{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:17:39Z","timestamp":1778671059685,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"1-2","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.vetpar.2014.02.049","type":"journal-article","created":{"date-parts":[[2014,3,2]],"date-time":"2014-03-02T20:30:35Z","timestamp":1393792235000},"page":"120-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Accumulation of monepantel and its sulphone derivative in tissues of nematode location in sheep: Pharmacokinetic support to its excellent nematodicidal activity"],"prefix":"10.1016","volume":"203","author":[{"given":"A.","family":"Lifschitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ballent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Virkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sallovitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Viviani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Lanusse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2014.02.049_bib0005","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/dmd.105.007757","article-title":"Modulation of the p-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments","volume":"34","author":"Ballent","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0010","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.vetpar.2011.11.060","article-title":"Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate","volume":"186","author":"Baker","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0015","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vetpar.2010.06.013","article-title":"Multiple resistance of gastrointestinal nematodes to nine different drugs in a sheep flock in southern Brazil","volume":"173","author":"Cezar","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pt.2013.01.001","article-title":"New advancement in anthelmintic drugs in veterinary medicine","volume":"29","author":"Epe","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0025","series-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"key":"10.1016\/j.vetpar.2014.02.049_bib0030","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0169-4758(93)90232-5","article-title":"Pharmacokinetic disposition of benzimidazole drugs in the ruminant gastrointestinal tract","volume":"9","author":"Hennessy","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.vetpar.2014.02.049_bib0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.vetpar.2008.11.028","article-title":"Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep","volume":"160","author":"Hosking","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0040","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00436-009-1636-1","article-title":"A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep","volume":"106","author":"Hosking","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0045","series-title":"PhD Thesis","first-page":"115","article-title":"The control of gastro-intestinal nematodes in sheep with the amino-acetonitrile derivative, monepantel with a particular focus on Australia and New Zealand","author":"Hosking","year":"2010"},{"key":"10.1016\/j.vetpar.2014.02.049_bib0050","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature06722","article-title":"A new class of anthelmintics effective against drug-resistant nematodes","volume":"452","author":"Kaminsky","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.vetpar.2014.02.049_bib0055","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijpara.2008.09.009","article-title":"Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep","volume":"39","author":"Kaminsky","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0060","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.vetpar.2013.04.009","article-title":"Worms\u2014a license to kill","volume":"195","author":"Kaminsky","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0065","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetpar.2011.11.048","article-title":"An inconvenient truth: global warming and anthelmintic resistance","volume":"186","author":"Kaplan","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0070","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2885.2008.01052.x","article-title":"Pharmacokinetics of monepantel and its suphone metabolite, monepantel suphone, after intravenous and oral administrations in sheep","volume":"32","author":"Karadzovska","year":"2009","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0075","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1124\/dmd.30.6.626","article-title":"Intestinal secretion is a major route for parent ivermectin elimination in the rat","volume":"30","author":"Laffont","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0080","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1124\/dmd.104.003319","article-title":"Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP\/ABCG2)","volume":"33","author":"Merino.","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0085","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1124\/mol.110.066498","article-title":"Monepantel allosterically activates DEG-3\/DES-2 channels of the gastrointestinal nematode Haemonchus contortus","volume":"78","author":"Rufener","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0090","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vetpar.2008.10.006","article-title":"Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep","volume":"159","author":"Sager","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0095","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.vetpar.2010.02.011","article-title":"Quarantine treatment of sheep with monepantel\u2014rapidity of fecal egg count reduction","volume":"170","author":"Sager","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0100","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vetpar.2013.07.037","article-title":"Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis","volume":"198","author":"Scott","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0105","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00216-012-6584-4","article-title":"Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC\/MS\/MS","volume":"405","author":"Stuchl\u00edkov\u00e1","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.vetpar.2014.02.049_bib0110","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pt.2010.11.008","article-title":"Anthelmintic resistance in nematode parasites of cattle: a global issue?","volume":"27","author":"Sutherland","year":"2011","journal-title":"Trends Parasitol."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030440171400137X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030440171400137X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T22:47:22Z","timestamp":1597531642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030440171400137X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":22,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S030440171400137X"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2014.02.049","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accumulation of monepantel and its sulphone derivative in tissues of nematode location in sheep: Pharmacokinetic support to its excellent nematodicidal activity","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2014.02.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}