{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:07:08Z","timestamp":1791230828060,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1801000"],"award-info":[{"award-number":["2022YFD1801000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012431","name":"Jiangsu Provincial Agricultural Science and Technology Independent Innovation Fund","doi-asserted-by":"publisher","award":["CX(22)2047"],"award-info":[{"award-number":["CX(22)2047"]}],"id":[{"id":"10.13039\/501100012431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220579"],"award-info":[{"award-number":["BK20220579"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX25-4073"],"award-info":[{"award-number":["KYCX25-4073"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302839"],"award-info":[{"award-number":["32302839"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["D18007"],"award-info":[{"award-number":["D18007"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.vetmic.2025.110847","type":"journal-article","created":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T06:50:24Z","timestamp":1766299824000},"page":"110847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Hemagglutinin-encoded mRNA vaccine confers efficient protection against H3N8 avian influenza virus in mice"],"prefix":"10.1016","volume":"313","author":[{"given":"Jiayan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuofan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2025.110847_bib1","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00166-12","article-title":"Emergence of fatal avian influenza in New England harbor seals","volume":"3","author":"Anthony","year":"2012","journal-title":"mBio"},{"key":"10.1016\/j.vetmic.2025.110847_bib2","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-021-00283-5","article-title":"mRNA vaccines for infectious diseases: principles, delivery and clinical translation","volume":"20","author":"Chaudhary","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.vetmic.2025.110847_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00434-23","article-title":"Characterization of an emergent chicken H3N8 influenza virus in Southern China: a potential threat to public health","volume":"97","author":"Chen","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110847_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jinf.2022.05.007","article-title":"A child with acute respiratory distress syndrome caused by avian influenza H3N8 virus","volume":"85","author":"Cheng","year":"2022","journal-title":"J. Infect."},{"key":"10.1016\/j.vetmic.2025.110847_bib5","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2023.28.41.2200871","article-title":"Analysis of avian influenza A (H3N8) viruses in poultry and their zoonotic potential, China, September 2021 to May 2022","volume":"28","author":"Cui","year":"2023","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.vetmic.2025.110847_bib6","article-title":"Advances in COVID-19 mRNA vaccine development","volume":"7","author":"Fang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.vetmic.2025.110847_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01065-24","article-title":"Structural basis of receptor-binding adaptation of human-infecting H3N8 influenza A virus","volume":"99","author":"Hao","year":"2025","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110847_bib8","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1016\/j.jinf.2022.08.033","article-title":"Human infection with H3N8 avian influenza virus: a novel H9N2-original reassortment virus","volume":"85","author":"Li","year":"2022","journal-title":"J. Infect."},{"key":"10.1016\/j.vetmic.2025.110847_bib9","article-title":"A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus","volume":"16","author":"Lin","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2025.110847_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12275-6","article-title":"Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells","volume":"10","author":"Maugeri","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2025.110847_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00116-19","article-title":"Equine influenza virus in Asia: phylogeographic pattern and molecular features reveal circulation of an autochthonous lineage","volume":"93","author":"Mino","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110847_bib12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines - a new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.vetmic.2025.110847_bib13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jconrel.2015.08.007","article-title":"Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes","volume":"217","author":"Pardi","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.vetmic.2025.110847_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ady6831","article-title":"Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial","volume":"17","author":"Parks","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.vetmic.2025.110847_bib15","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3201\/eid1406.071270","article-title":"Influenza a virus (H3N8) in dogs with respiratory disease, Florida","volume":"14","author":"Payungporn","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2025.110847_bib16","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/nbt.2436","article-title":"Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection","volume":"30","author":"Petsch","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.vetmic.2025.110847_bib17","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41591-025-03591-0","article-title":"mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine in healthy adults: a phase 1\/2 trial","volume":"31","author":"Rudman Spergel","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.vetmic.2025.110847_bib18","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.3201\/eid2810.221067","article-title":"Novel Zoonotic Avian Influenza A(H3N8) Virus in Chicken, Hong Kong, China","volume":"28","author":"Sit","year":"2022","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2025.110847_bib19","first-page":"50","article-title":"A phase 3 randomized safety and immunogenicity trial of mRNA-1010 seasonal influenza vaccine in adults","author":"Soens","year":"2025","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2025.110847_bib20","doi-asserted-by":"crossref","DOI":"10.3201\/eid2012.140867","article-title":"Equine Influenza A(H3N8) Virus Infection in Cats","volume":"20","author":"Su","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2025.110847_bib21","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1016\/j.cell.2023.08.011","article-title":"Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets","volume":"186","author":"Sun","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.vetmic.2025.110847_bib22","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1080\/22221751.2022.2117097","article-title":"A case of human infection by H3N8 influenza virus","volume":"11","author":"Tan","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.vetmic.2025.110847_bib23","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/08971900211009650","article-title":"Review of COVID-19 mRNA Vaccines: BNT162b2 and mRNA-1273","volume":"35","author":"Teo","year":"2021","journal-title":"J. Pharm. Pr."},{"key":"10.1016\/j.vetmic.2025.110847_bib24","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00705-009-0381-1","article-title":"Isolation and molecular characterization of equine H3N8 influenza viruses from pigs in China","volume":"154","author":"Tu","year":"2009","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2025.110847_bib25","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1080\/22221751.2022.2128437","article-title":"Emergence of chicken infection with novel reassortant H3N8 avian influenza viruses genetically close to human H3N8 isolate, China","volume":"11","author":"Wan","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.vetmic.2025.110847_bib26","article-title":"Avian influenza mRNA vaccine encoding hemagglutinin provides complete protection against divergent H5N1 viruses in specific-pathogen-free chickens","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.vetmic.2025.110847_bib27","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ymthe.2024.12.041","article-title":"A nucleoside-modified rabies mRNA vaccine induces long-lasting and comprehensive immune responses in mice and non-human primates","volume":"33","author":"Wang","year":"2025","journal-title":"Mol. Ther."},{"key":"10.1016\/j.vetmic.2025.110847_bib28","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2256422","article-title":"An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses","volume":"12","author":"Xiong","year":"2023","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.vetmic.2025.110847_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2025.106542","article-title":"Global spread of H3 subtype avian influenza viruses with an accelerated evolution after interspecies transmission","volume":"91","author":"Yang","year":"2025","journal-title":"J. Infect."},{"key":"10.1016\/j.vetmic.2025.110847_bib30","doi-asserted-by":"crossref","first-page":"e824","DOI":"10.1016\/S2666-5247(22)00192-6","article-title":"Human infection of avian influenza A H3N8 virus and the viral origins: a descriptive study","volume":"3","author":"Yang","year":"2022","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.vetmic.2025.110847_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines8010123","article-title":"mRNA Vaccines encoding the HA protein of influenza A H1N1 virus delivered by cationic lipid nanoparticles induce protective immune responses in mice","volume":"8","author":"Zhuang","year":"2020","journal-title":"Vaccines"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525004833?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113525004833?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:00:58Z","timestamp":1773932458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113525004833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":31,"alternative-id":["S0378113525004833"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110847","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemagglutinin-encoded mRNA vaccine confers efficient protection against H3N8 avian influenza virus in mice","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110847","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110847"}}