{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:27:49Z","timestamp":1780331269996,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.vetmic.2021.109237","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T20:39:33Z","timestamp":1632170373000},"page":"109237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Japanese encephalitis virus restricts HMGB1 expression to maintain MAPK pathway activation for viral replication"],"prefix":"10.1016","volume":"262","author":[{"given":"Jinchao","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-474X","authenticated-orcid":false,"given":"Lihong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingsheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbao","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2021.109237_bib0005","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1093\/emboj\/cdg516","article-title":"Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion","volume":"22","author":"Bonaldi","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.vetmic.2021.109237_bib0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2021.109237_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2014.07.046","article-title":"Porcine reproductive and respiratory syndrome virus infection triggers HMGB1 release to promote inflammatory cytokine production","volume":"468\u2013470","author":"Duan","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2021.109237_bib0020","doi-asserted-by":"crossref","first-page":"e1834","DOI":"10.1371\/journal.pntd.0001834","article-title":"Partially neutralizing potency against emerging genotype I virus among children received formalin-inactivated Japanese encephalitis virus vaccine","volume":"6","author":"Fan","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetmic.2021.109237_bib0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.vetmic.2013.01.017","article-title":"Reduced neutralizing antibody titer against genotype I virus in swine immunized with a live-attenuated genotype III Japanese encephalitis virus vaccine","volume":"163","author":"Fan","year":"2013","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0030","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.mib.2011.07.012","article-title":"Exploitation of cellular pathways by Dengue virus","volume":"14","author":"Fischl","year":"2011","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0035","doi-asserted-by":"crossref","first-page":"e2459","DOI":"10.1371\/journal.pntd.0002459","article-title":"Southernmost asia is the source of Japanese encephalitis virus (Genotype 1) diversity from which the viruses disperse and evolve throughout Asia","volume":"7","author":"Gao","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetmic.2021.109237_bib0040","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.3390\/ijms21082961","article-title":"Glycyrrhizin inhibits PEDV infection and proinflammatory cytokine secretion via the HMGB1\/TLR4-MAPK p38 pathway","volume":"21","author":"Gao","year":"2020","journal-title":"IJMS"},{"key":"10.1016\/j.vetmic.2021.109237_bib0045","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1074\/mcp.R116.065649","article-title":"Protein interactions during the flavivirus and hepacivirus life cycle","volume":"16","author":"Gerold","year":"2017","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.vetmic.2021.109237_bib0050","doi-asserted-by":"crossref","first-page":"3526","DOI":"10.1016\/j.yexcr.2006.07.020","article-title":"Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1","volume":"312","author":"Hoppe","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.vetmic.2021.109237_bib0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13567-020-00742-8","article-title":"High-mobility group box 1 protein (HMGB1) from Cherry Valley duck mediates signaling pathways and antiviral activity","volume":"51","author":"Hou","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2021.109237_bib0060","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1128\/JVI.00682-11","article-title":"Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells","volume":"85","author":"Jung","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0065","first-page":"1","article-title":"HMGB1 in health and disease","volume":"40","author":"Kang","year":"2014"},{"key":"10.1016\/j.vetmic.2021.109237_bib0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.virusres.2018.05.028","article-title":"Role of MAPK\/MNK1 signaling in virus replication","volume":"253","author":"Kumar","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2021.109237_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101203","article-title":"Peroxiredoxin-mediated disulfide bond formation is required for nucleocytoplasmic translocation and secretion of HMGB1 in response to inflammatory stimuli","volume":"24","author":"Kwak","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0080","doi-asserted-by":"crossref","first-page":"e1231","DOI":"10.1371\/journal.pntd.0001231","article-title":"Genotype V Japanese encephalitis virus is emerging","volume":"5","author":"Li","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetmic.2021.109237_bib0085","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0090","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1073\/pnas.1316925111","article-title":"JAK\/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation","volume":"111","author":"Lu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vetmic.2021.109237_bib0095","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/biom4040897","article-title":"Cullin E3 ligases and their rewiring by viral factors","volume":"4","author":"Mahon","year":"2014","journal-title":"Biomolecules"},{"key":"10.1016\/j.vetmic.2021.109237_bib0100","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1128\/JVI.00789-12","article-title":"HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication","volume":"86","author":"Moisy","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0105","doi-asserted-by":"crossref","first-page":"C870","DOI":"10.1152\/ajpcell.00322.2002","article-title":"Activation of gene expression in human neutrophils by high mobility group box 1 protein","volume":"284","author":"Park","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virol.2018.09.001","article-title":"Newcastle disease virus infection triggers HMGB1 release to promote the inflammatory response","volume":"525","author":"Qu","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2021.109237_bib0115","doi-asserted-by":"crossref","DOI":"10.2807\/ese.17.28.20221-en","article-title":"Japanese encephalitis virus RNA detected in Culex pipiens mosquitoes in Italy","volume":"17","author":"Ravanini","year":"2012","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.vetmic.2021.109237_bib0120","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3389\/fmicb.2019.01625","article-title":"Avian influenza a virus polymerase recruits cellular RNA helicase eIF4A3 to promote viral mRNA splicing and spliced mRNA nuclear export","volume":"10","author":"Ren","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0125","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.68.4.405","article-title":"Neurological aspects of tropical disease: Japanese encephalitis","volume":"68","author":"Solomon","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"10.1016\/j.vetmic.2021.109237_bib0130","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0042-6822(87)90144-9","article-title":"Complete nucleotide sequence of the Japanese encephalitis virus genome RNA","volume":"161","author":"Sumiyoshi","year":"1987","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2021.109237_bib0135","doi-asserted-by":"crossref","first-page":"e00238","DOI":"10.1128\/JVI.00238-20","article-title":"PCV2 induces reactive oxygen species to promote nucleocytoplasmic translocation of the viral DNA binding protein HMGB1 to enhance its replication","volume":"94","author":"Sun","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0140","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1089\/ars.2015.6409","article-title":"Regulation of posttranslational modifications of HMGB1 during immune responses","volume":"24","author":"Tang","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.vetmic.2021.109237_bib0145","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1189\/jlb.1212662","article-title":"The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis","volume":"93","author":"Yang","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0150","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.4049\/jimmunol.177.11.7889","article-title":"Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion","volume":"177","author":"Youn","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0155","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1128\/JVI.02795-15","article-title":"HMGB1 promotes hepatitis C virus replication by interaction with stem-loop 4 in the viral 5\u2032 untranslated region","volume":"90","author":"Yu","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0160","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12985-019-1266-x","article-title":"Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K\/Akt and ERK\/MAPK signaling pathways","volume":"16","author":"Yu","year":"2019","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2021.109237_bib0165","doi-asserted-by":"crossref","first-page":"42998","DOI":"10.1038\/srep42998","article-title":"Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection","volume":"7","author":"Zainal","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2021.109237_bib0170","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fcimb.2018.00398","article-title":"Cellular targets for the treatment of flavivirus infections","volume":"8","author":"Zakaria","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.vetmic.2021.109237_bib0175","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3201\/eid2306.152115","article-title":"Epidemiologic survey of Japanese encephalitis virus infection, Tibet, China, 2015","volume":"23","author":"Zhang","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2021.109237_bib0180","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01350-19","article-title":"Foot-and-mouth disease virus capsid protein VP1 interacts with host ribosomal protein SA to maintain activation of the MAPK signal pathway and promote virus replication","volume":"94","author":"Zhu","year":"2020","journal-title":"J. Virol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113521002601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113521002601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:15:54Z","timestamp":1759878954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113521002601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":36,"alternative-id":["S0378113521002601"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2021.109237","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Japanese encephalitis virus restricts HMGB1 expression to maintain MAPK pathway activation for viral replication","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2021.109237","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109237"}}