{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:37:25Z","timestamp":1788820645420,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.vetmic.2024.110212","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T23:53:41Z","timestamp":1722902021000},"page":"110212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A bifunctional amylopullulanase of Streptococcus suis ApuA contributes to immune evasion by interaction with host complement C3b"],"prefix":"10.1016","volume":"297","author":[{"given":"Jiajia","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiabing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2024.110212_bib1","doi-asserted-by":"crossref","first-page":"15833","DOI":"10.1074\/jbc.M113.530212","article-title":"Binding of Streptococcus pneumoniae endopeptidase O (PepO) to complement component C1q modulates the complement attack and promotes host cell adherence","volume":"289","author":"Agarwal","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2024.110212_bib2","doi-asserted-by":"crossref","first-page":"17579","DOI":"10.1074\/jbc.M800265200","article-title":"Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus","volume":"283","author":"Burman","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2024.110212_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.micpath.2006.04.001","article-title":"Phagocytosis and killing of Streptococcus suis by porcine neutrophils","volume":"41","author":"Chabot-Roy","year":"2006","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2024.110212_bib4","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1080\/21505594.2018.1520544","article-title":"Streptococcus suis synthesizes deoxyadenosine and adenosine by 5\u2019-nucleotidase to dampen host immune responses","volume":"9","author":"Dai","year":"2018","journal-title":"Virulence"},{"key":"10.1016\/j.vetmic.2024.110212_bib5","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1099\/mic.0.000040","article-title":"Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap degradation during exponential growth","volume":"161","author":"De Buhr","year":"2015","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2024.110212_bib6","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3389\/fimmu.2018.01063","article-title":"The surface-exposed protein SntA contributes to complement evasion in zoonotic Streptococcus suis","volume":"9","author":"Deng","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2024.110212_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108599","article-title":"Complement C3aR\/C5aR-binding protein Suilysin of Streptococcus suis contributes to monocyte chemotaxis","volume":"242","author":"Deng","year":"2020","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110212_bib8","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1099\/mic.0.037960-0","article-title":"ApuA, a multifunctional \u03b1-glucan-degrading enzyme of Streptococcus suis, mediates adhesion to porcine epithelium and mucus","volume":"156","author":"Ferrando","year":"2010","journal-title":"Microbiology"},{"key":"10.1016\/j.vetmic.2024.110212_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/imr.12472","article-title":"The \u201cins and outs\u201d of complement-driven immune responses","volume":"274","author":"Freeley","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetmic.2024.110212_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103730","article-title":"A novel small RNA contributes to restrain cellular chain length and anti-phagocytic ability in Streptococcus suis 2","volume":"137","author":"Gong","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2024.110212_bib11","doi-asserted-by":"crossref","first-page":"14973","DOI":"10.1074\/jbc.M109.091975","article-title":"Convertase inhibitory properties of staphylococcal extracellular complement-binding protein","volume":"285","author":"Jongerius","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2024.110212_bib12","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1084\/jem.20070818","article-title":"Staphylococcal complement evasion by various convertase-blocking molecules","volume":"204","author":"Jongerius","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.vetmic.2024.110212_bib13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nrmicro1824","article-title":"Complement evasion by human pathogens","volume":"6","author":"Lambris","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110212_bib14","doi-asserted-by":"crossref","first-page":"17122","DOI":"10.1074\/jbc.M116.719443","article-title":"Mechanisms of host-pathogen protein complex formation and bacterial immune evasion of Streptococcus suis protein Fhb","volume":"291","author":"Li","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2024.110212_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13223-018-0278-1","article-title":"An introduction to immunology and immunopathology","volume":"14","author":"Marshall","year":"2018","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.vetmic.2024.110212_bib16","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fimmu.2015.00262","article-title":"Complement system part I - molecular mechanisms of activation and regulation","volume":"6","author":"Merle","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2024.110212_bib17","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1128\/IAI.00488-10","article-title":"EspP, a serine protease of enterohemorrhagic Escherichia coli, impairs complement activation by cleaving complement factors C3\/C3b and C5","volume":"78","author":"Orth","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2024.110212_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/srep26966","article-title":"Binding of human fibrinogen to MRP enhances Streptococcus suis survival in host blood in a \u03b1X\u03b22 integrin-dependent manner","volume":"6","author":"Pian","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2024.110212_bib19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.micinf.2004.12.014","article-title":"Anti-opsonic properties of staphylokinase","volume":"7","author":"Rooijakkers","year":"2005","journal-title":"Microbes Infect."},{"key":"10.1016\/j.vetmic.2024.110212_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/pathogens5030047","article-title":"Recruitment of factor H to the Streptococcus suis cell surface is multifactorial","volume":"5","author":"Roy","year":"2016","journal-title":"Pathogens"},{"key":"10.1016\/j.vetmic.2024.110212_bib21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/pathogens11020240","article-title":"The C-terminal domain of Staphylococcus aureus zinc transport protein AdcA binds plasminogen and factor H in vitro","volume":"11","author":"Salazar","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.vetmic.2024.110212_bib22","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1128\/JB.01875-12","article-title":"Identification of a novel host-specific IgM protease in Streptococcus suis","volume":"195","author":"Seele","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.vetmic.2024.110212_bib23","article-title":"Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic","volume":"7","author":"Stevenson","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.vetmic.2024.110212_bib24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/plas.2001.1532","article-title":"Thermosensitive suicide vectors for gene replacement in Streptococcus suis","volume":"46","author":"Takamatsu","year":"2001","journal-title":"Plasmid"},{"key":"10.1016\/j.vetmic.2024.110212_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/plas.2000.1510","article-title":"Construction and characterization of Streptococcus suis\u2013Escherichia coli shuttle cloning vectors","volume":"45","author":"Takamatsu","year":"2001","journal-title":"Plasmid"},{"key":"10.1016\/j.vetmic.2024.110212_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.938286","article-title":"Exogenous glycogen utilization effects the transcriptome and pathogenicity of Streptococcus suis serotype 2","volume":"12","author":"Tan","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110212_bib27","doi-asserted-by":"crossref","first-page":"14215","DOI":"10.1074\/jbc.M513408200","article-title":"Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils","volume":"281","author":"Terao","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2024.110212_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00010-18","article-title":"Streptococcus pneumoniae PspC subgroup prevalence in invasive disease and differences in contribution to complement evasion","volume":"86","author":"Van Der Maten","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2024.110212_bib29","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/j.1462-5822.2007.00981.x","article-title":"Macrophage complement receptors and pathogen clearance","volume":"9","author":"Van Lookeren Campagne","year":"2007","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110212_bib30","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1128\/IAI.00321-12","article-title":"Prc contributes to Escherichia coli evasion of classical complement-mediated serum killing","volume":"80","author":"Wang","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2024.110212_bib31","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2024.2306691","article-title":"HylS\u2019, a fragment of truncated hyaluronidase of Streptococcus suis, contributes to immune evasion by interaction with host complement factor C3b","volume":"15","author":"Xu","year":"2024","journal-title":"Virulence"},{"key":"10.1016\/j.vetmic.2024.110212_bib32","doi-asserted-by":"crossref","first-page":"914","DOI":"10.3201\/eid1206.051194","article-title":"Human Streptococcus suis outbreak, Sichuan, China","volume":"12","author":"Yu","year":"2006","journal-title":"Emerg. Infect."},{"key":"10.1016\/j.vetmic.2024.110212_bib33","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.175.3.1813","article-title":"Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia","volume":"175","author":"Yuste","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2024.110212_bib34","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/imr.13147","article-title":"C3-dependent effector functions of complement","volume":"313","author":"Zarantonello","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetmic.2024.110212_bib35","article-title":"Binding of plasminogen to Streptococcus suis protein endopeptidase O facilitates evasion of innate immunity in Streptococcus suis","volume":"8","author":"Zhou","year":"2021","journal-title":"Front. Microbiol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524002347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524002347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T18:45:57Z","timestamp":1724438757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113524002347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":35,"alternative-id":["S0378113524002347"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110212","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A bifunctional amylopullulanase of Streptococcus suis ApuA contributes to immune evasion by interaction with host complement C3b","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110212"}}