{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:32:12Z","timestamp":1778866332575,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1802602"],"award-info":[{"award-number":["2023YFD1802602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD18026"],"award-info":[{"award-number":["2023YFD18026"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.vetmic.2025.110425","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:43:22Z","timestamp":1738889002000},"page":"110425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A novel recombinant chimeric Fiber-8a\/8b-AD subunit vaccine provides complete protection against both FAdV-8a and FAdV-8b"],"prefix":"10.1016","volume":"303","author":[{"given":"Xiangqin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanzhe","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2025.110425_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0261284","article-title":"Pathogenicity of field strain of fowl aviadenovirus serotype 11 isolated from chickens with inclusion body hepatitis in Morocco","volume":"16","author":"Abghour","year":"2021","journal-title":"PlOS One"},{"key":"10.1016\/j.vetmic.2025.110425_bib2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00705-012-1570-x","article-title":"Hydropericardium syndrome: current state and future developments","volume":"158","author":"Asthana","year":"2013","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2025.110425_bib3","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1128\/JCM.43.9.4426-4433.2005","article-title":"Detection of antibodies against adenovirus protein IX, fiber, and hexon in human sera by immunoblot assay","volume":"43","author":"Bauer","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110425_bib4","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.vaccine.2022.01.060","article-title":"Vaccination with a fowl adenovirus chimeric fiber protein (crecFib-4\/11) simultaneously protects chickens against hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH)","volume":"40","author":"De Luca","year":"2022","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110425_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13567-020-00869-8","article-title":"Fowl adenovirus (FAdV) fiber-based vaccine against inclusion body hepatitis (IBH) provides type-specific protection guided by humoral immunity and regulation of B and T cell response","volume":"51","author":"De Luca","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2025.110425_bib6","first-page":"182","article-title":"Cell-culture derived fowl adenovirus serotype 4 inactivated vaccine provides complete protection for virus infection on SPF chickens","volume":"28","author":"Du","year":"2017","journal-title":"Virus Dis."},{"key":"10.1016\/j.vetmic.2025.110425_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jim.2018.03.002","article-title":"Fiber-based fluorescent microsphere immunoassay (FMIA) as a novel multiplex serodiagnostic tool for simultaneous detection and differentiation of all clinically relevant fowl adenovirus (FAdV) serotypes","volume":"458","author":"Feichtner","year":"2018","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.vetmic.2025.110425_bib8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1006\/viro.1995.9949","article-title":"Antigenic sites on the receptor-binding domain of human adenovirus type 2 fiber","volume":"214","author":"Fender","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2025.110425_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.vaccine.2019.10.039","article-title":"Successful reproduction of adenoviral gizzard erosion in 20-week-old SPF layer-type chickens and efficacious prophylaxis due to live vaccination with apathogenic fowl adenovirus serotype 1 strain (CELO)","volume":"38","author":"Grafl","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110425_bib10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.vaccine.2017.12.047","article-title":"Inactivated and live bivalent fowl adenovirus (FAdV8b + FAdV11) breeder vaccines provide broad-spectrum protection in chicks against inclusion body hepatitis (IBH)","volume":"36","author":"Gupta","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110425_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/03079450050045440","article-title":"Detection and differentiation of avian adenoviruses: a review","volume":"29","author":"Hess","year":"2000","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2025.110425_bib12","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3382\/ps\/pey425","article-title":"Pathogenicity and complete genome sequence of a fowl adenovirus serotype 8b isolate from China","volume":"98","author":"Huang","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2025.110425_bib13","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.vaccine.2014.03.015","article-title":"An inactivated oil-emulsion fowl adenovirus serotype 4 vaccine provides broad cross-protection against various serotypes of fowl adenovirus","volume":"32","author":"Kim","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110425_bib14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.meegid.2016.09.006","article-title":"Fowl adenovirus species C serotype 4 is attributed to the emergence of hepatitis-hydropericardium syndrome in chickens in China","volume":"45","author":"Li","year":"2016","journal-title":"Infect. Genet. Evol."},{"issue":"01","key":"10.1016\/j.vetmic.2025.110425_bib15","first-page":"108","article-title":"Progress in research on fowl adenovirus species \u2160 and its vaccines","volume":"28","author":"Liu","year":"2020","journal-title":"Chin. J. Anim. Infect. Dis."},{"issue":"3-4","key":"10.1016\/j.vetmic.2025.110425_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.vetmic.2011.11.003","article-title":"Two fiber genes of nearly equal lengths are a common and distinctive feature of Fowl adenovirus C members","volume":"156","author":"Marek","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110425_bib17","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1080\/03079457.2016.1168513","article-title":"Selected clinical chemistry analytes correlate with the pathogenesis of inclusion body hepatitis experimentally induced by fowl aviadenoviruses","volume":"45","author":"Matos","year":"2016","journal-title":"Avian Pathol."},{"issue":"7","key":"10.1016\/j.vetmic.2025.110425_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/v11070627","article-title":"Identification, pathogenicity of novel fowl adenovirus serotype 4 SDJN0105 in Shandong, China and immunoprotective evaluation of the newly developed inactivated oil-emulsion FAdV-4 vaccine","volume":"11","author":"Meng","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110425_bib19","first-page":"314","article-title":"A primary occurrence of inclusion body hepatitis in absence of predisposing agents in commercial broilers in Iran: a case report","volume":"21","author":"Mirzazadeh","year":"2020","journal-title":"Iran. J. Vet. Res."},{"key":"10.1016\/j.vetmic.2025.110425_bib20","first-page":"267","article-title":"Adenovirus: from structure to genes vectorisation and vaccinology - I. Adenovirus and recombinant adenovirus virology","volume":"7","author":"Molinier-Frenkel","year":"2003","journal-title":"Virologie"},{"key":"10.1016\/j.vetmic.2025.110425_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1637\/11551-120516-Reg.1","article-title":"Fowl adenoviruses D and E cause inclusion body hepatitis outbreaks in broiler and broiler breeder pullet flocks","volume":"61","author":"Morshed","year":"2017","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2025.110425_bib22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3382\/ps\/pex338","article-title":"Molecular epidemiology and phylogenetic analysis of fowl adenoviruses caused hydropericardium outbreak in China during 2015","volume":"97","author":"Niu","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2025.110425_bib23","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ymthe.2005.05.008","article-title":"The influence of adenovirus fiber structure and function on vector development for gene therapy","volume":"12","author":"Nicklin","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.vetmic.2025.110425_bib24","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1007\/s00705-018-3965-9","article-title":"A comparative pathogenicity analysis of two adenovirus strains, 1\/A and 8a\/E, isolated from poultry in Poland","volume":"163","author":"Niczyporuk","year":"2018","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2025.110425_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.rvsc.2018.03.003","article-title":"Broad spectrum protection of broiler chickens against inclusion body hepatitis by immunizing their broiler breeder parents with a bivalent live fowl adenovirus vaccine","volume":"118","author":"Popowich","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2025.110425_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02123-21","article-title":"Recombinantly expressed chimeric fibers demonstrate discrete type-specific neutralizing epitopes in the Fowl aviadenovirus E (FAdV-E) fiber, promoting the optimization of FAdV fiber subunit vaccines towards cross-protection in vivo","volume":"10","author":"Schachner","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.vetmic.2025.110425_bib27","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.3390\/v11121094","article-title":"Fowl adenovirus (FAdV) recombination with intertypic crossovers in genomes of FAdV-D and FAdV-E, displaying hybrid serological phenotypes","volume":"11","author":"Schachner","year":"2019","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.vetmic.2025.110425_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/03079457.2017.1385724","article-title":"Fowl adenovirus induced diseases and strategies for their control\u2014a review on the current global situation","volume":"47","author":"Schachner","year":"2018","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2025.110425_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/03079457.2015.1007919","article-title":"Chronological analysis of gross and histological lesions induced by field strains of fowl adenovirus serotypes 1, 8b and 11 in one-day-old chickens","volume":"44","author":"Steer","year":"2015","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2025.110425_bib30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/03079457.2019.1612032","article-title":"Vaccination with FAdV-8a induces protection against inclusion body hepatitis caused by homologous and heterologous strains","volume":"48","author":"Steer-Cope","year":"2019","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2025.110425_bib31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1637\/7460-102605R.1","article-title":"Characterization of monoclonal antibodies against fowl adenovirus serotype 1 (FAV1) isolated from gizzard erosion","volume":"50","author":"Taharaguchi","year":"2006","journal-title":"Avian Dis."},{"key":"10.1016\/j.vetmic.2025.110425_bib32","article-title":"Isolation, identification and genetic characterization analysis of a Fowl adenovirus serotype 4 strain from Tianjin, China","volume":"196","author":"Wang","year":"2021","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.vetmic.2025.110425_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13567-018-0525-y","article-title":"A novel monoclonal antibody efficiently blocks the infection of serotype 4 fowl adenovirus by targeting fiber-2","volume":"49","author":"Wang","year":"2018","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2025.110425_bib34","doi-asserted-by":"crossref","first-page":"e00954","DOI":"10.1128\/JVI.00954-20","article-title":"Fiber-1, not fiber-2, directly mediates the infection of the pathogenic serotype 4 fowl adenovirus via its shaft and knob domains","volume":"94","author":"Wang","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110425_bib35","doi-asserted-by":"crossref","first-page":"7225","DOI":"10.1128\/JVI.77.13.7225-7235.2003","article-title":"Flexibility of the adenovirus fiber is required for efficient receptor interaction","volume":"77","author":"Wu","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110425_bib36","first-page":"1","article-title":"Pathogenicity and innate immune responses induced by fowl adenovirus serotype 8b in specific pathogen-free chicken","volume":"102","author":"Zhang","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2025.110425_bib37","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.virol.2012.12.014","article-title":"Characteristics of neutralizing antibodies to adenovirus capsid proteins in human and animal sera","volume":"437","author":"Yu","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2025.110425_bib38","first-page":"2341","article-title":"Truncated expression of FAdV-4 Fiber-2 protein and preparation of monoclonal antibodies","volume":"53","author":"Yu","year":"2022","journal-title":"J. South Agric."},{"issue":"1","key":"10.1016\/j.vetmic.2025.110425_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41426-018-0203-1","article-title":"Fiber2 and hexon genes are closely associated with the virulence of the emerging and highly pathogenic fowl adenovirus 4","volume":"7","author":"Zhang","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.vetmic.2025.110425_bib40","article-title":"Pathogenicity and complete genome characterization of fowl adenoviruses isolated from chickens associated with inclusion body hepatitis and hydropericardium syndrome in China","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2025.110425_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2023.109678","article-title":"Recombinant porcine Interferon-\u03b1 and Interleukin-2 fusion protein (rPoIFN\u03b1+IL-2) shows potent anti-pseudorabies virus activity in vitro and in vivo","volume":"279","author":"Zhao","year":"2023","journal-title":"Vet. Microbiol."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525000604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525000604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:26:32Z","timestamp":1741771592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113525000604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":41,"alternative-id":["S0378113525000604"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110425","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel recombinant chimeric Fiber-8a\/8b-AD subunit vaccine provides complete protection against both FAdV-8a and FAdV-8b","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110425","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110425"}}