{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:17:05Z","timestamp":1789438625240,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.vetmic.2024.110335","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T17:45:39Z","timestamp":1733334339000},"page":"110335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["MDV-encoded protein kinase US3 phosphorylates WTAP to inhibit transcriptomic m6A modification and cellular protein translation"],"prefix":"10.1016","volume":"300","author":[{"given":"Lele","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhe","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2024.110335_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2022.109409","article-title":"Deletion of miR-M8 and miR-M13 eliminates the bursa atrophy induced by Marek's disease virus infection","volume":"268","author":"Bai","year":"2022","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110335_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2024.110335_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118438","article-title":"N6-adenosine methylation in MiRNAs","volume":"10","author":"Berulava","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2024.110335_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110373","article-title":"TBK1-METTL3 axis facilitates antiviral immunity","volume":"38","author":"Chen","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.vetmic.2024.110335_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1099\/vir.0.025593-0","article-title":"Keep it in the subfamily: the conserved alphaherpesvirus US3 protein kinase","volume":"92","author":"Deruelle","year":"2011","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2024.110335_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2022.109364","article-title":"Marek's disease virus serine\/threonine kinase Us3 facilitates viral replication by targeting IRF7 to block IFN-beta production","volume":"266","author":"Du","year":"2022","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110335_bib7","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202052101","article-title":"Degradation of WTAP blocks antiviral responses by reducing the m6A levels of IRF3 and IFNAR1 mRNA","volume":"22","author":"Ge","year":"2021","journal-title":"Embo Rep."},{"key":"10.1016\/j.vetmic.2024.110335_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006995","article-title":"N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection","volume":"14","author":"Hesser","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2024.110335_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111693","article-title":"m6A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1\/3 and facilitating mRNA translation","volume":"41","author":"Huang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.vetmic.2024.110335_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111107","article-title":"Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex","volume":"40","author":"Jansens","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.vetmic.2024.110335_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007796","article-title":"EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis","volume":"15","author":"Lang","year":"2019","journal-title":"Plos Pathog."},{"key":"10.1016\/j.vetmic.2024.110335_bib12","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2023.2232910","article-title":"METTL14 and FTO mediated m(6)A modification regulate PCV2 replication by affecting miR-30a-5p maturity","volume":"14","author":"Li","year":"2023","journal-title":"Virulence"},{"key":"10.1016\/j.vetmic.2024.110335_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/v13060974","article-title":"Latest insights into unique open reading frames encoded by Unique Long (UL) and short (US) regions of Marek's disease virus","volume":"13","author":"Liao","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2024.110335_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9040685","article-title":"Manipulation of Promyelocytic Leukemia Protein Nuclear Bodies by Marek's Disease Virus Encoded US3 Protein Kinase","volume":"9","author":"Liao","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.vetmic.2024.110335_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009307","article-title":"Marek's disease virus US3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis","volume":"17","author":"Liao","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2024.110335_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00892-20","article-title":"Role of Marek's disease virus (MDV)-encoded U(S)3 Serine\/Threonine protein kinase in regulating MDV Meq and cellular CREB phosphorylation","volume":"94","author":"Liao","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110335_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010773","article-title":"Emerging mutual regulatory roles between m6A Modification and microRNAs","volume":"24","author":"Mei","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.vetmic.2024.110335_bib18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrmicro1382","article-title":"Marek's disease virus: from miasma to model","volume":"4","author":"Osterrieder","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110335_bib19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.vetmic.2016.11.024","article-title":"Marek's disease vaccines: current status, and strategies for improvement and development of vector vaccines","volume":"206","author":"Reddy","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110335_bib20","unstructured":"Release|ICTV, I.C.I.T. [(accessed on 30 July). Available online2024\u3008https:\/\/ictv.global\/taxonomy\u3009."},{"key":"10.1016\/j.vetmic.2024.110335_bib21","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1016\/j.vaccine.2020.09.013","article-title":"Current status of virus-vectored vaccines against pathogens that affect poultry","volume":"38","author":"Romanutti","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2024.110335_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.virol.2008.01.026","article-title":"Enzymatically inactive U(S)3 protein kinase of Marek's disease virus (MDV) is capable of depolymerizing F-actin but results in accumulation of virions in perinuclear invaginations and reduced virus growth","volume":"375","author":"Schumacher","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2024.110335_bib23","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1128\/JVI.79.7.3987-3997.2005","article-title":"The protein encoded by the US3 orthologue of Marek's disease virus is required for efficient de-envelopment of perinuclear virions and involved in actin stress fiber breakdown","volume":"79","author":"Schumacher","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110335_bib24","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol. Cell."},{"key":"10.1016\/j.vetmic.2024.110335_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18434","article-title":"Structural insights into the molecular mechanism of the m6A writer complex","volume":"5","author":"Sledz","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.vetmic.2024.110335_bib26","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2104805118","article-title":"Widespread remodeling of the m(6)A RNA-modification landscape by a viral regulator of RNA processing and export","volume":"118","author":"Srinivas","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vetmic.2024.110335_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109082","article-title":"Virus-encoded microRNA-M7 restricts early cytolytic replication and pathogenesis of Marek's disease virus","volume":"259","author":"Sun","year":"2021","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110335_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.vetmic.2019.06.020","article-title":"Lorf9 deletion significantly eliminated lymphoid organ atrophy induced by meq-deleted very virulent Marek's disease virus","volume":"235","author":"Sun","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110335_bib29","article-title":"Comprehensive profiling analysis of the N6-methyladenosine-modified circular RNA transcriptome in cultured cells infected with Marek's disease virus","volume":"11","author":"Sun","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2024.110335_bib30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13567-021-00901-5","article-title":"UL28 and UL33 homologs of Marek's disease virus terminase complex involved in the regulation of cleavage and packaging of viral DNA are indispensable for replication in cultured cells","volume":"52","author":"Sun","year":"2021","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2024.110335_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2020.10.026","article-title":"Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m(6)A Methylation","volume":"80","author":"Sun","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.vetmic.2024.110335_bib32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12864-021-07619-w","article-title":"Transcriptome-wide N6-methyladenosine modification profiling of long non-coding RNAs during replication of Marek's disease virus in vitro","volume":"22","author":"Sun","year":"2021","journal-title":"BMC Genom."},{"key":"10.1016\/j.vetmic.2024.110335_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11427-022-2258-4","article-title":"Critical roles of non-coding RNAs in lifecycle and biology of Marek's disease herpesvirus","volume":"66","author":"Teng","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.vetmic.2024.110335_bib34","doi-asserted-by":"crossref","first-page":"7980","DOI":"10.1128\/JVI.74.17.7980-7988.2000","article-title":"The genome of a very virulent Marek's disease virus","volume":"74","author":"Tulman","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110335_bib35","doi-asserted-by":"crossref","first-page":"11502","DOI":"10.1128\/JVI.01318-09","article-title":"Histone deacetylases 1 and 2 are phosphorylated at novel sites during varicella-zoster virus infection","volume":"83","author":"Walters","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110335_bib36","doi-asserted-by":"crossref","first-page":"9666","DOI":"10.1128\/JVI.00981-10","article-title":"Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases","volume":"84","author":"Walters","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110335_bib37","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature18298","article-title":"Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex","volume":"534","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2024.110335_bib38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41590-018-0275-z","article-title":"m(6)A modification controls the innate immune response to infection by targeting type I interferons","volume":"20","author":"Winkler","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetmic.2024.110335_bib39","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/cr.2017.31","article-title":"Extensive translation of circular RNAs driven by N6-methyladenosine","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.vetmic.2024.110335_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109248","article-title":"Marek's disease virus encoded miR-M6 and miR-M10 are dispensable for virus replication and pathogenesis in chickens","volume":"262","author":"Yang","year":"2021","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2024.110335_bib41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41419-023-06121-3","article-title":"METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.vetmic.2024.110335_bib42","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/iid3.396","article-title":"RNA m(6) A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection","volume":"9","author":"Zheng","year":"2021","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.vetmic.2024.110335_bib43","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1038\/s41467-023-40212-1","article-title":"Circular RNA encoded MET variant promotes glioblastoma tumorigenesis","volume":"14","author":"Zhong","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2024.110335_bib44","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01574-23","article-title":"LORF9 of Marek's disease virus is involved in the early cytolytic replication of B lymphocytes and can act as a target for gene deletion vaccine development","volume":"97","author":"Zhu","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2024.110335_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28324","article-title":"Infection phase-dependent dynamics of the viral and host N6-methyladenosine epitranscriptome in the lifecycle of an oncogenic virus in vivo","volume":"95","author":"Zhuang","year":"2023","journal-title":"J. Med. Virol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524003572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113524003572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T04:35:11Z","timestamp":1740717311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113524003572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S0378113524003572"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110335","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MDV-encoded protein kinase US3 phosphorylates WTAP to inhibit transcriptomic m6A modification and cellular protein translation","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2024.110335","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110335"}}