{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:49:12Z","timestamp":1792068552440,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130103"],"award-info":[{"award-number":["32130103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32573386"],"award-info":[{"award-number":["32573386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Microbiology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.vetmic.2026.111198","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:25:15Z","timestamp":1787034315000},"page":"111198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PRRSV Nsp2 promotes inflammatory responses by restricting ER-to-Golgi translocation of STING through HMGB1"],"prefix":"10.1016","volume":"321","author":[{"given":"Shuai","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenrui","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxiang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liurong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5484-3420","authenticated-orcid":false,"given":"Yanrong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetmic.2026.111198_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-immunol-030409-101323","article-title":"HMGB1 is a therapeutic target for sterile inflammation and infection","volume":"29","author":"Andersson","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2026.111198_bib2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature10429","article-title":"STING is a direct innate immune sensor of cyclic di-GMP","volume":"478","author":"Burdette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2026.111198_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ijrobp.2021.05.115","article-title":"ALKBH5-modified HMGB1-STING activation contributes to radiation induced liver disease via innate immune response","volume":"111","author":"Chen","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.vetmic.2026.111198_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00188-23","article-title":"The papain-like protease of porcine reproductive and respiratory syndrome virus impedes STING translocation from the endoplasmic reticulum to the golgi apparatus by deubiquitinating STIM1","volume":"97","author":"Diao","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.111198_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1743-422X-9-83","article-title":"Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-\u03baB activation","volume":"9","author":"Fang","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.vetmic.2026.111198_bib6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/CVI.00224-07","article-title":"Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production","volume":"15","author":"Flores-Mendoza","year":"2008","journal-title":"Clin. Vaccin. Immunol."},{"key":"10.1016\/j.vetmic.2026.111198_bib7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS-STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.vetmic.2026.111198_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.vetmic.2026.111198_bib9","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1182\/blood-2006-09-044776","article-title":"A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA","volume":"110","author":"Ivanov","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.vetmic.2026.111198_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41420-021-00409-z","article-title":"HMGB1 orchestrates STING-mediated senescence via TRIM30\u03b1 modulation in cancer cells","volume":"7","author":"Lee","year":"2021","journal-title":"Cell. Death Discov."},{"key":"10.1016\/j.vetmic.2026.111198_bib11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.vetmic.2010.05.011","article-title":"The genomic diversity of Chinese porcine reproductive and respiratory syndrome virus isolates from 1996 to 2009","volume":"146","author":"Li","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.vetmic.2026.111198_bib12","article-title":"cGAS restricts PRRSV replication by sensing the mtdna to increase the cGAMP Activity","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetmic.2026.111198_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-animal-022114-111025","article-title":"Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune system","volume":"4","author":"Lunney","year":"2016","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.vetmic.2026.111198_bib14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11262-010-0548-6","article-title":"Activation of NF-\u03baB by nucleocapsid protein of the porcine reproductive and respiratory syndrome virus","volume":"42","author":"Luo","year":"2011","journal-title":"Virus Genes."},{"key":"10.1016\/j.vetmic.2026.111198_bib15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.chom.2016.01.010","article-title":"The cGAS-STING defense pathway and its counteraction by viruses","volume":"19","author":"Ma","year":"2016","journal-title":"Cell. Host Microbe"},{"key":"10.1016\/j.vetmic.2026.111198_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2019.102701","article-title":"Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: implications in DNA repair and immune responses","volume":"83","author":"Mandke","year":"2019","journal-title":"DNA Repair."},{"key":"10.1016\/j.vetmic.2026.111198_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s42003-021-02983-5","article-title":"SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-\u03baB","volume":"5","author":"Neufeldt","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.vetmic.2026.111198_bib18","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1074\/jbc.M306793200","article-title":"Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein","volume":"279","author":"Park","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetmic.2026.111198_bib19","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1099\/vir.0.056341-0","article-title":"Arterivirus molecular biology and pathogenesis","volume":"94","author":"Snijder","year":"2013","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.vetmic.2026.111198_bib20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jprot.2016.05.009","article-title":"Quantitative interactome reveals that porcine reproductive and respiratory syndrome virus nonstructural protein 2 forms a complex with viral nucleocapsid protein and cellular vimentin","volume":"142","author":"Song","year":"2016","journal-title":"J. Proteom."},{"key":"10.1016\/j.vetmic.2026.111198_bib21","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100983","article-title":"The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-\u03baB signaling and STING's dual role during MCMV infection","volume":"38","author":"Stempel","year":"2019","journal-title":"Embo J."},{"key":"10.1016\/j.vetmic.2026.111198_bib22","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41577-023-00894-6","article-title":"The multifunctional protein HMGB1: 50 years of discovery","volume":"23","author":"Tang","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.vetmic.2026.111198_bib23","doi-asserted-by":"crossref","first-page":"12174","DOI":"10.18632\/oncotarget.24040","article-title":"Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infection","volume":"9","author":"Wang","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.vetmic.2026.111198_bib24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s44149-024-00135-w","article-title":"The critical role of miRNAs in modulating PRRSV infection in swine: a review","volume":"4","author":"Wang","year":"2024","journal-title":"Anim. Dis."},{"key":"10.1016\/j.vetmic.2026.111198_bib25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.virol.2018.02.021","article-title":"Porcine reproductive and respiratory syndrome virus induces HMGB1 secretion via activating PKC-delta to trigger inflammatory response","volume":"518","author":"Wang","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.vetmic.2026.111198_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00880-24","article-title":"Cell-surface d-glucuronyl C5-epimerase binds to porcine deltacoronavirus spike protein facilitating viral entry","volume":"98","author":"Xiao","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.111198_bib27","article-title":"Porcine reproductive and respiratory syndrome virus triggers Golgi apparatus fragmentation-mediated autophagy to facilitate viral self-replication","author":"Zhao","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.vetmic.2026.111198_bib28","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/SHK.0000000000002006","article-title":"Cardiopulmonary bypass-derived plasma exosomal hmgb1 contributes to alveolar epithelial cell necroptosis via mtDNA\/CGAS\/STING pathway","volume":"58","author":"Zhao","year":"2022","journal-title":"Shock"},{"key":"10.1016\/j.vetmic.2026.111198_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s44149-024-00152-9","article-title":"Epidemiological surveillance and economic impact analysis of different porcine reproductive and respiratory syndrome virus infection statuses in 23 breeding pig farms in Hubei, China","volume":"4","author":"Zhao","year":"2024","journal-title":"Anim. Dis."}],"container-title":["Veterinary Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526003354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378113526003354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:06:06Z","timestamp":1792065966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378113526003354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S0378113526003354"],"URL":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.111198","relation":{},"ISSN":["0378-1135"],"issn-type":[{"value":"0378-1135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRRSV Nsp2 promotes inflammatory responses by restricting ER-to-Golgi translocation of STING through HMGB1","name":"articletitle","label":"Article Title"},{"value":"Veterinary Microbiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetmic.2026.111198","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111198"}}