{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:51:44Z","timestamp":1773215504404,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015286","name":"Hebei Provincial Key Research Projects","doi-asserted-by":"publisher","award":["22326615D"],"award-info":[{"award-number":["22326615D"]}],"id":[{"id":"10.13039\/501100015286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015335","name":"The Modern Agricultural Industry Technology System","doi-asserted-by":"publisher","award":["CARS-40-S03"],"award-info":[{"award-number":["CARS-40-S03"]}],"id":[{"id":"10.13039\/501100015335","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.vetmic.2025.110738","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:06:10Z","timestamp":1758827170000},"page":"110738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Probiotic characteristics and protective effects of chicken-derived Enterococcus faecium against infection with Avian Pathogenic Escherichia coli and Salmonella in laying hens"],"prefix":"10.1016","volume":"310","author":[{"given":"Yanan","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xutao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2025.110738_bib1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3390\/microorganisms11040953","article-title":"Antimicrobial drug resistance in poultry production: current status and innovative strategies for bacterial control","volume":"11","author":"Abreu","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.vetmic.2025.110738_bib2","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1128\/IAI.73.3.1836-1846.2005","article-title":"Role for flagella but not intimin in the persistent infection of the gastrointestinal tissues of specific-pathogen-free chicks by shiga toxin-negative Escherichia coli O157:H7","volume":"73","author":"Best","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.vetmic.2025.110738_bib3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41579-022-00833-7","article-title":"Microbiota-mediated colonization resistance: mechanisms and regulation","volume":"21","author":"Caballero-Flores","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110738_bib4","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.immuni.2008.05.001","article-title":"The biology of intestinal immunoglobulin A responses","volume":"28","author":"Cerutti","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.vetmic.2025.110738_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3168\/jds.S0022-0302(99)75204-5","article-title":"Isolation and characterization of acid- and bile-tolerant isolates from strains of lactobacillus acidophilus","volume":"82","author":"Chou","year":"1999","journal-title":"J. Dairy. Sci."},{"key":"10.1016\/j.vetmic.2025.110738_bib6","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1128\/IAI.01375-10","article-title":"Immune response of chicken gut to natural colonization by gut microflora and to salmonella enterica serovar enteritidis infection","volume":"79","author":"Crhanova","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetmic.2025.110738_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2672.1993.tb02794.x","article-title":"Phenotypic identification of the genus enterococcus and differentiation of phylogenetically distinct enterococcal species and species groups","volume":"75","author":"Devriese","year":"1993","journal-title":"J. Appl. Bacteriol."},{"key":"10.1016\/j.vetmic.2025.110738_bib8","first-page":"299","article-title":"Avian pathogenic Escherichia coli (APEC)","volume":"30","author":"Dho-Moulin","year":"1999","journal-title":"Vet Res"},{"key":"10.1016\/j.vetmic.2025.110738_bib9","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.jaci.2018.09.036","article-title":"Synergistic convergence of microbiota-specific systemic IgG and secretory IgA","volume":"143","author":"Fadlallah","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.vetmic.2025.110738_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijfoodmicro.2005.06.026","article-title":"The role and application of enterococci in food and health","volume":"106","author":"Foulqui\u00e9 Moreno","year":"2006","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.vetmic.2025.110738_bib11","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3390\/antibiotics11121703","article-title":"Effects of a specific pre- and probiotic combination and parent stock vaccination on performance and bacterial communities in broilers challenged with a Multidrug-Resistant escherichia coli","volume":"11","author":"Fuhrmann","year":"2022","journal-title":"Antibiotics-Basel"},{"key":"10.1016\/j.vetmic.2025.110738_bib12","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.3390\/nu15092211","article-title":"Short-chain fatty-acid-producing bacteria: key components of the human gut microbiota","volume":"15","author":"Fusco","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.vetmic.2025.110738_bib13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/03079457.2024.2359596","article-title":"Efficacy of bacillus subtilis probiotic in preventing necrotic enteritis in broilers: a systematic review and meta-analysis","volume":"53","author":"Ghimire","year":"2024","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2025.110738_bib14","article-title":"Homologous and heterologous re-challenge with salmonella typhi and salmonella paratyphi a in a randomised controlled human infection model","volume":"14","author":"Gibani","year":"2020","journal-title":"PLoS Negl. Trop. D."},{"key":"10.1016\/j.vetmic.2025.110738_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1574-6941.2002.tb00978.x","article-title":"Molecular analysis of bacterial populations in the ileum of broiler chickens and comparison with bacteria in the cecum","volume":"41","author":"Gong","year":"2002","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.vetmic.2025.110738_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-3-031-58572-2_8","article-title":"Probiotics in the treatment of inflammatory bowel diseases","volume":"1449","author":"Guandalini","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.vetmic.2025.110738_bib17","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41579-021-00569-w","article-title":"The microbiome-shaping roles of bacteriocins","volume":"19","author":"Heilbronner","year":"2021","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1016\/j.vetmic.2025.110738_bib18","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.vetmic.2025.110738_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrmicro818","article-title":"Pathogenic Escherichia coli","volume":"2","author":"Kaper","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.vetmic.2025.110738_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/pathogens10040467","article-title":"Avian pathogenic escherichia coli (APEC): an overview of virulence and pathogenesis factors, zoonotic potential, and control strategies","volume":"10","author":"Kathayat","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/j.vetmic.2025.110738_bib21","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3390\/pathogens13080702","article-title":"Interplay between bile acids and intestinal microbiota: regulatory mechanisms and therapeutic potential for infections","volume":"13","author":"Li","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.vetmic.2025.110738_bib22","article-title":"The effects of secretory IgA in the mucosal immune system","volume":"2020","author":"Li","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.vetmic.2025.110738_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0168-1605(02)00047-8","article-title":"Gastrointestinal transit survival of an Enterococcus faecium probiotic strain administered with or without vancomycin","volume":"77","author":"Lund","year":"2002","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.vetmic.2025.110738_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103752","article-title":"Are there consistent effects of gut microbiota composition on performance, productivity and condition in poultry?","volume":"103","author":"Markov\u00e1","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2025.110738_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103607","article-title":"Systematic review on microbiome-related nutritional interventions interfering with the colonization of foodborne pathogens in broiler gut to prevent contamination of poultry meat","volume":"103","author":"Mekonnen","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2025.110738_bib26","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1038\/s41598-020-60892-9","article-title":"Integrative analysis of gut microbiome and metabolites revealed novel mechanisms of intestinal Salmonella carriage in chicken","volume":"10","author":"Mon","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.vetmic.2025.110738_bib27","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fvets.2017.00126","article-title":"Antimicrobial resistance in bacterial poultry pathogens: a review","volume":"4","author":"Nhung","year":"2017","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.vetmic.2025.110738_bib28","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3390\/foods10071519","article-title":"Lactic acid bacteria diversity and characterization of probiotic candidates in fermented meats","volume":"10","author":"Parlindungan","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.vetmic.2025.110738_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109187","article-title":"Protective effects of gut microbiota and gut microbiota-derived acetate on chicken colibacillosis induced by avian pathogenic escherichia coli","volume":"261","author":"Peng","year":"2021","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.vetmic.2025.110738_bib30","doi-asserted-by":"crossref","first-page":"101615","DOI":"10.1016\/j.fbio.2022.101615","article-title":"Organic acids production from lactic acid bacteria: A preservation approach","volume":"46","author":"Punia Bangar","year":"2022","journal-title":"Food Bioscience"},{"key":"10.1016\/j.vetmic.2025.110738_bib31","unstructured":"Ramsey, M., A. Hartke, and M. Huycke. 2014. The Physiology and Metabolism of Enterococci in Enterococci: From Commensals to Leading Causes of Drug Resistant Infection. M. S. Gilmore, D. B. Clewell, Y. Ike, and N. Shankar eds. Massachusetts Eye and Ear Infirmary, Boston."},{"key":"10.1016\/j.vetmic.2025.110738_bib32","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.aninu.2024.01.004","article-title":"Diet xylo-oligosaccharide supplementation improves growth performance, immune function, and intestinal health of broilers","volume":"17","author":"Rao","year":"2024","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.vetmic.2025.110738_bib33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3382\/ps\/pey416","article-title":"Possibilities of early life programming in broiler chickens via intestinal microbiota modulation","volume":"98","author":"Rubio","year":"2019","journal-title":"Poult Sci"},{"key":"10.1016\/j.vetmic.2025.110738_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2023.102367","article-title":"Bacterial acid stress response: from cellular changes to antibiotic tolerance and phenotypic heterogeneity","volume":"75","author":"Schumacher","year":"2023","journal-title":"Curr. Opin. Microbiol"},{"key":"10.1016\/j.vetmic.2025.110738_bib35","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.3390\/microorganisms11112814","article-title":"Salmonella infection in poultry: a review on the pathogen and control strategies","volume":"11","author":"Shaji","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.vetmic.2025.110738_bib36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s40104-022-00765-5","article-title":"Pretreatment with probiotics enterococcus faecium NCIMB 11181 attenuated salmonella Typhimurium-induced gut injury through modulating intestinal microbiome and immune responses with barrier function in broiler chickens","volume":"13","author":"Shao","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.vetmic.2025.110738_bib37","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1111\/j.1365-2672.2008.03935.x","article-title":"Isolation and characterization of bacteriocin-producing bacteria from the gastrointestinal tract of broiler chickens for probiotic use","volume":"105","author":"Shin","year":"2008","journal-title":"J. Appl. Microbiol"},{"key":"10.1016\/j.vetmic.2025.110738_bib38","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1111\/jam.15504","article-title":"Balancing reactive oxygen species generation by rebooting gut microbiota","volume":"132","author":"Singh","year":"2022","journal-title":"J. Appl. Microbiol"},{"key":"10.1016\/j.vetmic.2025.110738_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-1605(96)01233-0","article-title":"Lactic acid bacteria of foods and their current taxonomy","volume":"36","author":"Stiles","year":"1997","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.vetmic.2025.110738_bib40","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s13104-024-06958-7","article-title":"Role of migratory birds as a risk factor for the transmission of multidrug resistant salmonella enterica and escherichia coli to broiler poultry farms and its surrounding environment","volume":"17","author":"Tawakol","year":"2024","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.vetmic.2025.110738_bib41","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/jsfa.12946","article-title":"Software-based screening for efficient sgRNAs in lactococcus lactis","volume":"104","author":"Wang","year":"2024","journal-title":"J. Sci. Food Agric."},{"issue":"12","key":"10.1016\/j.vetmic.2025.110738_bib42","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.3390\/microorganisms10122515","article-title":"Probiotic Properties of Chicken-Derived Highly Adherent Lactic Acid Bacteria and Inhibition of Enteropathogenic Bacteria in Caco-2 Cells","volume":"10","author":"Wang","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.vetmic.2025.110738_bib43","doi-asserted-by":"crossref","first-page":"994","DOI":"10.3390\/microorganisms12050994","article-title":"Assessment of the safety and probiotic properties of enterococcus faecium B13 isolated from fermented chili","volume":"12","author":"Xiao","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.vetmic.2025.110738_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.104385","article-title":"Oral supplementation with lactic acid bacteria improve the intestinal epithelial barrier and gut microbiota of broiler chicks to alleviate salmonella enteritidis infection","volume":"103","author":"Yang","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2025.110738_bib45","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1186\/s12864-019-5975-8","article-title":"Comparative genomic analysis revealed great plasticity and environmental adaptation of the genomes of enterococcus faecium","volume":"20","author":"Zhong","year":"2019","journal-title":"BMC Genom."},{"key":"10.1016\/j.vetmic.2025.110738_bib46","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1038\/s41467-022-31171-0","article-title":"Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2025.110738_bib47","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s10529-023-03398-4","article-title":"Construction of a food-grade gene editing system based on CRISPR-Cas9 and its application in lactococcus lactis NZ9000","volume":"45","author":"Zhou","year":"2023","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.vetmic.2025.110738_bib48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s40168-022-01319-7","article-title":"Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure","volume":"10","author":"Zou","year":"2022","journal-title":"Microbiome"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525003748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525003748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:00:55Z","timestamp":1773136855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113525003748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":48,"alternative-id":["S0378113525003748"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110738","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probiotic characteristics and protective effects of chicken-derived Enterococcus faecium against infection with Avian Pathogenic Escherichia coli and Salmonella in laying hens","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110738"}}