{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:33:16Z","timestamp":1787311996701,"version":"build-2736575974"},"reference-count":19,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.vetpar.2014.08.018","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T05:28:20Z","timestamp":1409549300000},"page":"48-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Evaluation of C-reactive protein as a clinical biomarker in naturally heartworm-infected dogs: A field study"],"prefix":"10.1016","volume":"206","author":[{"given":"Luigi","family":"Venco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Bertazzolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Paltrinieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2014.08.018_bib0005","series-title":"Veterinary Echocardiography","first-page":"335","article-title":"Hypertensive heart disease","year":"2011"},{"key":"10.1016\/j.vetpar.2014.08.018_bib0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1939-165X.2005.tb00019.x","article-title":"Acute phase proteins in dogs and cats: current knowledge and future perspectives","volume":"34","author":"Ceron","year":"2005","journal-title":"Vet. Clin. Pathol."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0015","series-title":"Canine and Feline Cardiology","first-page":"519","article-title":"Canine heartworm disease","author":"Calvert","year":"1988"},{"key":"10.1016\/j.vetpar.2014.08.018_bib0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1258\/000456307780118127","article-title":"Evidence-based laboratory medicine \u2013 a guide for critical evaluation of in vitro laboratory testing","volume":"44","author":"Christenson","year":"2007","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0025","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1892\/0891-6640(2003)017<0315:SNANID>2.3.CO;2","article-title":"Serum nitrate and nitrite in dogs with spontaneous cardiac disease","volume":"17","author":"de Laforcade","year":"2003","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0030","series-title":"Proceedings of the Heartworm Symposium \u201895","first-page":"97","article-title":"Pulmonary parenchymal changes in dogs and cats after experimental transplantation of dead Dirofilaria immitis","author":"Dillon","year":"1995"},{"key":"10.1016\/j.vetpar.2014.08.018_bib0035","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1939-165X.2006.tb00082.x","article-title":"Receiver-operating characteristic curves and likelihood ratios: improvements over traditional methods for the evaluation and application of veterinary clinical pathology tests","volume":"35","author":"Gardner","year":"2006","journal-title":"Vet. Clin. Pathol."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0040","first-page":"A2661","article-title":"C-reactive protein as a biomarker in pulmonary arterial hypertension","volume":"179","author":"Heresi","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0065-308X(08)00204-2","article-title":"Heartworm disease in animals and humans","volume":"66","author":"McCall","year":"2008","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0050","series-title":"Textbook of Veterinary Internal Medicine","first-page":"1284","article-title":"Pulmonary hypertension and pulmonary thromboembolism","author":"MacDonald","year":"2005"},{"key":"10.1016\/j.vetpar.2014.08.018_bib0055","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.vetimm.2006.10.004","article-title":"Dogs with patent Dirofilaria immitis infection have higher expression of circulating IL-4, IL-10 and iNOS mRNA than those with occult infection","volume":"15","author":"Morch\u00f3n","year":"2007","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0060","first-page":"99","article-title":"Pulmonary hypertension and cardiovascular sequelae in 54 dogs","volume":"2","author":"Pyle","year":"2004","journal-title":"Int. J. Appl. Res. Vet. Med."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0065","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jacc.2008.12.038","article-title":"C-reactive protein: a new predictor of adverse outcome in pulmonary arterial hypertension","volume":"7","author":"Quarck","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0070","series-title":"Guide to Vector Borne Diseases of Pets","article-title":"Dirofilariosis of dogs and cats","author":"Rinaldi","year":"2013"},{"key":"10.1016\/j.vetpar.2014.08.018_bib0075","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1292\/jvms.54.739","article-title":"Relationship between pulmonary arterial pressure and lesions in the pulmonary arteries and parenchyma, and cardiac valves in canine dirofilariasis","volume":"54","author":"Sasaki","year":"1992","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0080","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.2460\/ajvr.1980.41.07.1082","article-title":"Pulmonary vascular response during phases of canine heartworm disease: scanning electron microscopic study","volume":"4","author":"Schaub","year":"1980","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0085","series-title":"Textbook of Canine and Feline Cardiology, Principles and Clinical Practice","first-page":"581","article-title":"Myocardial diseases of dogs","author":"Sisson","year":"1999"},{"key":"10.1016\/j.vetpar.2014.08.018_bib0090","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1292\/jvms.67.1155","article-title":"Elevated endotelin-1 expression in dogs with heartworm disease","volume":"67","author":"Uchide","year":"2005","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.vetpar.2014.08.018_bib0095","series-title":"Recent Advances in Heartworm Disease Symposium \u201801","first-page":"111","article-title":"Relative utility of echocardiography, radiography, serologic testing and microfilarie counts to predict adult worm burden in dogs naturally infected with heartworm","author":"Venco","year":"2001"}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401714004713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401714004713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T08:19:33Z","timestamp":1746346773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401714004713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":19,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0304401714004713"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2014.08.018","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of C-reactive protein as a clinical biomarker in naturally heartworm-infected dogs: A field study","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2014.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}