{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:38:04Z","timestamp":1770219484933,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Animal Management and Facilities"},{"name":"Biological Management and Efficacy teams at Yarrandoo R&D Centre"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.vetpar.2017.10.012","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T20:03:20Z","timestamp":1508789000000},"page":"4-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Characterization of multiple life stages of two Australian Fasciola hepatica isolates in sheep"],"prefix":"10.1016","volume":"248","author":[{"given":"S.D.","family":"George","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Vanhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"D\u2019Arcy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Emery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.F.","family":"Rolfe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2017.10.012_bib0005","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jee\/18.2.265a","article-title":"A method of computing the effectiveness of an insecticide","volume":"18","author":"Abbott","year":"1925","journal-title":"J. Econ. Entomol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0010","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/vr.159.13.424","article-title":"Resistance of Fasciola hepatica to triclabendazole and albendazole in sheep in Spain","volume":"159","author":"Alvarez-Sanchez","year":"2006","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0015","series-title":"Efficacy of Anthelmintics: Specific Recomendations for Ovines","first-page":"13","author":"Anonymous","year":"1999"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0020","series-title":"FlukeKill\u2122 360\u00b0 Liver Fluke Control Manual","author":"Anonymous","year":"2016"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.vetpar.2011.11.060","article-title":"Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep: including characterisation of the nematode isolate","volume":"186","author":"Baker","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0030","series-title":"Advances in Veterinary Medicine","first-page":"166","article-title":"Drug resistance in fasciola hepatica","author":"Boray","year":"1989"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0065-308X(08)60435-2","article-title":"Experimental fascioliasis in Australia","volume":"7","author":"Boray","year":"1969","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0040","series-title":"Chemotherapy of Parasitic Diseases","first-page":"401","article-title":"Trematode infections of domestic animals","author":"Boray","year":"1986"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0045","series-title":"Resistance to Antiparasitic Drugs","first-page":"51","article-title":"Drug resistance in Fasciola hepatica","author":"Boray","year":"1990"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0050","unstructured":"Boray J.C. 1994. Synergistic anthelmintic compositions against Fasciola hepatica and other Fasciola species. In European_Patent_Office (EP0710105 B1)."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0055","series-title":"Turning the Worm","article-title":"Drug resistance in Fasciola hepatica","author":"Boray","year":"2005"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0060","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yexmp.2007.01.009","article-title":"Understanding triclabendazole resistance","volume":"82","author":"Brennan","year":"2007","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0065","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.vetpar.2013.04.012","article-title":"Comparative kinetics of serological and coproantigen ELISA and faecal egg count in cattle experimentally infected with Fasciola hepatica and following treatment with triclabendazole","volume":"196","author":"Brockwell","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0304-4017(92)90141-U","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance","volume":"44","author":"Coles","year":"1992","journal-title":"Vet. Parasitol."},{"issue":"153","key":"10.1016\/j.vetpar.2017.10.012_bib0075","first-page":"151","article-title":"Composite faecal egg count reduction test to detect resistance to triclabendazole in Fasciola hepatica","volume":"171","author":"Daniel","year":"2012","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0080","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.exppara.2009.10.013","article-title":"Fasciola gigantica: parasitological and scanning electron microscopy study of the in vitro effects of ivermectin and\/or artemether","volume":"124","author":"Diab","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/vr.111.9.177","article-title":"Comparison of the activity of some fasciolicides against immature liver fluke in calves","volume":"111","author":"Dobbins","year":"1982","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/tvjl.1999.0377","article-title":"Fasciolicides: efficacy, actions, resistance and its management","volume":"158","author":"Fairweather","year":"1999","journal-title":"Vet. J."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0095","series-title":"Fasciolosis","first-page":"225","article-title":"Mechanisms of fasciolicide action and drug resistance in Fasciola hepatica","author":"Fairweather","year":"1999"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2010.12.011","article-title":"Liver fluke isolates: a question of provenance","volume":"176","author":"Fairweather","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.vetpar.2011.05.034","article-title":"Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?","volume":"180","author":"Fairweather","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0110","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.vetpar.2010.10.057","article-title":"Comparison of two assays, a faecal egg count reduction test (FECRT) and a coproantigen reduction test (CRT): for the diagnosis of resistance to triclabendazole in Fasciola hepatica in sheep","volume":"176","author":"Flanagan","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0115","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.vetpar.2012.09.004","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Guideline: anthelmintic combination products targeting nematode infections of ruminants and horses","volume":"190","author":"Geary","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0120","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.vetpar.2012.03.001","article-title":"The comparative efficacy of abamectin, monepantel and an abamectin\/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep","volume":"188","author":"George","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0125","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.vetpar.2017.08.028","article-title":"Application of a coproantigen ELISA as an indicator of efficacy against multiple life stages Fasciola hepatica infections in sheep","volume":"246","author":"George","year":"2017","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0130","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1751-0813.1981.tb00451.x","article-title":"The isolation of a field strain of Haemonchus contortus in Queensland showing multiple anthelmintic resistance","volume":"57","author":"Green","year":"1981","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0135","first-page":"317","volume":"2","author":"Guerrero","year":"1984"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0140","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1751-0813.1969.tb05009.x","article-title":"Quantitative diagnosis of chronic fasciolosis. 1. Comparative studies on quantitative faecal examinations for chronic Fasciola hepatica infection in sheep","volume":"45","author":"Happich","year":"1969","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0145","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.vetpar.2008.11.028","article-title":"Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep","volume":"160","author":"Hosking","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0150","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.vetpar.2009.03.032","article-title":"Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle","volume":"162","author":"Hutchinson","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00436-010-2216-0","article-title":"Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep","volume":"109","author":"Kaminsky","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/vr.97.1.9","article-title":"Chemotherapy of infection with Fasciola hepatica in cattle","volume":"97","author":"Kendall","year":"1975","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0165","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2460\/ajvr.1985.46.07.1553","article-title":"Comparative efficacy of clorsulon and albendazole against Fasciola hepatica in cattle","volume":"46","author":"Kilgore","year":"1985","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0170","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2460\/ajvr.1984.45.05.851","article-title":"Efficacy of clorsulon for treatment of mature naturally acquired and 8-week-old experimentally induced Fasciola hepatica infections in cattle","volume":"45","author":"Malone","year":"1984","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0175","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.vetpar.2012.06.002","article-title":"Comparison of three different techniques to diagnose Fasciola hepatica infection in experimentally and naturally infected sheep","volume":"190","author":"Martinez-Perez","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0180","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1017\/S0031182006001806","article-title":"Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica","author":"McManus","year":"2006","journal-title":"Parasitol"},{"key":"10.1016\/j.vetpar.2017.10.012_bib0185","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00436-006-0222-z","article-title":"Fasciola hepatica: morphological effects of a combination of triclabendazole and clorsulon against mature fluke","volume":"99","author":"Meaney","year":"2006","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0190","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00436-006-0378-6","article-title":"Fasciola hepatica: ultrastructural effects of a combination of triclabendazole and clorsulon against mature fluke","volume":"100","author":"Meaney","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0195","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1645\/GE-192R","article-title":"An ultrasensitive capture ELISA for detection of Fasciola hepatica coproantigens in sheep and cattle using a new monoclonal antibody (MM3)","volume":"90","author":"Mezo","year":"2004","journal-title":"J. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0200","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/inpract.24.7.378","article-title":"Update on fasciolosis in cattle and sheep","volume":"24","author":"Mitchell","year":"2002","journal-title":"In Pract."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2885.1987.tb00089.x","article-title":"The pharmacodynamics of the flukicidal salicylanilides, rafoxanide, closantel and oxyclosanide","volume":"10","author":"Mohammed-Ali","year":"1987","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0210","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0007-1935(17)34144-1","article-title":"The efficacy of 4-amino-6-trichloroethenyl-1,3-benzenedisulphonamide against liver fluke in sheep and cattle","volume":"133","author":"Ostlind","year":"1977","journal-title":"Br. Vet. J."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0215","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/vr.145.16.468","article-title":"Efficacy of an injectable ivermectin\/clorsulon combination against Fasciola hepatica in sheep","volume":"145","author":"Rehbein","year":"1999","journal-title":"Vet. Rec."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vetpar.2012.03.029","article-title":"Update on trematode infections in sheep","volume":"189","author":"Rojo-Vazquez","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0225","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vetpar.2008.10.006","article-title":"Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep","volume":"159","author":"Sager","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0230","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vetpar.2013.07.037","article-title":"Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis","volume":"198","author":"Scott","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0235","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-4017(00)00443-X","article-title":"International harmonisation of anthelmintic efficacy guidelines","volume":"96","author":"Vercruysse","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0240","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00436-004-1222-5","article-title":"Response of two isolates of Fasciola hepatica to treatment with triclabendazole in vivo and in vitro","volume":"94","author":"Walker","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2017.10.012_bib0245","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.biotechadv.2009.12.003","article-title":"Elucidating the transcriptome of Fasciola hepatica \u2212 a key to fundamental and biotechnological discoveries for a neglected parasite","volume":"28","author":"Young","year":"2010","journal-title":"Biotechnol. Adv."}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401717304491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401717304491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T17:49:59Z","timestamp":1750960199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401717304491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":49,"alternative-id":["S0304401717304491"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2017.10.012","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of multiple life stages of two Australian Fasciola hepatica isolates in sheep","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2017.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}