{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:21:06Z","timestamp":1790709666854,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2013\/00763-4"],"award-info":[{"award-number":["2013\/00763-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.vetpar.2016.06.032","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T12:45:26Z","timestamp":1466858726000},"page":"69-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Polarized M2 macrophages in dogs with visceral leishmaniasis"],"prefix":"10.1016","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5428-9047","authenticated-orcid":false,"given":"Pamela Rodrigues Reina","family":"Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe Santos","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio Jos\u00e9","family":"Montassier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Rog\u00e9rio","family":"Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemeri","family":"de Oliveira Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2016.06.032_bib0005","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-3024.2006.00840.x","article-title":"Immunology of canine leishamniasis","volume":"28","author":"Barbi\u00e9ri","year":"2006","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0010","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1128\/CDLI.8.4.828-831.2001","article-title":"Real-time PCR as a new tool for quantifying Leishmania infantum in liver in infected mice","volume":"8","author":"Bretagne","year":"2001","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0015","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1100\/2011\/213962","article-title":"Macrophage polarization in health and disease","volume":"11","author":"Casseta","year":"2011","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.vetpar.2016.06.032_bib0020","first-page":"1","article-title":"Deception and manipulation: the arms of Leishmania, a successful parasite","volume":"5","author":"Cec\u00edlio","year":"2014","journal-title":"Front. Immunol. Microbial Immunol."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0025","first-page":"791","article-title":"Peroxisome proliferator-activated receptor-\u03b3-mediated polarization of macrophages in Leishmania infection","volume":"12","author":"Chan","year":"2012","journal-title":"PPAR Res."},{"issue":"4","key":"10.1016\/j.vetpar.2016.06.032_bib0030","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jinf.2008.07.005","article-title":"Human visceral leishmaniasis expresses Th1 pattern in situ liver lesions","volume":"57","author":"Duarte","year":"2008","journal-title":"J. Infect."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0035","doi-asserted-by":"crossref","first-page":"e47045","DOI":"10.1371\/journal.pone.0047045","article-title":"The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer","volume":"7","author":"Edin","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.vetpar.2016.06.032_bib0040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-5699(99)01549-2","article-title":"Organ-specific immune responses associated with infectious diseasel","volume":"21","author":"Engwerda","year":"2000","journal-title":"Viewpoint Immunol. Today"},{"issue":"July(7)","key":"10.1016\/j.vetpar.2016.06.032_bib0045","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1369\/jhc.5A6871.2006","article-title":"AM-3K, an anti-macrophage antibody, recognizes CD163, a molecule associated with an anti-inflammatory macrophage phenotype","volume":"54","author":"Komohara","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.vetimm.2007.02.012","article-title":"Histopathological and immunohistochemical study of type 3 complement receptors (CD11b\/CD18) in livers and spleens of asymptomatic and symptomatic dogs naturally infected with Leishmania (Leishmania) chagasi","volume":"117","author":"Lima","year":"2007","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3748\/wjg.v6.i1.1","article-title":"On the cell biology of pit cells: the liver-specific NK cells","volume":"6","author":"Luo","year":"2000","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0060","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00436-010-1902-2","article-title":"Immune response pattern of the popliteal lymph nodes of dogs with visceral leishmaniasis","volume":"107","author":"Moreira","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0065","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.vetpar.2012.09.029","article-title":"Influence of apoptosis on the cutaneous and peripheral lymph node inflammatory response in dogs with visceral leishmaniasis","volume":"192","author":"Moreira","year":"2013","journal-title":"Vet. Parasitol."},{"issue":"10","key":"10.1016\/j.vetpar.2016.06.032_bib0070","doi-asserted-by":"crossref","first-page":"e0004145","DOI":"10.1371\/journal.pntd.0004145","article-title":"M2 Polarization of Monocytes-Macrophages is a hallmark of indian post kala-azar dermal leishmaniasis","volume":"9","author":"Mukhopadhyay","year":"2015","journal-title":"PLOS Negl. Trop. Dis."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00603","article-title":"Th1\/Th2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?","volume":"5","author":"Muraille","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1590\/S1984-29612008000100002","article-title":"A study of cross-reactivity in serum samples from dogs positive for Leishmania sp, Babesia canis and Ehrlichia canis in enzyme-linked immunosorbent assay and indirect fluorescent antibody test","volume":"17","author":"Oliveira","year":"2008","journal-title":"Rev. Bras. Parasitol. Vet."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0085","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.vetimm.2008.10.307","article-title":"Systemic and compartmentalized immune response in canine visceral leishmaniasis","volume":"128","author":"Reis","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"6","key":"10.1016\/j.vetpar.2016.06.032_bib0090","doi-asserted-by":"crossref","first-page":"618","DOI":"10.4269\/ajtmh.2004.70.618","article-title":"Organ-specific immunity in canine visceral leishmaniasis: analysis of symptomatic and asymptomatic dogs naturally infected with Leishmania chagasi","volume":"70","author":"Sanchez","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.vetpar.2016.06.032_bib0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1590\/S0036-46651996000200001","article-title":"Histopathology and immunocytochemical study of type 3 and 4 complement receptors in the liver and spleen of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi","volume":"38","author":"Tafuri","year":"1996","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.vetpar.2016.06.032_bib0100","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1354\/vp.37-2-168","article-title":"Distribution of cells immunopositive for AM-3K, a novel monoclonal antibody recognizing human macrophages, in normal and diseased tissues of dogs cats, horses, cattle, pigs, and rabbits","volume":"37","author":"Yamate","year":"2000","journal-title":"Vet. Pathol."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401716302515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401716302515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T18:34:28Z","timestamp":1600799668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401716302515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":20,"alternative-id":["S0304401716302515"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2016.06.032","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polarized M2 macrophages in dogs with visceral leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2016.06.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}