{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:45:51Z","timestamp":1769089551577,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"crossref","award":["P502\/10\/0217"],"award-info":[{"award-number":["P502\/10\/0217"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","award":["SVV 267 004"],"award-info":[{"award-number":["SVV 267 004"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.vetpar.2013.03.018","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T02:00:48Z","timestamp":1364263248000},"page":"373-381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Biotransformation of albendazole and activities of selected detoxification enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics"],"prefix":"10.1016","volume":"196","author":[{"given":"Ivan","family":"Vok\u0159\u00e1l","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Jir\u00e1sko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Stuchl\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"B\u00e1rt\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbora","family":"Szot\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Lamka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00e1n","family":"V\u00e1rady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenka","family":"Sk\u00e1lov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2013.03.018_bib0005","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S0031182005007997","article-title":"Altered drug influx\/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes","volume":"131","author":"Alvarez","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2013.03.018_bib0010","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s004360100408","article-title":"In vitro metabolism of moxidectin in Haemonchus contortus adult stages","volume":"87","author":"Alvinerie","year":"2001","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0015","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2885.2009.01112.x","article-title":"Flubendazole metabolism and biotransformation enzymes activities in healthy sheep and sheep with haemonchosis","volume":"33","author":"B\u00e1rt\u00edkov\u00e1","year":"2010","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0020","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/00498254.2010.497565","article-title":"In vitro oxidative metabolism of xenobiotics in the lancet fluke (Dicrocoelium dendriticum) and the effects of albendazole and albendazole sulphoxide ex vivo","volume":"40","author":"B\u00e1rt\u00edkov\u00e1","year":"2010","journal-title":"Xenobiotica"},{"key":"10.1016\/j.vetpar.2013.03.018_bib0170","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.vetpar.2012.02.008","article-title":"Import and efflux of flubendazole in Haemonchus contortus strains susceptible and resistant to anthelmintics","volume":"187","author":"B\u00e1rt\u00edkov\u00e1","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yexmp.2007.01.009","article-title":"Understanding triclabendazole resistance","volume":"82","author":"Brennan","year":"2007","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0030","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0006-2952(94)90363-8","article-title":"Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver","volume":"48","author":"Burke","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0006-291X(81)91881-7","article-title":"Microsomal oxidation of thiobenzamide. A photometric assay for the flavin-containing monooxygenase","volume":"98","author":"Cashman","year":"1981","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0040","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.vetpar.2007.10.010","article-title":"Biotransformation of flubendazole and selected model xenobiotics in Haemonchus contortus","volume":"151","author":"Cvilink","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00216-008-1863-9","article-title":"LC\u2013MS\u2013MS identification of albendazole and flubendazole metabolites formed ex vivo by Haemonchus contortus","volume":"391","author":"Cvilink","year":"2008","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/03602530802602880","article-title":"Xenobiotic metabolizing enzymes and metabolism of anthelminthics in helminths","volume":"41","author":"Cvilink","year":"2009","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.rvsc.2008.05.006","article-title":"Phase I biotransformation of albendazole in lancet fluke (Dicrocoelium dendriticum)","volume":"86","author":"Cvilink","year":"2009","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0060","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s00436-010-1806-1","article-title":"Potentiation of triclabendazole sulphoxide-induced tegumental disruption by methimazole in a triclabendazole-resistant isolate of Fasciola hepatica","volume":"106","author":"Devine","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0065","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00436-010-1866-2","article-title":"Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole","volume":"107","author":"Devine","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0070","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0076-6879(81)77029-0","article-title":"Glutathione S-transferases (rat and human)","volume":"77","author":"Habig","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0075","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0020-7519(03)00012-2","article-title":"Catalase induction protects Haemonchus contortus against hydrogen peroxide in vitro","volume":"33","author":"Kotze","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0080","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/S0020-7519(01)00303-4","article-title":"Haemonchus contortus utilizes catalase in defense against exogenous hydrogen peroxide in vitro","volume":"31","author":"Kotze","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0085","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1042\/BJ20101346","article-title":"Characterization of the xenobiotic response of Caenorhabditis elegans to anthelmintic drug albendazole a the identification of novel drug glucoside metabolites","volume":"432","author":"Laing","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0090","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1248\/bpb1978.5.811","article-title":"Correlation of drug conjugative metabolism rates between in vivo and in vitro: glucuronidation and sulfation of p-nitrophenol as a model compound in rat","volume":"5","author":"Mizuma","year":"1982","journal-title":"J. Pharmacobiodyn."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0095","first-page":"160","article-title":"Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes","volume":"23","author":"Moroni","year":"1995","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0100","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/00498250400015285","article-title":"Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica","volume":"34","author":"Mottier","year":"2004","journal-title":"Xenobiotica"},{"key":"10.1016\/j.vetpar.2013.03.018_bib0105","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0031-9422(02)00146-2","article-title":"Ascorbic acid and flavonoid-peroxidase reaction as a detoxifying system of H2O2 in grapevine leaves","volume":"60","author":"P\u00e9rez","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.vetpar.2013.03.018_bib0110","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00436-003-1003-6","article-title":"The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica","volume":"92","author":"Robinson","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpara.2003.10.002","article-title":"Genetic analysis of inbreeding of two strains of the parasitic nematode Haemonchus contortus","volume":"34","author":"Roos","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0120","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0020-7519(96)00200-7","article-title":"Haemonchus contortus: the uptake and metabolism of closantel","volume":"27","author":"Rothwell","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0125","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/PL00008578","article-title":"Comparative metabolism of albendazole and albendazole sulphoxide by different helminth parasites","volume":"87","author":"Solana","year":"2001","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0130","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.molbiopara.2011.09.011","article-title":"Expression differential of microsomal and cytosolic glutathione S-transferases in Fasciola hepatica resistant at triclabendazole","volume":"181","author":"Scarella","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0135","series-title":"The Metabolism of Drug and Other Xenobiotics. Biochemistry of Redox Reactions","year":"1995"},{"key":"10.1016\/j.vetpar.2013.03.018_bib0140","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.actatropica.2007.08.005","article-title":"Glutathione transferases from parasites: a biochemical view","volume":"105","author":"Torres-Rivera","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0145","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/vr.123.9.226","article-title":"Resistance of field strains of Haemonchus contortus to ivermectin, closantel, rafoxanide and the benzimidazoles in South Africa","volume":"123","author":"Van Wyk","year":"1988","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0150","first-page":"147","article-title":"A technique for recovery of nematodes from ruminants by migration from gastro-intestinal ingesta gelled in agar: large-scale application","volume":"47","author":"Van Wyk","year":"1980","journal-title":"Onderstepoort J. Vet. Res."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0155","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1017\/S0031182012000595","article-title":"The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics","volume":"139","author":"Vok\u0159\u00e1l","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2013.03.018_bib0160","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0006-2952(94)90475-8","article-title":"A comparative study of constitutive and induced alkoxyresorufin O-dealkylation and individual cytochrome-P450 forms in cynomolgus monkey (Macaca fascicularis), human, mouse, rat and hamster liver-microsomes","volume":"47","author":"Weaver","year":"1994","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetpar.2013.03.018_bib0165","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0003-2697(03)00356-7","article-title":"Determination of the activity of catalase using a europium(III)-tetracycline-derived fluorescent substrate","volume":"320","author":"Wu","year":"2003","journal-title":"Anal. Biochem."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401713001635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401713001635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T10:08:08Z","timestamp":1564654088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401713001635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":34,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0304401713001635"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2013.03.018","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biotransformation of albendazole and activities of selected detoxification enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2013.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}