) infections: clinical signs, pathology and laboratory diagnosis","volume":"164","author":"Segales","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2020.108887_bib0085","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1586\/14760584.2015.983084","article-title":"Best practice and future challenges for vaccination against porcine circovirus type 2","volume":"14","author":"Segales","year":"2015","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.vetmic.2020.108887_bib0090","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/vr.162.26.867","article-title":"PCV-2 genotype definition and nomenclature","volume":"162","author":"Segales","year":"2008","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetmic.2020.108887_bib0095","first-page":"213","article-title":"Role of cytokines in immune response to pulmonary tuberculosis","volume":"19","author":"Sharma","year":"2001","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.vetmic.2020.108887_bib0100","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/vim.2006.0106","article-title":"T lymphocyte epitope mapping of porcine circovirus type 2","volume":"20","author":"Stevenson","year":"2007","journal-title":"Viral Immunol."},{"key":"10.1016\/j.vetmic.2020.108887_bib0105","first-page":"280","article-title":"Viral DNA from cells infected with porcine circovirus","volume":"270","author":"Tischer","year":"1988","journal-title":"Zentralbl. Bakteriol. Mikrobiol. Hyg. A."},{"key":"10.1016\/j.vetmic.2020.108887_bib0110","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.virusres.2011.11.018","article-title":"Genetic variation of porcine circovirus type 2 (PCV2) and its relevance to vaccination, pathogenesis and diagnosis","volume":"164","author":"Trible","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2020.108887_bib0115","first-page":"11","article-title":"Porcine circovirus structure and replication: a minireview","volume":"1","author":"Weingartl","year":"2002","journal-title":"Agricultura"},{"key":"10.1016\/j.vetmic.2020.108887_bib0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.biologicals.2015.01.002","article-title":"A simple method for measuring porcine circovirus 2 whole virion particles and standardizing vaccine formulation","volume":"43","author":"Zanotti","year":"2015","journal-title":"Biologicals"},{"key":"10.1016\/j.vetmic.2020.108887_bib0125","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1089\/vim.2015.0021","article-title":"Correlates of protection following vaccination with inactivated porcine circovirus 2 vaccines","volume":"28","author":"Zanotti","year":"2015","journal-title":"Viral Immunol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113520310257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113520310257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:10:24Z","timestamp":1759878624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113520310257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":25,"alternative-id":["S0378113520310257"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2020.108887","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective immunity in swine induced by Porcine Circovirus 2b inactivated vaccines with different antigen payload","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2020.108887","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108887"}}