{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:58:47Z","timestamp":1785466727761,"version":"3.56.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31372428"],"award-info":[{"award-number":["31372428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental Research Funds for the Central Universities of China","award":["KYZ201631"],"award-info":[{"award-number":["KYZ201631"]}]},{"name":"Natural Science Foundation of Jiangsu Province of China","award":["BK20161442"],"award-info":[{"award-number":["BK20161442"]}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.vetpar.2016.09.010","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T04:18:56Z","timestamp":1474345136000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Evaluation of the persistence, integration, histopathology and environmental release of DNA vaccine encoding Eimeria tenella TA4 and chicken IL-2"],"prefix":"10.1016","volume":"229","author":[{"given":"Xiaokai","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2016.09.010_bib0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.trivac.2016.02.001","article-title":"Development of immunization trials against Eimeria spp","volume":"5","author":"Ahmad","year":"2016","journal-title":"Trials Vaccinol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0010","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1385\/MB:27:2:109","article-title":"The injection of plasmid DNA in mouse muscleresults in lifelong persistence of DNA, gene expression, and humoral response","volume":"27","author":"Armengol","year":"2004","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pt.2013.10.003","article-title":"Securing poultry production from the ever-present Eimeria challenge","volume":"30","author":"Blake","year":"2014","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0020","series-title":"Guidance for Industry: Considerations for Plasmid DNA Vaccines for Infectious","author":"CBER(Center for Biologics Evaluationand Research)","year":"2007"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0025","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.meatsci.2014.01.004","article-title":"A review of coccidiostats and the analysis of their residues in meat and other food","volume":"97","author":"Clarke","year":"2014","journal-title":"Meat Sci."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-0556-4-1","article-title":"Tissue distribution of a plasmid DNA encoding Hsp65 gene is dependent on the dose administered through intramuscular delivery","volume":"4","author":"Coelho-Castelo","year":"2006","journal-title":"Genet. Vaccines Ther."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1586\/14760584.5.1.143","article-title":"Poultry coccidiosis: recent advancements in control measures and vaccine development","volume":"5","author":"Dalloul","year":"2006","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0040","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.vaccine.2010.11.011","article-title":"Immunogenicity, safety, biodistribution and persistence of ADVAX, aprophylactic DNA vaccine for HIV-1, delivered by in vivo electroporation","volume":"29","author":"Dolter","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0045","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1016\/j.vaccine.2010.03.040","article-title":"Biosafety of DNA vaccines: new generation of DNA vectors and current knowledge on the fate of plasmids after injection","volume":"28","author":"Faurez","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.trivac.2014.04.001","article-title":"DNA vaccination for rabies: evaluation of preclinical safety and toxicology","volume":"3","author":"Garg","year":"2014","journal-title":"Trials Vaccinol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0055","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s10126-004-5129-z","article-title":"Analysis of DNA-vaccinated fish reveals viral antigen in muscle, kidney and thymus: and transient histopathologic changes","volume":"7","author":"Garver","year":"2005","journal-title":"Mar. Biotechnol. (NY)"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0060","doi-asserted-by":"crossref","first-page":"6930","DOI":"10.1016\/j.vaccine.2007.07.001","article-title":"In vivo tissue distribution and kinetics of a pseudorabies virus plasmid DNA vaccine after intramuscular injection in swine","volume":"25","author":"Gravier","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0065","first-page":"15","article-title":"Molecular Cloning: A Laboratory Manual.","year":"2012"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0070","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1191\/096032700678815891","article-title":"The PCR assay in the preclinical safety evaluation of nucleic acid medicines","volume":"19","author":"Haworth","year":"2000","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1479-0556-2-17","article-title":"DNA vaccines: designing strategies against parasitic infections","volume":"2","author":"Ivory","year":"2004","journal-title":"Genet. Vaccines Ther."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0080","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1046\/j.1365-2567.1999.00688.x","article-title":"The safety and longevity of DNA vaccines for fish","volume":"96","author":"Kanellos","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0085","doi-asserted-by":"crossref","first-page":"26","DOI":"10.11599\/germs.2013.1034","article-title":"DNA vaccines: roles against diseases","volume":"3","author":"Khan","year":"2013","journal-title":"Germs"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0090","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/BF02976869","article-title":"In vivo kinetics and biodistribution of a HIV-1 DNA vaccine after administration in mice","volume":"26","author":"Kim","year":"2003","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0095","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1016\/j.vaccine.2009.11.025","article-title":"FDA guidance on prophylactic DNA vaccines: analysis and recommendations","volume":"28","author":"Klinman","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1746-6148-2-18","article-title":"Evaluation of the persistenceand gene expression of an anti-chlamydophilapsittaci DNA vaccinein turkey muscle","volume":"2","author":"Loots","year":"2006","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0105","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1440-1711.2001.00979.x","article-title":"Rapid dissemination of intramuscularly inoculated DNA vaccines","volume":"79","author":"Mena","year":"2001","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0110","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.vaccine.2015.11.043","article-title":"DNA vaccination of poultry: the current status in 2015","volume":"34","author":"Meunier","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0115","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1101\/gr.168955.113","article-title":"Genomic analysis of the causative agents of coccidiosis in domestic chickens","volume":"24","author":"Reid","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0120","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1365-3024.2010.01209.x","article-title":"Chasing the golden egg: vaccination against poultry coccidiosis","volume":"32","author":"Sharman","year":"2010","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0125","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/toxsci\/kfj169","article-title":"Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts","volume":"91","author":"Sheets","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0130","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1093\/toxsci\/kfj170","article-title":"Toxicological safety evaluation of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar despite differing plasmid backbones or gene-inserts","volume":"91","author":"Sheets","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0135","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.vetpar.2008.10.015","article-title":"The optimal immunization procedure of DNA vaccine pcDNA-TA4-IL-2 of Eimeria tenella and its cross-immunity to Eimeria necatrix and Eimeria acervulina","volume":"159","author":"Song","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0140","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1016\/j.vaccine.2015.04.052","article-title":"Induction of protective immunity against Eimeria tenella, Eimeria necatrix, Eimeria maxima and Eimeria acervulina infections using multivalent epitope DNA vaccines","volume":"33","author":"Song","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0145","first-page":"HF05","article-title":"Hepatoprotectiverole of Caesalpeniabonduc: ahistopathological and biochemical study","volume":"8","author":"Sumalatha","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0150","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.vaccine.2004.08.004","article-title":"Biodistribution and general safety of a naked DNA plasmid, GTU-MultiHIV, in a rat, using a quantitative PCR method","volume":"23","author":"Tuomela","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0155","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1515\/ap-2015-0026","article-title":"Antiparasitic DNA vaccines in 21st century","volume":"60","author":"Wedrychowicz","year":"2015","journal-title":"Acta Parasitol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0160","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0020-7519(99)00086-7","article-title":"A compartmentalized model for estimation of the cost of coccidiosis to the world\u2019s chicken production industry","volume":"29","author":"William","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.vetpar.2016.09.010_bib0165","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1017\/S0031182014000195","article-title":"Strategies for anti-coccidial prophylaxis","volume":"141","author":"Witcombe","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.vetpar.2016.09.010_bib0170","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.vetpar.2008.05.025","article-title":"Vaccination of chickens with a chimeric DNA vaccine encoding Eimeria tenella TA4 and chicken IL-2 induces protective immunity against coccidiosis","volume":"156","author":"Xu","year":"2008","journal-title":"Vet. Parasitol."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401716303727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401716303727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T13:12:00Z","timestamp":1718802720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401716303727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":34,"alternative-id":["S0304401716303727"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2016.09.010","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the persistence, integration, histopathology and environmental release of DNA vaccine encoding Eimeria tenella TA4 and chicken IL-2","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2016.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}