{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:24:26Z","timestamp":1791267866885,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.vetpar.2012.02.011","type":"journal-article","created":{"date-parts":[[2012,2,25]],"date-time":"2012-02-25T11:33:44Z","timestamp":1330169624000},"page":"464-472","source":"Crossref","is-referenced-by-count":28,"title":["Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate"],"prefix":"10.1016","volume":"187","author":[{"given":"D.J.","family":"Bartley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dupuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Bartley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Sutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Menez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alvinerie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Devin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lespine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2012.02.011_bib0005","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s004360100408","article-title":"In vitro metabolism of moxidectin in Haemonchus contortus adult stages","volume":"87","author":"Alvinerie","year":"2001","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.vetpar.2008.06.017","article-title":"Ketoconazole increases the plasma levels of ivermectin in sheep","volume":"157","author":"Alvinerie","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0015","first-page":"113","article-title":"The pharmacokinetics of moxidectin after oral and subcutaneous administration to sheep","volume":"29","author":"Alvinerie","year":"1998","journal-title":"Vet. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1751-0813.1988.tb07355.x","article-title":"Mixtures of anthelmintics: a strategy against resistance","volume":"65","author":"Anderson","year":"1988","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1751-0813.1991.tb03154.x","article-title":"the efficacy of mixtures of albendazole sulfoxide and levamisole against sheep nematodes resistant to benzimidazole and levamisole","volume":"68","author":"Anderson","year":"1991","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0030","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/dmd.105.007757","article-title":"Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments","volume":"34","author":"Ballent","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0035","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2885.2007.00848.x","article-title":"Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition","volume":"30","author":"Ballent","year":"2007","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0040","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1017\/S0031182009990345","article-title":"P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus","volume":"136","author":"Bartley","year":"2009","journal-title":"Parasitology."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0169-4758(95)80117-0","article-title":"Worm control and anthelmintic resistance: adventures with a model","volume":"11","author":"Barnes","year":"1995","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0050","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1023\/A:1026179132599","article-title":"Sensitization of cells overexpressing multidrug-resistant proteins by Pluronic P85","volume":"20","author":"Batrakova","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0055","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1023\/A:1018990706838","article-title":"Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers","volume":"16","author":"Batrakova","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0060","first-page":"551","article-title":"Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies","volume":"296","author":"Batrakova","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0065","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.2042-7158.1996.tb03965.x","article-title":"Interaction between fenbendazole and piperonyl butoxide: pharmacokinetic and pharmacodynamic implications","volume":"48","author":"Benchaoui","year":"1996","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0070","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/vr.141.22.575","article-title":"Partial in vitro reversal of benzimidazole resistance by the free-living stages of Haemonchus contortus with verapamil","volume":"141","author":"Beugnet","year":"1997","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0075","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0005-2736(99)00167-4","article-title":"The multidrug resistance protein family","volume":"1461","author":"Borst","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0080","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1023\/A:1006496122684","article-title":"Pharmacokinetic behaviour of albendazole sulphoxide enantiomers in male and female sheep","volume":"24","author":"Capece","year":"2000","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0085","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.rvsc.2008.08.002","article-title":"Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats","volume":"86","author":"Capece","year":"2009","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0304-4017(92)90141-U","article-title":"World-Association-for-the-Advancement-of-Veterinary-Parasitol. WAAVP methods for the detection of anthelmintic resistance in nematodes of veterinary importance","volume":"44","author":"Coles","year":"1992","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0095","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0304-4017(98)00141-1","article-title":"Sex differences in the disposition of albendazole metabolites in sheep","volume":"78","author":"Cristofol","year":"1998","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0100","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0169-409X(02)00175-8","article-title":"Considerations in the design and development of transport inhibitors as adjuncts to drug therapy","volume":"53","author":"Dantzig","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0105","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0304-4017(03)00008-6","article-title":"Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin","volume":"112","author":"Dupuy","year":"2003","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0110","first-page":"802","article-title":"The multidrug resistance modulator valspodar PSC 833 is metabolizcd by human cytochrome P450 3A. Implications for drug\u2013drug interactions and pharmacological activity of the main metabolite","volume":"26","author":"Fischer","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2174\/1389557053402756","article-title":"Efflux transporters and their clinical relevance","volume":"5","author":"Fischer","year":"2005","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0120","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00436-009-1671-y","article-title":"The effect of sheep breed, age, and gender on the pharmacokinetics and efficacy of monepantel, an amino-acetonitrile derivative","volume":"106","author":"Hosking","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0125","first-page":"311","article-title":"Multiple oral dosing of ketoconazole increases dog exposure to ivermectin","volume":"10","author":"Hugnet","year":"2007","journal-title":"J. Pharm. Pharm. Sci."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0130","first-page":"65","article-title":"New technique for obtaining nematode ova from sheep faeces","volume":"23","author":"Jackson","year":"1974","journal-title":"Lab. Pract."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0135","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijpara.2008.06.009","article-title":"Increased expression of ABC transport proteins is associated with ivermectin resistance in the model nematode Caenorhabditis elegans","volume":"39","author":"James","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0140","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1053\/rvsc.2000.0381","article-title":"The effect of sex and age on caffeine pharmacokinetics in cattle","volume":"69","author":"Janus","year":"2000","journal-title":"Res. Vet. Sci."},{"issue":"1\u20133","key":"10.1016\/j.vetpar.2012.02.011_bib0145","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jconrel.2004.07.009","article-title":"Polymer genomics: shifting the gene and drug delivery paradigms","volume":"101","author":"Kabanov","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0150","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1248\/bpb.28.316","article-title":"In vivo effects of cyclosporin A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 (CYP) 3A in rats","volume":"28","author":"Kageyama","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0155","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0924-8579(03)00221-8","article-title":"P-glycoprotein in helminths: function and perspectives for anthelmintic treatment and reversal of resistance","volume":"22","author":"Kerboeuf","year":"2003","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0160","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00436-002-0654-z","article-title":"Analysis and partial reversal of multidrug resistance to anthelmintics due to P-giycoprotein in Haemonchus contortus eggs using Lens culinaris lectin","volume":"88","author":"Kerboeuf","year":"2002","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0165","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.vetpar.2005.11.001","article-title":"Synergism of rotenone by piperonyl butoxide in Haemonchus contortus and Trichostrongylus colubriformis in vitro: potential for drug-synergism through inhibition of nematode oxidative detoxification pathways","volume":"136","author":"Kotze","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0170","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/bdd.2510130204","article-title":"Methimazole increases the plasma concentrations of the albendazole metabolites of netobimin in sheep","volume":"13","author":"Lanusse","year":"1992","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2011.12.033","article-title":"A computer simulation study to evaluate resistance development with a derquantel\u2013abamectin combination on UK sheep farms","author":"Learmount","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0180","doi-asserted-by":"crossref","unstructured":"Leathwick, D.M. Modelling the benefits of a new class of anthelmintic in combination. Vet. Parasitol., doi:10.1016\/j.vetpar.2011.11.050.","DOI":"10.1016\/j.vetpar.2011.11.050"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0185","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1126\/science.1075090","article-title":"Transcriptional regulatory networks in Saccharomyces cerevisiae","volume":"298","author":"Lee","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0190","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejps.2006.10.004","article-title":"Interaction of macrocyclic lactones with P-glycoprotein: structure\u2013affinity relationship","volume":"30","author":"Lespine","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0195","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pt.2008.03.011","article-title":"ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics","volume":"24","author":"Lespine","year":"2008","journal-title":"Trends Parasitol."},{"issue":"3\u20134","key":"10.1016\/j.vetpar.2012.02.011_bib0200","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.vetpar.2010.04.039","article-title":"Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep","volume":"172","author":"Lifschitz","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0205","first-page":"74","article-title":"P-glycoprotein modulation modifies ivermectin pharmacokinetics and its efficacy against resistant nematodes in lambs","volume":"32","author":"Lifschitz","year":"2009","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0210","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.exppara.2010.01.009","article-title":"Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin","volume":"125","author":"Lifschitz","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0215","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2885.2002.00396.x","article-title":"Loperamide-induced enhancement of moxidectin availability in cattle","volume":"25","author":"Lifschitz","year":"2002","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0220","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0022-2836(92)90855-E","article-title":"The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences","volume":"228","author":"Lincke","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0225","first-page":"947","article-title":"Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel Lack of prediction by the erythromycin breath test","volume":"22","author":"Lown","year":"1994","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0230","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nature02782","article-title":"Genomic analysis of regulatory network dynamics reveals large topological changes","volume":"431","author":"Luscombe","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0235","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1592\/phco.21.9.778.34558","article-title":"Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation","volume":"217","author":"Matheny","year":"2001","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0240","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1096\/fasebj.6.2.1371482","article-title":"Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture","volume":"6","author":"Maurice","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0245","series-title":"Manual of Veterinary Parasitological Laboratory Techniques","author":"Ministry of Agriculture Fisheries Food","year":"1986"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0250","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00436-003-1022-3","article-title":"Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep","volume":"92","author":"Molento","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0255","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s004360050673","article-title":"Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds Meriones unguiculatus","volume":"85","author":"Molento","year":"1999","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0260","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0020-7519(96)00125-7","article-title":"The response of breeding does to nematodiasis: segregation into \u201cresponders\u201d and \u201cnon-responders\u201d","volume":"26","author":"Patterson","year":"1996","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0265","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.2174\/092986706777585077","article-title":"Multidrug resistance: retrospect and prospects in anti-cancer drug treatment","volume":"1316","author":"P\u00e9rez-Tom\u00e1s","year":"2006","journal-title":"Curr. Med. Chem."},{"issue":"2\u20133","key":"10.1016\/j.vetpar.2012.02.011_bib0270","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.smallrumres.2010.05.010","article-title":"Influence of verapamil on pharmacokinetics and transplacental transfer of ivermectin in sheep Sm","volume":"93","author":"P\u00e9rez","year":"2010","journal-title":"Rum. Res."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0275","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0006-2952(96)00656-9","article-title":"Reversal of P-glycoprotein-associated multidrug resistance by ivermectin","volume":"53","author":"Pouliot","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0280","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1017\/S0031182007000091","article-title":"ABC transporters and beta-tubulin in macrocyclic lactone resistance: prospects for marker development","volume":"134","author":"Prichard","year":"2007","journal-title":"Parasitology"},{"issue":"5","key":"10.1016\/j.vetpar.2012.02.011_bib0285","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0169-4758(93)90141-2","article-title":"Occurrence, genetics and management of insecticide resistance","volume":"9","author":"Roush","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.vetpar.2012.02.011_bib0290","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1046\/j.1365-2125.1999.00999.x","article-title":"The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of R\/S-verapamil in humans","volume":"48","author":"Sandstr\u00f6m","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0295","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1002\/jps.21372","article-title":"Interactions of pluronic block copolymers on P-gp efflux activity: experience with HIV-1 protease inhibitors","volume":"97","author":"Shaik","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0300","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.addr.2009.11.019","article-title":"Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs","volume":"62","author":"Sharma","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0305","doi-asserted-by":"crossref","first-page":"7735","DOI":"10.1073\/pnas.84.21.7735","article-title":"Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues","volume":"84","author":"Thiebaut","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0310","unstructured":"Van Wyk, J.A., 2007. FAO-University of Pretoria Electronic Conference IV: Drugs in anthelmintic resistance management: to mix or not\/ sometimes to mix \u2013 that's the question. Available at: http:\/\/cnia.inta.gov.ar\/helminto\/Foro%2007\/pretoria.htm."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0315","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/vr.123.9.226","article-title":"Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa","volume":"123","author":"Van Wyk","year":"1988","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0320","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2885.2008.01006.x","article-title":"Inhibition of cytochrome P450 activity enhances the systemic availability of triclabendazole metabolites in sheep","volume":"32","author":"Virkel","year":"2009","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0325","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1124\/dmd.32.2.172","article-title":"Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics II. Use of ketoconazole to identify P-glycoprotein\/CYP3A-limited bioavailability in the monkey","volume":"32","author":"Ward","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0330","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.pt.2004.07.010","article-title":"Drug resistance in veterinary helminths","volume":"20","author":"Wolstenholme","year":"2004","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0335","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0166-6851(97)00215-6","article-title":"Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog","volume":"91","author":"Xu","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.02.011_bib0340","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/004982598239597","article-title":"Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes","volume":"283","author":"Zeng","year":"1998","journal-title":"Xenobiotica"}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401712000830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401712000830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T02:20:01Z","timestamp":1593742801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401712000830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":68,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0304401712000830"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2012.02.011","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}