{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:29:03Z","timestamp":1790760543781,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.vetpar.2005.04.005","type":"journal-article","created":{"date-parts":[[2005,4,28]],"date-time":"2005-04-28T09:14:07Z","timestamp":1114679647000},"page":"197-206","source":"Crossref","is-referenced-by-count":101,"title":["The safety-net story about macrocyclic lactone heartworm preventives: A review, an update, and recommendations"],"prefix":"10.1016","volume":"133","author":[{"given":"John W.","family":"McCall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2005.04.005_bib1","unstructured":"American Heartworm Society, 2004. 2003 Updated guidelines for the diagnosis, prevention, and management of heartworm (Dirofilaria immitis) infection in dogs. In: McCall, et al., (Eds.), Proceedings of the Symposium Session on Recent Advances in Heartworm Disease, The 19th International Conference of the World Association for the Advancement of Veterinary Parasitology, New Orleans, LA, 10\u201314 August, 2003. Vet. Parasitol. 125, 105\u2013130."},{"key":"10.1016\/j.vetpar.2005.04.005_bib2","first-page":"310","article-title":"Is there a better way to administer heartworm adulticidal therapy?","author":"Atkins","year":"2003","journal-title":"Vet. Med."},{"key":"10.1016\/j.vetpar.2005.04.005_bib3","series-title":"Recent Advances in Heartworm Disease: Symposium \u201901.","first-page":"159","article-title":"Safety of moxidectin canine SR (sustained release) injectable in ivermectin-sensitive collies and in naturally infected mongrel dogs","author":"Blagburn","year":"2001"},{"key":"10.1016\/j.vetpar.2005.04.005_bib4","first-page":"2108","article-title":"Efficacy of ivermectin against Dirofilaria immitis larvae in dogs (31, 60 and 90 days after infection)","volume":"41","author":"Blair","year":"1980","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetpar.2005.04.005_bib5","series-title":"Proceedings of the Heartworm Symposium \u201992","first-page":"151","article-title":"Effects of long-term administration of ivermectin and milbemycin oxime on circulating microfilariae and parasite antigenemia in dogs with patent heartworm infections","author":"Bowman","year":"1992"},{"key":"10.1016\/j.vetpar.2005.04.005_bib6","series-title":"Recent Advances in Heartworm Disease: Symposium \u201901","first-page":"173","article-title":"Effects of avermectins on microfilariae in dogs with existing and developing heartworm infections","author":"Bowman","year":"2001"},{"key":"10.1016\/j.vetpar.2005.04.005_bib7","series-title":"Recent Advances in Heartworm Disease: Symposium \u201998","first-page":"193","article-title":"The effect of chronic administration of milbemycin oxime and ivermectin on microfilaremias in heartworm-infected dogs","author":"Courtney","year":"1998"},{"key":"10.1016\/j.vetpar.2005.04.005_bib8","series-title":"Proceedings of the Heartworm Symposium \u201995","first-page":"183","article-title":"Evaluation of veterinary dispensing records to measure \u201cclinic compliance\u201d with recommended heartworm prevention programs","author":"Cummings","year":"1995"},{"key":"10.1016\/j.vetpar.2005.04.005_bib9","series-title":"Proceedings of the Heartworm Symposium \u201995","first-page":"113","article-title":"Influence of number of parasites and exercise on the severity of heartworm disease in dogs","author":"Dillon","year":"1995"},{"key":"10.1016\/j.vetpar.2005.04.005_bib10","series-title":"Recent Advances in Heartworm Disease: Symposium \u201901","first-page":"135","article-title":"The safety of SEL in heartworm infected dogs and its effect on adult worms and microfilariae","author":"Dzimianski","year":"2001"},{"key":"10.1016\/j.vetpar.2005.04.005_bib11","series-title":"Recent Advances in Heartworm Disease: Symposium \u201998","first-page":"225","article-title":"Influence of exercise on recovery of dogs following heartworm adulticide treatment with melarsomine","author":"Fukami","year":"1998"},{"key":"10.1016\/j.vetpar.2005.04.005_bib12","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.2460\/ajvr.1991.52.12.2040","article-title":"Chemoprophylactic effects of milbemycin oxime against larvae of Dirofilaria immitis during prepatent development","volume":"52","author":"Grieve","year":"1991","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetpar.2005.04.005_bib13","series-title":"Macrocyclic Lactones in Antiparasitic Therapy","first-page":"353","article-title":"The use of macrocyclic lactones in the control and prevention of heartworm and other parasites in dogs and cats","author":"Guerrero","year":"2002"},{"key":"10.1016\/j.vetpar.2005.04.005_bib14","series-title":"Proceedings of the Heartworm Symposium \u201992","first-page":"183","article-title":"The safety of moxidectin in dogs infected with microfilariae and adults of Dirofilaria immitis","author":"Hendrix","year":"1992"},{"key":"10.1016\/j.vetpar.2005.04.005_bib15","series-title":"Proceedings of the Heartworm Symposium \u201992","first-page":"225","article-title":"Dose selection and confirmation of RM 340, a new filaricide for the treatment of dogs with immature and mature Dirofilaria immitis","author":"Keister","year":"1992"},{"key":"10.1016\/j.vetpar.2005.04.005_bib16","series-title":"Proceedings of the Heartworm Symposium \u201992","first-page":"143","article-title":"Kinetics of microfilaremia suppression in Dirofilaria immitis-infected dogs during and after a prophylactic regimen of milbemycin oxime","author":"Lok","year":"1992"},{"key":"10.1016\/j.vetpar.2005.04.005_bib17","series-title":"Proceedings of the Heartworm Symposium \u201989","first-page":"85","article-title":"Effects of ivermectin on embryogenesis in Dirofilaria immitis: age structure and spatial distribution of intrauterine forms as a function of dosage and time posttreatment","author":"Lok","year":"1989"},{"key":"10.1016\/j.vetpar.2005.04.005_bib18","unstructured":"McCall, J.W., 2003. Heartworm-positive dog requires tailored treatment. DVM Best Practices, Special Issue on Parasite Control, 16\u201321 March."},{"key":"10.1016\/j.vetpar.2005.04.005_bib19","series-title":"Proceedings of the Heartworm Symposium \u201986","first-page":"9","article-title":"Ivermectin in heartworm prophylaxis: studies with experimentally induced and naturally acquired infections","author":"McCall","year":"1986"},{"key":"10.1016\/j.vetpar.2005.04.005_bib20","series-title":"Recent Advances in Heartworm Disease: Symposium \u201901","first-page":"189","article-title":"Further evidence of clinical prophylactic, retro-active (reach-back) and adulticidal activity of monthly administrations of ivermectin (Heartgard Plus\u2122) in dogs experimentally infected with heartworms","author":"McCall","year":"2001"},{"key":"10.1016\/j.vetpar.2005.04.005_bib21","series-title":"Recent Advances in Heartworm Disease: Symposium \u201901","first-page":"141","article-title":"Evaluation of repeated monthly dosing of SEL against Dirofilaria immitis beginning three months after experimental inoculation of heartworm larvae in dogs","author":"McCall","year":"2001"},{"key":"10.1016\/j.vetpar.2005.04.005_bib22","series-title":"Proceedings of the Heartworm Symposium \u201980","first-page":"126","article-title":"Prophylactic activity of avermectins against experimentally induced Dirofilaria immitis infections in dogs","author":"McCall","year":"1981"},{"key":"10.1016\/j.vetpar.2005.04.005_bib23","series-title":"Proceedings of the Heartworm Symposium \u201992","first-page":"169","article-title":"Prevention of naturally acquired heartworm infection in heartworm-naive beagles by oral administration of moxidectin at an interval of either one or two months","author":"McCall","year":"1992"},{"key":"10.1016\/j.vetpar.2005.04.005_bib24","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2460\/ajvr.1996.57.08.1189","article-title":"Evaluation of ivermectin and milbemycin oxime efficacy against Dirofilaria immitis infections of three and four months\u2019 duration in dogs","volume":"57","author":"McCall","year":"1996","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetpar.2005.04.005_bib25","series-title":"Proceedings of the Heartworm Symposium \u201995","first-page":"187","article-title":"Clinical prophylactic activity of macrolides on young adult heartworms","author":"McCall","year":"1995"},{"key":"10.1016\/j.vetpar.2005.04.005_bib26","series-title":"Recent Advances in Heartworm Disease: Symposium \u201998","first-page":"209","article-title":"Heartworm adulticidal activity of prophylactic doses of ivermectin (6\u03bcg\/kg) plus pyrantel administered monthly to dogs","author":"McCall","year":"1998"},{"key":"10.1016\/j.vetpar.2005.04.005_bib27","series-title":"Recent Advances in Heartworm Disease: Symposium \u201901","first-page":"97","article-title":"Evaluation of the performance of canine heartworm antigen test kits licensed for use by veterinarians and canine heartworm antigen tests conducted by diagnostic laboratories","author":"McCall","year":"2001"},{"key":"10.1016\/j.vetpar.2005.04.005_bib28","series-title":"Recent Advances in Heartworm Disease: Symposium \u201901","first-page":"165","article-title":"Evaluation of retroactive and adulticidal activity of moxidectin canine SR (sustained-release) injectable formulation against Dirofilaria immitis infection in dogs","author":"McCall","year":"2001"},{"key":"10.1016\/j.vetpar.2005.04.005_bib29","series-title":"Proceedings of the Heartworm Symposium \u201992","first-page":"165","article-title":"Prevention of experimental heartworm infection in dogs with single, oral doses of moxidectin","author":"McTier","year":"1992"},{"key":"10.1016\/j.vetpar.2005.04.005_bib30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0304-4017(00)00297-1","article-title":"Prevention of experimentally induced heartworm (Dirofilaria immitis) infections in dogs and cats with a single topical application of selamectin","volume":"91","author":"McTier","year":"2000","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2005.04.005_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1292\/jvms1939.49.115","article-title":"Prophylactic activity of ivermectin against Dirofilaria immitis infection in dogs: larvicidal activity of ivermectin against D. immitis larvae 30 days after infection (in Japanese)","volume":"49","author":"Ohishi","year":"1987","journal-title":"Jpn. J. Vet. Sci."},{"key":"10.1016\/j.vetpar.2005.04.005_bib32","series-title":"Proceedings of the Heartworm Symposium \u201986","first-page":"33","article-title":"Efficacy of ivermectin against Dirofilaria immitis larvae in dogs forty-five days after induced infection","author":"Paul","year":"1986"},{"key":"10.1016\/j.vetpar.2005.04.005_bib33","first-page":"883","article-title":"Efficacy of ivermectin against Dirofilaria immitis larvae in dogs 30 and 45 days after induced infection","volume":"47","author":"Paul","year":"1986","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetpar.2005.04.005_bib34","series-title":"Recent Advances in Heartworm Disease: Symposium \u201901","first-page":"179","article-title":"Disease response to trickle-kill when ivermectin or milbemycin oxime is started during Dirofilaria immitis infection in dogs","author":"Rawlings","year":"2001"},{"key":"10.1016\/j.vetpar.2005.04.005_bib35","series-title":"Proceedings of the Heartworm Symposium \u201986","first-page":"29","article-title":"Safety and acceptability of ivermectin in dogs with naturally acquired patent infection of Dirofilaria immitis","author":"Schlotthauer","year":"1986"},{"key":"10.1016\/j.vetpar.2005.04.005_bib36","series-title":"Recent Advances in Heartworm Disease: Symposium \u201998","first-page":"217","article-title":"Fine structural observations of gut epithelium changes in adult heartworms induced by monthly treatment of dogs with ivermectin\/pyrantel","author":"Steffens","year":"1998"},{"key":"10.1016\/j.vetpar.2005.04.005_bib37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.vetpar.2004.06.024","article-title":"Efficacy of long-term monthly administration of ivermectin on the progress of naturally acquired heartworm infection in dogs","volume":"124","author":"Venco","year":"2004","journal-title":"Vet. Parasitol."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401705001500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401705001500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T04:27:20Z","timestamp":1706156840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401705001500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":37,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0304401705001500"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2005.04.005","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}