{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:09:40Z","timestamp":1793905780235,"version":"4.8.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010012","name":"National Aerospace Science Foundation of China","doi-asserted-by":"publisher","award":["32202807"],"award-info":[{"award-number":["32202807"]}],"id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010012","name":"National Aerospace Science Foundation of China","doi-asserted-by":"publisher","award":["31972723"],"award-info":[{"award-number":["31972723"]}],"id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010012","name":"National Aerospace Science Foundation of China","doi-asserted-by":"publisher","award":["32002318"],"award-info":[{"award-number":["32002318"]}],"id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017937","name":"Tianjin Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M700167"],"award-info":[{"award-number":["2021M700167"]}],"id":[{"id":"10.13039\/100017937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017937","name":"Tianjin Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022T150709"],"award-info":[{"award-number":["2022T150709"]}],"id":[{"id":"10.13039\/100017937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2021YFD1800402"],"award-info":[{"award-number":["2021YFD1800402"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.vetmic.2024.110224","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T23:49:32Z","timestamp":1723679372000},"page":"110224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Brucella rough RB51 infection activates P53-Slc7a11-Gpx4\/GSH pathway to induce ferroptosis to attenuate the intracellular survival on macrophages"],"prefix":"10.1016","volume":"298","author":[{"given":"Hai","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2024.110224_bib1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1084\/jem.20181776","article-title":"A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis","volume":"216","author":"Amaral","year":"2019","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.vetmic.2024.110224_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-030-62026-4_5","article-title":"Emerging Role for Ferroptosis in Infectious Diseases","volume":"1301","author":"Amaral","year":"2021","journal-title":"Adv. Exp. Med Biol."},{"key":"10.1016\/j.vetmic.2024.110224_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.vetmic.2024.110224_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fcimb.2013.00083","article-title":"Caspase-2 mediates a Brucella abortus RB51-induced hybrid cell death having features of apoptosis and pyroptosis","volume":"3","author":"Bronner","year":"2013","journal-title":"Front Cell Infect. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110224_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12985-022-01825-y","article-title":"Swine influenza virus triggers ferroptosis in A549 cells to enhance virus replication","volume":"19","author":"Cheng","year":"2022","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2024.110224_bib6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.4049\/jimmunol.1700725","article-title":"Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation","volume":"200","author":"Costa Franco","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2024.110224_bib7","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2024.110224_bib8","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2024.110224_bib9","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vetmic.2024.110224_bib10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41420-022-01140-z","article-title":"Knockdown of RRM1 in tumor cells promotes radio-\/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis","volume":"8","author":"Gao","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.vetmic.2024.110224_bib11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3389\/fcimb.2017.00437","article-title":"Activation of NF-kB-Mediated TNF-Induced Antimicrobial Immunity Is Required for the Efficient Brucella abortus Clearance in RAW 264.7 Cells","volume":"7","author":"Hop","year":"2017","journal-title":"Front Cell Infect. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110224_bib12","doi-asserted-by":"crossref","first-page":"632","DOI":"10.4049\/jimmunol.1801550","article-title":"Brucella Infection Regulates Thioredoxin-Interacting Protein Expression to Facilitate Intracellular Survival by Reducing the Production of Nitric Oxide and Reactive Oxygen Species","volume":"204","author":"Hu","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2024.110224_bib13","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1111\/tbed.14422","article-title":"Brucella induces heme oxygenase-1 expression to promote its infection","volume":"69","author":"Hu","year":"2022","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2024.110224_bib14","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3390\/pathogens12101189","article-title":"Brucella abortus Rough-Type Mutant Induces Ferroptosis and More Oxidative Stress in Infected Macrophages","volume":"12","author":"Hu","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.vetmic.2024.110224_bib15","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s12223-020-00798-1","article-title":"Survival of Brucella abortus S19 and other Brucella spp. in the presence of oxidative stress and within macrophages","volume":"65","author":"Jacob","year":"2020","journal-title":"Folia Microbiol."},{"key":"10.1016\/j.vetmic.2024.110224_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106013","article-title":"p53: A double-edged sword in tumor ferroptosis","volume":"177","author":"Ji","year":"2022","journal-title":"Pharm. Res"},{"key":"10.1016\/j.vetmic.2024.110224_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2024.110224_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102837","article-title":"Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells","volume":"24","author":"Kan","year":"2021","journal-title":"Iscience"},{"key":"10.1016\/j.vetmic.2024.110224_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2018.05.074","article-title":"The tumor suppressor protein p53 and the ferroptosis network","volume":"133","author":"Kang","year":"2019","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.vetmic.2024.110224_bib20","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4014\/jmb.2303.03041","article-title":"The Modulatory Effect of Sodium Propionate Treatment in the Expression of Inflammatory Cytokines and Intracellular Growth of Brucella abortus 544 in Raw 264.7 Cells","volume":"33","author":"Kim","year":"2023","journal-title":"J. Microbiol Biotechnol."},{"key":"10.1016\/j.vetmic.2024.110224_bib21","article-title":"Brucella Rough Mutant Induce Macrophage Death via Activating IRE1 alpha Pathway of Endoplasmic Reticulum Stress by Enhanced T4SS Secretion","volume":"7","author":"Li","year":"2017","journal-title":"Front Cell Infect. Mi"},{"key":"10.1016\/j.vetmic.2024.110224_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2024.110089","article-title":"Insights into the effect of guanylate-binding protein 1 on the survival of Brucella intracellularly","volume":"293","author":"Li","year":"2024","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110224_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218387","article-title":"The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway","volume":"21","author":"Liu","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.vetmic.2024.110224_bib24","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.7150\/thno.66663","article-title":"Ferroptotic stress promotes macrophages against intracellular bacteria","volume":"12","author":"Ma","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.vetmic.2024.110224_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.diagmicrobio.2024.116401","article-title":"Transcriptome analysis of macrophages during Brucella abortus infection clarifies the survival mechanisms of the bacteria","volume":"110","author":"Pannetta","year":"2024","journal-title":"Diagn. Microbiol Infect. Dis."},{"key":"10.1016\/j.vetmic.2024.110224_bib26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/IAI.72.1.440-450.2004","article-title":"Brucella abortus rough mutants are cytopathic for macrophages in culture","volume":"72","author":"Pei","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2024.110224_bib27","first-page":"516","article-title":"Ruscogenin induces ferroptosis in pancreatic cancer cells","volume":"43","author":"Song","year":"2020","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.vetmic.2024.110224_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03338-22","article-title":"Brucella Egresses from Host Cells Exploiting Multivesicular Bodies","volume":"14","author":"Spera","year":"2023","journal-title":"Mbio"},{"key":"10.1016\/j.vetmic.2024.110224_bib29","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2024.110224_bib30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2024.110224_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.713157","article-title":"When the Going Gets Rough: The Significance of Brucella Lipopolysaccharide Phenotype in Host-Pathogen Interactions","volume":"12","author":"Stranahan","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.vetmic.2024.110224_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbrc.2022.02.112","article-title":"Dexamethasone induces ferroptosis via P53\/SLC7A11\/GPX4 pathway in glucocorticoid-induced osteonecrosis of the femoral head","volume":"602","author":"Sun","year":"2022","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.vetmic.2024.110224_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2024.110224_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1342684","article-title":"Brucella infection and Toll-like receptors","volume":"14","author":"Yu","year":"2024","journal-title":"Front Cell Infect. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110224_bib35","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/s41467-021-21841-w","article-title":"mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524002463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524002463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T07:42:03Z","timestamp":1731656523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113524002463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":35,"alternative-id":["S0378113524002463"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110224","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brucella rough RB51 infection activates P53-Slc7a11-Gpx4\/GSH pathway to induce ferroptosis to attenuate the intracellular survival on macrophages","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110224"}}