{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:26:15Z","timestamp":1777634775990,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.vetpar.2010.02.043","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T14:41:04Z","timestamp":1267713664000},"page":"172-175","source":"Crossref","is-referenced-by-count":15,"title":["Binding of serum albumin to the anthelmintic drugs albendazole, triclabendazole and their sulphoxides"],"prefix":"10.1016","volume":"171","author":[{"given":"Emma","family":"Chambers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Hoey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Trudgett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Fairweather","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Timson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2010.02.043_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-4017(00)00320-4","article-title":"Uptake of albendazole and albendazole sulphoxide by Haemonchus contortus and Fasciola hepatica in sheep","volume":"94","author":"Alvarez","year":"2000","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib2","first-page":"805","article-title":"Pharmacokinetics of triclabendazole in rabbits","volume":"106","author":"Alvarez-Bujidos","year":"1993","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.vetpar.2010.02.043_bib3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/vr.159.13.424","article-title":"Resistance of Fasciola hepatica to triclabendazole and albendazole in sheep in Spain","volume":"159","author":"Alvarez-Sanchez","year":"2006","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2010.02.043_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0014-4894(87)90077-4","article-title":"Fasciola hepatica: action in vitro of triclabendazole on immature and adult stages","volume":"63","author":"Bennett","year":"1987","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib5","series-title":"Diseases of Domestic Animals Caused by Flukes","author":"Boray","year":"1994"},{"key":"10.1016\/j.vetpar.2010.02.043_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yexmp.2007.01.009","article-title":"Understanding triclabendazole resistance","volume":"82","author":"Brennan","year":"2007","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0031182002002664","article-title":"Fasciola hepatica: surface and internal tegumental changes induced by treatment in vitro with the sulphoxide metabolite of albendazole (\u2018Valbazen\u2019)","volume":"126","author":"Buchanan","year":"2003","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2010.02.043_bib8","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2165\/00003495-199753050-00004","article-title":"Anthelmintics. A comparative review of their clinical pharmacology","volume":"53","author":"de Silva","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.vetpar.2010.02.043_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0034-5288(18)31012-9","article-title":"Pharmacokinetics in sheep and cattle of albendazole administered by an intraruminal slow release capsule","volume":"48","author":"Delatour","year":"1990","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetpar.2010.02.043_bib10","first-page":"697","article-title":"Bioavailability comparison between albendazole and albendazole sulphoxide in rats and man","volume":"50","author":"Dominguez","year":"1995","journal-title":"Farmaco"},{"key":"10.1016\/j.vetpar.2010.02.043_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1079\/JOH2005298","article-title":"Triclabendazole: new skills to unravel an old(ish) enigma","volume":"79","author":"Fairweather","year":"2005","journal-title":"J. Helminthol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2885.1986.tb00011.x","article-title":"The effect of albendazole and triclabendazole on colchicine binding in the liver fluke Fasciola hepatica","volume":"9","author":"Fetterer","year":"1986","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2010.02.043_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jmb.2005.07.075","article-title":"Structural basis of the drug-binding specificity of human serum albumin","volume":"353","author":"Ghuman","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2885.1987.tb00078.x","article-title":"The kinetics of triclabendazole disposition in sheep","volume":"10","author":"Hennessy","year":"1987","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2010.02.043_bib15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.2042-7158.1998.tb03303.x","article-title":"Absorption studies of albendazole and some physicochemical properties of the drug and its metabolite albendazole sulphoxide","volume":"50","author":"Jung","year":"1998","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.vetpar.2009.03.027","article-title":"Sheep helminth parasitic disease in south eastern Scotland arising as a possible consequence of climate change","volume":"163","author":"Kenyon","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2885.1988.tb00150.x","article-title":"Pharmacokinetics and efficacy of triclabendazole in goats with induced fascioliasis","volume":"11","author":"Kinabo","year":"1988","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2010.02.043_bib18","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1248\/bpb.25.695","article-title":"Practical aspects of the ligand-binding and enzymatic properties of human serum albumin","volume":"25","author":"Kragh-Hansen","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.vetpar.2010.02.043_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0166-6851(86)90122-2","article-title":"Interactions of benzimidazoles (BZ) with tubulin from BZ-sensitive and BZ-resistant isolates of Haemonchus contortus","volume":"19","author":"Lacey","year":"1986","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0014-4894(91)90023-P","article-title":"Interaction of benzimidazole anthelmintics with Haemonchus contortus tubulin: binding affinity and anthelmintic efficacy","volume":"73","author":"Lubega","year":"1991","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molbiopara.2004.08.001","article-title":"Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis. Encephalitozoon intestinalis, and Cryptosporidium parvum","volume":"138","author":"MacDonald","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1137\/0111030","article-title":"An algorithm for least squares estimation of nonlinear parameters","volume":"11","author":"Marquardt","year":"1963","journal-title":"SIAM J. Appl. Math."},{"key":"10.1016\/j.vetpar.2010.02.043_bib23","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2460\/ajvr.1980.41.07.1126","article-title":"Pharmacokinetics of albendazole in sheep","volume":"41","author":"Marriner","year":"1980","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetpar.2010.02.043_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-308X(09)69002-3","article-title":"Fasciola, lymnaeids and human fascioliasis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control","volume":"69","author":"Mas-Coma","year":"2009","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vetpar.2009.03.024","article-title":"Climate change effects on trematodiases, with emphasis on zoonotic fascioliasis and schistosomiasis","volume":"163","author":"Mas-Coma","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2885.1986.tb00067.x","article-title":"Pharmacokinetics of triclabendazole alone or in combination with fenbendazole in sheep","volume":"9","author":"Mohammed Ali","year":"1986","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2010.02.043_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-4017(00)00267-3","article-title":"Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The Netherlands","volume":"91","author":"Moll","year":"2000","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.exppara.2005.12.004","article-title":"Drug transport mechanisms in helminth parasites: passive diffusion of benzimidazole anthelmintics","volume":"113","author":"Mottier","year":"2006","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/prep.2000.1347","article-title":"Individual expression of recombinant \u03b1- and \u03b2-tubulin from Haemonchus contortus: polymerization and drug effects","volume":"21","author":"Oxberry","year":"2001","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.vetpar.2010.02.043_bib30","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0021-9258(18)56273-6","article-title":"Net production of serum albumin by liver slices","volume":"186","author":"Peters","year":"1950","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetpar.2010.02.043_bib31","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1098\/rstb.2009.0089","article-title":"Zoonotic helminth infections with particular emphasis on fasciolosis and other trematodiases","volume":"364","author":"Robinson","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B. Biol. Sci."},{"key":"10.1016\/j.vetpar.2010.02.043_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00436-003-0953-z","article-title":"The effect of the microtubule inhibitor tubulozole-C on the tegument of triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica","volume":"91","author":"Robinson","year":"2003","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2010.02.043_bib33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S003118200100124X","article-title":"Triclabendazole-resistant Fasciola hepatica: \u03b2-tubulin and response to in vitro treatment with triclabendazole","volume":"124","author":"Robinson","year":"2002","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2010.02.043_bib34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.molbiopara.2008.02.001","article-title":"Fasciola hepatica expresses multiple \u03b1- and \u03b2-tubulin isotypes","volume":"159","author":"Ryan","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib35","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S0031182000077428","article-title":"The effect of the sulphoxide metabolite of triclabendazole (\u2018Fasinex\u2019) on the tegument of mature and immature stages of the liver fluke, Fasciola hepatica","volume":"108","author":"Stitt","year":"1994","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2010.02.043_bib36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/BF00932235","article-title":"Fasciola hepatica: tegumental surface changes in adult and juvenile flukes following treatment in vitro with the sulphoxide metabolite of triclabendazole (Fasinex)","volume":"79","author":"Stitt","year":"1993","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2010.02.043_bib37","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0026-895X(25)10691-3","article-title":"The characterization of two specific drug binding sites on human serum albumin","volume":"11","author":"Sudlow","year":"1975","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.vetpar.2010.02.043_bib38","first-page":"200","article-title":"Triclabendazole-resistant Fasciola hepatica in southwest Wales","volume":"146","author":"Thomas","year":"2000","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2010.02.043_bib39","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1017\/S0031182009005642","article-title":"A scanning electron microscope study on the route of entry of triclabendazole into the liver fluke Fasciola hepatica","volume":"136","author":"Toner","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2010.02.043_bib40","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1046\/j.1365-2885.2002.00442.x","article-title":"Free drug fraction vs free drug concentration: a matter of frequent confusion","volume":"25","author":"Toutain","year":"2002","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2010.02.043_bib41","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1517\/14656560902722463","article-title":"Pharmacotherapy of helminth infection","volume":"10","author":"van den Enden","year":"2009","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.vetpar.2010.02.043_bib42","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2885.2006.00735.x","article-title":"Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheep","volume":"29","author":"Virkel","year":"2006","journal-title":"J. Vet. Pharmacol. Ther."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401710001366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401710001366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:41:17Z","timestamp":1739925677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401710001366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":42,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0304401710001366"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2010.02.043","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}