{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:07:33Z","timestamp":1790024853861,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Parasitology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.vetpar.2019.07.011","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T10:54:13Z","timestamp":1564224853000},"page":"11-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Efficacy of imidacloprid 10%\/moxidectin 2.5% spot on (Advocate\u00ae, Advantage Multi\u00ae) and doxycycline for the treatment of natural Dirofilaria immitis infections in dogs"],"prefix":"10.1016","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3768-2482","authenticated-orcid":false,"given":"Marco","family":"Genchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-5804","authenticated-orcid":false,"given":"Alice","family":"Vismarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lucchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Viglietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Crosara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Gnudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Quintavalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Schaper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vetpar.2019.07.011_bib0005","series-title":"Heartworm incidence maps","author":"American Heartworm Society","year":"2016"},{"key":"10.1016\/j.vetpar.2019.07.011_bib0010","series-title":"The AHS guidelines, update","author":"American Heartworm Society","year":"2018"},{"key":"10.1016\/j.vetpar.2019.07.011_bib0015","first-page":"18","article-title":"La filariasi del cane","volume":"44","author":"Balbo","year":"1968","journal-title":"La Nuova Vet."},{"key":"10.1016\/j.vetpar.2019.07.011_bib0020","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2307\/2533441","article-title":"Evaluation of experiments with adaptive interim analysis","volume":"50","author":"Bauer","year":"1994","journal-title":"Biometrics"},{"issue":"12","key":"10.1016\/j.vetpar.2019.07.011_bib0025","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.ijpara.2008.03.002","article-title":"Combined ivermectin and doxycycline treatment has microfilaricidal and adulticidal activity against Dirofilaria immitis in experimentally infected dogs","volume":"38","author":"Bazzocchi","year":"2008","journal-title":"Int. J. Parasitol."},{"issue":"246","key":"10.1016\/j.vetpar.2019.07.011_bib0030","article-title":"Heat pretreatment of canine samples to evaluate efficacy of imidacloprid + moxidectin and doxycycline in heartworm treatment","volume":"10","author":"Bendas","year":"2017","journal-title":"Parasites Vectors"},{"issue":"12","key":"10.1016\/j.vetpar.2019.07.011_bib0035","article-title":"Protection of dogs against canine heartworm infection 28 days after four monthly treatments with Advantage Multi (R) for dogs","volume":"9","author":"Bowman","year":"2016","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.vetpar.2019.07.011_bib0040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.vetpar.2016.05.032","article-title":"Heat treatment of serum samples from stray dogs naturally exposed to Dirofilaria immitis and Dirofilaria repens in Romania","volume":"225","author":"Ciuc\u0103","year":"2016","journal-title":"Vet. Parasitol."},{"issue":"39","key":"10.1016\/j.vetpar.2019.07.011_bib0045","article-title":"Increasing incidence of Dirofilaria immitis in dogs in USA with focus on the southeast region 2013-2016","volume":"11","author":"Drake","year":"2018","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.vetpar.2019.07.011_bib0050","series-title":"Guidelines for clinical management of canine heartworm disease","author":"European Society of Dirofilariosis and Angiostrongylosis (ESDA)","year":"2017"},{"issue":"4","key":"10.1016\/j.vetpar.2019.07.011_bib0055","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.vetpar.2009.03.026","article-title":"Climate and dirofilaria infection in Europe","volume":"163","author":"Genchi","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.07.011_bib0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.vetpar.2019.01.014","article-title":"Dirofilaria immitis and D. repens in dog and cat: a questionnaire study in Italy","volume":"267","author":"Genchi","year":"2019","journal-title":"Vet. Parasitol."},{"issue":"3\u20134","key":"10.1016\/j.vetpar.2019.07.011_bib0065","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.vetpar.2010.01.025","article-title":"A combination of doxycycline and ivermectin is adulticidal in dogs with naturally acquired heartworm disease (Dirofilaria immitis)","volume":"169","author":"Grandi","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.07.011_bib0070","first-page":"225","article-title":"Dose selection and confirmation of RM 340, a new filaricide for the treatment of dogs with immature and mature Dirofilaria immitis","author":"Keister","year":"1992","journal-title":"Proceedings of the Heartworm Symposium\u2019 92"},{"issue":"4","key":"10.1016\/j.vetpar.2019.07.011_bib0075","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/dmd.109.030700","article-title":"Role of P-glycoprotein in the disposition of macrocyclic lactones: a comparison between ivermectin, eprinomectin, and moxidectin in mice","volume":"38","author":"Kiki-Mvouaka","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.vetpar.2019.07.011_bib0080","first-page":"124","article-title":"Wolbachia and its importance in veterinary filariasis","volume":"5","author":"Kramer","year":"2007","journal-title":"Issues Infect. Dis."},{"issue":"4","key":"10.1016\/j.vetpar.2019.07.011_bib0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.vetpar.2011.01.021","article-title":"Evaluation of lung pathology in Dirofilaria immitis-experimentally infected dogs treated with doxycycline or a combination of doxycycline and ivermectin before administration of melarsomine dihydrochloride","volume":"176","author":"Kramer","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.vetpar.2019.07.011_bib0090","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.vetpar.2018.03.005","article-title":"Wolbachia, doxycycline and macrocyclic lactones: New prospects in the treatment of canine heartworm disease","volume":"254","author":"Kramer","year":"2018","journal-title":"Vet. Parasitol."},{"issue":"1","key":"10.1016\/j.vetpar.2019.07.011_bib0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejps.2006.10.004","article-title":"Interaction of macrocyclic lactones with P-glycoprotein: structure\u2013affinity relationship","volume":"30","author":"Lespine","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1\u20132","key":"10.1016\/j.vetpar.2019.07.011_bib0100","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.vetpar.2014.06.014","article-title":"Clinical assessment of post-adulticide complications in Dirofilaria immitis-naturally infected dogs treated with doxycycline and ivermectin","volume":"205","author":"Mavropoulou","year":"2014","journal-title":"Vet. Parasitol."},{"issue":"9","key":"10.1016\/j.vetpar.2019.07.011_bib0105","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1007\/s00436-014-3991-9","article-title":"First findings and prevalence of adult heartworms (Dirofilaria immitis) in wild carnivores from Serbia","volume":"113","author":"Penezi\u0107","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.vetpar.2019.07.011_bib0110","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijpddr.2012.04.001","article-title":"Moxidectin and the avermectins: consanguinity but not identity","volume":"2","author":"Prichard","year":"2012","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"issue":"245","key":"10.1016\/j.vetpar.2019.07.011_bib0115","article-title":"Assessment of parasitological findings in heartworm-infected beagles treated with Advantage Multi\u00ae for dogs (10% imidacloprid + 2.5% moxidectin) and doxycycline","volume":"10","author":"Savadelis","year":"2017","journal-title":"Parasites Vectors"},{"issue":"98","key":"10.1016\/j.vetpar.2019.07.011_bib0120","article-title":"Evaluation of heat-treating heartworm-positive canine serum samples during treatment with Advantage Multi\u00ae for dogs and doxycycline","volume":"11","author":"Savadelis","year":"2018","journal-title":"Parasites Vectors"},{"issue":"3\u20134","key":"10.1016\/j.vetpar.2019.07.011_bib0125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.vetpar.2004.06.024","article-title":"Efficacy of long-term monthly administration of ivermectin on the progress of naturally acquired heartworm infections in dogs","volume":"124","author":"Venco","year":"2004","journal-title":"Vet. Parasitol."},{"issue":"476","key":"10.1016\/j.vetpar.2019.07.011_bib0130","article-title":"Heat treatment and false-positive heartworm antigen testing in ex vivo parasites and dogs naturally infected by Dirofilaria repens and Angiostrongylus vasorum","volume":"10","author":"Venco","year":"2017","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.vetpar.2019.07.011_bib0135","first-page":"231","article-title":"Adulticide efficacy of RM 340 in dogs with mild and severe natural infections","author":"Vezzoni","year":"1992","journal-title":"Proceedings of the Heartworm Symposium\u2019 92"}],"container-title":["Veterinary Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401719301748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304401719301748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T01:31:24Z","timestamp":1759627884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304401719301748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":27,"alternative-id":["S0304401719301748"],"URL":"https:\/\/doi.org\/10.1016\/j.vetpar.2019.07.011","relation":{},"ISSN":["0304-4017"],"issn-type":[{"value":"0304-4017","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of imidacloprid 10%\/moxidectin 2.5% spot on (Advocate\u00ae, Advantage Multi\u00ae) and doxycycline for the treatment of natural Dirofilaria immitis infections in dogs","name":"articletitle","label":"Article Title"},{"value":"Veterinary Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vetpar.2019.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}