{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:10:47Z","timestamp":1762161047349},"reference-count":18,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T00:00:00Z","timestamp":1397433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.vetpar.2014.04.002","type":"journal-article","created":{"date-parts":[[2014,4,13]],"date-time":"2014-04-13T12:31:12Z","timestamp":1397392272000},"page":"270-275","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["The susceptibility of Trypanosoma congolense and Trypanosoma brucei to isometamidium chloride and its synthetic impurities"],"prefix":"10.1016","volume":"203","author":[{"given":"Annelise","family":"Sahin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Asencio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Izotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davita","family":"Pillay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Coustou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamadi","family":"Karembe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u00e9o","family":"Baltz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2014.04.002_bib0005","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/j.1460-2075.1985.tb03772.x","article-title":"Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense","volume":"4","author":"Baltz","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0010","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1039\/jr9630003635","article-title":"The search for new trypanocides. Part VIII. Coupling of m-amidinobenzenediazonium chloride with 3,8-diamino-5-ethyl-6-phenylphenanthridinium chloride","volume":"684","author":"Berg","year":"1963","journal-title":"J. Chem. Soc. (Resumed)"},{"key":"10.1016\/j.vetpar.2014.04.002_bib0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0001-706X(02)00188-2","article-title":"Metabolism and distribution of phenanthridine trypanocides in Trypanosoma brucei","volume":"84","author":"Boibessot","year":"2002","journal-title":"Acta Trop."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0020","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1476-5381.1961.tb01125.x","article-title":"Anti-trypanosomal activity of certain phenyldiazoamino- and phenylazoamino-phenanthridinium compounds","volume":"17","author":"Brown","year":"1961","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0025","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1371\/journal.pntd.0000618","article-title":"Complete in vitro life cycle of Trypanosoma congolense: development of genetic tools","volume":"4","author":"Coustou","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0030","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pt.2008.02.006","article-title":"Molecular tools for the rapid detection of drug resistance in animal trypanosomes","volume":"24","author":"Delespaux","year":"2008","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0035","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1128\/AAC.42.5.1012","article-title":"Field evaluation of the prophylactic effect of an isometamidium sustained-release device against trypanosomiasis in cattle","volume":"42","author":"Diarra","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-4017(01)00415-0","article-title":"Standardised tests in mice and cattle for the detection of drug resistance in tsetse-transmitted trypanosomes of African domestic cattle","volume":"97","author":"Eisler","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0001-706X(93)90043-B","article-title":"Drug sensitivity screening in vitro of populations of Trypanosoma congolense originating from cattle and tsetse flies at Nguruman, Kenya","volume":"55","author":"Gray","year":"1993","journal-title":"Acta Trop."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0001-706X(93)90101-G","article-title":"An in vitro assay for drug sensitivity of Trypanosoma congolense using in vitro-derived metacyclic trypanosomes","volume":"54","author":"Gray","year":"1993","journal-title":"Acta Trop."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0055","first-page":"52","article-title":"Axenic culture of Trypanosoma congolense: application to the detection of sensitivity levels of bloodstream trypomastigotes to diminazene aceturate, homidium chloride, isometamidium chloride and quinapyramine sulphate","volume":"3","author":"Hirumi","year":"1993","journal-title":"J. Protozool. Res."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0060","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s004360050346","article-title":"Susceptibility of dyskinetoplastic Trypanosoma evansi and T. equiperdum to isometamidium chloride","volume":"83","author":"Kaminsky","year":"1997","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2885.1988.tb00148.x","article-title":"The pharmacology of isometamidium","volume":"11","author":"Kinabo","year":"1988","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-4017(88)90018-0","article-title":"Factors influencing the duration of isometamidium chloride (Samorin) prophylaxis against experimental challenge with metacyclic forms of Trypanosoma congolense","volume":"28","author":"Peregrine","year":"1988","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpba.2007.08.026","article-title":"Development and validation of an improved HPLC method for the control of potentially counterfeit isometamidium products","volume":"46","author":"Schad","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0731-7085(99)00110-7","article-title":"Investigation of the chemical equivalence of the trypanocidal products, Samorin and Veridium","volume":"21","author":"Tettey","year":"1999","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.vetpar.2014.04.002_bib0085","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.pt.2009.07.007","article-title":"Surprising variety in energy metabolism within Trypanosomatidae","volume":"25","author":"Tielens","year":"2009","journal-title":"Trends Parasitol."},{"issue":"Pt 3","key":"10.1016\/j.vetpar.2014.04.002_bib0090","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1042\/bj3260755","article-title":"Modulation of mitochondrial electrical potential: a candidate mechanism for drug resistance in African trypanosomes","volume":"326","author":"Wilkes","year":"1997","journal-title":"Biochem. J."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401714002118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401714002118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T13:33:46Z","timestamp":1565357626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401714002118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":18,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0304401714002118"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2014.04.002","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The susceptibility of Trypanosoma congolense and Trypanosoma brucei to isometamidium chloride and its synthetic impurities","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2014.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}