{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:19:52Z","timestamp":1783059592131,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1801600"],"award-info":[{"award-number":["2023YFD1801600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Henan Province Natural Science Foundation","doi-asserted-by":"publisher","award":["252300423057"],"award-info":[{"award-number":["252300423057"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["2023YFD1801600"],"award-info":[{"award-number":["2023YFD1801600"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.vetmic.2026.111034","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:03:10Z","timestamp":1776668590000},"page":"111034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Narciclasine restricts pseudorabies virus replication in vitro and in vivo and has potential broad-spectrum antiviral activity"],"prefix":"10.1016","volume":"317","author":[{"given":"Jie-Yuan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Pei","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Miao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-Bei","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Qian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3068-883X","authenticated-orcid":false,"given":"Jia-Jia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.vetmic.2026.111034_bib1","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3201\/eid2406.171612","article-title":"Human endophthalmitis caused by pseudorabies virus infection, China, 2017","volume":"24","author":"Ai","year":"2018","journal-title":"Emerg. Infect. Dis."},{"issue":"5","key":"10.1016\/j.vetmic.2026.111034_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/v14051003","article-title":"A review of pseudorabies virus variants: genomics, vaccination, transmission, and zoonotic potential","volume":"14","author":"Bo","year":"2022","journal-title":"Viruses"},{"issue":"18","key":"10.1016\/j.vetmic.2026.111034_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28186567","article-title":"Emodin as an inhibitor of PRV infection in vitro and in vivo","volume":"28","author":"Cai","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.vetmic.2026.111034_bib4","article-title":"Resveratrol inhibits pseudorabies virus replication by targeting IE180 protein","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.vetmic.2026.111034_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12985-022-01751-z","article-title":"Searching for plant-derived antivirals against dengue virus and Zika virus","volume":"19","author":"De Castro Barbosa","year":"2022","journal-title":"Virol. J."},{"issue":"7","key":"10.1016\/j.vetmic.2026.111034_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02107-18","article-title":"Expression of the pseudorabies virus gB glycoprotein triggers NK cell cytotoxicity and increases binding of the activating NK cell receptor PILR\u03b2","volume":"93","author":"De Pelsmaeker","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.111034_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138303","article-title":"Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage","volume":"285","author":"Fan","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"16","key":"10.1016\/j.vetmic.2026.111034_bib8","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1055\/s-0042-115034","article-title":"Narciclasine - an amaryllidaceae alkaloid with potent antitumor and anti-inflammatory properties","volume":"82","author":"F\u00fcrst","year":"2016","journal-title":"Planta Med."},{"issue":"5","key":"10.1016\/j.vetmic.2026.111034_bib9","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/1040638715593599","article-title":"Outbreak of variant pseudorabies virus in Bartha-K61-vaccinated piglets in central Shandong Province, China","volume":"27","author":"Hu","year":"2015","journal-title":"J. Vet. Diagn. Investig."},{"issue":"5","key":"10.1016\/j.vetmic.2026.111034_bib10","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1002\/med.21664","article-title":"Medicinal chemistry strategies toward host targeting antiviral agents","volume":"40","author":"Ji","year":"2020","journal-title":"Med. Res. Rev."},{"issue":"7","key":"10.1016\/j.vetmic.2026.111034_bib11","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1158\/1535-7163.MCT-08-0932","article-title":"Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells","volume":"8","author":"Lefranc","year":"2009","journal-title":"Mol. Cancer Ther."},{"issue":"11","key":"10.1016\/j.vetmic.2026.111034_bib12","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.3390\/v7112913","article-title":"Antiviral activity of porcine interferon regulatory factor 1 against swine viruses in cell culture","volume":"7","author":"Li","year":"2015","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.vetmic.2026.111034_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12917-021-02953-3","article-title":"The antiviral activity of kaempferol against pseudorabies virus in mice","volume":"17","author":"Li","year":"2021","journal-title":"BMC Vet. Res."},{"issue":"1","key":"10.1016\/j.vetmic.2026.111034_bib14","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12985-023-02229-2","article-title":"RhoA suppresses pseudorabies virus replication in vitro","volume":"20","author":"Li","year":"2023","journal-title":"Virol. J."},{"issue":"1","key":"10.1016\/j.vetmic.2026.111034_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13567-024-01328-4","article-title":"Pseudorabies virus hijacks the Rab6 protein to promote viral assembly and egress","volume":"55","author":"Liang","year":"2024","journal-title":"Vet. Res."},{"issue":"11","key":"10.1016\/j.vetmic.2026.111034_bib16","doi-asserted-by":"crossref","first-page":"e3690","DOI":"10.1093\/cid\/ciaa987","article-title":"A novel human acute encephalitis caused by pseudorabies virus variant strain","volume":"73","author":"Liu","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.vetmic.2026.111034_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174669","article-title":"Narciclasine suppresses esophageal cancer cell proliferation and migration by inhibiting the FAK signaling pathway","volume":"921","author":"Qiu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vetmic.2026.111034_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115322","article-title":"Acyclovir resistance in herpes simplex viruses: prevalence and therapeutic alternatives","volume":"206","author":"Schalkwijk","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetmic.2026.111034_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114159","article-title":"Narciclasine suppresses oral cancer metastasis by modulating cathepsin B and extracellular signal-related kinase pathways","volume":"158","author":"Shieu","year":"2023","journal-title":"Biomed. Pharmacol."},{"issue":"2","key":"10.1016\/j.vetmic.2026.111034_bib20","doi-asserted-by":"crossref","DOI":"10.4142\/jvs.24243","article-title":"Molecular epidemiology and genetic characteristics of pseudorabies virus between 2021 and 2023 in Henan Province of China","volume":"26","author":"Sun","year":"2025","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.vetmic.2026.111034_bib21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.copbio.2020.10.004","article-title":"Virus-induced metabolic reprogramming and innate sensing hereof by the infected host","volume":"68","author":"Thyrsted","year":"2021","journal-title":"Curr. Opin. Biotechnol."},{"issue":"1","key":"10.1016\/j.vetmic.2026.111034_bib22","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41467-022-29250-3","article-title":"Structures of pseudorabies virus capsids","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.vetmic.2026.111034_bib23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bsheal.2024.11.002","article-title":"Narciclasine inhibits vaccinia virus infection by activating the RhoA signaling pathway","volume":"6","author":"Xu","year":"2024","journal-title":"Biosaf. Health"},{"issue":"3","key":"10.1016\/j.vetmic.2026.111034_bib24","doi-asserted-by":"crossref","first-page":"34122","DOI":"10.1063\/1.4756793","article-title":"A microfluidic platform for real-time and in situ monitoring of virus infection process","volume":"6","author":"Xu","year":"2012","journal-title":"Biomicrofluidics"},{"issue":"1","key":"10.1016\/j.vetmic.2026.111034_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/vms3.289","article-title":"The epidemiological investigation of co-infection of major respiratory bacteria with pseudorabies virus in intensive pig farms in China","volume":"7","author":"Yu","year":"2021","journal-title":"Vet. Med. Sci."},{"issue":"1","key":"10.1016\/j.vetmic.2026.111034_bib26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40360-021-00537-3","article-title":"Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt\/mTOR signaling pathway","volume":"22","author":"Yuan","year":"2021","journal-title":"BMC Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.vetmic.2026.111034_bib27","doi-asserted-by":"crossref","first-page":"8782","DOI":"10.1038\/s41598-017-09365-0","article-title":"Antiviral properties of resveratrol against pseudorabies virus are associated with the inhibition of I\u03baB kinase activation","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.vetmic.2026.111034_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/v10090457","article-title":"Antiviral effect of resveratrol in piglets infected with virulent pseudorabies virus","volume":"10","author":"Zhao","year":"2018","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.vetmic.2026.111034_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/v14050928","article-title":"A broad antiviral strategy: inhibitors of human DHODH pave the way for host-targeting antivirals against emerging and re-emerging viruses","volume":"14","author":"Zheng","year":"2022","journal-title":"Viruses"}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526001665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526001665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:31:39Z","timestamp":1783056699000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113526001665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":29,"alternative-id":["S0378113526001665"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.111034","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Narciclasine restricts pseudorabies virus replication in vitro and in vivo and has potential broad-spectrum antiviral activity","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.111034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111034"}}