{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:31:22Z","timestamp":1778866282061,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202769"],"award-info":[{"award-number":["32202769"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["D18007"],"award-info":[{"award-number":["D18007"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012431","name":"Jiangsu Provincial Agricultural Science and Technology Independent Innovation Fund","doi-asserted-by":"publisher","award":["CX(22)2047"],"award-info":[{"award-number":["CX(22)2047"]}],"id":[{"id":"10.13039\/501100012431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1801000"],"award-info":[{"award-number":["2022YFD1801000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220578"],"award-info":[{"award-number":["BK20220578"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.vetmic.2025.110772","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T22:19:59Z","timestamp":1760998799000},"page":"110772","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A novel recombinant serotype 4 fowl adenovirus efficiently protects both serotype 4 and 11 fowl adenovirus"],"prefix":"10.1016","volume":"311","author":[{"given":"Shi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuofan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2025.110772_bib1","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001721","article-title":"ICTV virus taxonomy profile: adenoviridae 2022","volume":"103","author":"Benk\u0151","year":"2022","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2025.110772_bib2","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/j.vaccine.2022.01.060","article-title":"Vaccination with a fowl adenovirus chimeric fiber protein (crecFib-4\/11) simultaneously protects chickens against hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH)","volume":"40","author":"De Luca","year":"2022","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110772_bib3","article-title":"An efficient double-fluorescence approach for generating fiber-2-edited recombinant serotype 4 fowl adenovirus expressing foreign gene","volume":"14","author":"Guo","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110772_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.919100","article-title":"Probiotics surface-delivering Fiber2 protein of fowl adenovirus 4 stimulate protective immunity against hepatitis-hydropericardium syndrome in chickens","volume":"13","author":"Jia","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2025.110772_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2019.108427","article-title":"Characterization of fowl adenovirus serotype 4 circulating in chickens in China","volume":"238","author":"Jiang","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110772_bib6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3390\/v14020376","article-title":"A novel recombinant FAdV-4 virus with fiber of FAdV-8b provides efficient protection against both FAdV-4 and FAdV-8b","volume":"14","author":"Lu","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110772_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/tbed.13730","article-title":"Emerging of a novel natural recombinant fowl adenovirus in China","volume":"68","author":"Lv","year":"2021","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2025.110772_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2022.105277","article-title":"Epidemiological survey of avian adenovirus in China from 2015 to 2021 and the genetic variability of highly pathogenic Fadv-4 isolates","volume":"101","author":"Niu","year":"2022","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.vetmic.2025.110772_bib9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1080\/22221751.2020.1736954","article-title":"Identification of chicken CAR homology as a cellular receptor for the emerging highly pathogenic fowl adenovirus 4 via unique binding mechanism","volume":"9","author":"Pan","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.vetmic.2025.110772_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2024.103642","article-title":"Genomic characterization and pathogenicity of a novel fowl adenovirus serotype 11 isolated from chickens with inclusion body hepatitis in China","volume":"103","author":"Qiao","year":"2024","journal-title":"Poult. Sci."},{"key":"10.1016\/j.vetmic.2025.110772_bib11","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.vaccine.2013.12.056","article-title":"Recombinant FAdV-4 fiber-2 protein protects chickens against hepatitis-hydropericardium syndrome (HHS)","volume":"32","author":"Schachner","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110772_bib12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/03079457.2019.1566595","article-title":"A novel monoclonal antibodies-based sandwich ELISA for detection of serotype 4 fowl adenovirus","volume":"48","author":"Shao","year":"2019","journal-title":"Avian Pathol."},{"key":"10.1016\/j.vetmic.2025.110772_bib13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.5455\/OVJ.2021.v11.i4.6","article-title":"A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - a review","volume":"11","author":"Sohaimi","year":"2021","journal-title":"Open Vet. J."},{"key":"10.1016\/j.vetmic.2025.110772_bib14","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1128\/JCM.01567-08","article-title":"Classification of fowl adenovirus serotypes by use of high-resolution melting-curve analysis of the hexon gene region","volume":"47","author":"Steer","year":"2009","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110772_bib15","doi-asserted-by":"crossref","first-page":"e00954","DOI":"10.1128\/JVI.00954-20","article-title":"Fiber-1, not Fiber-2, directly mediates the infection of the pathogenic serotype 4 fowl adenovirus via its shaft and knob domains","volume":"94","author":"Wang","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110772_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13567-021-00907-z","article-title":"A novel fiber-2-edited live attenuated vaccine candidate against the highly pathogenic serotype 4 fowl adenovirus","volume":"52","author":"Xie","year":"2021","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2025.110772_bib17","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/21505594.2021.1888458","article-title":"Domain in Fiber-2 interacted with KPNA3\/4 significantly affects the replication and pathogenicity of the highly pathogenic FAdV-4","volume":"12","author":"Xie","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/j.vetmic.2025.110772_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/jgm.3368","article-title":"Fiber modifications enable fowl adenovirus 4 vectors to transduce human cells","volume":"23","author":"Zhang","year":"2021","journal-title":"J. Gene Med."},{"key":"10.1016\/j.vetmic.2025.110772_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109285","article-title":"An inactivated vaccine based on artificial non-pathogenic fowl adenovirus 4 protects chickens against hepatitis-hydropericardium syndrome","volume":"264","author":"Zhang","year":"2022","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110772_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198652","article-title":"Immunity analysis against fowl adenovirus serotype 4 (FAdV-4) based on Fiber-2 trimer protein with the different virulence","volume":"308","author":"Zhao","year":"2022","journal-title":"Virus Res."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525004080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525004080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:22:34Z","timestamp":1773822154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113525004080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":20,"alternative-id":["S0378113525004080"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110772","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel recombinant serotype 4 fowl adenovirus efficiently protects both serotype 4 and 11 fowl adenovirus","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110772","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110772"}}