{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:38:54Z","timestamp":1790908734833,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800802"],"award-info":[{"award-number":["2022YFD1800802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012453","name":"China Agricultural Research System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011798","name":"Ministry of Agriculture and Rural Affairs of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.vetmic.2026.110996","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:03:18Z","timestamp":1774857798000},"page":"110996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Deletion of NS6 attenuates Porcine Deltacoronavirus pathogenicity without compromising immunogenicity"],"prefix":"10.1016","volume":"317","author":[{"given":"Yangyang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2026.110996_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2024.110303","article-title":"A new S1 subunit truncation vaccine induces effective protection against porcine deltacoronavirus in suckling piglets","volume":"299","author":"Chen","year":"2024","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.110996_bib2","doi-asserted-by":"crossref","unstructured":"Da, A., Qi, P., Yong-Hao, M., Wenguang, H., Yi, P., Shiyu, L., Yan, L., Jizong, L., Yanke, S., yulong, Y., Bin, L., Fei, L., 2025. Receptor affinity-selective differential dynamics of membrane fusion initiation govern deltacoronavirus cross-species transmission. https:\/\/doi.org\/10.1007\/s11427-025-2985-1.","DOI":"10.1007\/s11427-025-2985-1"},{"key":"10.1016\/j.vetmic.2026.110996_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00712-18","article-title":"Porcine deltacoronavirus accessory protein NS6 antagonizes interferon beta production by interfering with the binding of RIG-I\/MDA5 to double-stranded RNA","volume":"92","author":"Fang","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.110996_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fcimb.2020.00257","article-title":"Porcine deltacoronavirus accessory protein NS7a antagonizes IFN-\u03b2 production by competing with TRAF3 and IRF3 for binding to IKK\u03b5","volume":"10","author":"Fang","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.vetmic.2026.110996_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/v13061139","article-title":"Functions of coronavirus accessory proteins: overview of the state of the art","volume":"13","author":"Fang","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2026.110996_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00957-23","article-title":"Porcine deltacoronavirus accessory protein NS6 harnesses VPS35-mediated retrograde trafficking to facilitate efficient viral infection","volume":"97","author":"Fang","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.110996_bib7","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/tbed.12690","article-title":"Prevalence, complete genome sequencing and phylogenetic analysis of porcine deltacoronavirus in South Korea, 2014-2016","volume":"64","author":"Jang","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2026.110996_bib8","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/s41467-022-29062-5","article-title":"Structures of a deltacoronavirus spike protein bound to porcine and human receptors","volume":"13","author":"Ji","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2026.110996_bib9","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1007\/s00705-017-3351-z","article-title":"Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus","volume":"162","author":"Jung","year":"2017","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2026.110996_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00265-18","article-title":"Discovery and sequence analysis of four deltacoronaviruses from birds in the middle east reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission","volume":"92","author":"Lau","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.110996_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-021-04111-z","article-title":"Independent infections of porcine deltacoronavirus among Haitian children","volume":"600","author":"Lednicky","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2026.110996_bib12","article-title":"Genetic and evolutionary analysis of porcine deltacoronavirus in Guangxi Province, Southern China, from 2020 to 2023","volume":"12","author":"Li","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.vetmic.2026.110996_bib13","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190676","article-title":"Porcine deltacoronavirus causes diarrhea in various ages of field-infected pigs in China","volume":"39","author":"Li","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.vetmic.2026.110996_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00278-14","article-title":"Full-length genome sequence of porcine deltacoronavirus strain USA\/IA\/2014\/8734","volume":"2","author":"Li","year":"2014","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2026.110996_bib15","doi-asserted-by":"crossref","first-page":"e1670","DOI":"10.1111\/tbed.14503","article-title":"Phylogeography and evolutionary dynamics analysis of porcine delta-coronavirus with host expansion to humans","volume":"69","author":"Li","year":"2022","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2026.110996_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/v11060573","article-title":"Susceptibility of chickens to porcine deltacoronavirus infection","volume":"11","author":"Liang","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2026.110996_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11259-021-09808-0","article-title":"Porcine enteric coronaviruses: an updated overview of the pathogenesis, prevalence, and diagnosis","volume":"45","author":"Liu","year":"2021","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.vetmic.2026.110996_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00408-16","article-title":"Complete genome sequence of porcine deltacoronavirus isolated in Thailand in 2015","volume":"4","author":"Madapong","year":"2016","journal-title":"Genome Announc."},{"key":"10.1016\/j.vetmic.2026.110996_bib19","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1016\/j.vaccine.2023.09.053","article-title":"Adenovirus-vectored PDCoV vaccines induce potent humoral and cellular immune responses in mice","volume":"41","author":"Miao","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2026.110996_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2019.113772","article-title":"Rapid manipulation of the porcine epidemic diarrhea virus genome by CRISPR\/Cas9 technology","volume":"276","author":"Peng","year":"2020","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.vetmic.2026.110996_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10142-024-01346-7","article-title":"Epidemiology, pathogenesis, immune evasion mechanism and vaccine development of porcine Deltacoronavirus","volume":"24","author":"Shan","year":"2024","journal-title":"Funct. Integr. Genom."},{"key":"10.1016\/j.vetmic.2026.110996_bib22","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s12250-021-00364-0","article-title":"Porcine coronaviruses: overview of the state of the art","volume":"36","author":"Turlewicz-Podbielska","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.vetmic.2026.110996_bib23","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1177\/1040638716654200","article-title":"Experimental infection of conventional nursing pigs and their dams with Porcine deltacoronavirus","volume":"28","author":"Vitosh-Sillman","year":"2016","journal-title":"J. Vet. Diagn. Investig. Off. Publ. Am. Assoc. Vet. Lab. Diagn. Inc."},{"key":"10.1016\/j.vetmic.2026.110996_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02180-19","article-title":"Generation of DelNS1 influenza viruses: a strategy for optimizing live attenuated influenza vaccines","volume":"10","author":"Wang","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.vetmic.2026.110996_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coviro.2018.12.001","article-title":"Emerging and re-emerging coronaviruses in pigs","volume":"34","author":"Wang","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.vetmic.2026.110996_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106118","article-title":"Prevalence and potential risk factors of PDCoV in pigs based on publications during 2015-2021 in China: comprehensive literature review and meta-analysis","volume":"179","author":"Wang","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2026.110996_bib27","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/JVI.06540-11","volume":"86","author":"Woo","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.110996_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s43556-025-00266-7","article-title":"Development of viral infectious clones and their applications based on yeast and bacterial artificial chromosome platforms","volume":"6","author":"Wu","year":"2025","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.vetmic.2026.110996_bib29","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2024.2446742","article-title":"The highly pathogenic strain of porcine deltacoronavirus disrupts the intestinal barrier and causes diarrhea in newborn piglets","volume":"16","author":"Yao","year":"2025","journal-title":"Virulence"},{"key":"10.1016\/j.vetmic.2026.110996_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00849-25","article-title":"Single self-cleaving mRNA vaccine expressing multiple viral structural proteins elicits robust immune responses and protects nursing piglets against PDCoV infection","volume":"99","author":"Yu","year":"2025","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.110996_bib31","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1002\/jmv.28048","article-title":"Susceptibility to mice and potential evolutionary characteristics of porcine deltacoronavirus","volume":"94","author":"Zhang","year":"2022","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.vetmic.2026.110996_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/22221751.2019.1701391","article-title":"Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design","volume":"9","author":"Zhang","year":"2020","journal-title":"Emerg. Microbes Infect."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526001288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526001288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:23:54Z","timestamp":1778750634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113526001288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":32,"alternative-id":["S0378113526001288"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.110996","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletion of NS6 attenuates Porcine Deltacoronavirus pathogenicity without compromising immunogenicity","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.110996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110996"}}