{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:53:29Z","timestamp":1794491609433,"version":"4.9.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.vetmic.2024.109987","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:24:20Z","timestamp":1704835460000},"page":"109987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["2A2 protein of DHAV-1 induces duck embryo fibroblasts gasdermin E-mediated pyroptosis"],"prefix":"10.1016","volume":"290","author":[{"given":"Jingyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Bei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2024.109987_bib1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.vetmic.2024.109987_bib2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s11262-016-1364-4","article-title":"The 2A2 protein of Duck hepatitis A virus type 1 induces apoptosis in primary cell culture","volume":"52","author":"Cao","year":"2016","journal-title":"Virus Genes."},{"issue":"1-2","key":"10.1016\/j.vetmic.2024.109987_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jviromet.2013.04.012","article-title":"Improved duplex RT-PCR assay for differential diagnosis of mixed infection of duck hepatitis a virus type 1 and type 3 in ducklings","volume":"192","author":"Chen","year":"2013","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.vetmic.2024.109987_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.00237","article-title":"Identification of the PANoptosome: a molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Christgen","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"7610","key":"10.1016\/j.vetmic.2024.109987_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.vetmic.2024.109987_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri.2016.147","article-title":"Programmed cell death as a defence against infection","volume":"17","author":"Jorgensen","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2024.109987_bib7","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1038\/cdd.2017.44","article-title":"Caspases and their substrates","volume":"24","author":"Julien","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.vetmic.2024.109987_bib8","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1099\/vir.0.81804-0","article-title":"Molecular analysis of duck hepatitis virus type 1 reveals a novel lineage close to the genus Parechovirus in the family Picornaviridae","volume":"87","author":"Kim","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2024.109987_bib9","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1007\/s00705-007-1023-0","article-title":"Recent Korean isolates of duck hepatitis virus reveal the presence of a new geno- and serotype when compared to duck hepatitis virus type 1 type strains","volume":"152","author":"Kim","year":"2007","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2024.109987_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.700434","article-title":"DHAV-1 blocks the signaling pathway upstream of type I interferon by inhibiting the interferon regulatory factor 7 protein","volume":"12","author":"Lai","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2024.109987_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005466","article-title":"MAVS-mediated apoptosis and its inhibition by viral proteins","volume":"4","author":"Lei","year":"2009","journal-title":"PLOS. One"},{"key":"10.1016\/j.vetmic.2024.109987_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1078526","article-title":"Duck gasdermin E is a substrate of caspase-3\/-7 and an executioner of pyroptosis","volume":"13","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2024.109987_bib13","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.4049\/jimmunol.1301170","article-title":"The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity","volume":"191","author":"Park","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2024.109987_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2024.109987_bib15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2024.109987_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00705-014-2264-3","article-title":"The prevalence of duck hepatitis a virus types 1 and 3 on Korean duck farms","volume":"160","author":"Soliman","year":"2015","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2024.109987_bib17","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cell.2013.02.054","article-title":"The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation","volume":"153","author":"Subramanian","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2024.109987_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.811556","article-title":"Integrated miRNA and mRNA expression profiles reveal differentially expressed miR-222a as an antiviral factor against duck hepatitis A virus type 1 infection","volume":"11","author":"Sui","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.vetmic.2024.109987_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2023.109679","article-title":"Nonstructural protein 2A2 from duck hepatitis A virus type 1 inhibits interferon beta production by interaction with mitochondrial antiviral signaling protein and TANK-binding kinase 1","volume":"280","author":"Sui","year":"2023","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.109987_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16484-1","article-title":"Cleavage of poly(A)-binding protein by duck hepatitis A virus 3C protease","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2024.109987_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virusres.2007.01.012","article-title":"Molecular characterization of a new serotype of duck hepatitis virus","volume":"126","author":"Tseng","year":"2007","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2024.109987_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2024.109987_bib23","article-title":"Cytokine storms are primarily responsible for the rapid death of ducklings infected with duck hepatitis A virus type 1","volume":"8","author":"Xie","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2024.109987_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2022.109621","article-title":"Duck hepatitis A virus type 1 transmission by exosomes establishes a productive infection in vivo and in vitro","volume":"277","author":"Xu","year":"2023","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.109987_bib25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.vetmic.2015.09.008","article-title":"Identification of a conserved neutralizing linear B-cell epitope in the VP1 proteins of duck hepatitis A virus type 1 and 3","volume":"180","author":"Zhang","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.109987_bib26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/vaccines8010121","article-title":"A novel peptide isolated from a phage display peptide library modeling antigenic epitope of DHAV-1 and DHAV-3","volume":"8","author":"Zhang","year":"2020","journal-title":"Vaccine"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524000099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524000099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:23:46Z","timestamp":1759879426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113524000099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":26,"alternative-id":["S0378113524000099"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.109987","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"2A2 protein of DHAV-1 induces duck embryo fibroblasts gasdermin E-mediated pyroptosis","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.109987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109987"}}