{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:18:01Z","timestamp":1786997881394,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JCQY201906"],"award-info":[{"award-number":["JCQY201906"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972631"],"award-info":[{"award-number":["31972631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2018YFE0127300"],"award-info":[{"award-number":["2018YFE0127300"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.vetmic.2022.109357","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T12:16:21Z","timestamp":1643112981000},"page":"109357","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Effect of Bacillus coagulans on maintaining the integrity intestinal mucosal barrier in broilers"],"prefix":"10.1016","volume":"266","author":[{"given":"Chunru","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-0735","authenticated-orcid":false,"given":"Stoffel Matjeke","family":"Radebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaolei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2022.109357_bib0005","series-title":"Development of Innate Immunity in Chicken Embryos and Newly Hatched Chicks: a Disease Control Perspective","first-page":"288","author":"Alkie","year":"2019"},{"key":"10.1016\/j.vetmic.2022.109357_bib0010","series-title":"The Intestinal Epithelium: Central Coordinator of Mucosal Immunity.","first-page":"677","author":"Allaire","year":"2018"},{"key":"10.1016\/j.vetmic.2022.109357_bib0015","series-title":"Advances in Poultry Nutrition Research","article-title":"Probiotics as a promising additive in broiler feed: advances and limitations","author":"Bahule","year":"2021"},{"key":"10.1016\/j.vetmic.2022.109357_bib0020","series-title":"T Cell Control of the Gut IgA Response Against Commensal Bacteria.","first-page":"762","author":"Bos","year":"2001"},{"key":"10.1016\/j.vetmic.2022.109357_bib0025","series-title":"The Probiotic Bacillus licheniformis Ameliorates Heat Stress-induced Impairment of Egg Production, Gut Morphology, and Intestinal Mucosal Immunity in Laying Hens","first-page":"575","author":"Deng","year":"2012"},{"key":"10.1016\/j.vetmic.2022.109357_bib0030","series-title":"Survival of Entrapped Lactobacillus rhamnosus GG in Whey Protein Micro-beads During Simulated Ex Vivo Gastro-intestinal Transit","first-page":"31","author":"Doherty","year":"2012"},{"key":"10.1016\/j.vetmic.2022.109357_bib0035","series-title":"An Alternative for Antibiotic Se in Poultry: Probiotics","first-page":"75","author":"F.J.B.Jo.P.S. Edens","year":"2003"},{"key":"10.1016\/j.vetmic.2022.109357_bib0040","series-title":"Potential Probiotic Attributes of a New Strain of Bacillus coagulans CGMCC 9951 Isolated From Healthy Piglet Feces","first-page":"851","author":"Gu","year":"2015"},{"key":"10.1016\/j.vetmic.2022.109357_bib0045","series-title":"The Impact of the Level of the Intestinal Short Chain Fatty Acids in Inflammatory Bowel Disease Patients Versus Healthy Subjects","first-page":"53","author":"Huda-Faujan","year":"2010"},{"key":"10.1016\/j.vetmic.2022.109357_bib0050","series-title":". Secretome of Intestinal Bacilli: a Natural Guard Against Pathologies","first-page":"1666","author":"Ilinskaya","year":"2017"},{"key":"10.1016\/j.vetmic.2022.109357_bib0055","series-title":"Probiotic Administration Increases Amino Acid Absorption From Plant Protein: a Placebo-controlled, Randomized, Double-blind, Multicenter, Crossover Study","first-page":"1330","author":"J\u00e4ger","year":"2020"},{"key":"10.1016\/j.vetmic.2022.109357_bib0060","series-title":"A Prospective, Randomized, Double-blind, Placebo-controlled Parallel-group Dual Site Trial to Evaluate the Effects of a Bacillus coagulans-based Product on Functional Intestinal Gas Symptoms","first-page":"1","author":"Kalman","year":"2009"},{"key":"10.1016\/j.vetmic.2022.109357_bib0065","series-title":"Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress","first-page":"319","author":"Kim","year":"2010"},{"key":"10.1016\/j.vetmic.2022.109357_bib0070","series-title":"Gut Health in Poultry","first-page":"1","author":"Kogut","year":"2017"},{"key":"10.1016\/j.vetmic.2022.109357_bib0075","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/ijc.31559","article-title":"Parabacteroides distasonis attenuates toll\u2010like receptor 4 signaling and Akt activation and blocks colon tumor formation in high\u2010fat diet\u2010fed azoxymethane\u2010treated mice","volume":"143","author":"Koh","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.vetmic.2022.109357_bib0080","series-title":"Dietary Supplementation of Young Broiler Chickens With Capsicum and Turmeric Oleoresins Increases Resistance to Necrotic Enteritis","first-page":"840","author":"Lee","year":"2013"},{"key":"10.1016\/j.vetmic.2022.109357_bib0085","series-title":"Poultry Metabolic Disorders and Mycotoxins","author":"Leeson","year":"1995"},{"key":"10.1016\/j.vetmic.2022.109357_bib0090","series-title":"Broilers Fed Dietary Vitamins Harbor Higher Diversity of Cecal Bacteria and Higher Ratio of Clostridium, Faecalibacterium, and Lactobacillus than Broilers With No Dietary Vitamins Revealed by 16S rRNA Gene Clone Libraries","first-page":"2358","author":"Luo","year":"2013"},{"key":"10.1016\/j.vetmic.2022.109357_bib0095","series-title":"Wnt Pathway Regulation of Intestinal Stem Cells","first-page":"594","author":"Mah","year":"2016"},{"key":"10.1016\/j.vetmic.2022.109357_bib0100","series-title":"Diet, Gut Microbiota and Immune Responses","first-page":"5","author":"Maslowski","year":"2011"},{"key":"10.1016\/j.vetmic.2022.109357_bib0105","series-title":"Contributions of Intestinal Bacteria to Nutrition and Metabolism in the Critically Ill","first-page":"771","author":"Morowitz","year":"2011"},{"key":"10.1016\/j.vetmic.2022.109357_bib0110","series-title":"Bacillus Coagulans GBI-30, 6086 Modulates Faecalibacterium prausnitzii in Older Men and Women","first-page":"1446","author":"Nyangale","year":"2015"},{"key":"10.1016\/j.vetmic.2022.109357_bib0115","series-title":"Maintenance of Intestinal Homeostasis by Mucosal Barriers","first-page":"1","author":"Okumura","year":"2018"},{"key":"10.1016\/j.vetmic.2022.109357_bib0120","first-page":"52","article-title":"Molecular basis of sodium butyrate-dependent proapoptotic activity in cancer cells","author":"Pajak","year":"2007","journal-title":"Advances in Medical Sciences (De Gruyter Open)"},{"key":"10.1016\/j.vetmic.2022.109357_bib0125","series-title":"Changes in Blood Chemistry in Broiler Chickens During the Fattening Period","first-page":"183","author":"Piotrowska","year":"2011"},{"key":"10.1016\/j.vetmic.2022.109357_bib0130","series-title":"Intestinal Morphology in Broiler Chickens Supplemented With Propolis and Bee Pollen","first-page":"301","author":"Prakatur","year":"2019"},{"key":"10.1016\/j.vetmic.2022.109357_bib0135","series-title":"#150}, He, J., Zheng, P., Mao, X., Yu, J., Huang, Z., Zhu, L., Luo, J.J.B.r.i., 2018. Protective Effects of Benzoic Acid, Bacillus coagulans, and Oregano Oil on Intestinal Injury Caused by Enterotoxigenic Escherichia coli in Weaned Piglets","first-page":"2018","author":"Pu","year":"2018"},{"key":"10.1016\/j.vetmic.2022.109357_bib0140","series-title":"Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions","first-page":"47","author":"Rao","year":"2012"},{"key":"10.1016\/j.vetmic.2022.109357_bib0145","series-title":"Deciphering Chicken Gut Microbial Dynamics Based on High-throughput 16S rRNA Metagenomics Analyses","first-page":"1","author":"Shaufi","year":"2015"},{"key":"10.1016\/j.vetmic.2022.109357_bib0150","doi-asserted-by":"crossref","unstructured":"Takahashi, T.J.I.i., 2020. Roles of nAChR and Wnt Signaling in Intestinal Stem Cell Function and Inflammation. 81, 106260.","DOI":"10.1016\/j.intimp.2020.106260"},{"key":"10.1016\/j.vetmic.2022.109357_bib0155","series-title":"The Gut Microbiome: Connecting Spatial Organization to Function","first-page":"433","author":"Tropini","year":"2017"},{"key":"10.1016\/j.vetmic.2022.109357_bib0160","first-page":"799","volume":"9","author":"Turner","year":"2009","journal-title":"Intestinal mucosal barrier function in health and disease."},{"key":"10.1016\/j.vetmic.2022.109357_bib0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2018.12.028","article-title":"Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.vetmic.2022.109357_bib0170","series-title":"High-density Lipoprotein, Low-density Lipoprotein and Coronary Artery Disease","first-page":"A7","author":"Wilson","year":"1990"},{"key":"10.1016\/j.vetmic.2022.109357_bib0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/gutjnl-2017-315458","article-title":"Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis","volume":"68","author":"Wu","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.vetmic.2022.109357_bib0180","doi-asserted-by":"crossref","unstructured":"Zhang, B., Zhang, H., Yu, Y., Zhang, R., Wu, Y., Yue, M., Yang, C.J.P.S., 2021. Effects of Bacillus Coagulans on Growth Performance, Antioxidant Capacity, Immunity Function, and Gut Health in Broilers. 100, 101168.","DOI":"10.1016\/j.psj.2021.101168"},{"key":"10.1016\/j.vetmic.2022.109357_bib0185","series-title":"Effect of Direct-fed Microbial on Growth Performance, Nutrient Digestibility, Fecal Noxious Gas Emission, Fecal Microbial Flora and Diarrhea Score in Weanling Pigs","first-page":"86","author":"Zhao","year":"2015"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811352200027X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811352200027X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:17:08Z","timestamp":1759879028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811352200027X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":37,"alternative-id":["S037811352200027X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2022.109357","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Bacillus coagulans on maintaining the integrity intestinal mucosal barrier in broilers","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2022.109357","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109357"}}