{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:31:40Z","timestamp":1776954700578,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.vetmic.2023.109679","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T16:59:30Z","timestamp":1676048370000},"page":"109679","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Nonstructural protein 2A2 from Duck hepatitis A virus type 1 inhibits interferon beta production by interaction with mitochondrial antiviral signaling protein and TANK-binding kinase 1"],"prefix":"10.1016","volume":"280","author":[{"given":"Nana","family":"Sui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guige","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8753-4034","authenticated-orcid":false,"given":"Jiaqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4747-8410","authenticated-orcid":false,"given":"Shijin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2023.109679_bib1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-immunol-031210-101340","article-title":"Nucleic acid recognition by the innate immune system","volume":"29","author":"Barbalat","year":"2011","journal-title":"Annu. Rev. Immunol."},{"issue":"13","key":"10.1016\/j.vetmic.2023.109679_bib2","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1073\/pnas.1001755107","article-title":"Association of RIG-I with innate immunity of ducks to influenza","volume":"107","author":"Barber","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vetmic.2023.109679_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.coviro.2015.01.004","article-title":"RIG-I-like receptor regulation in virus infection and immunity","volume":"12","author":"Chan","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virol.2007.01.007","article-title":"Molecular analysis of duck hepatitis virus type 1","volume":"361","author":"Ding","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2023.109679_bib5","doi-asserted-by":"crossref","first-page":"13228","DOI":"10.1038\/ncomms13228","article-title":"Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF","volume":"7","author":"Felix","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2023.109679_bib6","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1128\/JVI.02712-13","article-title":"Enterovirus 2Apro targets MDA5 and MAVS in infected cells","volume":"88","author":"Feng","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12250-012-3255-8","article-title":"Genetic variation of the VP1 gene of the virulent duck hepatitis A virus type 1 (DHAV-1) isolates in Shandong province of China","volume":"27","author":"Gao","year":"2012","journal-title":"Virol. Sin."},{"key":"10.1016\/j.vetmic.2023.109679_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023971","article-title":"Functional dissection of the TBK1 molecular network","volume":"6","author":"Goncalves","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.vetmic.2023.109679_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01590-20","article-title":"Encephalomyocarditis virus abrogates the interferon beta signaling pathway via its structural protein vp2","volume":"95","author":"Han","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib10","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.febslet.2013.01.059","article-title":"Recent insights into the complexity of Tank-binding kinase 1 signaling networks: the emerging role of cellular localization in the activation and substrate specificity of TBK1","volume":"587","author":"Helgason","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.vetmic.2023.109679_bib11","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1042\/BCJ20161037","article-title":"Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK\u2013TBK1\u2013IKK\u03b5\u2013IRF3 complex","volume":"474","author":"Huang","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.vetmic.2023.109679_bib12","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1038\/sj.emboj.7601773","article-title":"Involvement of the ubiquitin-like domain of TBK1\/IKK-i kinases in regulation of IFN-inducible genes","volume":"26","author":"Ikeda","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.vetmic.2023.109679_bib13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2023.109679_bib14","doi-asserted-by":"crossref","first-page":"e01856","DOI":"10.1128\/JVI.01856-20","article-title":"Enterovirus D68 protease 2Apro targets TRAF3 to subvert host innate immune responses","volume":"95","author":"Kang","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/cells10020271","article-title":"Foot-and-mouth disease virus evades innate immune response by 3C-targeting of MDA5","volume":"10","author":"Kim","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.vetmic.2023.109679_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.700434","article-title":"DHAV-1 blocks the signaling pathway upstream of type I interferon by inhibiting the interferon regulatory factor 7 Protein","volume":"12","author":"Lai","year":"2021","journal-title":"Front. Microbiol."},{"issue":"24","key":"10.1016\/j.vetmic.2023.109679_bib17","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.3390\/ijms20246160","article-title":"Quantitative proteomic analysis uncovers the mediation of endoplasmic reticulum stress-induced autophagy in DHAV-1-infected DEF cells","volume":"20","author":"Lan","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.vetmic.2023.109679_bib18","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1128\/JVI.02491-09","article-title":"The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses","volume":"84","author":"Lei","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib19","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1096\/fj.15-281410","article-title":"The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-beta signaling pathway","volume":"30","author":"Li","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.vetmic.2023.109679_bib20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00705-015-2648-z","article-title":"Circulation and in vivo distribution of duck hepatitis A virus types 1 and 3 in infected ducklings","volume":"161","author":"Lin","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib21","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41419-020-02931-x","article-title":"MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response","volume":"11","author":"Pulido","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.vetmic.2023.109679_bib22","doi-asserted-by":"crossref","first-page":"e00823","DOI":"10.1128\/JVI.00823-17","article-title":"Seneca Valley virus suppresses host type I interferon production by targeting adaptor proteins MAVS, TRIF, and TANK for cleavage","volume":"91","author":"Qian","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib23","doi-asserted-by":"crossref","first-page":"28672","DOI":"10.1038\/srep28672","article-title":"SARS coronavirus fusion peptide-derived sequence suppresses collagen-induced arthritis in DBA\/1J mice","volume":"6","author":"Shen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2023.109679_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.sbi.2016.01.011","article-title":"Filament assemblies in foreign nucleic acid sensors","volume":"37","author":"Sohn","year":"2016","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.vetmic.2023.109679_bib25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.virusres.2006.09.007","article-title":"Molecular analysis of duck hepatitis virus type 1 indicates that it should be assigned to a new genus","volume":"123","author":"Tseng","year":"2007","journal-title":"Virus Res"},{"key":"10.1016\/j.vetmic.2023.109679_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003231","article-title":"Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses","volume":"9","author":"Wang","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2023.109679_bib27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nrm1700","article-title":"Ubiquitin and ubiquitin-like proteins as multifunctional signals","volume":"6","author":"Welchman","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.vetmic.2023.109679_bib28","doi-asserted-by":"crossref","first-page":"e02086","DOI":"10.1128\/JVI.02086-19","article-title":"Foot-and-mouth disease virus 3A protein causes upregulation of autophagy-related protein LRRC25 to inhibit the G3BP1-mediated RIG-like helicase-signaling pathway","volume":"94","author":"Yang","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib29","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.3389\/fmicb.2018.02727","article-title":"DHAV-1 2A1 Peptide - a newly discovered co-expression tool that mediates the ribosomal \"Skipping\" function","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2023.109679_bib30","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1073\/pnas.0611506104","article-title":"Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor","volume":"104","author":"Yang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vetmic.2023.109679_bib31","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1600-065X.2008.00727.x","article-title":"RNA recognition and signal transduction by RIG-I-like receptors","volume":"227","author":"Yoneyama","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetmic.2023.109679_bib32","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1128\/JVI.02174-09","article-title":"The interferon stimulator mitochondrial antiviral signaling protein facilitates cell death by disrupting the mitochondrial membrane potential and by activating caspases","volume":"84","author":"Yu","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009300","article-title":"The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation","volume":"17","author":"Zeng","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2023.109679_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.vetmic.2018.05.023","article-title":"Novel duck hepatitis A virus type 1 isolates from adult ducks showing egg drop syndrome","volume":"221","author":"Zhang","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2023.109679_bib35","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.4049\/jimmunol.1901333","article-title":"Foot-and-Mouth disease virus 3B protein interacts with pattern recognition receptor RIG-I to block RIG-I-mediated immune signaling and inhibit host antiviral response","volume":"205","author":"Zhang","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2023.109679_bib36","doi-asserted-by":"crossref","first-page":"e00362","DOI":"10.1128\/JVI.00362-19","article-title":"Peste des petits ruminants virus nucleocapsid protein inhibits beta interferon production by interacting with IRF3 to block its activation","volume":"93","author":"Zhu","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2023.109679_bib37","doi-asserted-by":"crossref","first-page":"11106","DOI":"10.1128\/JVI.01310-16","article-title":"Foot-and-mouth disease virus viroporin 2B antagonizes RIG-I-mediated antiviral effects by inhibition of its protein expression","volume":"90","author":"Zhu","year":"2016","journal-title":"J. Virol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113523000317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113523000317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:20:30Z","timestamp":1759879230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113523000317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":37,"alternative-id":["S0378113523000317"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2023.109679","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonstructural protein 2A2 from Duck hepatitis A virus type 1 inhibits interferon beta production by interaction with mitochondrial antiviral signaling protein and TANK-binding kinase 1","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2023.109679","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109679"}}