{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:18:51Z","timestamp":1786997931432,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.vetmic.2024.110160","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T03:11:54Z","timestamp":1718853114000},"page":"110160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Activation of the NLRP3-CASP-1 inflammasome is restrained by controlling autophagy during Glaesserella parasuis infection"],"prefix":"10.1016","volume":"295","author":[{"given":"Chaoxiong","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiao","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2024.110160_bib1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/imr.12288","article-title":"The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other?","volume":"265","author":"Abdelaziz","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetmic.2024.110160_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168780","article-title":"NLRP3 ubiquitination-a new approach to target NLRP3 inflammasome activation","volume":"22","author":"Akther","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.vetmic.2024.110160_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.591803","article-title":"Interplay between NLRP3 inflammasome and autophagy","volume":"11","author":"Biasizzo","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4161\/auto.4450","article-title":"Listeria monocytogenes evades killing by autophagy during colonization of host cells","volume":"3","author":"Birmingham","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2024.110160_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tips.2023.11.005","article-title":"Pharmacological targets at the lysosomal autophagy-NLRP3 inflammasome crossroads","volume":"45","author":"Bonam","year":"2024","journal-title":"Trends Pharm. Sci."},{"key":"10.1016\/j.vetmic.2024.110160_bib6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3389\/fcimb.2013.00062","article-title":"Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship","volume":"3","author":"Briken","year":"2013","journal-title":"Front Cell Infect. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110160_bib7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nri.2016.100","article-title":"Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis","volume":"16","author":"Cadwell","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.molimm.2015.02.016","article-title":"Haemophilus parasuis induces activation of NF-\u03baB and MAP kinase signaling pathways mediated by toll-like receptors","volume":"65","author":"Chen","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.molimm.2015.06.029","article-title":"Haemophilus parasuis infection activates chemokine RANTES in PK-15 cells","volume":"67","author":"Chen","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib10","doi-asserted-by":"crossref","first-page":"16079","DOI":"10.1073\/pnas.1306556110","article-title":"TLR-induced PAI-2 expression suppresses IL-1\u03b2 processing via increasing autophagy and NLRP3 degradation","volume":"110","author":"Chuang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vetmic.2024.110160_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018666","article-title":"Inflammasome-independent modulation of cytokine response by autophagy in human cells","volume":"6","author":"Cri\u015fan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2024.110160_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.coi.2011.10.006","article-title":"Autophagy as an innate immunity paradigm: expanding the scope and repertoire of pattern recognition receptors","volume":"24","author":"Deretic","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-024-00995-w","article-title":"Mechanistic insights from inflammasome structures","author":"Fu","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13567-016-0359-4","article-title":"Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-\u03baB) signaling during Haemophilus parasuis infection","volume":"47","author":"Fu","year":"2016","journal-title":"Vet. Res"},{"key":"10.1016\/j.vetmic.2024.110160_bib16","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.cell.2019.05.026","article-title":"Autophagy-independent functions of the autophagy machinery","volume":"177","author":"Galluzzi","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2024.110160_bib17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41564-023-01354-6","article-title":"Autophagy restricts Mycobacterium tuberculosis during acute infection in mice","volume":"8","author":"Golovkine","year":"2023","journal-title":"Nat. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110160_bib18","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cell.2004.11.038","article-title":"Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages","volume":"119","author":"Gutierrez","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2024.110160_bib19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fimmu.2013.00083","article-title":"Autophagy and IL-1 family cytokines","volume":"4","author":"Harris","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib20","doi-asserted-by":"crossref","first-page":"9587","DOI":"10.1074\/jbc.M110.202911","article-title":"Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation","volume":"286","author":"Harris","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2024.110160_bib21","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.vetmic.2024.110160_bib22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrmicro3160","article-title":"Bacteria-autophagy interplay: a battle for survival","volume":"12","author":"Huang","year":"2014","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110160_bib23","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.vetmic.2024.110160_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010912","article-title":"Glaesserella parasuis serotype 5 breaches the porcine respiratory epithelial barrier by inducing autophagy and blocking the cell membrane Claudin-1 replenishment","volume":"18","author":"Liu","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2024.110160_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109057","article-title":"Glaesserella parasuis induces inflammatory response in 3D4\/21 cells through activation of NLRP3 inflammasome signaling pathway via ROS","volume":"256","author":"Luo","year":"2021","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110160_bib27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.vetmic.2024.110160_bib28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib29","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1128\/IAI.00110-15","article-title":"Avoidance of autophagy mediated by PlcA or ActA is required for Listeria monocytogenes growth in macrophages","volume":"83","author":"Mitchell","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2024.110160_bib30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chom.2017.07.005","article-title":"Innate immunity to intracellular pathogens: balancing microbial elimination and inflammation","volume":"22","author":"Mitchell","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vetmic.2024.110160_bib31","doi-asserted-by":"crossref","first-page":"26987","DOI":"10.1074\/jbc.M111.223610","article-title":"p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways","volume":"286","author":"Mostowy","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2024.110160_bib32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2003.12.001","article-title":"Haemophilus parasuis: new trends on diagnosis, epidemiology and control","volume":"99","author":"Oliveira","year":"2004","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110160_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4161\/auto.3618","article-title":"Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection","volume":"3","author":"Py","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2024.110160_bib35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaci.2016.05.009","article-title":"Regulation of inflammasomes by autophagy","volume":"138","author":"Saitoh","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature07383","article-title":"Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production","volume":"456","author":"Saitoh","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2024.110160_bib37","doi-asserted-by":"crossref","first-page":"12419","DOI":"10.1073\/pnas.1019041108","article-title":"Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity","volume":"108","author":"Sauer","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vetmic.2024.110160_bib38","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.vetmic.2024.110160_bib39","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jmb.2017.11.006","article-title":"Checks and balances between Autophagy and Inflammasomes during Infection","volume":"430","author":"Seveau","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetmic.2024.110160_bib40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/15548627.2021.2021495","article-title":"The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection","volume":"19","author":"Shariq","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2024.110160_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13031","article-title":"Haemophilus parasuis infection in 3D4\/21 cells induces autophagy through the AMPK pathway","volume":"21","author":"Shen","year":"2019","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.vetmic.2024.110160_bib42","doi-asserted-by":"crossref","first-page":"986","DOI":"10.4161\/auto.6.7.13288","article-title":"Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1","volume":"6","author":"Shi","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2024.110160_bib43","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ni.2215","article-title":"Activation of autophagy by inflammatory signals limits IL-1\u03b2 production by targeting ubiquitinated inflammasomes for destruction","volume":"13","author":"Shi","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetmic.2024.110160_bib44","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.bbrc.2017.01.008","article-title":"The mechanism of NLRP3 inflammasome initiation: Trimerization but not dimerization of the NLRP3 pyrin domain induces robust activation of IL-1\u03b2","volume":"483","author":"Su\u0161jan","year":"2017","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.vetmic.2024.110160_bib45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41573-023-00822-2","article-title":"Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets","volume":"23","author":"Vande Walle","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.vetmic.2024.110160_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100889","article-title":"The NLRP3 inflammasome: mechanism of action, role in disease and therapies","volume":"76","author":"Wang","year":"2020","journal-title":"Mol. Asp. Med"},{"key":"10.1016\/j.vetmic.2024.110160_bib47","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1080\/15548627.2019.1569916","article-title":"The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion","volume":"15","author":"Xia","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.vetmic.2024.110160_bib48","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.vetmic.2024.110160_bib49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fcimb.2019.00093","article-title":"Autophagy Is a defense mechanism inhibiting invasion and inflammation during high-virulent haemophilus parasuis infection in PK-15 Cells","volume":"9","author":"Yue","year":"2019","journal-title":"Front Cell Infect. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110160_bib50","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524001822?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524001822?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T12:37:01Z","timestamp":1720442221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113524001822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":50,"alternative-id":["S0378113524001822"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110160","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of the NLRP3-CASP-1 inflammasome is restrained by controlling autophagy during Glaesserella parasuis infection","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110160","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110160"}}