{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:30:46Z","timestamp":1790951446664,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2020-67015-31561"],"award-info":[{"award-number":["2020-67015-31561"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35 GM118145"],"award-info":[{"award-number":["R35 GM118145"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.vetmic.2024.110245","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T01:41:44Z","timestamp":1726278104000},"page":"110245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["An effective vaccine against influenza A virus based on the matrix protein 2 (M2)"],"prefix":"10.1016","volume":"298","author":[{"given":"Federico A.","family":"Zuckermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena V.","family":"Grinkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Husmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Pires-Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanna","family":"Storms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Sligar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.vetmic.2024.110245_bib1","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01323-18","article-title":"Comparison of adjuvanted-whole inactivated virus and live-attenuated virus vaccines against challenge with contemporary, antigenically distinct H3N2 influenza a viruses","volume":"92","author":"Abente","year":"2018","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.vetmic.2024.110245_bib2","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.vaccine.2018.12.071","article-title":"Alphavirus-vectored hemagglutinin subunit vaccine provides partial protection against heterologous challenge in pigs","volume":"37","author":"Abente","year":"2019","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.vetmic.2024.110245_bib3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.vaccine.2014.11.054","article-title":"Virus-specific T cells as correlate of (cross-) protective immunity against influenza","volume":"33","author":"Altenburg","year":"2015","journal-title":"Vaccine"},{"issue":"Suppl 4","key":"10.1016\/j.vetmic.2024.110245_bib4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/irv.12193","article-title":"Population dynamics of cocirculating swine influenza A viruses in the United States from 2009 to 2012","volume":"Suppl 4","author":"Anderson","year":"2013","journal-title":"Influenza Other Respir. Virus"},{"issue":"3","key":"10.1016\/j.vetmic.2024.110245_bib5","doi-asserted-by":"crossref","first-page":"a038737","DOI":"10.1101\/cshperspect.a038737","article-title":"Swine influenza a viruses and the tangled relationship with humans","volume":"11","author":"Anderson","year":"2021","journal-title":"Cold Spring Harb. Perspect. Med"},{"issue":"50","key":"10.1016\/j.vetmic.2024.110245_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/MRA.01081-21","article-title":"octoFLUshow: an interactive tool describing spatial and temporal trends in the genetic diversity of influenza a virus in U.S. swine","volume":"10","author":"Arendsee","year":"2021","journal-title":"Microbiol Resour. Announc"},{"key":"10.1016\/j.vetmic.2024.110245_bib7","doi-asserted-by":"crossref","unstructured":"Baker, Steven. 2022. Influenza virus plaque assay. Protocols.io dx.doi.org\/10.17504\/protocols.io.n2bvj63bxlk5\/v1.","DOI":"10.17504\/protocols.io.b5yjq7un"},{"issue":"8","key":"10.1016\/j.vetmic.2024.110245_bib8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1021\/nl025623k","article-title":"Self-assembly of discoidal phospholipid bilayer nanoparticles with membrane scaffold proteins","volume":"2","author":"Bayburt","year":"2002","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1128\/JVI.01355-09","article-title":"Nanodisc-incorporated hemagglutinin provides protective immunity against influenza virus infection","volume":"84","author":"Bhattacharya","year":"2010","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/irv.12610","article-title":"Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016","volume":"13","author":"Bolton","year":"2019","journal-title":"Influenza Other Respir. Virus"},{"issue":"1-2","key":"10.1016\/j.vetmic.2024.110245_bib11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.vetimm.2009.10.026","article-title":"Characterization of the cytokine and maturation responses of pure populations of porcine plasmacytoid dendritic cells to porcine viruses and toll-like receptor agonists","volume":"135","author":"Calzada-Nova","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"6","key":"10.1016\/j.vetmic.2024.110245_bib12","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1128\/JVI.01616-10","article-title":"North American porcine reproductive and respiratory syndrome viruses inhibit type I interferon production by plasmacytoid dendritic cells","volume":"85","author":"Calzada-Nova","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110245_bib13","unstructured":"CDC Vaccine Effectiveness:How Well Do Flu Vaccines Work? Questions & Answers. https:\/\/www.cdc.gov\/flu\/vaccineswork\/vaccineeffect.htm#:\u223c:text=While%20vaccine%20effectiveness%20(VE)%20can,used%20to%20make%20flu%20vaccines."},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.virol.2005.04.004","article-title":"Universal influenza A vaccine: optimization of M2-based constructs","volume":"337","author":"De Filette","year":"2005","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/vaccines3010105","article-title":"M2e-Based Universal Influenza A Vaccines","volume":"3","author":"Deng","year":"2015","journal-title":"Vaccines"},{"issue":"6","key":"10.1016\/j.vetmic.2024.110245_bib16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nsmb.3195","article-title":"Nanodiscs for structural and functional studies of membrane proteins","volume":"23","author":"Denisov","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"6","key":"10.1016\/j.vetmic.2024.110245_bib17","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1021\/acs.chemrev.6b00690","article-title":"Nanodiscs in Membrane Biochemistry and Biophysics","volume":"117","author":"Denisov","year":"2017","journal-title":"Chem. Rev."},{"issue":"1-2","key":"10.1016\/j.vetmic.2024.110245_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.vetimm.2004.04.017","article-title":"Characteristics of oligodeoxyribonucleotides that induce interferon (IFN)-alpha in the pig and the phenotype of the IFN-alpha producing cells","volume":"101","author":"Domeika","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"23","key":"10.1016\/j.vetmic.2024.110245_bib19","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1016\/j.vaccine.2011.03.005","article-title":"Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs","volume":"29","author":"Dwivedi","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2024.110245_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.604913","article-title":"Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in inbred babraham pigs and outbred pigs","volume":"11","author":"Edmans","year":"2021","journal-title":"Front Immunol."},{"issue":"2","key":"10.1016\/j.vetmic.2024.110245_bib21","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4049\/jimmunol.0902147","article-title":"Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection","volume":"186","author":"El Bakkouri","year":"2011","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.vetmic.2024.110245_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/infdis\/jiy103","article-title":"A universal influenza vaccine: the strategic plan for the national institute of allergy and infectious diseases","volume":"218","author":"Erbelding","year":"2018","journal-title":"J. Infect. Dis."},{"issue":"17","key":"10.1016\/j.vetmic.2024.110245_bib23","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.vaccine.2019.02.078","article-title":"Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus","volume":"37","author":"Everett","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2024.110245_bib24","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1743-422X-3-102","article-title":"Influenza A virus infection engenders a poor antibody response against the ectodomain of matrix protein 2","volume":"3","author":"Feng","year":"2006","journal-title":"Virol. J."},{"issue":"6","key":"10.1016\/j.vetmic.2024.110245_bib25","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1021\/ja3063293","article-title":"Colocalized delivery of adjuvant and antigen using nanolipoprotein particles enhances the immune response to recombinant antigens","volume":"135","author":"Fischer","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"5937","key":"10.1016\/j.vetmic.2024.110245_bib26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1126\/science.1176225","article-title":"Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans","volume":"325","author":"Garten","year":"2009","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.vetmic.2024.110245_bib27","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/030098589503200606","article-title":"Comparison of the pathogenicity of two US porcine reproductive and respiratory syndrome virus isolates with that of the Lelystad virus","volume":"32","author":"Halbur","year":"1995","journal-title":"Vet. Pathol."},{"issue":"Pt 8","key":"10.1016\/j.vetmic.2024.110245_bib28","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1099\/0022-1317-83-8-1851","article-title":"Vaccination of pigs with a DNA construct expressing an influenza virus M2-nucleoprotein fusion protein exacerbates disease after challenge with influenza A virus","volume":"83","author":"Heinen","year":"2002","journal-title":"J. Gen. Virol."},{"issue":"8","key":"10.1016\/j.vetmic.2024.110245_bib29","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1439-0442.2007.00944.x","article-title":"Comparison of three common methods of lung lavage in healthy pigs","volume":"54","author":"Hennig-Pauka","year":"2007","journal-title":"J. Vet. Med A Physiol. Pathol. Clin. Med"},{"issue":"Pt 10","key":"10.1016\/j.vetmic.2024.110245_bib30","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1099\/vir.0.033076-0","article-title":"Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells","volume":"92","author":"Hillaire","year":"2011","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0042-6822(91)90115-R","article-title":"Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds","volume":"183","author":"Holsinger","year":"1991","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.vetmic.2024.110245_bib32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0378-1135(00)00300-X","article-title":"Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides","volume":"78","author":"Kamstrup","year":"2001","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110245_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/978-1-0716-0872-2_4","article-title":"CpG oligonucleotides as vaccine adjuvants","volume":"2197","author":"Kayraklioglu","year":"2021","journal-title":"Methods Mol. Biol."},{"issue":"7","key":"10.1016\/j.vetmic.2024.110245_bib34","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/mt.2014.33","article-title":"Supplementation of influenza split vaccines with conserved M2 ectodomains overcomes strain specificity and provides long-term cross protection","volume":"22","author":"Kim","year":"2014","journal-title":"Mol. Ther."},{"issue":"1-3","key":"10.1016\/j.vetmic.2024.110245_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.vetmic.2007.07.009","article-title":"The antibody responses to swine influenza virus (SIV) recombinant matrix 1 (rM1), matrix 2 (M2), and hemagglutinin (HA) proteins in pigs with different SIV exposure","volume":"126","author":"Kitikoon","year":"2008","journal-title":"Vet. Microbiol"},{"issue":"2","key":"10.1016\/j.vetmic.2024.110245_bib36","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.vaccine.2009.09.130","article-title":"Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates","volume":"28","author":"Kitikoon","year":"2009","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vetmic.2024.110245_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/14760584.2017.1240041","article-title":"M2-based influenza vaccines: recent advances and clinical potential","volume":"16","author":"Kolpe","year":"2017","journal-title":"Expert Rev. Vaccin."},{"issue":"4","key":"10.1016\/j.vetmic.2024.110245_bib38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nmat4822","article-title":"Designer vaccine nanodiscs for personalized cancer immunotherapy","volume":"16","author":"Kuai","year":"2017","journal-title":"Nat. Mater."},{"issue":"1-2","key":"10.1016\/j.vetmic.2024.110245_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-1135(00)00172-3","article-title":"Systemic and mucosal immune responses to H1N1 influenza virus infection in pigs","volume":"74","author":"Larsen","year":"2000","journal-title":"Vet. Microbiol"},{"issue":"5","key":"10.1016\/j.vetmic.2024.110245_bib40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4110\/in.2015.15.5.213","article-title":"Mechanisms of Cross-protection by Influenza Virus M2-based Vaccines","volume":"15","author":"Lee","year":"2015","journal-title":"Immune Netw."},{"key":"10.1016\/j.vetmic.2024.110245_bib41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.virol.2019.01.017","article-title":"Enhancing the cross protective efficacy of live attenuated influenza virus vaccine by supplemented vaccination with M2 ectodomain virus-like particles","volume":"529","author":"Lee","year":"2019","journal-title":"Virology"},{"issue":"17","key":"10.1016\/j.vetmic.2024.110245_bib42","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1128\/JVI.01038-13","article-title":"Efficacy in pigs of inactivated and live attenuated influenza virus vaccines against infection and transmission of an emerging H3N2 similar to the 2011-2012 H3N2v","volume":"87","author":"Loving","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110245_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-62703-321-3_10","article-title":"Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes","volume":"987","author":"Luthra","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.vetmic.2024.110245_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198118","article-title":"Swine influenza virus: current status and challenge","volume":"288","author":"Ma","year":"2020","journal-title":"Virus Res"},{"issue":"8","key":"10.1016\/j.vetmic.2024.110245_bib45","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.4049\/jimmunol.2300385","article-title":"From snoot to tail: a brief review of influenza virus infection and immunity in pigs","volume":"211","author":"Ma","year":"2023","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetmic.2024.110245_bib46","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3389\/fvets.2020.00647","article-title":"Influenza A virus in swine: epidemiology, challenges and vaccination strategies","volume":"7","author":"Mancera Gracia","year":"2020","journal-title":"Front Vet. Sci."},{"issue":"4","key":"10.1016\/j.vetmic.2024.110245_bib47","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/pathogens3040845","article-title":"Animal models for influenza viruses: implications for universal vaccine development","volume":"3","author":"Margine","year":"2014","journal-title":"Pathogens"},{"issue":"3","key":"10.1016\/j.vetmic.2024.110245_bib48","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4049\/jimmunol.2001086","article-title":"Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective Local T cell and systemic antibody immune responses in pigs","volume":"206","author":"Martini","year":"2021","journal-title":"J. Immunol."},{"issue":"2-4","key":"10.1016\/j.vetmic.2024.110245_bib49","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0165-2427(97)00141-4","article-title":"Quantitative detection of porcine interferon-gamma in response to mitogen, superantigen and recall viral antigen","volume":"61","author":"Mateu de Antonio","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJM198307073090103","article-title":"Cytotoxic T-cell immunity to influenza","volume":"309","author":"McMichael","year":"1983","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.vetmic.2024.110245_bib51","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0042-6822(03)00009-6","article-title":"Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination","volume":"309","author":"Meier","year":"2003","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib52","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12929-019-0572-3","article-title":"M2e-based universal influenza vaccines: a historical overview and new approaches to development","volume":"26","author":"Mezhenskaya","year":"2019","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib53","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tim.2011.11.002","article-title":"The pig: a model for human infectious diseases","volume":"20","author":"Meurens","year":"2012","journal-title":"Trends Microbiol"},{"issue":"3","key":"10.1016\/j.vetmic.2024.110245_bib54","doi-asserted-by":"crossref","first-page":"648","DOI":"10.4049\/jimmunol.2000429","article-title":"Establishment of a pig influenza challenge model for evaluation of monoclonal antibody delivery platforms","volume":"205","author":"McNee","year":"2020","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.vetmic.2024.110245_bib55","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.4049\/jimmunol.1502632","article-title":"Aerosol delivery of a candidate universal influenza vaccine reduces viral load in pigs challenged with pandemic H1N1 virus","volume":"196","author":"Morgan","year":"2016","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.vetmic.2024.110245_bib56","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/13484","article-title":"A universal influenza A vaccine based on the extracellular domain of the M2 protein","volume":"5","author":"Neirynck","year":"1999","journal-title":"Nat. Med"},{"issue":"6","key":"10.1016\/j.vetmic.2024.110245_bib57","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3390\/v13061011","article-title":"Animal models for influenza research: strengths and weaknesses","volume":"13","author":"Nguyen","year":"2021","journal-title":"Viruses"},{"issue":"9","key":"10.1016\/j.vetmic.2024.110245_bib58","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3390\/vaccines10091528","article-title":"FLU-v, a broad-spectrum influenza vaccine, induces cross-reactive cellular immune responses in humans measured by dual IFN-\u03b3 and granzyme B ELISpot assay","volume":"10","author":"Oftung","year":"2022","journal-title":"Vaccin. (Basel)"},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191739","article-title":"Comparison of the efficacy of a commercial inactivated influenza A\/H1N1\/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing pig model","volume":"13","author":"Opriessnig","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2024.110245_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.903755","article-title":"Fc-mediated functions of porcine IgG subclasses","volume":"13","author":"Paudyal","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.vetmic.2024.110245_bib61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0076-6879(09)64011-8","article-title":"Chapter 11 - reconstitution of membrane proteins in phospholipid bilayer nanodiscs","volume":"464","author":"Ritchie","year":"2009","journal-title":"Methods Enzym."},{"issue":"Suppl_1","key":"10.1016\/j.vetmic.2024.110245_bib62","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1093\/infdis\/jiz003","article-title":"The role of matrix protein 2 ectodomain in the development of universal influenza vaccines","volume":"219","author":"Saelens","year":"2019","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40813-021-00196-0","article-title":"Current and prospective control strategies of influenza A virus in swine","volume":"7","author":"Salvesen","year":"2021","journal-title":"Porc. Health Manag"},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib64","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/imr.12662","article-title":"CD4 T cells in protection from influenza virus: viral antigen specificity and functional potential","volume":"284","author":"Sant","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.vetmic.2024.110245_bib65","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.coi.2018.03.024","article-title":"Vaccine options for influenza: thinking small","volume":"53","author":"Schepens","year":"2018","journal-title":"Curr. Opin. Immunol."},{"issue":"15","key":"10.1016\/j.vetmic.2024.110245_bib66","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/0264-410X(95)92777-Y","article-title":"Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein","volume":"13","author":"Slepushkin","year":"1995","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.vetmic.2024.110245_bib67","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/pro.3994","article-title":"Nanodiscs: a toolkit for membrane protein science","volume":"30","author":"Sligar","year":"2021","journal-title":"Protein Sci."},{"issue":"2","key":"10.1016\/j.vetmic.2024.110245_bib68","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1073\/pnas.1012199108","article-title":"Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus","volume":"108","author":"Song","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.vetmic.2024.110245_bib69","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/nm.3350","article-title":"Cellular immune correlates of protection against symptomatic pandemic influenza","volume":"19","author":"Sridhar","year":"2013","journal-title":"Nat. Med"},{"issue":"9","key":"10.1016\/j.vetmic.2024.110245_bib70","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/eji.200737254","article-title":"Synthetic multi-epitope peptides identified in silico induce protective immunity against multiple influenza serotypes","volume":"37","author":"Stoloff","year":"2007","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.vetmic.2024.110245_bib71","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/0042-6822(91)90075-M","article-title":"Structural characteristics of the M2 protein of influenza A viruses: evidence that it forms a tetrameric channel","volume":"180","author":"Sugrue","year":"1991","journal-title":"Virology"},{"issue":"20","key":"10.1016\/j.vetmic.2024.110245_bib72","doi-asserted-by":"crossref","first-page":"9364","DOI":"10.1128\/JVI.01211-16","article-title":"Influenza A virus infection in pigs attracts multifunctional and cross-reactive T cells to the lung","volume":"90","author":"Talker","year":"2016","journal-title":"J. Virol."},{"issue":"36","key":"10.1016\/j.vetmic.2024.110245_bib73","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1016\/j.vaccine.2019.07.032","article-title":"CpG ODN G9.1 as a novel nasal ODN adjuvant elicits complete protection from influenza virus infection without causing inflammatory immune responses","volume":"37","author":"Tateishi","year":"2019","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vetmic.2024.110245_bib74","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3201\/eid1303.061125","article-title":"Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1","volume":"13","author":"Tompkins","year":"2007","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"10.1016\/j.vetmic.2024.110245_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191574","article-title":"Vaccination potential of B and T epitope-enriched NP and M2 against influenza A viruses from different clades and hosts","volume":"13","author":"Tutykhina","year":"2018","journal-title":"PLoS One"},{"issue":"1-2","key":"10.1016\/j.vetmic.2024.110245_bib76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.vetmic.2009.01.003","article-title":"Characterization of an influenza A virus isolated from pigs during an outbreak of respiratory disease in swine and people during a county fair in the United States","volume":"137","author":"Vincent","year":"2009","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.vetmic.2024.110245_bib77","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vetmic.2016.11.026","article-title":"Influenza A virus vaccines for swine","volume":"206","author":"Vincent","year":"2017","journal-title":"Vet. Microbiol"},{"issue":"15","key":"10.1016\/j.vetmic.2024.110245_bib78","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1016\/j.vaccine.2010.01.049","article-title":"Efficacy of inactivated swine influenza virus vaccines against the 2009 A\/H1N1 influenza virus in pigs","volume":"28","author":"Vincent","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2024.110245_bib79","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-0716-0346-8_18","article-title":"A brief introduction to Influenza A virus in swine","volume":"2123","author":"Vincent","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.vetmic.2024.110245_bib80","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nano.2013.08.005","article-title":"Nanoclusters self-assembled from conformation-stabilized influenza M2e as broadly cross-protective influenza vaccines","volume":"10","author":"Wang","year":"2014","journal-title":"Nanomed.: Nanotechnol., Biol., Med."},{"issue":"8","key":"10.1016\/j.vetmic.2024.110245_bib81","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1128\/jvi.62.8.2762-2772.1988","article-title":"Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions","volume":"62","author":"Zebedee","year":"1988","journal-title":"J. Virol."},{"issue":"D1","key":"10.1016\/j.vetmic.2024.110245_bib82","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw857","article-title":"Influenza research database: an integrated bioinformatics resource for influenza virus research","volume":"45","author":"Zhang","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.vetmic.2024.110245_bib83","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.3390\/v6051974","article-title":"Universal influenza vaccines, a dream to be realized soon","volume":"6","author":"Zhang","year":"2014","journal-title":"Viruses"},{"issue":"1-2","key":"10.1016\/j.vetmic.2024.110245_bib84","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0165-2427(98)00082-8","article-title":"Interleukin-12 enhances the virus-specific interferon gamma response of pigs to an inactivated pseudorabies virus vaccine","volume":"63","author":"Zuckermann","year":"1998","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2024.110245_bib85","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0065-3519(99)80034-2","article-title":"Use of interleukin 12 to enhance the cellular immune response of swine to an inactivated herpesvirus vaccine","volume":"41","author":"Zuckermann","year":"1999","journal-title":"Adv. Vet. Med."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524002670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524002670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T07:42:46Z","timestamp":1731656566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113524002670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":85,"alternative-id":["S0378113524002670"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110245","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An effective vaccine against influenza A virus based on the matrix protein 2 (M2)","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110245","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110245"}}