{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T14:56:22Z","timestamp":1794322582052,"version":"4.9.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018532","name":"Major Scientific and Technological Innovation Project of Shandong Province","doi-asserted-by":"publisher","award":["2022CXGC020711\\u20132"],"award-info":[{"award-number":["2022CXGC020711\\u20132"]}],"id":[{"id":"10.13039\/501100018532","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018532","name":"Major Scientific and Technological Innovation Project of Shandong Province","doi-asserted-by":"publisher","award":["202228060"],"award-info":[{"award-number":["202228060"]}],"id":[{"id":"10.13039\/501100018532","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.vetmic.2025.110776","type":"journal-article","created":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T22:20:08Z","timestamp":1760998808000},"page":"110776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Sanguinarine inhibits bovine parainfluenza virus type 3 replication through CD97 suppression"],"prefix":"10.1016","volume":"311","author":[{"given":"Huasong","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2025.110776_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109185","article-title":"Homologous recombination as a mechanism of genetic changes in bovine parainfluenza-3 virus[J]","volume":"261","author":"Alatorre-Garc\u00eda","year":"2021","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110776_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9040337","article-title":"The bacterial and viral agents of BRDC: immune evasion and vaccine Developments[J]","volume":"9","author":"Bell","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.vetmic.2025.110776_bib3","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41423-023-01103-z","article-title":"CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation","volume":"20","author":"Chang","year":"2023","journal-title":"J. ]. Cell. Mol. Immunol."},{"key":"10.1016\/j.vetmic.2025.110776_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17030323","article-title":"Sanguinarine-Chelerythrine from coptis chinensis offers analgesic and Anti-Inflammatory effects without Gastrotoxicity[J]","volume":"17","author":"Danielewski","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.vetmic.2025.110776_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12917-020-02291-w","article-title":"Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway[J]","volume":"16","author":"Du","year":"2020","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetmic.2025.110776_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25158375","article-title":"Natural alkaloids in cancer therapy: berberine, sanguinarine and chelerythrine against colorectal and gastric Cancer[J]","volume":"25","author":"Duda-Madej","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.vetmic.2025.110776_bib7","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1128\/JVI.02502-15","article-title":"Parainfluenza virus 3 blocks antiviral mediators downstream of the interferon lambda receptor by modulating Stat1 Phosphorylation[J]","volume":"90","author":"Eberle","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110776_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4251\/wjgo.v8.i1.30","article-title":"Antitumor effects of the benzophenanthridine alkaloid sanguinarine: evidence and perspectives[J]","volume":"8","author":"Gaziano","year":"2016","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.vetmic.2025.110776_bib9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41467-024-54882-y","article-title":"Phenazine biosynthesis-like domain-containing protein (PBLD) and cedrelone promote antiviral immune response by activating NF-\u0138B[J]","volume":"16","author":"Hou","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2025.110776_bib10","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2305420120","article-title":"Targeting STING oligomerization with small-molecule inhibitors[J]","volume":"120","author":"Humphries","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vetmic.2025.110776_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.778479","article-title":"Inhibition of PI3K\/AKT\/mTOR signalling pathway activates autophagy and suppresses peritoneal fibrosis in the process of peritoneal Dialysis[J]","volume":"13","author":"Jia","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.vetmic.2025.110776_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/v15030688","article-title":"Sanguinarine exhibits antiviral activity against porcine reproductive and respiratory syndrome virus via multisite inhibition Mechanisms[J]","volume":"15","author":"Ke","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110776_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103254","article-title":"Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)\/PPAR\u03b4 agonists as potential anti-diabetic agents[J]","volume":"92","author":"Li","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.vetmic.2025.110776_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2019.108456","article-title":"Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways[J]","volume":"239","author":"Lv","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110776_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.141768","article-title":"Sanguinarine induces the unfolding of staphylococcus aureus-derived FtsZ and reduces the conformational flexibility necessary for assembly[J]","volume":"306","author":"Ma","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.vetmic.2025.110776_bib16","first-page":"75","article-title":"Sanguinarine[J]","volume":"26","author":"Mackraj","year":"2008","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.vetmic.2025.110776_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11686-024-00977-x","article-title":"The potential role of sanguinarine as an inhibitor of leishmania PP2C in the induction of Apoptosis[J]","volume":"70","author":"Ornelas-Cruces","year":"2025","journal-title":"Acta Parasitol."},{"key":"10.1016\/j.vetmic.2025.110776_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/v13061035","article-title":"Bovine parainfluenza virus type 3 (BPIV3) enters HeLa cells via Clathrin-Mediated endocytosis in a Cholesterol- and Dynamin-Dependent Manner[J]","volume":"13","author":"Pan","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110776_bib19","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/s41598-018-38045-w","article-title":"The RGD motif is involved in CD97\/ADGRE5-promoted cell adhesion and viability of HT1080 cells[J]","volume":"9","author":"Tjong","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2025.110776_bib20","first-page":"6574","article-title":"Analysis of CD97 expression and manipulation: antibody treatment but not gene targeting curtails granulocyte migration[J]","volume":"181","author":"Veninga","year":"2008","journal-title":"Journal Immunology (Baltimore Md. 1950"},{"key":"10.1016\/j.vetmic.2025.110776_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105721","article-title":"Brivanib alaninate inhibited dengue virus proliferation through VEGFR2\/AMPK pathway[J]","volume":"170","author":"Wan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.vetmic.2025.110776_bib22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3892\/etm.2016.3947","article-title":"Anti-inflammatory and neuroprotective effects of sanguinarine following cerebral ischemia in rats[J]","volume":"13","author":"Wang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.vetmic.2025.110776_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1605948","article-title":"CD97\/ADGRE5 inhibits LPS induced NF-\u03baB activation through PPAR-\u03b3 upregulation in Macrophages[J]","volume":"2016","author":"Wang","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.vetmic.2025.110776_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/v14102221","article-title":"Isolation, identification, and genetic phylogenetic analysis of two different genotypes of bovine parainfluenza 3 virus in China[J]","volume":"14","author":"Wang","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2025.110776_bib25","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1002\/hep.30068","article-title":"CD97 promotes tumor aggressiveness through the traditional g Protein-Coupled Receptor-Mediated signaling in hepatocellular carcinoma","volume":"68","author":"Yin","year":"2018","journal-title":"J. ]. Hepatol. (Baltim. Md. )"},{"key":"10.1016\/j.vetmic.2025.110776_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139767","article-title":"The effect and mechanism of sanguinarine against PCV2 based on the analysis of network pharmacology and TMT quantitative proteomics[J]","volume":"296","author":"Zhang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.vetmic.2025.110776_bib27","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/22221751.2020.1738278","article-title":"MERTK is a host factor that promotes classical swine fever virus entry and antagonizes innate immune response in PK-15 cells[J]","volume":"9","author":"Zheng","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.vetmic.2025.110776_bib28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.chom.2008.10.004","article-title":"Genome-scale RNAi screen for host factors required for HIV replication[J]","volume":"4","author":"Zhou","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.vetmic.2025.110776_bib29","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41419-024-07083-w","article-title":"PBLD promotes IRF3 mediated the type I interferon (IFN-I) response and apoptosis to inhibit viral replication","volume":"15","author":"Zhu","year":"2024","journal-title":"J. ]. Cell Death Dis."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525004122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525004122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:54:00Z","timestamp":1773802440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113525004122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":29,"alternative-id":["S0378113525004122"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110776","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sanguinarine inhibits bovine parainfluenza virus type 3 replication through CD97 suppression","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110776","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110776"}}