{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:44:23Z","timestamp":1791333863205,"version":"4.3.1"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2022-KYY-517101\\u20130005"],"award-info":[{"award-number":["2022-KYY-517101\\u20130005"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32192454"],"award-info":[{"award-number":["32192454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.vetmic.2025.110529","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:23:15Z","timestamp":1745436195000},"page":"110529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Immunological characteristics of the recombinant pseudorabies virus with chimeric PCV Cap protein in pigs"],"prefix":"10.1016","volume":"305","author":[{"given":"Chenhe","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiren","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.vetmic.2025.110529_bib1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.immuni.2007.07.009","article-title":"Germinal-center organization and cellular dynamics","volume":"27","author":"Allen","year":"2007","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.vetmic.2025.110529_bib2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/ni0703-616","article-title":"An epigenetic view of helper T cell differentiation","volume":"4","author":"Ansel","year":"2003","journal-title":"Nat. Immunol."},{"issue":"31","key":"10.1016\/j.vetmic.2025.110529_bib3","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1016\/S0264-410X(03)00503-6","article-title":"Protection of swine against post-weaning multisystemic wasting syndrome (PMWS) by porcine circovirus type 2 (PCV2) proteins","volume":"21","author":"Blanchard","year":"2003","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.vetmic.2025.110529_bib4","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.tvjl.2004.01.012","article-title":"A review of porcine circovirus 2-associated syndromes and diseases","volume":"169","author":"Chae","year":"2005","journal-title":"Vet. J."},{"key":"10.1016\/j.vetmic.2025.110529_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/1743-422X-8-307","article-title":"A novel recombinant pseudorabies virus expressing parvovirus VP2 gene: Immunogenicity and protective efficacy in swine","volume":"8","author":"Chen","year":"2011","journal-title":"Virol. J."},{"issue":"1","key":"10.1016\/j.vetmic.2025.110529_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13567-021-00944-8","article-title":"Chimeric HP-PRRSV2 containing an ORF2-6 consensus sequence induces antibodies with broadly neutralizing activity and confers cross protection against virulent NADC30-like isolate","volume":"52","author":"Chen","year":"2021","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2025.110529_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu Rev. Immunol."},{"issue":"6","key":"10.1016\/j.vetmic.2025.110529_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41590-021-00926-0","article-title":"Dynamic regulation of B cell complement signaling is integral to germinal center responses","volume":"22","author":"Cumpelik","year":"2021","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.vetmic.2025.110529_bib9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cell.2019.03.016","article-title":"B CEll Responses: Cell Interaction Dynamics and Decisions","volume":"177","author":"Cyster","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2025.110529_bib10","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/824630","article-title":"An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines","volume":"2014","author":"Dong","year":"2014","journal-title":"J. Immunol. Res."},{"issue":"5","key":"10.1016\/j.vetmic.2025.110529_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1158\/2326-6066.CIR-14-0029","article-title":"Affinity enhancement of antibodies: how low-affinity antibodies produced early in immune responses are followed by high-affinity antibodies later and in memory B-cell responses","volume":"2","author":"Eisen","year":"2014","journal-title":"Cancer Immunol. Res."},{"issue":"12","key":"10.1016\/j.vetmic.2025.110529_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208585","article-title":"Porcine circovirus 2 (PCV-2) genotype update and proposal of a new genotyping methodology","volume":"13","author":"Franzo","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2025.110529_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.vetmic.2016.11.019","article-title":"Vaccines against pseudorabies virus (PrV)","volume":"206","author":"Freuling","year":"2017","journal-title":"Vet. Microbiol."},{"issue":"Pt 9","key":"10.1016\/j.vetmic.2025.110529_bib14","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1099\/0022-1317-78-9-2139","article-title":"Mettenleiter TC: protection of pigs against Aujeszky's disease by DNA vaccination","volume":"78","author":"Gerdts","year":"1997","journal-title":"J. Gen. Virol."},{"issue":"9","key":"10.1016\/j.vetmic.2025.110529_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/v14092005","article-title":"Porcine circovirus type 2 vaccines: commercial application and research advances","volume":"14","author":"Guo","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110529_bib16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.immunol.18.1.275","article-title":"CD8+ T cell effector mechanisms in resistance to infection","volume":"18","author":"Harty","year":"2000","journal-title":"Annu Rev. Immunol."},{"issue":"43","key":"10.1016\/j.vetmic.2025.110529_bib17","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1016\/j.vaccine.2015.09.066","article-title":"Novel pseudorabies virus variant with defects in TK, gE and gI protects growing pigs against lethal challenge","volume":"33","author":"Hu","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110529_bib18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fmicb.2018.00455","article-title":"Evaluation of the efficacy and cross-protective immunity of live-attenuated chimeric PCV1-2b vaccine against PCV2b and PCV2d subtype challenge in pigs","volume":"9","author":"Huan","year":"2018","journal-title":"Front. Microbiol."},{"issue":"13","key":"10.1016\/j.vetmic.2025.110529_bib19","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1007\/s00253-016-7459-y","article-title":"Capsid proteins from PCV2a genotype confer greater protection against a PCV2b strain than those from PCV2b genotype in pigs: evidence for PCV2b strains becoming more predominant than PCV2a strains from 2000 to 2010s","volume":"100","author":"Huang","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"3","key":"10.1016\/j.vetmic.2025.110529_bib20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.vaccine.2006.07.032","article-title":"Immunogenicity and protective efficacy of recombinant pseudorabies virus expressing the two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus","volume":"25","author":"Jiang","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110529_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.943707","article-title":"The inactivated gE\/TK gene-deleted vaccine against pseudorabies virus type II confers effective protection in mice and pigs","volume":"13","author":"Jin","year":"2022","journal-title":"Front. Microbiol."},{"issue":"3-4","key":"10.1016\/j.vetmic.2025.110529_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.vetmic.2005.06.001","article-title":"Immunogenicity of a recombinant pseudorabies virus expressing ORF1-ORF2 fusion protein of porcine circovirus type 2","volume":"109","author":"Ju","year":"2005","journal-title":"Vet. Microbiol."},{"issue":"9","key":"10.1016\/j.vetmic.2025.110529_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines11091447","article-title":"Selection and evaluation of Porcine circovirus (PCV) 2d vaccine strains to protect against currently prevalent PCV2","volume":"11","author":"Ju","year":"2023","journal-title":"Vaccines"},{"issue":"16","key":"10.1016\/j.vetmic.2025.110529_bib24","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1128\/JVI.00228-07","article-title":"Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells","volume":"81","author":"Kannanganat","year":"2007","journal-title":"J. Virol."},{"issue":"1-2","key":"10.1016\/j.vetmic.2025.110529_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.vetimm.2008.01.031","article-title":"Porcine circovirus type 2 (PCV2) viral components immunomodulate recall antigen responses","volume":"124","author":"Kekarainen","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"2","key":"10.1016\/j.vetmic.2025.110529_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9020106","article-title":"Maternal autogenous inactivated virus vaccination boosts immunity to PRRSV in piglets","volume":"9","author":"Kick","year":"2021","journal-title":"Vaccines"},{"issue":"4","key":"10.1016\/j.vetmic.2025.110529_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9040254","article-title":"The Neuropathic Itch Caused by Pseudorabies Virus","volume":"9","author":"Laval","year":"2020","journal-title":"Pathogens"},{"issue":"15","key":"10.1016\/j.vetmic.2025.110529_bib28","doi-asserted-by":"crossref","first-page":"8135","DOI":"10.1128\/JVI.78.15.8135-8145.2004","article-title":"Epitope mapping of the major capsid protein of type 2 porcine circovirus (PCV2) by using chimeric PCV1 and PCV2","volume":"78","author":"Lekcharoensuk","year":"2004","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.vetmic.2025.110529_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084469","article-title":"Coinfection of Porcine Circovirus 2 and Pseudorabies virus enhances immunosuppression and inflammation through NF-kappaB, JAK\/STAT, MAPK, and NLRP3 pathways","volume":"23","author":"Li","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.vetmic.2025.110529_bib30","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001850","article-title":"A potent CD8 T-cell response may be associated with partial cross-protection conferred by an attenuated Chinese HP-PRRSV vaccine against NADC30-like PRRSV challenge","volume":"104","author":"Li","year":"2023","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2025.110529_bib31","article-title":"Maintenance and recall of memory T cell populations against tuberculosis: Implications for vaccine design","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.vetmic.2025.110529_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-51473-6","article-title":"Environmental distribution of Porcine Circovirus Type 2 (PCV2) in swine herds with natural infection","volume":"9","author":"Lopez-Lorenzo","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2025.110529_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1515309","article-title":"Immunological characteristics of a recombinant alphaherpesvirus with an envelope-embedded Cap protein of circovirus","volume":"15","author":"Lu","year":"2024","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.vetmic.2025.110529_bib34","doi-asserted-by":"crossref","DOI":"10.4142\/jvs.2020.21.e36","article-title":"Epidemiological investigation of porcine pseudorabies virus and its coinfection rate in Shandong Province in China from 2015 to 2018","volume":"21","author":"Ma","year":"2020","journal-title":"J. Vet. Sci."},{"issue":"3","key":"10.1016\/j.vetmic.2025.110529_bib35","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41385-021-00478-4","article-title":"Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells","volume":"15","author":"Martini","year":"2022","journal-title":"Mucosal Immunol."},{"issue":"9","key":"10.1016\/j.vetmic.2025.110529_bib36","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1016\/j.ymthe.2022.04.014","article-title":"A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity","volume":"30","author":"McCafferty","year":"2022","journal-title":"Mol. Ther."},{"issue":"Pt 9","key":"10.1016\/j.vetmic.2025.110529_bib37","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1099\/0022-1317-79-9-2171","article-title":"Characterization of novel circovirus DNAs associated with wasting syndromes in pigs","volume":"79","author":"Meehan","year":"1998","journal-title":"J. Gen. Virol."},{"issue":"2","key":"10.1016\/j.vetmic.2025.110529_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.02002-23","article-title":"Enhanced antigen-specific CD8 T cells contribute to early protection against FMDV through swine DC vaccination","volume":"98","author":"Mu","year":"2024","journal-title":"J. Virol."},{"issue":"Pt 9","key":"10.1016\/j.vetmic.2025.110529_bib39","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1099\/0022-1317-81-9-2281","article-title":"Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein","volume":"81","author":"Nawagitgul","year":"2000","journal-title":"J. Gen. Virol."},{"issue":"9","key":"10.1016\/j.vetmic.2025.110529_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines10091469","article-title":"Pathological evaluation of Porcine Circovirus 2d (PCV2d) strain and comparative evaluation of PCV2d and PCV2b inactivated vaccines against PCV2d infection in a specific pathogen-free (SPF) Yucatan Miniature pig model","volume":"10","author":"Noh","year":"2022","journal-title":"Vaccines"},{"issue":"5943","key":"10.1016\/j.vetmic.2025.110529_bib41","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","article-title":"Bcl6 mediates the development of T follicular helper cells","volume":"325","author":"Nurieva","year":"2009","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.vetmic.2025.110529_bib42","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/104063870701900601","article-title":"Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies","volume":"19","author":"Opriessnig","year":"2007","journal-title":"J. Vet. Diagn. Invest"},{"issue":"2","key":"10.1016\/j.vetmic.2025.110529_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/v11020185","article-title":"Co-Infection of swine with porcine circovirus type 2 and other swine viruses","volume":"11","author":"Ouyang","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110529_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1215893","article-title":"Characterization of the humoral and cellular immunity induced by a recombinant BCG vaccine for the respiratory syncytial virus in healthy adults","volume":"14","author":"Pacheco","year":"2023","journal-title":"Front.Immunol."},{"issue":"2","key":"10.1016\/j.vetmic.2025.110529_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines10020305","article-title":"A triple gene-deleted pseudorabies virus-vectored subunit PCV2b and CSFV vaccine protects pigs against PCV2b challenge and induces serum neutralizing antibody response against CSFV","volume":"10","author":"Pavulraj","year":"2022","journal-title":"Vaccines"},{"issue":"17-18","key":"10.1016\/j.vetmic.2025.110529_bib46","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.vaccine.2003.12.005","article-title":"An approach to a FMD vaccine based on genetic engineered attenuated pseudorabies virus: one experiment using VP1 gene alone generates an antibody responds on FMD and pseudorabies in swine","volume":"22","author":"Qian","year":"2004","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.vetmic.2025.110529_bib47","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00705-018-3823-9","article-title":"High prevalence of PCV2d in Hunan province, China: a retrospective analysis of samples collected from 2006 to 2016","volume":"163","author":"Qu","year":"2018","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2025.110529_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.896689","article-title":"Same Dosages of rPRV\/XJ5-gI(-)\/gE(-)\/TK(-) prototype vaccine or Bartha-K61 vaccine similarly protects growing pigs against lethal challenge of emerging vPRV\/XJ-5 strain","volume":"9","author":"Ren","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.vetmic.2025.110529_bib49","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T cell subsets: function, generation, and maintenance","volume":"22","author":"Sallusto","year":"2004","journal-title":"Annu Rev. Immunol."},{"issue":"7","key":"10.1016\/j.vetmic.2025.110529_bib50","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41423-019-0220-6","article-title":"Helper T cell differentiation","volume":"16","author":"Saravia","year":"2019","journal-title":"Cell Mol. Immunol."},{"issue":"4","key":"10.1016\/j.vetmic.2025.110529_bib51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.vetmic.2025.110529_bib52","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.molimm.2008.10.028","article-title":"Fine mapping of antigenic epitopes on capsid proteins of porcine circovirus, and antigenic phenotype of porcine circovirus Type 2","volume":"46","author":"Shang","year":"2009","journal-title":"Mol. Immunol."},{"issue":"20","key":"10.1016\/j.vetmic.2025.110529_bib53","doi-asserted-by":"crossref","first-page":"9364","DOI":"10.1128\/JVI.01211-16","article-title":"Influenza A virus infection in Pigs attracts multifunctional and cross-reactive T cells to the lung","volume":"90","author":"Talker","year":"2016","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.vetmic.2025.110529_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/v14061343","article-title":"Development of a monoclonal antibody to pig CD69 reveals early activation of T cells in pig after PRRSV and ASFV infection","volume":"14","author":"Tian","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110529_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1328177","article-title":"Immune cell early activation, apoptotic kinetic, and T-cell functional impairment in domestic pigs after ASFV CADC_HN09 strain infection","volume":"15","author":"Tian","year":"2024","journal-title":"Front. Microbiol."},{"issue":"5844","key":"10.1016\/j.vetmic.2025.110529_bib56","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/295064a0","article-title":"A very small porcine virus with circular single-stranded DNA","volume":"295","author":"Tischer","year":"1982","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.vetmic.2025.110529_bib57","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12917-018-1536-7","article-title":"Safety and immunogenicity of an attenuated Chinese pseudorabies variant by dual deletion of TK&gE genes","volume":"14","author":"Wang","year":"2018","journal-title":"BMC Vet. Res."},{"issue":"11","key":"10.1016\/j.vetmic.2025.110529_bib58","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/eji.201848026","article-title":"Multifunctional cytokine production reveals functional superiority of memory CD4 T cells","volume":"49","author":"Westerhof","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.vetmic.2025.110529_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109022","article-title":"A new strategy to develop pseudorabies virus-based bivalent vaccine with high immunogenicity of porcine circovirus type 2","volume":"255","author":"Wu","year":"2021","journal-title":"Vet. Microbiol."},{"issue":"Pt 7","key":"10.1016\/j.vetmic.2025.110529_bib60","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1099\/vir.0.000100","article-title":"Global molecular genetic analysis of porcine circovirus type 2 (PCV2) sequences confirms the presence of four main PCV2 genotypes and reveals a rapid increase of PCV2d","volume":"96","author":"Xiao","year":"2015","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2025.110529_bib61","article-title":"Construction of recombinant pseudorabies virus expressing PCV2 Cap, PCV3 Cap, and IL-4: investigation of their biological characteristics and immunogenicity","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.vetmic.2025.110529_bib62","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12917-019-1859-z","article-title":"Genetic analysis of porcine circovirus type 2 (PCV2) strains between 2002 and 2016 reveals PCV2 mutant predominating in porcine population in Guangxi, China","volume":"15","author":"Yao","year":"2019","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetmic.2025.110529_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2023.109796","article-title":"Evaluation of cross-immunity among major porcine circovirus type 2 genotypes by infection with PCV2b and PCV2d circulating strains","volume":"283","author":"Yu","year":"2023","journal-title":"Vet. Microbiol."},{"issue":"2","key":"10.1016\/j.vetmic.2025.110529_bib64","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11259-006-3203-x","article-title":"Serological investigation and genomic characterization of PCV2 isolates from different geographic regions of Zhejiang province in China","volume":"30","author":"Zhou","year":"2006","journal-title":"Vet. Res. Commun."},{"issue":"8","key":"10.1016\/j.vetmic.2025.110529_bib65","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1089\/vim.2020.0025","article-title":"Prevalence of porcine pseudorabies virus and its coinfection rate in Heilongjiang Province in China from 2013 to 2018","volume":"33","author":"Zhou","year":"2020","journal-title":"Viral Immunol."},{"issue":"2","key":"10.1016\/j.vetmic.2025.110529_bib66","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jbiotec.2005.02.017","article-title":"In vitro expression, monoclonal antibody and bioactivity for capsid protein of porcine circovirus type II without nuclear localization signal","volume":"118","author":"Zhou","year":"2005","journal-title":"J. Biotechnol."},{"issue":"5","key":"10.1016\/j.vetmic.2025.110529_bib67","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood-2008-05-078154","article-title":"CD4 T cells: fates, functions, and faults","volume":"112","author":"Zhu","year":"2008","journal-title":"Blood"}],"updated-by":[{"DOI":"10.1016\/j.vetmic.2025.110727","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000}}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525001646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525001646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:07:05Z","timestamp":1768392425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113525001646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":67,"alternative-id":["S0378113525001646"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110529","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunological characteristics of the recombinant pseudorabies virus with chimeric PCV Cap protein in pigs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110529","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110529"}}