{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:19:27Z","timestamp":1778692767134,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007765","name":"Kansas State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["AFRI 2013-67015-26517"],"award-info":[{"award-number":["AFRI 2013-67015-26517"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["USDA-NIFA-AFRI 2018-67016-28313"],"award-info":[{"award-number":["USDA-NIFA-AFRI 2018-67016-28313"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["NC229"],"award-info":[{"award-number":["NC229"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.vetmic.2025.110366","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T20:43:26Z","timestamp":1736023406000},"page":"110366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Replication-competent recombinant porcine reproductive and respiratory syndrome (PRRS) virus expressing antiviral cytokine interferon-\u03c95 as a modified live virus vaccine"],"prefix":"10.1016","volume":"301","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-9416","authenticated-orcid":false,"given":"Laura C.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra C.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin E.","family":"Schirtzinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahamudul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn M.","family":"Sarlo Davila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damarius S.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M.","family":"Lager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-2854","authenticated-orcid":false,"given":"Yongming","family":"Sang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2025.110366_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.197980","article-title":"Molecular and cellular mechanisms for PRRSV pathogenesis and host response to infection","volume":"286","author":"An","year":"2020","journal-title":"Virus Res"},{"key":"10.1016\/j.vetmic.2025.110366_bib2","doi-asserted-by":"crossref","first-page":"26996","DOI":"10.1038\/srep26996","article-title":"The statistical value of raw fluorescence signal in Luminex xMAP based multiplex immunoassays","volume":"6","author":"Breen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2025.110366_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/CVI.05490-11","article-title":"The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus","volume":"19","author":"Brockmeier","year":"2012","journal-title":"Clin. Vaccin. Immunol."},{"key":"10.1016\/j.vetmic.2025.110366_bib4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cytogfr.2014.10.011","article-title":"Type I IFN family members: similarity, differences and interaction","volume":"26","author":"Capobianchi","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.vetmic.2025.110366_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/v12111245","article-title":"Porcine reproductive and respiratory syndrome virus reverse genetics and the major applications","volume":"12","author":"Chaudhari","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110366_bib6","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3390\/v16060939","article-title":"Transcriptome analysis in air\u2013liquid interface porcine respiratory epithelial cell cultures reveals that the betacoronavirus porcine encephalomyelitis hemagglutinating virus induces a robust interferon response to infection","volume":"16","author":"Davila","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110366_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.791034","article-title":"Transcriptomic analysis of liver indicates novel vaccine to porcine reproductive and respiratory virus promotes homeostasis in t-cell and inflammatory immune responses compared to a commercial vaccine in pigs","volume":"9","author":"Fleming","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.vetmic.2025.110366_bib8","first-page":"11","article-title":"Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model","volume":"8","author":"Halbur","year":"1996"},{"key":"10.1016\/j.vetmic.2025.110366_bib9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFN\u03b3: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2025.110366_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/v11060555","article-title":"Porcine interferon complex and co-evolution with increasing viral pressure after domestication","volume":"11","author":"Jennings","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110366_bib11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jmv.25272","article-title":"Antiviral activity of porcine interferon omega 7 against foot-and-mouth disease virus in vitro","volume":"91","author":"Li","year":"2019","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.vetmic.2025.110366_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.intimp.2017.08.028","article-title":"Interferon-omega: current status in clinical applications","volume":"52","author":"Li","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"13","key":"10.1016\/j.vetmic.2025.110366_bib13","article-title":"Comparative transcriptomics reveals small RNA composition and differential microRNA responses underlying interferon-mediated antiviral regulation in porcine alveolar macrophages","volume":"28","author":"Li","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.vetmic.2025.110366_bib14","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/vaccines12060606","article-title":"Current status of vaccines for porcine reproductive and respiratory syndrome: interferon response, immunological overview, and future prospects","volume":"12","author":"Li","year":"2024","journal-title":"Vaccines"},{"key":"10.1016\/j.vetmic.2025.110366_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-animal-022114-111025","article-title":"Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune system","volume":"4","author":"Lunney","year":"2016","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.vetmic.2025.110366_bib16","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3389\/fmicb.2017.01635","article-title":"Improved Vaccine against PRRSV: Current Progress and Future Perspective","volume":"8","author":"Nan","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110366_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.virol.2009.03.036","article-title":"Porcine reproductive and respiratory syndrome virus as a vector: immunogenicity of green fluorescent protein and porcine circovirus type 2 capsid expressed from dedicated subgenomic RNAs","volume":"389","author":"Pei","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2025.110366_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01714-14","article-title":"Antiviral regulation in porcine monocytic cells at different activation states","volume":"88","author":"Sang","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110366_bib19","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3390\/v4010102","article-title":"Replication-competent recombinant porcine reproductive and respiratory syndrome (PRRS) viruses expressing indicator proteins and antiviral cytokines","volume":"4","author":"Sang","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110366_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01431","article-title":"Cross-species genome-wide analysis reveals molecular and functional diversity of the unconventional interferon-\u03c9 subtype","volume":"10","author":"Shields","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2025.110366_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fvets.2018.00102","article-title":"Production losses from an endemic animal disease: porcine reproductive and respiratory syndrome (PRRS) in selected midwest US Sow Farms","volume":"5","author":"Valdes-Donoso","year":"2018","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.vetmic.2025.110366_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2017.10.002","article-title":"Porcine reproductive and respiratory disease virus: evolution and recombination yields distinct ORF5 RFLP 1-7-4 viruses with individual pathogenicity","volume":"513","author":"van Geelen","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2025.110366_bib23","article-title":"Evasion of antiviral innate immunity by porcine reproductive and respiratory syndrome virus","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110366_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.vetimm.2004.09.019","article-title":"Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and their potential as vaccine vectors","volume":"102","author":"Yoo","year":"2004","journal-title":"Vet. Immuno. Immunopathol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811352500001X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811352500001X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:49:09Z","timestamp":1778690949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811352500001X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":24,"alternative-id":["S037811352500001X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110366","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Replication-competent recombinant porcine reproductive and respiratory syndrome (PRRS) virus expressing antiviral cytokine interferon-\u03c95 as a modified live virus vaccine","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110366"}}