{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:29:59Z","timestamp":1786490999762,"version":"build-2736575974"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172890"],"award-info":[{"award-number":["32172890"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472998"],"award-info":[{"award-number":["32472998"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013211","name":"Central Public-interest Scientific Institution Basal Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012428","name":"Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["1610302024009"],"award-info":[{"award-number":["1610302024009"]}],"id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["ZD2024C004"],"award-info":[{"award-number":["ZD2024C004"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.vetmic.2026.111117","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:04:52Z","timestamp":1781107492000},"page":"111117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Factors underlying early cross-protection elicited by a lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate"],"prefix":"10.1016","volume":"320","author":[{"given":"Chao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangjun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirun","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Dong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongqing","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Jun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 2","key":"10.1016\/j.vetmic.2026.111117_bib1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1099\/0022-1317-80-2-307","article-title":"North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions","volume":"80","author":"Allende","year":"1999","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2026.111117_bib2","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.3201\/eid1709.110411","article-title":"Highly pathogenic porcine reproductive and respiratory syndrome virus, Asia","volume":"17","author":"An","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.vetmic.2010.11.001","article-title":"Comparative genomic analysis of five pairs of virulent parental\/attenuated vaccine strains of PRRSV","volume":"149","author":"An","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib4","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1016\/j.vaccine.2016.09.048","article-title":"Commercial vaccines provide limited protection to NADC30-like PRRSV infection","volume":"34","author":"Bai","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2026.111117_bib5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40813-018-0112-7","article-title":"Immune response development after vaccination of 1-day-old naive pigs with a Porcine Reproductive and Respiratory Syndrome 1-based modified live virus vaccine","volume":"5","author":"Balasch","year":"2019","journal-title":"Porc. Health Manag."},{"key":"10.1016\/j.vetmic.2026.111117_bib6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/vim.1997.10.83","article-title":"Cell-mediated immunity to porcine reproductive and respiratory syndrome virus in swine","volume":"10","author":"Bautista","year":"1997","journal-title":"Viral Immunol."},{"key":"10.1016\/j.vetmic.2026.111117_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.meegid.2017.07.016","article-title":"A recombinant type 2 porcine reproductive and respiratory syndrome virus between NADC30-like and a MLV-like: Genetic characterization and pathogenicity for piglets","volume":"54","author":"Bian","year":"2017","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.vetmic.2026.111117_bib8","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001632","article-title":"ICTV Virus Taxonomy Profile: Arteriviridae 2021","volume":"102","author":"Brinton","year":"2021","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2026.111117_bib9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.virusres.2012.07.030","article-title":"Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains","volume":"169","author":"Brockmeier","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2026.111117_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-animal-022516-022818","article-title":"Antibody Repertoire Development in Swine","volume":"5","author":"Butler","year":"2017","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.vetmic.2026.111117_bib11","article-title":"Protection efficacy and the safety of the synergy between modified Bazhen powder and PRRSV modified-live virus vaccine against HP-PRRSV in piglets","volume":"11","author":"Chai","year":"2024","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.vetmic.2026.111117_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108805","article-title":"Efficacy of two porcine reproductive and respiratory syndrome (PRRS) modified-live virus (MLV) vaccines against heterologous NADC30-like PRRS virus challenge","volume":"248","author":"Chai","year":"2020","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib13","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1111\/tbed.12952","article-title":"Emergence of a novel highly pathogenic recombinant virus from three lineages of porcine reproductive and respiratory syndrome virus 2 in China 2017","volume":"65","author":"Chen","year":"2018","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13567-022-01082-5","article-title":"A porcine reproductive and respiratory syndrome virus (PRRSV)-specific IgM as a novel adjuvant for an inactivated PRRSV vaccine improves protection efficiency and enhances cell-mediated immunity against heterologous PRRSV challenge","volume":"53","author":"Chen","year":"2022","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2026.111117_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165450","article-title":"Recognition of Highly Diverse Type-1 and -2 Porcine Reproductive and Respiratory Syndrome Viruses (PRRSVs) by T-Lymphocytes Induced in Pigs after Experimental Infection with a Type-2 PRRSV Strain","volume":"11","author":"Chung","year":"2016","journal-title":"PLoS. One"},{"key":"10.1016\/j.vetmic.2026.111117_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/viro.1993.1129","article-title":"Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group","volume":"193","author":"Conzelmann","year":"1993","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2026.111117_bib17","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.vaccine.2016.12.040","article-title":"Cross reactivity of immune responses to porcine reproductive and respiratory syndrome virus infection","volume":"35","author":"Correas","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2026.111117_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/6206857","article-title":"Establishment of a Triplex qPCR Assay for Differentiating Highly Virulent Genotype I Recombinant Virus From Low-Virulence Genotype I and Genotype II African Swine Fever Viruses Circulating in China","volume":"2024","author":"Ding","year":"2024","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1743-422X-9-45","article-title":"Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions","volume":"9","author":"Dwivedi","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2026.111117_bib20","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.3201\/eid1411.071676","article-title":"Porcine respiratory and reproductive syndrome virus variants, Vietnam and China, 2007","volume":"14","author":"Feng","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.vetmic.2018.02.001","article-title":"A highly pathogenic porcine reproductive and respiratory syndrome virus type 1 (PRRSV-1) strongly modulates cellular innate and adaptive immune subsets upon experimental infection","volume":"216","author":"Ferrari","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.rvsc.2015.09.018","article-title":"Immunoregulatory signal FoxP3, cytokine gene expression and IFN-gamma cell responsiveness upon porcine reproductive and respiratory syndrome virus (PRRSV) natural infection","volume":"103","author":"Ferrarini","year":"2015","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2026.111117_bib23","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1128\/CVI.00415-13","article-title":"Assessment of the phenotype and functionality of porcine CD8 T cell responses following vaccination with live attenuated classical swine fever virus (CSFV) and virulent CSFV challenge","volume":"20","author":"Franzoni","year":"2013","journal-title":"Clin. Vaccin. Immunol."},{"key":"10.1016\/j.vetmic.2026.111117_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084246","article-title":"Proteome-wide screening reveals immunodominance in the CD8 T cell response against classical swine fever virus with antigen-specificity dependent on MHC class I haplotype expression","volume":"8","author":"Franzoni","year":"2013","journal-title":"PLoS. One"},{"key":"10.1016\/j.vetmic.2026.111117_bib25","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-animal-013120-044226","article-title":"Local and Systemic T Cell Immunity in Fighting Pig Viral and Bacterial Infections","volume":"10","author":"Gerner","year":"2022","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.vetmic.2026.111117_bib26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12985-017-0910-6","article-title":"The prevalent status and genetic diversity of porcine reproductive and respiratory syndrome virus in China: a molecular epidemiological perspective","volume":"15","author":"Guo","year":"2018","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2026.111117_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103657","article-title":"Prevalence and genetic characteristics of porcine reproductive and respiratory syndrome virus in central China during 2016-2017: NADC30-like PRRSVs are predominant","volume":"135","author":"Guo","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2026.111117_bib28","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1111\/tbed.13491","article-title":"Genetic characterization of a novel recombinant PRRSV2 from lineage 8, 1 and 3 in China with significant variation in replication efficiency and cytopathic effects","volume":"67","author":"Han","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib29","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1016\/j.apsb.2023.01.006","article-title":"Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies","volume":"13","author":"Hou","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.vetmic.2026.111117_bib30","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/tbed.12862","article-title":"A modified-live porcine reproductive and respiratory syndrome virus (PRRSV)-1 vaccine protects late-term pregnancy gilts against heterologous PRRSV-1 but not PRRSV-2 challenge","volume":"65","author":"Jeong","year":"2018","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib31","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.vetmic.2026.111117_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/v11090796","article-title":"The T-Cell Response to Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)","volume":"11","author":"Kick","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2026.111117_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.637613","article-title":"The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus","volume":"12","author":"Kick","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2026.111117_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines11030594","article-title":"Testable Candidate Immune Correlates of Protection for Porcine Reproductive and Respiratory Syndrome Virus Vaccination","volume":"11","author":"Kick","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.vetmic.2026.111117_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.vetmic.2011.12.012","article-title":"Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation","volume":"157","author":"Leng","year":"2012","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib36","article-title":"A lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate provides broad cross-protection against HP-like PRRSV in piglets","volume":"16","author":"Li","year":"2025","journal-title":"Virulence"},{"key":"10.1016\/j.vetmic.2026.111117_bib37","article-title":"Genetic evolution and alterations in pathogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus","volume":"16","author":"Li","year":"2025","journal-title":"Virulence"},{"key":"10.1016\/j.vetmic.2026.111117_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40813-024-00356-y","article-title":"Prevalence and genetic evolution of porcine reproductive and respiratory syndrome virus in commercial fattening pig farms in China","volume":"10","author":"Li","year":"2024","journal-title":"Porc. Health Manag."},{"key":"10.1016\/j.vetmic.2026.111117_bib39","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.virs.2023.08.010","article-title":"Genomic similarity and antibody-dependent enhancement of immune serum potentially affect the protective efficacy of commercial MLV vaccines against NADC30-like PRRSV","volume":"38","author":"Li","year":"2023","journal-title":"Virol. Sin."},{"key":"10.1016\/j.vetmic.2026.111117_bib40","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jcpa.2015.04.002","article-title":"Comparative Respiratory Pathogenicity and Dynamic Tissue Distribution of Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and its Attenuated Strain in Piglets","volume":"153","author":"Liu","year":"2015","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.vetmic.2026.111117_bib41","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetmic.2017.04.017","article-title":"Recombination in JXA1-R vaccine and NADC30-like strain of porcine reproductive and respiratory syndrome viruses","volume":"204","author":"Liu","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib42","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1111\/tbed.12617","article-title":"Emergence of a novel highly pathogenic porcine reproductive and respiratory syndrome virus in China","volume":"64","author":"Liu","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/CVI.00304-06","article-title":"Protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection through passive transfer of PRRSV-neutralizing antibodies is dose dependent","volume":"14","author":"Lopez","year":"2007","journal-title":"Clin. Vaccin. Immunol."},{"key":"10.1016\/j.vetmic.2026.111117_bib44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.vetimm.2004.09.005","article-title":"Role of neutralizing antibodies in PRRSV protective immunity","volume":"102","author":"Lopez","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2026.111117_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2015.07.003","article-title":"Innate and adaptive immunity against Porcine Reproductive and Respiratory Syndrome Virus","volume":"167","author":"Loving","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2026.111117_bib46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1017\/S1466252310000034","article-title":"The role of porcine reproductive and respiratory syndrome (PRRS) virus structural and non-structural proteins in virus pathogenesis","volume":"11","author":"Music","year":"2010","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.vetmic.2026.111117_bib47","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13567-020-00789-7","article-title":"Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus","volume":"51","author":"Nazki","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2026.111117_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/viro.2002.1612","article-title":"Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity","volume":"302","author":"Osorio","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2026.111117_bib49","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1128\/CVI.00417-10","article-title":"Induction of foot-and-mouth disease virus-specific cytotoxic T cell killing by vaccination","volume":"18","author":"Patch","year":"2011","journal-title":"Clin. Vaccin. Immunol."},{"key":"10.1016\/j.vetmic.2026.111117_bib50","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13567-016-0391-4","article-title":"Review on the transmission porcine reproductive and respiratory syndrome virus between pigs and farms and impact on vaccination","volume":"47","author":"Pileri","year":"2016","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2026.111117_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.977796","article-title":"Heterologous vaccine immunogenicity, efficacy, and immune correlates of protection of a modified-live virus porcine reproductive and respiratory syndrome virus vaccine","volume":"13","author":"Proctor","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib52","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1016\/j.vaccine.2015.06.092","article-title":"Live porcine reproductive and respiratory syndrome virus vaccines: Current status and future direction","volume":"33","author":"Renukaradhya","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vetmic.2026.111117_bib53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.virusres.2010.08.014","article-title":"Molecular epidemiology of PRRSV: a phylogenetic perspective","volume":"154","author":"Shi","year":"2010","journal-title":"Virus Res."},{"key":"10.1016\/j.vetmic.2026.111117_bib54","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.micpath.2018.08.048","article-title":"Genomic sequence and virulence of a novel NADC30-like porcine reproductive and respiratory syndrome virus isolate from the Hebei province of China","volume":"125","author":"Sui","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.vetmic.2026.111117_bib55","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.vetmic.2018.02.016","article-title":"Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus","volume":"216","author":"Sun","year":"2018","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib56","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1007\/s00705-016-2883-y","article-title":"Pathogenicity comparison between highly pathogenic and NADC30-like porcine reproductive and respiratory syndrome virus","volume":"161","author":"Sun","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2026.111117_bib57","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.vetmic.2009.03.003","article-title":"An attenuated live vaccine based on highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) protects piglets against HP-PRRS","volume":"138","author":"Tian","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib58","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.3201\/eid1309.070399","article-title":"Highly pathogenic porcine reproductive and respiratory syndrome, China","volume":"13","author":"Tong","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.vetimm.2011.05.004","article-title":"Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus","volume":"142","author":"Wang","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2026.111117_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dci.2016.04.019","article-title":"Immune responses to modified live virus vaccines developed from classical or highly pathogenic PRRSV following challenge with a highly pathogenic PRRSV strain","volume":"62","author":"Wang","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.vetmic.2026.111117_bib61","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/tbed.12852","article-title":"A natural recombinant PRRSV between HP-PRRSV JXA1-like and NADC30-like strains","volume":"65","author":"Wang","year":"2018","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.vetmic.2026.111117_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47239-9","article-title":"Efficacy of Type 2 PRRSV vaccine against challenge with the Chinese lineage 1 (NADC30-like) PRRSVs in pigs","volume":"9","author":"Wei","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.vetmic.2026.111117_bib63","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.apsb.2021.03.027","article-title":"Role of CD8(+) T lymphocyte cells: Interplay with stromal cells in tumor microenvironment","volume":"11","author":"Xie","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.vetmic.2026.111117_bib64","article-title":"Protective Efficacy of a Candidate Live-Attenuated Vaccine Derived from the SD-R Strain against NADC34-like Porcine Reproductive and Respiratory Syndrome Virus","volume":"11","author":"Xu","year":"2023","journal-title":"Vaccin.es"},{"key":"10.1016\/j.vetmic.2026.111117_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/v14081739","article-title":"Antibody-Dependent Enhancement: ''Evil'' Antibodies Favorable for Viral Infections","volume":"14","author":"Yang","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2026.111117_bib66","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02916-23","article-title":"Refining PRRSV-2 genetic classification based on global ORF5 sequences and investigation of their geographic distributions and temporal changes","volume":"11","author":"Yim-Im","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.vetmic.2026.111117_bib67","doi-asserted-by":"crossref","DOI":"10.1093\/procel\/pwaf026","article-title":"The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus","author":"Yu","year":"2025","journal-title":"Protein Cell."},{"key":"10.1016\/j.vetmic.2026.111117_bib68","article-title":"Recent Advances in Porcine Reproductive and Respiratory Syndrome Virus NADC30-Like Research in China: Molecular Characterization, Pathogenicity, and Control","volume":"12","author":"Yu","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib69","first-page":"296","article-title":"Efficacy of vaccination with the attenuated highly pathogenic PRRSV HuN4-F112 against NADC30-like PRRSV","volume":"43","author":"Zhang","year":"2021","journal-title":"Zhongguo Yufang Shouyi Xuebao \/ Chin. J. Prev. Vet. Med."},{"key":"10.1016\/j.vetmic.2026.111117_bib70","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00705-018-4080-7","article-title":"Characterization of newly emerged NADC30-like strains of porcine reproductive and respiratory syndrome virus in China","volume":"164","author":"Zhang","year":"2019","journal-title":"Arch. Virol."},{"key":"10.1016\/j.vetmic.2026.111117_bib71","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01984-23","article-title":"Protective efficacy of a candidate live attenuated vaccine derived from the SD-R strain of lineage 1 porcine reproductive and respiratory syndrome virus against a lethal challenge with HP-PRRSV HuN4 in piglets","volume":"11","author":"Zhang","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.vetmic.2026.111117_bib72","article-title":"Lineage 1 Porcine Reproductive and Respiratory Syndrome Virus Attenuated Live Vaccine Provides Broad Cross-Protection against Homologous and Heterologous NADC30-Like Virus Challenge in Piglets","volume":"10","author":"Zhang","year":"2022","journal-title":"Vaccin. (Basel)"},{"key":"10.1016\/j.vetmic.2026.111117_bib73","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2469636","article-title":"An attenuated African swine fever virus expressing the E2 glycoprotein of classical swine fever virus protects pigs against challenge of both viruses","volume":"14","author":"Zhang","year":"2025","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.vetmic.2026.111117_bib74","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54461-1","article-title":"Transcription regulation of African swine fever virus: dual role of M1249L","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.vetmic.2026.111117_bib75","doi-asserted-by":"crossref","first-page":"10712","DOI":"10.1128\/JVI.01446-15","article-title":"Importation and Recombination Are Responsible for the Latest Emergence of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus in China","volume":"89","author":"Zhao","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.111117_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2024.110252","article-title":"The evolution and diversity of porcine reproductive and respiratory syndrome virus in China","volume":"298","author":"Zhou","year":"2024","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib77","doi-asserted-by":"crossref","DOI":"10.3390\/v10100551","article-title":"Genetic Characterization and Pathogenicity of a Novel Recombined Porcine Reproductive and Respiratory Syndrome Virus 2 among Nadc30-Like, Jxa1-Like, and Mlv-Like Strains","volume":"10","author":"Zhou","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.vetmic.2026.111117_bib78","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.vetmic.2019.01.026","article-title":"Emergence of two novel recombinant porcine reproductive and respiratory syndrome viruses 2 (lineage 3) in Southwestern China","volume":"232","author":"Zhou","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib79","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.vetmic.2017.05.031","article-title":"Efficacy evaluation of three modified-live virus vaccines against a strain of porcine reproductive and respiratory syndrome virus NADC30-like","volume":"207","author":"Zhou","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111117_bib80","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1865-1682.2008.01020.x","article-title":"Highly virulent porcine reproductive and respiratory syndrome virus emerged in China","volume":"55","author":"Zhou","year":"2008","journal-title":"Transbound. Emerg. Dis."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526002543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526002543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:01:11Z","timestamp":1786489271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113526002543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":80,"alternative-id":["S0378113526002543"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.111117","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Factors underlying early cross-protection elicited by a lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.111117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111117"}}