{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:49:04Z","timestamp":1794019744911,"version":"4.8.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFD1800203"],"award-info":[{"award-number":["2024YFD1800203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002365","name":"China Agricultural University","doi-asserted-by":"publisher","award":["00109015"],"award-info":[{"award-number":["00109015"]}],"id":[{"id":"10.13039\/501100002365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100156"],"award-info":[{"award-number":["32100156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.vetmic.2025.110730","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T21:47:22Z","timestamp":1758059242000},"page":"110730","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Identification and evaluation of Nordihydroguaiaretic acid (NDGA) as an active traditional Chinese medicine compound inhibiting the 3C-like protease of feline infectious peritonitis virus"],"prefix":"10.1016","volume":"310","author":[{"given":"Wei","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoen","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuna","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changbin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-6428","authenticated-orcid":false,"given":"Yueping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.vetmic.2025.110730_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/vr.135.8.177","article-title":"Antiviral studies of feline infectious peritonitis virus in vitro","volume":"135","author":"Barlough","year":"1994","journal-title":"Vet. Rec."},{"issue":"9","key":"10.1016\/j.vetmic.2025.110730_bib2","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.3390\/pathogens10091150","article-title":"Feline coronavirus antivirals: a review","volume":"10","author":"Delaplace","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.vetmic.2025.110730_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.virusres.2015.04.011","article-title":"Identification of the peptide derived from S1 domain that inhibits type I and type II feline infectious peritonitis virus infection","volume":"204","author":"Doki","year":"2015","journal-title":"Virus Res."},{"issue":"5","key":"10.1016\/j.vetmic.2025.110730_bib4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein\u2013ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.vetmic.2025.110730_bib5","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1038\/s41467-020-18233-x","article-title":"Both boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease","volume":"11","author":"Fu","year":"2020","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.vetmic.2025.110730_bib6","article-title":"Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke","volume":"5","author":"Guan","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"9","key":"10.1016\/j.vetmic.2025.110730_bib7","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.3390\/ijms23095268","article-title":"Dimerization tendency of 3CLpros of human coronaviruses based on the X-ray crystal structure of the catalytic domain of SARS-CoV-2 3CLpro","volume":"23","author":"Jo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.vetmic.2025.110730_bib8","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0041-0101(02)00203-9","article-title":"Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse","volume":"40","author":"Lambert","year":"2002","journal-title":"Toxicon Off. J. Int. Soc. Toxinol."},{"issue":"12","key":"10.1016\/j.vetmic.2025.110730_bib9","article-title":"Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.vetmic.2025.110730_bib10","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.apsb.2021.10.026","article-title":"Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays","volume":"12","author":"Ma","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"3\u20134","key":"10.1016\/j.vetmic.2025.110730_bib11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.vetmic.2014.10.030","article-title":"Identification and characterisation of small molecule inhibitors of feline coronavirus replication","volume":"174","author":"McDonagh","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110730_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2020.107376","article-title":"Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease","volume":"89","author":"Mirza","year":"2020","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.vetmic.2025.110730_bib13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.vetmic.2018.04.026","article-title":"The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies","volume":"219","author":"Murphy","year":"2018","journal-title":"Vet. Microbiol."},{"issue":"4","key":"10.1016\/j.vetmic.2025.110730_bib14","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1111\/tbed.13856","article-title":"Feline infectious peritonitis (FIP) and coronavirus disease 19 (COVID-19): are they similar?","volume":"68","author":"Paltrinieri","year":"2021","journal-title":"Transbound. Emerg. Dis."},{"issue":"2","key":"10.1016\/j.vetmic.2025.110730_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tvjl.2014.04.016","article-title":"An update on feline infectious peritonitis: diagnostics and therapeutics","volume":"201","author":"Pedersen","year":"2014","journal-title":"Vet. J."},{"issue":"4","key":"10.1016\/j.vetmic.2025.110730_bib16","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1177\/1098612X17729626","article-title":"Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis","volume":"20","author":"Pedersen","year":"2018","journal-title":"J. Feline Med. Surg."},{"issue":"4","key":"10.1016\/j.vetmic.2025.110730_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/1098612X19825701","article-title":"Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis","volume":"21","author":"Pedersen","year":"2019","journal-title":"J. Feline Med. Surg."},{"issue":"10","key":"10.1016\/j.vetmic.2025.110730_bib18","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.fct.2006.05.016","article-title":"Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures","volume":"44","author":"Sahu","year":"2006","journal-title":"Food Chemical Toxicology International Journal Published British Industrial Biological Research Association"},{"key":"10.1016\/j.vetmic.2025.110730_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1422408","article-title":"GS-441524 and molnupiravir are similarly effective for the treatment of cats with feline infectious peritonitis","volume":"11","author":"Sase","year":"2024","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.vetmic.2025.110730_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.antiviral.2017.07.022","article-title":"The cholesterol transport inhibitor U18666A inhibits type I feline coronavirus infection","volume":"145","author":"Takano","year":"2017","journal-title":"Antivir. Res."},{"issue":"1","key":"10.1016\/j.vetmic.2025.110730_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1297-9716-43-41","article-title":"Suppression of feline coronavirus replication in vitro by cyclosporin A","volume":"43","author":"Tanaka","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2025.110730_bib22","doi-asserted-by":"crossref","first-page":"618","DOI":"10.14202\/vetworld.2023.618-630","article-title":"First study on in vitro antiviral and virucidal effects of flavonoids against feline infectious peritonitis virus at the early stage of infection","author":"Triratapiban","year":"2023","journal-title":"Vet. World"},{"key":"10.1016\/j.vetmic.2025.110730_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.virusres.2015.05.018","article-title":"Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus","volume":"208","author":"Wu","year":"2015","journal-title":"Virus Res."},{"issue":"6489","key":"10.1016\/j.vetmic.2025.110730_bib24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","article-title":"Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved \u03b1-ketoamide inhibitors","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.vetmic.2025.110730_bib25","article-title":"Development of a yeast-based CRISPR genome editing system for feline coronavirus","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Microbiol."},{"issue":"Pt 3","key":"10.1016\/j.vetmic.2025.110730_bib26","article-title":"Nordihydroguaiaretic acid suppresses ferroptosis and mitigates intervertebral disc degeneration through the NRF2\/GPX4 axis","volume":"143","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"44","key":"10.1016\/j.vetmic.2025.110730_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202407766","article-title":"The S2 pocket governs the Genus-Specific substrate selectivity of coronavirus 3C-Like protease","volume":"11","author":"Zhou","year":"2024","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.vetmic.2025.110730_bib28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jhep.2025.01.008","article-title":"Hepatocellular CMPK2 promotes the development of metabolic dysfunction-associated steatohepatitis","volume":"83","author":"Zhu","year":"2025","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.vetmic.2025.110730_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237613","article-title":"Nordihydroguaiaretic acid reduces secondary organ injury in septic rats after cecal ligation and puncture","volume":"15","author":"Zubrow","year":"2020","journal-title":"PLOS ONE"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525003669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525003669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T01:11:36Z","timestamp":1772845896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113525003669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":29,"alternative-id":["S0378113525003669"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110730","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and evaluation of Nordihydroguaiaretic acid (NDGA) as an active traditional Chinese medicine compound inhibiting the 3C-like protease of feline infectious peritonitis virus","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110730","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110730"}}