{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:40:38Z","timestamp":1771915238044,"version":"3.50.1"},"reference-count":98,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.vetpar.2015.07.015","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T02:39:00Z","timestamp":1437532740000},"page":"35-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Basic and clinical pharmacology contribution to extend anthelmintic molecules lifespan"],"prefix":"10.1016","volume":"212","author":[{"given":"Carlos","family":"Lanusse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Lifschitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2015.07.015_bib0005","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1124\/dmd.107.019430","article-title":"Comparative disposition and metabolism of paraherquamide in sheep, gerbils and dogs","volume":"36","author":"Aloysius","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0010","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S0031182005007997","article-title":"Altered drug influx\/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes","volume":"131","author":"Alvarez","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0015","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-2885.2008.00953.x","article-title":"Evaluation of the interaction between ivermectin and albendazole following their combined use in lambs","volume":"31","author":"Alvarez","year":"2008","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.vetpar.2015.03.001","article-title":"Integrated assessment of ivermectin pharmacokinetics, efficacy against resistant Haemonchus contortus and P-glycoprotein expression in lambs treated at three different dosage levels","volume":"210","author":"Alvarez","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.vetpar.2008.06.017","article-title":"Ketoconazole increases the plasma levels of ivermectin in sheep","volume":"157","author":"Alvinerie","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1751-0813.1988.tb07355.x","article-title":"Mixtures of anthelmintics: a strategy against resistance","volume":"65","author":"Anderson","year":"1988","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1751-0813.1991.tb03155.x","article-title":"Field evaluation of a mixture of albendazole sulphoxide and levamisole against Ostertagia and Trichostrongylus spp. in sheep","volume":"68","author":"Anderson","year":"1991","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0040","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.vetpar.2011.11.060","article-title":"Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate","volume":"186","author":"Baker","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0045","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/dmd.105.007757","article-title":"Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments","volume":"34","author":"Ballent","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0050","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2885.2007.00848.x","article-title":"Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition","volume":"30","author":"Ballent","year":"2007","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0169-4758(95)80117-0","article-title":"Worm control and anthelmintic resistance: adventures with a model","volume":"11","author":"Barnes","year":"1995","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0060","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.vetpar.2011.11.068","article-title":"Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the beta-tubulin isotype 1 encoding gene in Haemonchus contortus","volume":"186","author":"Barr\u00e8re","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0065","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1017\/S0031182009990345","article-title":"P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus","volume":"136","author":"Bartley","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0070","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.vetpar.2012.02.011","article-title":"Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate","volume":"187","author":"Bartley","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0075","first-page":"35","article-title":"A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris spp.","volume":"81","author":"Belizario","year":"2003","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0080","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.2042-7158.1996.tb03965.x","article-title":"Interaction between fenbendazole and piperonyl butoxide: pharmacokinetic and pharmacodynamic implications","volume":"48","author":"Benchaoui","year":"1996","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0085","series-title":"Proceedings of the XVIII Congresso Brasileiro de Parasitologia Veterin\u00e1ria","article-title":"Evaluation of the combined use of ivermectin and ricobendazole in cattle: pharmacokinetic and\/or pharmacodynamic interactions","author":"Canton","year":"2014"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0090","series-title":"Proceedings of the 25th International Conference of the World Association for the Advancement of Veterinary Parasitology","article-title":"Assessment of the ricobendazole plus levamisole nematodicidal combination in cattle","author":"Canton","year":"2015"},{"issue":"1","key":"10.1016\/j.vetpar.2015.07.015_bib0095","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1746-6148-6-8","article-title":"Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes","volume":"6","author":"Ceballos","year":"2010","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2885.2006.00738.x","article-title":"Pharmacokinetics of a novel closantel\/ivermectin injection in cattle","volume":"29","author":"Cromie","year":"2006","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0105","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0165-6147(83)90490-X","article-title":"Analysis of combined drug effects: a new look at a very old problem","volume":"4","author":"Chou","year":"1983","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0110","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molbiopara.2013.01.004","article-title":"Potential contribution of P-glycoproteins to macrocyclic lactone resistance in the cattle parasitic nematode Cooperia oncophora","volume":"188","author":"Demeler","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0031182008005222","article-title":"Effect of the metabolic inhibitor, methimazole on the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica","volume":"136","author":"Devine","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0125","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1017\/S0031182010001125","article-title":"Piperonyl butoxide enhance triclabendazole action against triclabendazole-resistant Fasciola hepatica","volume":"138","author":"Devine","year":"2011","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0130","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.vetpar.2011.08.006","article-title":"Potentiation of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica following its co-administration with the metabolic inhibitor, ketoconazole","volume":"84","author":"Devine","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0135","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/j.1751-0813.2001.tb10892.x","article-title":"Principles of use of macrocyclic lactones to minimise selection for resistance","volume":"79","author":"Dobson","year":"2001","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0140","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0304-4017(03)00008-6","article-title":"Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin","volume":"112","author":"Dupuy","year":"2003","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0145","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.vetpar.2008.04.015","article-title":"Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes","volume":"155","author":"Entrocasso","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0150","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pt.2013.01.001","article-title":"New advancement in anthelmintic drugs in veterinary medicine","volume":"29","author":"Epe","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0155","series-title":"Committee for Medicinal Products for Veterinary use (CVMP), Guideline on Pharmaceutical Fixed Combination Products, EMEA\/CVMP\/83804\/2005","author":"EMEA (European Medicines Agency)","year":"2006"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0160","series-title":"European Public MRL Assessment Report, Committee for Medicinal Products for Veterinary Use, EMEA\/CVMP\/529651\/2009","author":"EMEA (European Medicines Agency)","year":"2010"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0165","series-title":"Derquantel. Evaluations of the Joint FAO\/WHO Expert Committee on Food Additives (JECFA)","first-page":"1","author":"Friedlander","year":"2012"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0170","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.vetpar.2012.09.004","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: anthelmintic combination products targeting nematode infections of ruminants and horses","volume":"190","author":"Geary","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0175","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.vetpar.2012.03.001","article-title":"The comparative efficacy of abamectin, monepantel and an abamectin\/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep","volume":"188","author":"George","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0180","first-page":"635","article-title":"The employment of combinations of drugs in the chemotherapy of neoplasia: a review","volume":"17","author":"Goldin","year":"1957","journal-title":"Cancer Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0185","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.tiv.2013.12.015","article-title":"A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides","volume":"28","author":"Halwachs","year":"2014","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0190","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0169-4758(93)90232-5","article-title":"Pharmacokinetic disposition of benzimidazole drugs in the ruminant gastrointestinal tract","volume":"9","author":"Hennessy","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0195","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.vetpar.2008.11.028","article-title":"Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep","volume":"160","author":"Hosking","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0200","series-title":"The Control of Gastro-Intestinal Nematodes in Sheep With the Amino-Acetonitrile Derivative, Monepantel With a Particular Focus on Australia and New Zealand","first-page":"115","author":"Hosking","year":"2010"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0205","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/vr.b4830","article-title":"Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep","volume":"166","author":"Hosking","year":"2010","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0210","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature06722","article-title":"A new class of anthelmintics effective against drug-resistant nematodes","volume":"452","author":"Kaminsky","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0215","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijpara.2008.09.009","article-title":"Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep","volume":"39","author":"Kaminsky","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0220","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00436-010-2216-0","article-title":"Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep","volume":"109","author":"Kaminsky","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0225","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.vetpar.2013.04.009","article-title":"Worms-a \u201clicense to kill\u201d","volume":"195","author":"Kaminsky","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0230","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2885.2008.01052.x","article-title":"Pharmacokinetics of monepantel and its suphone metabolite, monepantel suphone, after intravenous and oral administrations in sheep","volume":"32","author":"Karadzovska","year":"2009","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0235","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0240","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-308X(10)73008-6","article-title":"The drugs we have and the drugs we need against major helminth infections","volume":"73","author":"Keiser","year":"2010","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0245","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/1756-3305-5-292","article-title":"Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo","volume":"5","author":"Keiser","year":"2012","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0250","doi-asserted-by":"crossref","first-page":"e2119","DOI":"10.1371\/journal.pntd.0002119","article-title":"Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug","volume":"7","author":"Keiser","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0255","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00436-002-0654-z","article-title":"Analysis and partial reversal of multidrug resistance to anthelmintics due to P-glycoprotein in Haemonchus contortus eggs using Lens culinaris lectin","volume":"88","author":"Kerboeuf","year":"2002","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0260","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1086\/657310","article-title":"Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial","volume":"51","author":"Knopp","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0265","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1124\/dmd.30.6.626","article-title":"Intestinal secretion is a major route for parent ivermectin elimination in the rat","volume":"30","author":"Laffont","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0270","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/00498259209053108","article-title":"Effects of methimazole on the kinetics of netobimin metabolites in cattle","volume":"22","author":"Lanusse","year":"1992","journal-title":"Xenobiotica"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0275","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.vetpar.2013.11.003","article-title":"Pharmacological knowledge and sustainable anthelmintic therapy in ruminants","volume":"204","author":"Lanusse","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0280","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.vetpar.2011.12.033","article-title":"A computer simulation study to evaluate resistance development with a derquantel-abamectin combination on UK sheep farms","volume":"187","author":"Learmount","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0285","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/00480169.2009.36900","article-title":"Managing anthelmintic resistance: is it feasible in New Zealand to delay the emergence of resistance to a new anthelmintic class?","volume":"57","author":"Leathwick","year":"2009","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0295","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2174\/1568026023393705","article-title":"Marcfortine and paraherquamide class of anthelmintics: discovery of PNU-141962","volume":"2","author":"Lee","year":"2002","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0300","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijpddr.2011.10.001","article-title":"P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: prospects for reversing transport-dependent anthelmintic resistance","volume":"2","author":"Lespine","year":"2012","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0305","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2885.2002.00396.x","article-title":"Loperamide-induced enhancement of moxidectin availability in cattle","volume":"25","author":"Lifschitz","year":"2002","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0310","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.exppara.2010.01.009","article-title":"Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin","volume":"125","author":"Lifschitz","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0315","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.vetpar.2010.04.039","article-title":"Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep","volume":"172","author":"Lifschitz","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0320","doi-asserted-by":"crossref","first-page":"912","DOI":"10.2174\/138920112800399211","article-title":"Macrocyclic lactones and cellular transport-related drug interactions. A perspective from in vitro assays to nematode control in the field","volume":"13","author":"Lifschitz","year":"2012","journal-title":"Curr. Pharmacol. Biotech."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0325","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.vetpar.2014.02.049","article-title":"Accumulation of monepantel and its sulphone derivative in tissues of nematode location in sheep-pharmacokinetic support to its excellent nematodicidal activity","volume":"203","author":"Lifschitz","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0330","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0169-409X(02)00171-0","article-title":"Drug\u2013drug interaction mediated by inhibition and induction of P-glycoprotein","volume":"55","author":"Lin","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0335","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.vetpar.2011.05.008","article-title":"Efficacy of a combined oral formulation of derquantel-abamectin against the adult and larval stages of nematodes in sheep, including anthelmintic-resistant strains","volume":"181","author":"Little","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0340","first-page":"1","article-title":"Comparative pharmacokinetic and efficacy assessments of single and double ivermectin and moxidectin doses in nematode-infected lambs","volume":"17","author":"Lloberas","year":"2015","journal-title":"N. Z. Vet."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0345","series-title":"Proceedings of the 25th International Conference of the World Association for the Advancement of Veterinary Parasitology","article-title":"Pharmacological evaluation of a 5-fold incremented dosage of the ivermectin+fenbendazole combination against highly resistant Haemonchus contortus in lambs","author":"Luque","year":"2015"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0350","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1186\/s13071-014-0598-z","article-title":"First report of monepantel Haemonchus contortus resistance on sheep farms in Uruguay","volume":"7","author":"Mederos","year":"2014","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0355","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00436-003-0923-5","article-title":"A light and electron microscopic study on the synergistic effect of pyrantel and the febantel metabolite febendazole on adult Toxocara canis in vitro","volume":"90","author":"Mehlhorn","year":"2003","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0360","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1124\/dmd.104.003319","article-title":"Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP\/ABCG2)","volume":"33","author":"Merino","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0365","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0921-4488(95)00761-X","article-title":"Use of anthelmintic combinations against multiple resistant Haemonchus contortus in Angora goats","volume":"19","author":"Miller","year":"1996","journal-title":"Small Rumin. Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0370","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00436-003-1022-3","article-title":"Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep","volume":"92","author":"Molento","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0375","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.exppara.2004.03.003","article-title":"Dose-dependent activity of albendazole against benzimidazole-resistant nematodes in sheep: relationship between pharmacokinetics and efficacy","volume":"106","author":"Moreno","year":"2004","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0380","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1645\/GE-922R.1","article-title":"Resistance induced changes on triclabendazole transport in Fasciola hepatica: ivermectin reversal effect","volume":"92","author":"Mottier","year":"2006","journal-title":"J. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0385","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.trstmh.2011.07.009","article-title":"Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda","volume":"105","author":"Namwanje","year":"2011","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0390","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4269\/ajtmh.2008.79.856","article-title":"Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi district, western Uganda","volume":"79","author":"Ndyomugyenyi","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0395","series-title":"The Pharmacological Basis of Therapeutics","first-page":"43","article-title":"Principles of therapeutics","author":"Nies","year":"1996"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0400","series-title":"Antimicrobial Therapy in Veterinary Medicine","first-page":"3","article-title":"Antimicrobial drug action and interaction: an introduction","author":"Prescott","year":"2000"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0405","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1017\/S0031182007000091","article-title":"ABC transporters and \u03b2-tubulin in macrocyclic lactones resistance: prospects for marker development","volume":"134","author":"Prichard","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0410","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.molbiopara.2013.02.004","article-title":"Derquantel and abamectin: effects and interactions on isolated tissues of Ascaris suum","volume":"188","author":"Puttachary","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0415","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00436-003-1003-6","article-title":"The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica","volume":"92","author":"Robinson","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0420","doi-asserted-by":"crossref","first-page":"e1000380","DOI":"10.1371\/journal.ppat.1000380","article-title":"Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel","volume":"5","author":"Rufener","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0425","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1124\/mol.110.066498","article-title":"Monepantel allosterically activates DEG-3\/DES-2 channels of the gastrointestinal nematode Haemonchus contortus","volume":"78","author":"Rufener","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0430","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ijpara.2010.11.009","article-title":"Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans","volume":"41","author":"Ruiz-Lancheros","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0435","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.vetpar.2010.02.011","article-title":"Quarantine treatment of sheep with monepantel-rapidity of fecal egg count reduction","volume":"170","author":"Sager","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0440","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2746\/0425164054530669","article-title":"Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses","volume":"37","author":"Sanchez Bruni","year":"2005","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0445","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vetpar.2013.07.037","article-title":"Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis","volume":"198","author":"Scott","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0450","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.vetpar.2013.12.020","article-title":"Combination anthelmintics effectively control ML-resistantparasites: a real-world case history","volume":"204","author":"Smith","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0455","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s00216-012-6584-4","article-title":"Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC\/MS\/MS","volume":"405","author":"Stuchl\u00edkov\u00e1","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0460","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/dta.1630","article-title":"Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus)","volume":"6","author":"Stuchl\u00edkov\u00e1","year":"2014","journal-title":"Drug Test Anal."},{"key":"10.1016\/j.vetpar.2015.07.015_bib9495","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cbi.2014.12.025","article-title":"Monepantel induces hepatic cytochromes p450 in sheep in vitro and in vivo","volume":"227","author":"Stuchl\u00edkov\u00e1","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0465","series-title":"Proceedings of the 24th International Conference of the World Association for the Advancement of Veterinary Parasitology","article-title":"Pharmaco-therapeutic evaluation of the closantel-moxidectin combination in lambs","author":"Suarez","year":"2013"},{"key":"10.1016\/j.vetpar.2015.07.015_bib0470","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetpar.2013.12.015","article-title":"Evaluation of pharmacological interactions after administration of a levamisole, albendazole and ivermectin triple combination in lambs","volume":"201","author":"Suarez","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0475","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pt.2010.11.008","article-title":"Anthelmintic resistance in nematode parasites of cattle: a global issue?","volume":"27","author":"Sutherland","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0495","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.vetpar.2015.02.026","article-title":"Haemonchus contortus resistance to monepantel in sheep","volume":"209","author":"Van den Brom","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0485","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0020-7519(96)00007-0","article-title":"The efficacy of ivermectin against nodular worms of pigs: the response to treatment using three different dose levels against Oesophagostomum dentatum and Oesophagostomum quadrispinulatum","volume":"26","author":"V\u00e1rady","year":"1996","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2015.07.015_bib0490","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0166-6851(97)00215-6","article-title":"Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog","volume":"91","author":"Xu","year":"1998","journal-title":"Mol. Biochem. Parasitol."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401715003441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401715003441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T11:24:08Z","timestamp":1599305048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401715003441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":98,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0304401715003441"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2015.07.015","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basic and clinical pharmacology contribution to extend anthelmintic molecules lifespan","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2015.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}