{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:34:38Z","timestamp":1776216878031,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.vetpar.2007.12.020","type":"journal-article","created":{"date-parts":[[2008,2,2]],"date-time":"2008-02-02T07:24:01Z","timestamp":1201937041000},"page":"284-293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Application of in vitro anthelmintic sensitivity assays to canine parasitology: Detecting resistance to pyrantel in Ancylostoma caninum"],"prefix":"10.1016","volume":"152","author":[{"given":"Steven R.","family":"Kopp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen T.","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Kotze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2007.12.020_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0001-706X(03)00043-3","article-title":"Methods to sustain drug efficacy in helminth control programmes","volume":"86","author":"Albonico","year":"2003","journal-title":"Acta Tropica"},{"key":"10.1016\/j.vetpar.2007.12.020_bib2","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.ijpara.2004.08.001","article-title":"Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control","volume":"34","author":"Albonico","year":"2004","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.ijpara.2005.02.016","article-title":"Development of the egg hatch assay for detection of anthelminthic resistance in human hookworms","volume":"35","author":"Albonico","year":"2005","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.exppara.2005.02.002","article-title":"The larval feeding inhibition assay for the diagnosis of nematode anthelmintic resistance","volume":"110","author":"Alvarez-Sanchez","year":"2005","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib5","unstructured":"APVMA, 2006. Registered Products Database. http:\/\/services.apvma.gov.au\/PubcrisWebClient\/welcome.do."},{"key":"10.1016\/j.vetpar.2007.12.020_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0020-7519(83)90002-4","article-title":"Development of anthelmintic resistance in nematodes from sheep in Australia subjected to different treatment frequencies","volume":"13","author":"Barton","year":"1983","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0306-3623(75)90030-0","article-title":"The mechanism of action of the anthelmintic levamisole","volume":"6","author":"Coles","year":"1975","journal-title":"General Pharmacology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0034-5288(18)30893-2","article-title":"Larval development test for detection of anthelmintic resistant nematodes","volume":"45","author":"Coles","year":"1988","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/j.vetpar.2007.12.020_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.vetpar.2005.11.019","article-title":"The detection of anthelmintic resistance in nematodes of veterinary importance","volume":"136","author":"Coles","year":"2006","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/expr.1993.1064","article-title":"Haemonchus contortus: ivermectin-induced paralysis of the pharynx","volume":"77","author":"Geary","year":"1993","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/CMR.13.2.207","article-title":"Drug resistance in human helminths: current situation and lessons from livestock","volume":"13","author":"Geerts","year":"2000","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.vetpar.2007.12.020_bib12","series-title":"Australian Standard Diagnostic Techniques for Animal Diseases","first-page":"29","article-title":"Diagnosis of anthelmintic resistance in sheep and goats","author":"Hall","year":"1987"},{"key":"10.1016\/j.vetpar.2007.12.020_bib13","series-title":"Veterinary Dentistry","author":"Harvey","year":"1985"},{"key":"10.1016\/j.vetpar.2007.12.020_bib14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2307\/3282673","article-title":"Serum-stimulated feeding in vitro by third-stage infective larvae of the canine hookworm Ancylostoma caninum","volume":"76","author":"Hawdon","year":"1990","journal-title":"Journal of Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib15","first-page":"19","article-title":"The estimation of the number of hookworms harboured by the use of the dilution egg count method","volume":"6","author":"Hill","year":"1926","journal-title":"American Journal of Hygiene"},{"key":"10.1016\/j.vetpar.2007.12.020_bib16","first-page":"3","article-title":"Synergism of a combination of febantel and pyrantel embonate against Ancylostoma caninum on dogs","volume":"61","author":"Hopkins","year":"1991","journal-title":"Veterinary Medical Review"},{"key":"10.1016\/j.vetpar.2007.12.020_bib17","first-page":"53","article-title":"The effect of pyrantel embonate with oxantel embonate-praziquantal, pyrantel embonate with febantel-praziquantal and milbemycin oxime on natural infestations of Ancylostoma caninum in dogs","volume":"28","author":"Hopkins","year":"1989","journal-title":"Australian Veterinary Practitioner"},{"key":"10.1016\/j.vetpar.2007.12.020_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/00480169.\/1987.35456","article-title":"Isolation of anthelmintic resistant Ancylostoma caninum","volume":"35","author":"Jackson","year":"1987","journal-title":"New Zealand Veterinary Journal"},{"key":"10.1016\/j.vetpar.2007.12.020_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0304-4017(94)90110-4","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guidelines for evaluating the efficacy of anthelmintics for dogs and cats","volume":"52","author":"Jacobs","year":"1994","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib20","series-title":"Veterinary Helminthology","author":"Kassai","year":"1999"},{"key":"10.1016\/j.vetpar.2007.12.020_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.vetpar.2006.08.036","article-title":"High-level pyrantel resistance in the hookworm Ancylostoma caninum","volume":"143","author":"Kopp","year":"2007","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib22","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0020-7519(99)00064-8","article-title":"Investigation of intestinal nematode responses to naphthalophos and pyrantel using a larval development assay","volume":"29","author":"Kotze","year":"1999","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib23","doi-asserted-by":"crossref","first-page":"608","DOI":"10.4269\/ajtmh.2004.71.608","article-title":"An in vitro larval motility assay to determine anthelmintic sensitivity for human hookworm and Strongyloides species","volume":"71","author":"Kotze","year":"2004","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/j.vetpar.2007.12.020_bib24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ijpara.2004.12.007","article-title":"Field evaluation of anthelmintic drug sensitivity using in vitro egg hatch and larval motility assays with Necator americanus recovered from human clinical isolates","volume":"35","author":"Kotze","year":"2005","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib25","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.vetpar.2006.01.017","article-title":"A modified larval migration assay for detection of resistance to macrocyclic lactones in Haemonchus contortus, and drug screening with Trichostrongylidae parasites","volume":"137","author":"Kotze","year":"2006","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib26","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2307\/3275030","article-title":"Effects of crowding and of superinfection on habitat selection and egg production in Ancylostoma caninum","volume":"47","author":"Krupp","year":"1961","journal-title":"Journal of Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib27","series-title":"Nematode Parasites of Domestic Animals and of Man","author":"Levine","year":"1968"},{"key":"10.1016\/j.vetpar.2007.12.020_bib28","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.vetpar.2004.11.029","article-title":"Larval development assay for detection of anthelmintic resistance in cyathostomins of Swedish horses","volume":"128","author":"Lind","year":"2005","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF02268963","article-title":"Larval paralysis as an in vitro assay of levamisole and morantel tartrate resistance in Ostertagia","volume":"3","author":"Martin","year":"1979","journal-title":"Veterinary Science Communications"},{"key":"10.1016\/j.vetpar.2007.12.020_bib30","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exppara.2004.03.007","article-title":"Haemonchus contortus: in vitro drug screening assays with the adult life stage","volume":"106","author":"O\u2019Grady","year":"2004","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0001-706X(97)00106-X","article-title":"Failure of pyrantel in treatment of human hookworm infections (Ancylostoma duodenale) in the Kimberley region of north west Australia","volume":"68","author":"Reynoldson","year":"1997","journal-title":"Acta Tropica"},{"key":"10.1016\/j.vetpar.2007.12.020_bib32","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/0020-7519(95)00036-2","article-title":"In vitro studies on the relative sensitivity to ivermectin of Necator americanus and Ancylostoma ceylanicum","volume":"25","author":"Richards","year":"1995","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0020-7519(91)90080-Q","article-title":"Effects of cholinergic drugs on longitudinal contraction in levamisole-susceptible and -resistant Haemonchus contortus","volume":"21","author":"Sangster","year":"1991","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib34","first-page":"658","article-title":"The effect of age and size of infection on the egg production of the dog hookworm, Ancylostoma caninum","volume":"10","author":"Sarles","year":"1929","journal-title":"American Journal of Hygiene"},{"key":"10.1016\/j.vetpar.2007.12.020_bib35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0014-4894(82)90039-X","article-title":"Ancylostoma caninum: adult worm removal, corticosteroid treatment, and resumed development of arrested larvae in dogs","volume":"54","author":"Schad","year":"1982","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib36","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1017\/S0031182002002391","article-title":"Vertical migration by the infective larvae of three species of parasitic nematodes: is the behaviour really a response to gravity?","volume":"125","author":"Sciacca","year":"2002","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.vetpar.2004.12.008","article-title":"Effect of ivermectin on feeding by Haemonchus contortus in vivo","volume":"128","author":"Sheriff","year":"2005","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.vetpar.2003.09.016","article-title":"Evaluation of a larval development assay (DrenchRite) for the detection of anthelmintic resistance in cyathostomin nematodes of horses","volume":"121","author":"Tandon","year":"2004","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0304-4017(01)00604-5","article-title":"Anthelmintic resistance detection methods","volume":"103","author":"Taylor","year":"2002","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib40","series-title":"Proceedings of the National Academy of Science 97","first-page":"460","article-title":"A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum","author":"Tissenbaum","year":"2000"},{"key":"10.1016\/j.vetpar.2007.12.020_bib41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.vetpar.2004.05.026","article-title":"Application of a species-specific PCR-RFLP to identify Ancylostoma eggs directly from canine faeces","volume":"123","author":"Traub","year":"2004","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1017\/S0031182006001211","article-title":"A case of mistaken identity\u2014reappraisal of the species of canid and felid hookworms (Ancylostoma) present in Australia and India","volume":"134","author":"Traub","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2007.12.020_bib43","unstructured":"United States Food and Drug Administration, 2006. United States Food and Drug Administration Centre for Veterinary Medicine Online Green Book 2006. http:\/\/www.fda.gov\/cvm\/Green_Book\/elecgbook.html."},{"key":"10.1016\/j.vetpar.2007.12.020_bib44","unstructured":"World Health Organization, 2000. WHO Model List of Essential Drugs. WHO."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401707006632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401707006632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T01:27:29Z","timestamp":1759627649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401707006632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":44,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0304401707006632"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2007.12.020","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Application of in vitro anthelmintic sensitivity assays to canine parasitology: Detecting resistance to pyrantel in Ancylostoma caninum","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2007.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}