{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:49:12Z","timestamp":1792068552948,"version":"4.4.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1800503"],"award-info":[{"award-number":["2023YFD1800503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.vetmic.2026.111172","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:22:44Z","timestamp":1786033364000},"page":"111172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development and protection evaluation of a nanoparticle vaccine against transferrin-binding protein TbpBY167A of Glaesserella parasuis"],"prefix":"10.1016","volume":"321","author":[{"given":"Lumen","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoge","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-6319","authenticated-orcid":false,"given":"Yufeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2026.111172_bib1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.addr.2012.09.039","article-title":"Fusion protein linkers: property, design and functionality","volume":"65","author":"Chen","year":"2013","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.vetmic.2026.111172_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13567-020-00822-9","article-title":"The Glaesserella parasuis phosphoglucomutase is partially required for lipooligosaccharide synthesis","volume":"51","author":"Feng","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2026.111172_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.rvsc.2023.02.003","article-title":"Phylogenetic study and comparison of different TbpB obtained from Glaesserella parasuis present in Spanish clinical isolates","volume":"157","author":"Fern\u00e1ndez","year":"2023","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetmic.2026.111172_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121673","article-title":"Dissecting antibodies with regards to linear and conformational epitopes","volume":"10","author":"Forsstr\u00f6m","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.vetmic.2026.111172_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40813-024-00404-7","article-title":"TbpB-based oral mucosal vaccine provides heterologous protection against Gl\u00e4sser\u2019s disease caused by different serovars of Spanish field isolates of Glaesserella parasuis","volume":"10","author":"Gonz\u00e1lez-Fern\u00e1ndez","year":"2024","journal-title":"Porc. Health Manag."},{"key":"10.1016\/j.vetmic.2026.111172_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetimm.2021.110205","article-title":"Importance of strain selection in the generation of heterologous immunity to Glaesserella (Haemophilus) parasuis","volume":"234","author":"Hau","year":"2021","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2026.111172_bib7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s12274-019-2301-3","article-title":"Critical size limit of biodegradable nanoparticles for enhanced lymph node trafficking and paracortex penetration","volume":"12","author":"Howard","year":"2019","journal-title":"Nano Res."},{"key":"10.1016\/j.vetmic.2026.111172_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/bs.mie.2020.12.004","article-title":"Design and construction of chimeric linker library with controllable flexibilities for precision protein engineering","volume":"647","author":"Huang","year":"2021","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.vetmic.2026.111172_bib9","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.4161\/hv.25249","article-title":"Comparative immunogenicity in mice of rotavirus VP6 tubular structures and virus-like particles","volume":"9","author":"Lappalainen","year":"2013","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.vetmic.2026.111172_bib10","article-title":"SARS-CoV-2 RBD dimers elicit response comparable to VLPs in mice","author":"Love","year":"2023","journal-title":"Res. Sq."},{"key":"10.1016\/j.vetmic.2026.111172_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.vetimm.2016.07.011","article-title":"A vaccine based on a mutant transferrin binding protein B of Haemophilus parasuis induces a strong T-helper 2 response and bacterial clearance after experimental infection","volume":"179","author":"Mart\u00ednez-Mart\u00ednez","year":"2016","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetmic.2026.111172_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2003.12.001","article-title":"Haemophilus parasuis: new trends on diagnosis, epidemiology and control","volume":"99","author":"Oliveira","year":"2004","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111172_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134955","article-title":"Efficacy comparison in cap VLPs of PCV2 and PCV3 as swine vaccine vehicle","volume":"278","author":"Qiu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.vetmic.2026.111172_bib14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13567-024-01383-x","article-title":"Use of virus-like particles and nanoparticle-based vaccines for combating picornavirus infections","volume":"55","author":"Ren","year":"2024","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetmic.2026.111172_bib15","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1021\/ac400596g","article-title":"Discovery and investigation of O-xylosylation in engineered proteins containing a (GGGGS)n linker","volume":"85","author":"Wen","year":"2013","journal-title":"Anal. Chem."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526003093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526003093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:06:43Z","timestamp":1792066003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113526003093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":15,"alternative-id":["S0378113526003093"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.111172","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and protection evaluation of a nanoparticle vaccine against transferrin-binding protein TbpBY167A of Glaesserella parasuis","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.111172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111172"}}