{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:30:49Z","timestamp":1762079449981,"version":"3.40.5"},"reference-count":48,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005672","name":"FUNDECT","doi-asserted-by":"crossref","award":["0134\/09"],"award-info":[{"award-number":["0134\/09"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.vetpar.2014.08.002","type":"journal-article","created":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T05:46:39Z","timestamp":1408340799000},"page":"638-645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["P-gp modulating drugs greatly potentiate the in vitro effect of ivermectin against resistant larvae of Haemonchus placei"],"prefix":"10.1016","volume":"205","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1595-4213","authenticated-orcid":false,"given":"R.P.","family":"Heckler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.D.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.B.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.G.L.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.L.","family":"Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.K.V.","family":"Onizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.A.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2014.08.002_bib0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.vetpar.2012.08.012","article-title":"Ivermectin and moxidectin resistance characterization by larval migration inhibition test in field isolates of Cooperia spp. in beef cattle, Mato Grosso do Sul, Brazil","volume":"191","author":"Almeida","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.vetpar.2008.06.017","article-title":"Ketokonazole increases the plasma levels of ivermectin in sheep","volume":"157","author":"Alvinerie","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0015","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.vetpar.2004.05.018","article-title":"Resistance to benzimidazole and macrocyclic lactone anthelmintics in cattle nematodes in Argentina","volume":"122","author":"Anziani","year":"2004","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2013.02.008","article-title":"Transport proteins of the ABC systems superfamily and their role in drug action and resistance in nematodes","author":"Ardelli","year":"2013","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vetpar.2012.09.021","article-title":"Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin","volume":"191","author":"Ardelli","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0030","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.vetpar.2012.07.011","article-title":"Dexamethasone treatment interferes with the pharmacokinetics of ivermectin in young cattle","volume":"190","author":"Areskog","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0040","first-page":"36","article-title":"Implicancias fisio-farmacol\u00f3gicas de La glicoprote\u00edna-P en animales dom\u00e9sticos","volume":"25","author":"Ballent","year":"2005","journal-title":"Analecta Vet."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0045","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-2885.2009.01129.x","article-title":"Pretreatment with the inducers rifampicin and phenobarbital alters ivermectin gastrointestinal disposition","volume":"33","author":"Ballent","year":"2009","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0050","first-page":"9","article-title":"Revers\u00e3o fenot\u00edpica da resist\u00eancia \u00e0 ivermectina em isolado de campo de Haemonchus contortus pelo verapamil","volume":"31","author":"Borges","year":"2011","journal-title":"Pesq. Vet. Bras."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0055","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3390\/molecules15020857","article-title":"Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin","volume":"15","author":"Borska","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.vetpar.2014.08.002_bib0060","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1002\/j.1460-2075.1995.tb07178.x","article-title":"A P-glycoprotein protects Caenohabditis elegans against natural toxins","volume":"14","author":"Broeks","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0065","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/dbio.1999.9398","article-title":"Cystic canal mutants in Caenorhabditis elegans are detective in apical membrane domain of the renal (excretory) cell","volume":"214","author":"Buechner","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0070","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1128\/AAC.15.3.361","article-title":"Avermectins, new family of potent anthelmintic agents: producing organism and fermentation","volume":"15","author":"Burg","year":"1979","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.vetpar.2014.08.002_bib0075","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.vetpar.2011.07.029","article-title":"Prevalence of cattle herds with ivermectin resistant nematodes in the hot sub-humid tropics of Mexico","volume":"183","author":"Canul-Ku","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0079","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0304-4017(92)90141-U","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance","volume":"44","author":"Coles","year":"1992","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0304-4017(95)00807-1","article-title":"In vitro screening of Haemonchus contortus third stage larvae for ivermectin resistance","volume":"61","author":"D\u2018Assonville","year":"1996","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0085","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.vetpar.2010.08.020","article-title":"Standartization of larval migration inhibition test for the detection of resistance to ivermectin in gastro intestinal nematodes of ruminants","volume":"174","author":"Demeler","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0090","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molbiopara.2013.01.004","article-title":"Potential contribution of P-glycoprotein to macrocyclic lactone resistance in the cattle parasitic nematode Cooperia oncophora","volume":"188","author":"Demeler","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0095","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2885.2006.00780.x","article-title":"Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes","volume":"29","author":"Dupuy","year":"2006","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0100","series-title":"Resist\u00eancia a anti-helm\u00ednticos em nematodas gastrintestinais de bovinos de corte, no Mato Grosso do Sul, Brasil","first-page":"51","author":"Feliz","year":"2011"},{"key":"10.1016\/j.vetpar.2014.08.002_bib0105","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejphar.2011.03.023","article-title":"Reversal effect of two new milbemycin compounds on multidrug resistance in MSF-7\/adr cells in vitro","volume":"659","author":"Gao","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-4017(91)90126-G","article-title":"Pathophisiology of Haemonchus placei infection in calves","volume":"38","author":"Gennari","year":"1991","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0115","first-page":"6901","article-title":"Reversal by cefoperazone of resistance to etoposide, doxorubicin, and vinblastine in multidrug resistant human sarcoma cells","volume":"49","author":"Gosland","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0120","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1590\/S0100-40422010001000027","article-title":"Glicoprote\u00edna-P, resist\u00eancia \u00e0 m\u00faltiplas drogas (MDR) e rela\u00e7\u00e3o estrutura-atividade de moduladores","volume":"33","author":"Huber","year":"2010","journal-title":"Quim. Nova."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetpar.2011.11.048","article-title":"An inconvenient truth: global worming and anthelmintic resistance","volume":"186","author":"Kaplan","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0130","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1248\/bpb.28.2274","article-title":"Structure\u2013activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells","volume":"28","author":"Kitagawa","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0135","first-page":"58","article-title":"P-glycoprotein on other multidrug resistance transporters in the pharmacology of anthelmintics: prospects for reversing transport-dependent anthelmintic resistance","volume":"2","author":"Lespine","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0140","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.vetpar.2010.04.039","article-title":"Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep","volume":"172","author":"Lifschitz","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0145","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.exppara.2010.01.009","article-title":"Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin","volume":"125","author":"Lifschitz","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0150","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00003088-200342010-00003","article-title":"Role of P-glycoprotein in pharmacokinetics: clinical implications","volume":"42","author":"Lin","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0160","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/j.1460-2075.1993.tb05806.x","article-title":"The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans in confined to intestinal cells","volume":"12","author":"Lincke","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0155","first-page":"20","article-title":"Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes, impact of drug treatment on parasite P-glycoprotein expression","volume":"3","author":"Lloberas","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0165","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.cbi.2013.03.009","article-title":"Avermectin induces P-glycoprotein expression in S2 cells via the calcium\/calmodulin\/NF-kB pathway","volume":"203","author":"Luo","year":"2013","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-0773.1999.tb00887.x","article-title":"Cyclosporin A and trifluoperazine, two resistance-modulating agents, increase ivermectin neurotoxicity in mice","volume":"84","author":"Marques-Santos","year":"1999","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0175","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2885.2004.00607.x","article-title":"Therapeutic implications of the MDR-1 gene","volume":"27","author":"Mealey","year":"2004","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0180","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bcp.2011.10.010","article-title":"Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line","volume":"83","author":"M\u00e9nez","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0185","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1590\/S0100-736X2001000300004","article-title":"Effect of multidrug resistance modulators on the activity of ivermectin and moxidectin against selected strains of Haemonchus contortus infective larvae","volume":"21","author":"Molento","year":"2001","journal-title":"Pesq. Vet. Bras."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0190","first-page":"74","article-title":"Bases moleculares de la resistencia a f\u00e1rmacos antihelm\u00ednticos","volume":"82","author":"Mottier","year":"2001","journal-title":"Ver. Med. Vet."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0195","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exppara.2004.03.007","article-title":"Haemonchus contortus: in vitro drug screening assays with the adult life stage","volume":"106","author":"\u00d3Grady","year":"2004","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0200","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1071\/AR9500099","article-title":"Methods for egg counts and larval cultures for strongyles infesting the gastrointestinal tract of cattle","volume":"1","author":"Roberts","year":"1950","journal-title":"Aust. J. Agric. Res."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0205","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.addr.2012.09.027","article-title":"Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview","volume":"64","author":"Schinkel","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0210","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.vetpar.2007.06.023","article-title":"Anthelmintic resistance in cattle nematodes in northwestern S\u00e3o Paulo State, Brazil","volume":"148","author":"Soutello","year":"2007","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0215","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1590\/S0103-84782008000500026","article-title":"Resist\u00eancia de helmintos gastrintestinais de bovinos a anti-helm\u00ednticos no Planalto Catarinense","volume":"38","author":"Souza","year":"2008","journal-title":"Cienc. Rural"},{"key":"10.1016\/j.vetpar.2014.08.002_bib0220","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0169-409X(02)00006-6","article-title":"Progress in understanding the structure\u2013activity relationships of P-glycoprotein","volume":"54","author":"Stouch","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0225","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pt.2010.11.008","article-title":"Anthelmintic resistance in nematode parasites of cattle: a global issue?","volume":"27","author":"Sutherland","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0230","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1080\/00498250802499467","article-title":"Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models","volume":"38","author":"Taur","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1016\/j.vetpar.2014.08.002_bib0235","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s00436-011-2378-4","article-title":"The role of Brugia malayi ATP-binding cassette (ABC) transporters in potentiating drug sensitivity","volume":"109","author":"Tompkins","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2014.08.002_bib0240","doi-asserted-by":"crossref","first-page":"103","DOI":"10.32635\/2176-9745.RBC.2003v49n2.2112","article-title":"Ciclosporina A e seus an\u00e1logos como reversores da resist\u00eancia a m\u00faltiplas drogas em c\u00e9lulas tumorais","volume":"49","author":"Wagner-Souza","year":"2003","journal-title":"Rev. Bras. Cancerol."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401714004397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401714004397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T22:49:11Z","timestamp":1649976551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401714004397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":48,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0304401714004397"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2014.08.002","relation":{},"ISSN":["0304-4017"],"issn-type":[{"type":"print","value":"0304-4017"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P-gp modulating drugs greatly potentiate the in vitro effect of ivermectin against resistant larvae of Haemonchus placei","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2014.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}