{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:16:39Z","timestamp":1784556999408,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972655"],"award-info":[{"award-number":["31972655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32373006"],"award-info":[{"award-number":["32373006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["246Z2401G"],"award-info":[{"award-number":["246Z2401G"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2022201081"],"award-info":[{"award-number":["H2022201081"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.vetmic.2024.110334","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T12:45:32Z","timestamp":1733316332000},"page":"110334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["53BP1, a known chromatin-associated factor that promotes DNA damage repair, is differentially modulated during bovine herpesvirus 1 infection in vitro and in vivo"],"prefix":"10.1016","volume":"300","author":[{"given":"Heci","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2024.110334_bib1","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00773-18","article-title":"The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis","volume":"92","author":"Afroz","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110334_bib2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/BF03210851","article-title":"A bovine herpesvirus type 1 mutant virus with truncated glycoprotein E cytoplasmic tail has defective anterograde neuronal transport in rabbit dorsal root ganglia primary neuronal cultures in a microfluidic chamber system","volume":"16","author":"Chowdhury","year":"2010","journal-title":"J. Neurovirol"},{"key":"10.1016\/j.vetmic.2024.110334_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00328-20","article-title":"gammaH2AX in the S Phase after UV Irradiation Corresponds to DNA Replication and Does Not Report on the Extent of DNA Damage","volume":"40","author":"Dhuppar","year":"2020","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.vetmic.2024.110334_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23042328","article-title":"beta-Catenin-Specific Inhibitor, iCRT14, Promotes BoHV-1 Infection-Induced DNA Damage in Human A549 Lung Adenocarcinoma Cells by Enhancing Viral Protein Expression","volume":"23","author":"Ding","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.vetmic.2024.110334_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2019.197803","article-title":"Progesterone increases the incidence of bovine herpesvirus 1 reactivation from latency and stimulates productive infection","volume":"276","author":"El-Mayet","year":"2020","journal-title":"Virus Res"},{"key":"10.1016\/j.vetmic.2024.110334_bib6","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.molcel.2023.03.017","article-title":"The APE2 nuclease is essential for DNA double-strand break repair by microhomology-mediated end joining","volume":"83","author":"Fleury","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.vetmic.2024.110334_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12318","article-title":"53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark","volume":"499","author":"Fradet-Turcotte","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2024.110334_bib8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/cfg.474","article-title":"Effect of stress on viral-bacterial synergy in bovine respiratory disease: novel mechanisms to regulate inflammation","volume":"6","author":"Hodgson","year":"2005","journal-title":"Comp. Funct. Genom."},{"key":"10.1016\/j.vetmic.2024.110334_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1017\/S146625230700134X","article-title":"A review of the biology of bovine herpesvirus type 1 (BHV-1), its role as a cofactor in the bovine respiratory disease complex and development of improved vaccines","volume":"8","author":"Jones","year":"2007","journal-title":"Anim. Health Res Rev."},{"key":"10.1016\/j.vetmic.2024.110334_bib10","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/emboj.2009.400","article-title":"A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses","volume":"29","author":"Lilley","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.vetmic.2024.110334_bib11","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1093\/nar\/gkab019","article-title":"Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair","volume":"49","author":"Murray-Nerger","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.vetmic.2024.110334_bib12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1051\/vetres:2006059","article-title":"Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis","volume":"38","author":"Muylkens","year":"2007","journal-title":"Vet. Res"},{"key":"10.1016\/j.vetmic.2024.110334_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41586-018-0340-7","article-title":"The shieldin complex mediates 53BP1-dependent DNA repair","volume":"560","author":"Noordermeer","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2024.110334_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/v11010023","article-title":"Antibody responses to bovine Alphaherpesvirus 1 (BoHV-1) in passively immunized calves","volume":"11","author":"Petrini","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2024.110334_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168582","article-title":"Oncolytic Bovine Herpesvirus 1 Inhibits Human Lung Adenocarcinoma A549 Cell Proliferation and Tumor Growth by Inducing DNA Damage","volume":"22","author":"Qiu","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.vetmic.2024.110334_bib16","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1128\/jvi.61.12.3827-3831.1987","article-title":"Mapping bovine herpesvirus type 1 latency-related RNA in trigeminal ganglia of latently infected rabbits","volume":"61","author":"Rock","year":"1987","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110334_bib17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/iai.35.1.371-373.1982","article-title":"Persistent infection with bovine herpesvirus type 1: rabbit model","volume":"35","author":"Rock","year":"1982","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2024.110334_bib18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00007890-198005000-00019","article-title":"Suppression of the immune response by steroids. Comparative potency of hydrocortisone, methylprednisolone, and dexamethasone","volume":"29","author":"Rosenberg","year":"1980","journal-title":"Transplantation"},{"key":"10.1016\/j.vetmic.2024.110334_bib19","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/em.21944","article-title":"DNA damage foci: Meaning and significance","volume":"56","author":"Rothkamm","year":"2015","journal-title":"Environ. Mol. Mutagen"},{"key":"10.1016\/j.vetmic.2024.110334_bib20","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1158\/0008-5472.CAN-03-3207","article-title":"ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation","volume":"64","author":"Stiff","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.vetmic.2024.110334_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10092282","article-title":"DNA Damage Response Differentially Affects BoHV-1 Gene Transcription in Cell Type-Dependent Manners","volume":"10","author":"Tang","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.vetmic.2024.110334_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0065-3527(08)60061-5","article-title":"Bovine herpesvirus 1 (BHV-1): biology, pathogenesis, and control","volume":"45","author":"Tikoo","year":"1995","journal-title":"Adv. Virus Res"},{"key":"10.1016\/j.vetmic.2024.110334_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.rvsc.2013.03.017","article-title":"Systemic infection induced by intranasal inoculation of Bovine herpesvirus 1.1 in pregnant and non-pregnant rabbits","volume":"95","author":"Valera","year":"2013","journal-title":"Res Vet. Sci."},{"key":"10.1016\/j.vetmic.2024.110334_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.virusres.2012.04.005","article-title":"Bovine herpesvirus-1 VP8 interacts with DNA damage binding protein-1 (DDB1) and is monoubiquitinated during infection","volume":"167","author":"Vasilenko","year":"2012","journal-title":"Virus Res"},{"key":"10.1016\/j.vetmic.2024.110334_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01937-17","article-title":"The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency","volume":"92","author":"Workman","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110334_bib26","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1074\/jbc.M117.777474","article-title":"The p53-binding protein 1-Tudor-interacting repair regulator complex participates in the DNA damage response","volume":"292","author":"Zhang","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2024.110334_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/v10080393","article-title":"Induction of Oxidative DNA Damage in Bovine Herpesvirus 1 Infected Bovine Kidney Cells (MDBK Cells) and Human Tumor Cells (A549 Cells and U2OS Cells)","volume":"10","author":"Zhu","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2024.110334_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02132-16","article-title":"Potential role for a beta-catenin coactivator (High-Mobility Group AT-Hook 1 Protein) during the latency-reactivation cycle of bovine herpesvirus 1","volume":"91","author":"Zhu","year":"2017","journal-title":"J. Virol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524003560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524003560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:49:05Z","timestamp":1778690945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113524003560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":28,"alternative-id":["S0378113524003560"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110334","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"53BP1, a known chromatin-associated factor that promotes DNA damage repair, is differentially modulated during bovine herpesvirus 1 infection in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110334"}}