{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:44:19Z","timestamp":1791009859752,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012164","name":"863 program","doi-asserted-by":"crossref","award":["2006AA10A207"],"award-info":[{"award-number":["2006AA10A207"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004775","name":"Gansu Natural Science Foundation","doi-asserted-by":"crossref","award":["1010RJZA002"],"award-info":[{"award-number":["1010RJZA002"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Project of Scientific and Technical Supporting program","award":["2007BAD40B03"],"award-info":[{"award-number":["2007BAD40B03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.vetpar.2012.12.055","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T15:43:17Z","timestamp":1357746197000},"page":"26-34","source":"Crossref","is-referenced-by-count":7,"title":["Cloning and characterization of a cathepsin L-like cysteine protease from Taenia pisiformis"],"prefix":"10.1016","volume":"194","author":[{"given":"Qiuxia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuenong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuepeng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2012.12.055_bib0005","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molbiopara.2007.07.021","article-title":"Cloning, site-directed mutagenesis and expression of cathepsin L-like cysteine protease from Uronema marinum (Ciliophora: Scuticociliatida)","volume":"156","author":"Ahn","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0010","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1017\/S0031182005007821","article-title":"Purification and characterization of a metacestode cysteine proteinase from Taenia solium involved in the breakdown of human IgG","volume":"131","author":"Baig","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2012.12.055_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3284308","article-title":"Proteinases secreted by Fasciola hepatica degrade extracellular matrix and basement membrane components","volume":"83","author":"Berasain","year":"1997","journal-title":"J. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/expr.1999.4479","article-title":"Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced","volume":"94","author":"Berasain","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0166-6851(01)00309-7","article-title":"Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity","volume":"116","author":"Cordova","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0030","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mcp.2008.11.003","article-title":"Cathepsin L-like genes of Trypanosoma vivax from Africa and South America \u2013 characterization, relationships and diagnostic implications","volume":"23","author":"Cortez","year":"2009","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.vetpar.2012.12.055_bib0035","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0020-7519(03)00171-1","article-title":"Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines","volume":"33","author":"Dalton","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0040","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijpara.2005.02.018","article-title":"Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition","volume":"35","author":"Dvo\u0159ak","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0045","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.molbiopara.2004.03.015","article-title":"A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling","volume":"136","author":"Guiliano","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0031182003004335","article-title":"A cathepsin F of adult Clonorchis sinensis and its phylogenetic conservation in trematodes","volume":"128","author":"Kang","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2012.12.055_bib0055","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1073\/pnas.90.7.3063","article-title":"Two distinct gene subfamilies within the family of cysteine protease genes","volume":"90","author":"Karrer","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0060","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3347\/kjp.2005.43.4.157","article-title":"Partial characterization of a 29kDa cysteine protease purified from Taenia solium metacestodes","volume":"43","author":"Kim","year":"2005","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.molbiopara.2008.05.001","article-title":"Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum","volume":"160","author":"Kongkerda","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0070","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.exppara.2006.09.011","article-title":"Leishmania aethiopica: identification and characterization of cathepsin L-like cysteine protease genes","volume":"115","author":"Kuru","year":"2007","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0075","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.vetpar.2006.05.015","article-title":"Identification and characterization of a cathepsin L-like cysteine protease from Taenia solium metacestode","volume":"141","author":"Li","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0080","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00436-009-1406-0","article-title":"Molecular cloning and analysis of stage and tissue-specific expression of cathepsin L-like protease from Clonorchis sinensis","volume":"105","author":"Li","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0085","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.molbiopara.2004.08.003","article-title":"RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting","volume":"138","author":"Lustigman","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/expr.2000.4490","article-title":"Taenia solium: a cysteine protease secreted by metacestodes depletes human CD4 lymphocytes in vitro","volume":"94","author":"Molinari","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0095","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.parint.2009.11.001","article-title":"Cathepsin B- and L-like cysteine protease activities during the in vitro development of Hysterothylacium aduncum (Nematoda: Anisakidae), a worldwide fish parasite","volume":"59","author":"Malag\u00f3n","year":"2010","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0100","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1462-5822.2006.00685.x","article-title":"Critical roles for excretory\u2013secretory cysteine proteases during tissue invasion of Paragonimus westermani newly excysted metacercariae","volume":"8","author":"Na","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.actatropica.2009.07.036","article-title":"Genes of cathepsin L-like proteases in Trypanosoma rangeli isolates: markers for diagnosis, genotyping and phylogenetic relationships","volume":"112","author":"Ortiz","year":"2009","journal-title":"Acta Trop."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0110","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.0141-9838.2001.00438.x","article-title":"Fasciola hepatica cathepsin L suppresses sheep lymphocyte proliferation in vitro and modulates surfaceCD4 expression on human and ovine T cells","volume":"24","author":"Prowse","year":"2002","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1179\/136485911X12987676649782","article-title":"A dot-ELISA using a partially purified cathepsin-L-like protein fraction from Taenia soliumcysticerci, for the diagnosis of human neurocysticercosis","volume":"105","author":"Pina","year":"2011","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0120","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.fsi.2007.10.015","article-title":"Molecular cloning and functional characterisation of a cathepsin L-like proteinase from the fish kinetoplastid parasite Trypanosoma carassii","volume":"24","author":"Ruszczyk","year":"2008","journal-title":"Fish Shellfish Immun"},{"key":"10.1016\/j.vetpar.2012.12.055_bib0125","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2307\/3284072","article-title":"Extracellularmatrix degradation by Haemonchus contortus","volume":"82","author":"Rhoads","year":"1996","journal-title":"J. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0130","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.parint.2010.03.002","article-title":"Cysteine proteases of Trypanosoma (Megatrypanum) theileri: cathepsin L-like gene sequences as targets for phylogenetic analysis, genotyping diagnosis","volume":"59","author":"Rodrigues","year":"2010","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(01)00438-8","article-title":"Cysteine proteases of parasitic organisms","volume":"120","author":"Sajid","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0140","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molbiopara.2007.04.016","article-title":"Cloning and characterization of cathepsin L-like peptidases of Echinococcus multilocularis metacestodes","volume":"154","author":"Sako","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0145","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00436-003-1008-1","article-title":"A cysteine protease from Taenia solium metacestodes induces apoptosis in human CD4+ T-cells","volume":"92","author":"Tato","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0150","doi-asserted-by":"crossref","first-page":"10838","DOI":"10.1074\/jbc.270.18.10838","article-title":"Processing of the papain precursor. The ionization state of a conserved amino acid motif within the Pro region participates in the regulation of intramolecular processing","volume":"270","author":"Vernet","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0166-6851(96)02839-3","article-title":"Characterization of a cysteine proteinase from Taenia crassiceps cysts","volume":"85","author":"White","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0160","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1271\/bbb.70741","article-title":"Purification and characterization of a cathepsin L-like enzyme from the body wall of the sea cucumber Stichopus japonicus","volume":"72","author":"Zhu","year":"2008","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.vetpar.2012.12.055_bib0165","doi-asserted-by":"crossref","first-page":"964","DOI":"10.4269\/ajtmh.2009.80.964","article-title":"Utility of a protein fraction with cathepsin L-like activity purified from cysticercus fluid of Taenia solium in the diagnosis of human cysticercosis","volume":"80","author":"Zimic","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401713000071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401713000071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T07:21:10Z","timestamp":1588836070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401713000071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0304401713000071"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2012.12.055","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}