{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:13:57Z","timestamp":1763367237719,"version":"3.37.3"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25450425"],"award-info":[{"award-number":["25450425"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Echinococcosis Prevention and Contro-Ganzi Workstation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.vetpar.2017.05.006","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T14:17:19Z","timestamp":1494598639000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Comparative study on secretome and transmembranome of immature and mature metacestodes of Echinococcus multilocularis"],"prefix":"10.1016","volume":"245","author":[{"given":"Fuqiang","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhisheng","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinpei","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeongsoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magona","family":"Joseph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzaburo","family":"Oku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2017.05.006_bib0005","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"year":"2014","series-title":"edgeR: Differential Expression Analysis of Digital Gene Expression Data User\u2019s Guide","author":"Chen","key":"10.1016\/j.vetpar.2017.05.006_bib0010"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0015","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/bioinformatics\/bts062","article-title":"WegoLoc: accurate prediction of protein subcellular localization using weighted Gene Ontology terms","volume":"28","author":"Chi","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0020","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.1016\/j.vaccine.2009.09.045","article-title":"Evaluation of Echinococcus multilocularis tetraspanins as vaccine candidates against primary alveolar echinococcosis","volume":"27","author":"Dang","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0025","doi-asserted-by":"crossref","first-page":"e1570","DOI":"10.1371\/journal.pntd.0001570","article-title":"A pilot study on developing mucosal vaccine against alveolar echinococcosis (AE) using recombinant tetraspanin 3: vaccine efficacy and immunology","volume":"6","author":"Dang","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.exppara.2015.03.019","article-title":"The laminated layer: recent advances and insights into Echinococcus biology and evolution","volume":"158","author":"D\u00edaz","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0035","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nprot.2007.131","article-title":"Locating proteins in the cell using TargetP, SignalP and related tools","volume":"2","author":"Emanuelsson","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0040","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1093\/nar\/gkn176","article-title":"High-throughput functional annotation and data mining with the Blast2GO suite","volume":"36","author":"G\u00f6tz","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0045","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1128\/IAI.70.7.3969-3972.2002","article-title":"Molecular cloning of a vaccine antigen against infection with the larval stage of Echinococcus multilocularis","volume":"70","author":"Gauci","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0050","doi-asserted-by":"crossref","first-page":"e0004634","DOI":"10.1371\/journal.pntd.0004634","article-title":"Analysis on gene expression profile in oncospheres and early stage metacestodes from Echinococcus multilocularis","volume":"10","author":"Huang","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/glycob\/cwp155","article-title":"An Echinococcus multilocularis coproantigen is a surface glycoprotein with unique O-gycosylation","volume":"20","author":"H\u00fclsmeier","year":"2010","journal-title":"Glycobiology"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0060","doi-asserted-by":"crossref","first-page":"W429","DOI":"10.1093\/nar\/gkm256","article-title":"Advantages of combined transmembrane topology and signal peptide prediction\u2014the Phobius web server","volume":"35","author":"K\u00e4ll","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0065","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jmb.2015.11.006","article-title":"BlastKOALA and GhostKOALA: KEGG tools for functional characterization of genome and metagenome sequences","volume":"428","author":"Kanehisa","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0070","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.gene.2013.08.005","article-title":"Screening for possible miRNA\u2013mRNA associations in a colon cancer cell line","volume":"533","author":"Kanematsu","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0075","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1017\/S0022149X15001169","article-title":"The timing of worm exclusion in dogs repeatedly infected with the cestode Echinococcus multilocularis","volume":"90","author":"Kouguchi","year":"2016","journal-title":"J. Helminthol."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0080","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0085","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u25b3\u25b3CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0090","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.parint.2010.06.003","article-title":"Primary alveolar echinococcosis: course of larval development and antibody responses in intermediate host rodents with different genetic backgrounds after oral infection with eggs of Echinococcus multilocularis","volume":"59","author":"Matsumoto","year":"2010","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0095","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1471-2105-10-159","article-title":"Transmembrane protein topology prediction using support vector machines","volume":"10","author":"Nugent","year":"2009","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0100","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0105","doi-asserted-by":"crossref","first-page":"D343","DOI":"10.1093\/nar\/gkv1118","article-title":"Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors","volume":"44","author":"Rawlings","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0110","doi-asserted-by":"crossref","first-page":"639362","DOI":"10.1155\/2012\/639362","article-title":"Host-parasite relationship in cystic echinococcosis: an evolving story","volume":"2012","author":"Siracusano","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"Tsai","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0120","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0125","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molbiopara.2012.01.001","article-title":"Excretory\/secretory products from in vitro-cultured Echinococcus granulosus protoscoleces","volume":"183","author":"Virginio","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0130","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1186\/s13071-015-1282-7","article-title":"Genome-wide analysis of excretory\/secretory proteins in Echinococcus multilocularis: insights into functional characteristics of the tapeworm secretome","volume":"8","author":"Wang","year":"2015","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.vetpar.2017.05.006_bib0135","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.4049\/jimmunol.181.10.6679","article-title":"Mechanisms of immunity in hydatid disease: implications for vaccine development","volume":"181","author":"Zhang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.vetpar.2017.05.006_bib0140","series-title":"InTech","article-title":"Recent Advances in the Immunology and Serological Diagnosis of Echinococcosis, Serological Diagnosis of Certain Human, Animal and Plant Diseases","author":"Zhang","year":"2012"}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401717302078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401717302078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T23:16:06Z","timestamp":1538003766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401717302078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":28,"alternative-id":["S0304401717302078"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2017.05.006","relation":{},"ISSN":["0304-4017"],"issn-type":[{"type":"print","value":"0304-4017"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative study on secretome and transmembranome of immature and mature metacestodes of Echinococcus multilocularis","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2017.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}