{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:25:26Z","timestamp":1776943526423,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.vetmic.2021.109130","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T12:14:18Z","timestamp":1621944858000},"page":"109130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["ATP-dependent activation of NLRP3 inflammasome in primary murine macrophages infected by pseudorabies virus"],"prefix":"10.1016","volume":"259","author":[{"given":"Chao","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiali","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianci","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rendong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2021.109130_bib0005","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bcp.2017.12.021","article-title":"The P2X7 receptor: a main player in inflammation","volume":"151","author":"Adinolfi","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2020.09.004","article-title":"Interplays between inflammasomes and viruses, bacteria (pathogenic and probiotic), yeasts and parasites","volume":"228","author":"Antushevich","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.vetmic.2021.109130_bib0015","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0020","doi-asserted-by":"crossref","first-page":"932","DOI":"10.3390\/v12090932","article-title":"Lytic cell death mechanisms in human respiratory syncytial virus-infected macrophages: roles of pyroptosis and necroptosis","volume":"12","author":"Bedient","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2021.109130_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1746-6148-8-7","article-title":"Wild boar: an increasing concern for Aujeszky\u2019s disease control in pigs?","volume":"8","author":"Boadella","year":"2012","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetmic.2021.109130_bib0030","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-016-0559-z","article-title":"The IL-1 cytokine family and its role in inflammation and fibrosis in the lung","volume":"38","author":"Borthwick","year":"2016","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tim.2014.09.007","article-title":"Response of host inflammasomes to viral infection","volume":"23","author":"Chen","year":"2015","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.vetmic.2018.10.030","article-title":"Porcine reproductive and respiratory syndrome virus induces interleukin-1\u03b2 through MyD88\/ERK\/AP-1 and NLRP3 inflammasome in microglia","volume":"227","author":"Chen","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0045","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.imbio.2016.02.003","article-title":"The purinergic receptor P2X7 role in control of Dengue virus-2 infection and cytokine\/chemokine production in infected human monocytes","volume":"221","author":"Corr\u00eaa","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.vetmic.2021.109130_bib0050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.vetmic.2019.03.019","article-title":"NLRP3 inflammasome plays an important role in caspase-1 activation and IL-1\u03b2 secretion in macrophages infected with Pasteurella multocida","volume":"231","author":"Fang","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0055","doi-asserted-by":"crossref","first-page":"S504","DOI":"10.1093\/infdis\/jiy433","article-title":"The induction of IL-1\u03b2 secretion through the NLRP3 inflammasome during Ebola virus infection","volume":"218","author":"Halfmann","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vetmic.2021.109130_bib0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229570","article-title":"Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1","volume":"15","author":"Karaba","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2021.109130_bib0065","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.chom.2011.04.008","article-title":"IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection","volume":"9","author":"Kerur","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vetmic.2021.109130_bib0070","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1073\/pnas.0308057100","article-title":"Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis","volume":"101","author":"Kurt-Jones","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vetmic.2021.109130_bib0075","doi-asserted-by":"crossref","first-page":"e01614","DOI":"10.1128\/JVI.01614-18","article-title":"Virulent pseudorabies virus infection induces a specific and lethal systemic inflammatory response in mice","volume":"92","author":"Laval","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0080","article-title":"Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2021.109130_bib0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.coviro.2015.02.007","article-title":"Inflammasome control of viral infection","volume":"12","author":"Lupfer","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0090","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.chom.2017.12.014","article-title":"Herpes simplex virus 1 VP22 inhibits AIM2-dependent inflammasome activation to enable efficient viral replication","volume":"23","author":"Maruzuru","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vetmic.2021.109130_bib0095","first-page":"99","article-title":"Aujeszky\u2019s disease (pseudorabies) virus: the virus and molecular pathogenesis\u2014state of the art, June 1999","volume":"31","author":"Mettenleiter","year":"2000","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2021.109130_bib0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.rvsc.2020.04.014","article-title":"The NADL strain of bovine viral diarrhea virus induces the secretion of IL-1\u03b2 through caspase 1 in bovine macrophages","volume":"131","author":"Morales-Aguilar","year":"2020","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2021.109130_bib0105","doi-asserted-by":"crossref","first-page":"17921","DOI":"10.1074\/jbc.M110.210575","article-title":"Varicella-zoster virus infection triggers formation of an interleukin-1\u03b2 (IL-1\u03b2)-processing inflammasome complex","volume":"286","author":"Nour","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2021.109130_bib0110","doi-asserted-by":"crossref","first-page":"R328","DOI":"10.1016\/j.cub.2010.01.044","article-title":"Sensing and signaling in antiviral innate immunity","volume":"20","author":"O\u2019Neill","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0115","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/MMBR.69.3.462-500.2005","article-title":"Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine","volume":"69","author":"Pomeranz","year":"2005","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.vetmic.2021.109130_bib0120","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1100\/2011\/212680","article-title":"Role of the inflammasome, IL-1\u03b2, and IL-18 in bacterial infections","volume":"11","author":"Sahoo","year":"2011","journal-title":"Sci. World J."},{"key":"10.1016\/j.vetmic.2021.109130_bib0125","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.vetmic.2015.09.021","article-title":"Emergence of a pseudorabies virus variant with increased virulence to piglets","volume":"181","author":"Tong","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.it.2011.01.003","article-title":"Inflammasome activation and IL-1\u03b2 and IL-18 processing during infection","volume":"32","author":"van de Veerdonk","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.vetmic.2021.109130_bib0135","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.virusres.2014.03.006","article-title":"Bovine herpesvirus 1 productive infection stimulates inflammasome formation and caspase 1 activity","volume":"185","author":"Wang","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2021.109130_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110660","article-title":"The role of IL-1\u03b2 and TNF-\u03b1 in intervertebral disc degeneration","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.vetmic.2021.109130_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063759","article-title":"Adenosine-5\u2019-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome","volume":"8","author":"Xiang","year":"2013","journal-title":"PLoS One"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811352100153X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811352100153X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:13:34Z","timestamp":1759878814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811352100153X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":29,"alternative-id":["S037811352100153X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2021.109130","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATP-dependent activation of NLRP3 inflammasome in primary murine macrophages infected by pseudorabies virus","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2021.109130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109130"}}