{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:25:19Z","timestamp":1773962719991,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402858"],"award-info":[{"award-number":["32402858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["2025R412A003"],"award-info":[{"award-number":["2025R412A003"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008827","name":"Zhejiang A and F University","doi-asserted-by":"publisher","award":["203402009002"],"award-info":[{"award-number":["203402009002"]}],"id":[{"id":"10.13039\/501100008827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQN25C180003"],"award-info":[{"award-number":["LQN25C180003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.vetmic.2025.110869","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:13:13Z","timestamp":1767139993000},"page":"110869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["SERPINB1 promotes porcine deltacoronavirus replication by targeting the viral accessory protein NS7a"],"prefix":"10.1016","volume":"313","author":[{"given":"Junfang","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongye","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjie","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiutian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houhui","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7667-869X","authenticated-orcid":false,"given":"Mingjun","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2025.110869_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243270","article-title":"The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1","volume":"15","author":"Alsamman","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2025.110869_bib2","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.cmet.2023.05.007","article-title":"Excess pancreatic elastase alters acinar-\u03b2 cell communication by impairing the mechano-signaling and the PAR2 pathways","volume":"35","author":"Basile","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.vetmic.2025.110869_bib3","first-page":"162","article-title":"SARS-CoV-2 variant biology: immune escape, transmission and fitness","volume":"21","author":"Carabelli","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110869_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41590-018-0303-z","article-title":"SERPINB1-mediated checkpoint of inflammatory caspase activation","volume":"20","author":"Choi","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.vetmic.2025.110869_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00712-18","article-title":"Porcine deltacoronavirus accessory protein NS6 antagonizes interferon beta production by interfering with the binding of RIG-I\/MDA5 to double-stranded RNA","volume":"92","author":"Fang","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110869_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fcimb.2020.00257","article-title":"Porcine deltacoronavirus accessory protein NS7a antagonizes IFN-\u03b2 production by competing with TRAF3 and IRF3 for binding to IKK\u03b5","volume":"10","author":"Fang","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.vetmic.2025.110869_bib7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/infdis\/jir352","article-title":"Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection","volume":"204","author":"Gong","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vetmic.2025.110869_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28919","article-title":"Potential cross-species transmission risks of emerging swine enteric coronavirus to human beings","volume":"95","author":"Guo","year":"2023","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.vetmic.2025.110869_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abi8823","article-title":"TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy","volume":"6","author":"Gupta","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.vetmic.2025.110869_bib10","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1158\/0008-5472.CAN-19-2961","article-title":"Proteomic Profiling of the ECM of xenograft breast cancer metastases in different organs reveals distinct metastatic niches","volume":"80","author":"Hebert","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.vetmic.2025.110869_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01682-23","article-title":"Porcine deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving IFIT3","volume":"98","author":"Huang","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110869_bib12","first-page":"77","article-title":"Proteomic profiling reveals engineered chitosan nanoparticles mediated cellular crosstalk and immunomodulation for therapeutic application in apical periodontitis","volume":"11","author":"Hussein","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.vetmic.2025.110869_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 entry into cells","volume":"23","author":"Jackson","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.vetmic.2025.110869_bib14","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1164\/rccm.202108-1901OC","article-title":"Increased SARS-CoV-2 infection, protease, and inflammatory responses in chronic obstructive pulmonary disease primary bronchial epithelial cells defined with single-cell RNA sequencing","volume":"206","author":"Johansen","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.vetmic.2025.110869_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41586-021-03237-4","article-title":"Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis","volume":"591","author":"Johnson","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2025.110869_bib16","article-title":"Cleavage of HDAC6 to dampen its antiviral activity by nsp5 is a common strategy of swine enteric coronaviruses","volume":"98","author":"Li","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110869_bib17","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/s41467-023-36522-z","article-title":"Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus","volume":"14","author":"Miao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2025.110869_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00892-22","article-title":"Serine Protease inhibitors restrict host susceptibility to SARS-CoV-2 infections","volume":"13","author":"Rosendal","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.vetmic.2025.110869_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41586-023-06761-7","article-title":"TMPRSS2 is a functional receptor for human coronavirus HKU1","volume":"624","author":"Saunders","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2025.110869_bib20","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1136\/jnnp-2023-331142","article-title":"Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer\u2019s disease","volume":"94","author":"Su","year":"2023","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.vetmic.2025.110869_bib21","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1038\/s41467-023-42527-5","article-title":"Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2025.110869_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011702","article-title":"Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3","volume":"19","author":"Wu","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetmic.2025.110869_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2207688","article-title":"Porcine deltacoronavirus resists antibody neutralization through cell-to-cell transmission","volume":"12","author":"Xia","year":"2023","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.vetmic.2025.110869_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01045-23","article-title":"SERPINB1 promotes Senecavirus A replication by degrading IKBKE and regulating the IFN pathway via autophagy","volume":"97","author":"Yan","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2025.110869_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41541-024-01007-7","article-title":"CRISPR\/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production","volume":"9","author":"Zhu","year":"2024","journal-title":"NPJ Vaccin."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811352500505X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037811352500505X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:31:55Z","timestamp":1773952315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037811352500505X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":25,"alternative-id":["S037811352500505X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110869","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SERPINB1 promotes porcine deltacoronavirus replication by targeting the viral accessory protein NS7a","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2025.110869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110869"}}